| | This journal provides immediate access to some articles. Letters On BC1 RNA and the fragile X mental retardation protein Claudia Bagni PMCID: PMC2359794 Acetylcholinesterase inhibition and Gulf War illnesses: Conclusions are not supported by independent reviews of the same evidence Dan Blazer, Gregory C. Gray, Matthew Hotopf, Gary Macfarlane, Malcolm Sim, Tyler C. Smith, and Simon Wessely PMCID: PMC2359790 This Week in PNAS Proc Natl Acad Sci U S A. 2008 April 29; 105(17): 6209–6210. doi: 10.1073/iti1708105.PMCID: PMC2359784 Commentaries Engineering channels: Atomic biology Bob Eisenberg PMCID: PMC2359799 Gastric O-acyl transferase activates hunger signal to the brain Jenny Tong, Paul T. Pfluger, and Matthias H. Tschöp PMCID: PMC2359824 Perspective Cell–cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype Harry Rubin PMCID: PMC2359782 Physical Sciences Applied Mathematics Ephaptic conduction in a cardiac strand model with 3D electrodiffusion Yoichiro Mori, Glenn I. Fishman, and Charles S. Peskin PMCID: PMC2359793 Applied Physical Sciences From the Cover:
Giant saltation on Mars Murilo P. Almeida, Eric J. R. Parteli, José S. Andrade, Jr, and Hans J. Herrmann PMCID: PMC2359785 Chemistry HF(v′ = 3) forward scattering in the F + H2 reaction: Shape resonance and slow-down mechanism Xingan Wang, Wenrui Dong, Minghui Qiu, Zefeng Ren, Li Che, Dongxu Dai, Xiuyan Wang, Xueming Yang, Zhigang Sun, Bina Fu, Soo-Y. Lee, Xin Xu, and Dong H. Zhang PMCID: PMC2359809 Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate Tsutomu Nakamura, Takahiko Yamamoto, Manabu Abe, Hiroyoshi Matsumura, Yoshihisa Hagihara, Tadashi Goto, Takafumi Yamaguchi, and Tsuyoshi Inoue PMCID: PMC2359787 Biological Sciences Biochemistry Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate Tsutomu Nakamura, Takahiko Yamamoto, Manabu Abe, Hiroyoshi Matsumura, Yoshihisa Hagihara, Tadashi Goto, Takafumi Yamaguchi, and Tsuyoshi Inoue PMCID: PMC2359787 Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation Kevin C. Slep, Michele A. Kercher, Thomas Wieland, Ching-Kang Chen, Melvin I. Simon, and Paul B. Sigler PMCID: PMC2359805 A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae Hui Zhou, Jixun Zhan, Kenji Watanabe, Xinkai Xie, and Yi Tang PMCID: PMC2359803 Biophysics Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase Ville R. I. Kaila, Michael I. Verkhovsky, Gerhard Hummer, and Mårten Wikström PMCID: PMC2359812 The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy Carsten Kötting, Angela Kallenbach, Yan Suveyzdis, Alfred Wittinghofer, and Klaus Gerwert PMCID: PMC2359817 Cell water dynamics on multiple time scales Erik Persson and Bertil Halle PMCID: PMC2359779 From the Cover:
Outer membrane protein G: Engineering a quiet pore for biosensing Min Chen, Syma Khalid, Mark S. P. Sansom, and Hagan Bayley PMCID: PMC2359795 Modeling transient collapsed states of an unfolded protein to provide insights into early folding events Daniel J. Felitsky, Michael A. Lietzow, H. Jane Dyson, and Peter E. Wright PMCID: PMC2359776 Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils Jonathan J. Helmus, Krystyna Surewicz, Philippe S. Nadaud, Witold K. Surewicz, and Christopher P. Jaroniec PMCID: PMC2359773 Calculation of protein–ligand binding free energy by using a polarizable potential Dian Jiao, Pavel A. Golubkov, Thomas A. Darden, and Pengyu Ren PMCID: PMC2359813 From the Cover:
A dry ligand-binding cavity in a solvated protein Johan Qvist, Monika Davidovic, Donald Hamelberg, and Bertil Halle PMCID: PMC2359778 Cell Biology Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway J. E. Kravchenko, G. V. Ilyinskaya, P. G. Komarov, L. S. Agapova, D. V. Kochetkov, E. Strom, E. I. Frolova, I. Kovriga, A. V. Gudkov, E. Feinstein, and P. M. Chumakov PMCID: PMC2327210 The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis Aurelie Doyotte, Aleksandr Mironov, Edward McKenzie, and Philip Woodman PMCID: PMC2359801 DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation Kedar Hastak, Rajib K. Paul, Mukesh K. Agarwal, Vijay S. Thakur, A. R. M. Ruhul Amin, Sudesh Agrawal, R. Michael Sramkoski, James W. Jacobberger, Mark W. Jackson, George R. Stark, and Munna L. Agarwal PMCID: PMC2359797 From the Cover:
Ghrelin octanoylation mediated by an orphan lipid transferase Jesus A. Gutierrez, Patricia J. Solenberg, Douglas R. Perkins, Jill A. Willency, Michael D. Knierman, Zhaoyan Jin, Derrick R. Witcher, Shuang Luo, Jude E. Onyia, and John E. Hale PMCID: PMC2359796 Developmental Biology Requirement of Nanog dimerization for stem cell self-renewal and pluripotency Jianlong Wang, Dana N. Levasseur, and Stuart H. Orkin PMCID: PMC2359802 Genetic approaches identify adult pituitary stem cells Anatoli S. Gleiberman, Tatyana Michurina, Juan M. Encinas, Jose L. Roig, Peter Krasnov, Francesca Balordi, Gord Fishell, Michael G. Rosenfeld, and Grigori Enikolopov PMCID: PMC2359820 Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice Jan C. Holstege, Wim de Graaff, Mehdi Hossaini, Sebastian Cardona Cano, Dick Jaarsma, Eric van den Akker, and Jacqueline Deschamps PMCID: PMC2359815 Ecology Strong human association with plant invasion success for Trifolium introductions to New Zealand Kelly Gravuer, Jon J. Sullivan, Peter A. Williams, and Richard P. Duncan PMCID: PMC2359821 DNA barcodes and cryptic species of skipper butterflies in the genus Perichares in Area de Conservación Guanacaste, Costa Rica John M. Burns, Daniel H. Janzen, Mehrdad Hajibabaei, Winnie Hallwachs, and Paul D. N. Hebert PMCID: PMC2359806 Evolution Ancient associations of aquatic beetles and tank bromeliads in the Neotropical forest canopy Michael Balke, Jesús Gómez-Zurita, Ignacio Ribera, Angel Viloria, Anne Zillikens, Josephina Steiner, Mauricio García, Lars Hendrich, and Alfried P. Vogler PMCID: PMC2359786 Complex genetic interactions underlying expression differences between Drosophila races: Analysis of chromosome substitutions Hurng-Yi Wang, Yonggui Fu, Mary Sara McPeek, Xuemei Lu, Sergey Nuzhdin, Anlong Xu, Jian Lu, Mao-Lien Wu, and Chung-I Wu PMCID: PMC2359775 Genetics Drosophila germ-line modulation of insulin signaling and lifespan Thomas Flatt, Kyung-Jin Min, Cecilia D'Alterio, Eugenia Villa-Cuesta, John Cumbers, Ruth Lehmann, D. Leanne Jones, and Marc Tatar PMCID: PMC2359818 Immunology Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice Arunika Mukhopadhaya, Tadashi Hanafusa, Irene Jarchum, Yi-Guang Chen, Yoshiko Iwai, David V. Serreze, Ralph M. Steinman, Kristin V. Tarbell, and Teresa P. DiLorenzo PMCID: PMC2359791 Medical Sciences Bromodomain 4 activation predicts breast cancer survival Nigel P. S. Crawford, Jude Alsarraj, Luanne Lukes, Renard C. Walker, Jennifer S. Officewala, Howard H. Yang, Maxwell P. Lee, Keiko Ozato, and Kent W. Hunter PMCID: PMC2359777 The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals Utako Yokoyama, Hemal H. Patel, N. Chin Lai, Nakon Aroonsakool, David M. Roth, and Paul A. Insel PMCID: PMC2359804 Notch signaling mediates hypoxia-induced tumor cell migration and invasion Cecilia Sahlgren, Maria V. Gustafsson, Shaobo Jin, Lorenz Poellinger, and Urban Lendahl PMCID: PMC2359811 Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption Peter Ellekvist, Jorge Maciel, Godfree Mlambo, Christina H. Ricke, Hanne Colding, Dan A. Klaerke, and Nirbhay Kumar PMCID: PMC2359770 Microbiology Protein exchange dynamics at chemoreceptor clusters in Escherichia coli Sonja Schulmeister, Michaela Ruttorf, Sebastian Thiem, David Kentner, Dirk Lebiedz, and Victor Sourjik PMCID: PMC2359816 Neuroscience From the Cover:
Tightly coupled brain activity and cerebral ATP metabolic rate Fei Du, Xiao-Hong Zhu, Yi Zhang, Michael Friedman, Nanyin Zhang, Kâmil Uğurbil, and Wei Chen PMCID: PMC2359810 Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, Aikaterini S. Papadopoulou, Wim Mandemakers, Asli N. Silahtaroglu, Sakari Kauppinen, André Delacourte, and Bart De Strooper PMCID: PMC2359789 Unusually rapid evolution of Neuroligin-4 in mice Marc F. Bolliger, Jimin Pei, Stephan Maxeiner, Antony A. Boucard, Nick V. Grishin, and Thomas C. Südhof PMCID: PMC2359808 Selective disruption of the mammalian secretory apparatus enhances or eliminates calcium current modulation in nerve endings Eugene M. Silinsky PMCID: PMC2359788 The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvae Yuanfeng Xia, Guirong Wang, Daniela Buscariollo, R. Jason Pitts, Heidi Wenger, and Laurence J. Zwiebel PMCID: PMC2359781 A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity Brian S. Johnson, J. Michael McCaffery, Susan Lindquist, and Aaron D. Gitler PMCID: PMC2359814 Role of epsin 1 in synaptic vesicle endocytosis Joel Jakobsson, Helge Gad, Fredrik Andersson, Peter Löw, Oleg Shupliakov, and Lennart Brodin PMCID: PMC2359800 Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1 Nicolas Stifani, Adriana R. O. Freitas, Anna Liakhovitskaia, Alexander Medvinsky, Artur Kania, and Stefano Stifani PMCID: PMC2359807 Pharmacology Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits Meera Soundararajan, Francis S. Willard, Adam J. Kimple, Andrew P. Turnbull, Linda J. Ball, Guillaume A. Schoch, Carina Gileadi, Oleg Y. Fedorov, Elizabeth F. Dowler, Victoria A. Higman, Stephanie Q. Hutsell, Michael Sundström, Declan A. Doyle, and David P. Siderovski PMCID: PMC2359823 Physiology Ephaptic conduction in a cardiac strand model with 3D electrodiffusion Yoichiro Mori, Glenn I. Fishman, and Charles S. Peskin PMCID: PMC2359793 Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor Swasti Tiwari, Nikhil Sharma, Pritmohinder S. Gill, Peter Igarashi, C. Ronald Kahn, James B. Wade, and Carolyn M. A. Ecelbarger PMCID: PMC2359822 Plant Biology Sunflower (Helianthus annuus L.) as a pre-Columbian domesticate in Mexico David L. Lentz, Mary DeLand Pohl, José Luis Alvarado, Somayeh Tarighat, and Robert Bye PMCID: PMC2359819 Arabidopsis TAO1 is a TIR-NB-LRR protein that contributes to disease resistance induced by the Pseudomonas syringae effector AvrB Timothy K. Eitas, Zachary L. Nimchuk, and Jeffery L. Dangl PMCID: PMC2327211 Dual-targeted tRNA-dependent amidotransferase ensures both mitochondrial and chloroplastic Gln-tRNAGln synthesis in plants Claire Pujol, Marc Bailly, Daniel Kern, Laurence Maréchal-Drouard, Hubert Becker, and Anne-Marie Duchêne PMCID: PMC2359783 The MUT9p kinase phosphorylates histone H3 threonine 3 and is necessary for heritable epigenetic silencing in Chlamydomonas J. Armando Casas-Mollano, Byeong-ryool Jeong, Jianping Xu, Hideaki Moriyama, and Heriberto Cerutti PMCID: PMC2359792 Psychology Compression of auditory space during rapid head turns Johahn Leung, David Alais, and Simon Carlile PMCID: PMC2359774 Sustainability Science Cost-effective global conservation spending is robust to taxonomic group Michael Bode, Kerrie A. Wilson, Thomas M. Brooks, Will R. Turner, Russell A. Mittermeier, Marissa F. McBride, Emma C. Underwood, and Hugh P. Possingham PMCID: PMC2359771 Social Sciences Anthropology Sunflower (Helianthus annuus L.) as a pre-Columbian domesticate in Mexico David L. Lentz, Mary DeLand Pohl, José Luis Alvarado, Somayeh Tarighat, and Robert Bye PMCID: PMC2359819 Correction Correction for Yu et al., Nucleoprotein structure of the CD4 locus: Implications for the mechanisms underlying CD4 regulation during T cell development PMCID: PMC2359798 Corrects: Ming Yu, et al. Nucleoprotein structure of the CD4 locus: Implications for the mechanisms underlying CD4 regulation during T cell development. Proc Natl Acad Sci U S A. 2008 March 11; 105(10): 3873–3878. |
