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Volume 4(2);  February 2008
Opinions
Novel Insights into Disseminated Candidiasis: Pathogenesis Research and Clinical Experience Converge
Brad Spellberg
PLoS Pathog. 2008 February; 4(2): e38. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040038.
PMCID: PMC2242839
Review
Parallels between Pathogens and Gluten Peptides in Celiac Sprue
Michael T Bethune and Chaitan Khosla
PLoS Pathog. 2008 February; 4(2): e34. Published online 2008 February 29. doi: 10.1371/journal.ppat.0040034.
PMCID: PMC2323203
Research Articles
Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus
Gülsah Gabriel, Astrid Herwig, and Hans-Dieter Klenk
PLoS Pathog. 2008 February; 4(2): e11. Published online 2008 February 1. doi: 10.1371/journal.ppat.0040011.
PMCID: PMC2222953
TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle
Pradeep D Uchil, Brian D Quinlan, Wai-Tsing Chan, Joseph M Luna, and Walther Mothes
PLoS Pathog. 2008 February; 4(2): e16. Published online 2008 February 1. doi: 10.1371/journal.ppat.0040016.
PMCID: PMC2222954
The Mannose Receptor Mediates Dengue Virus Infection of Macrophages
Joanna L Miller, Barend J. M deWet, Luisa Martinez-Pomares, Catherine M Radcliffe, Raymond A Dwek, Pauline M Rudd, and Siamon Gordon
PLoS Pathog. 2008 February; 4(2): e17. Published online 2008 February 8. doi: 10.1371/journal.ppat.0040017.
PMCID: PMC2233670
The Effect of Trim5 Polymorphisms on the Clinical Course of HIV-1 Infection
Daniëlle van Manen, Maarten A. N Rits, Corrine Beugeling, Karel van Dort, Hanneke Schuitemaker, and Neeltje A Kootstra
PLoS Pathog. 2008 February; 4(2): e18. Published online 2008 February 1. doi: 10.1371/journal.ppat.0040018.
PMCID: PMC2222955
Plasmodium falciparum Regulatory Subunit of cAMP-Dependent PKA and Anion Channel Conductance
Anaïs Merckx, Marie-Paule Nivez, Guillaume Bouyer, Pietro Alano, Gordon Langsley, Kirk Deitsch, Serge Thomas, Christian Doerig, and Stéphane Egée
PLoS Pathog. 2008 February; 4(2): e19. Published online 2008 February 1. doi: 10.1371/journal.ppat.0040019.
PMCID: PMC2222956
The Macaque Gut Microbiome in Health, Lentiviral Infection, and Chronic Enterocolitis
Philip McKenna, Christian Hoffmann, Nana Minkah, Pyone Pyone Aye, Andrew Lackner, Zongzhi Liu, Catherine A Lozupone, Micah Hamady, Rob Knight, and Frederic D Bushman
PLoS Pathog. 2008 February; 4(2): e20. Published online 2008 February 1. doi: 10.1371/journal.ppat.0040020.
PMCID: PMC2222957
Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1
Suzana P Salcedo, María Ines Marchesini, Hugues Lelouard, Emilie Fugier, Gilles Jolly, Stephanie Balor, Alexandre Muller, Nicolas Lapaque, Olivier Demaria, Lena Alexopoulou, Diego J Comerci, Rodolfo A Ugalde, Philippe Pierre, and Jean-Pierre Gorvel
PLoS Pathog. 2008 February; 4(2): e21. Published online 2008 February 8. doi: 10.1371/journal.ppat.0040021.
PMCID: PMC2233671
Inhibition of IκB Kinase by Vaccinia Virus Virulence Factor B14
Ron A.-J Chen, Grigory Ryzhakov, Samantha Cooray, Felix Randow, and Geoffrey L Smith
PLoS Pathog. 2008 February; 4(2): e22. Published online 2008 February 8. doi: 10.1371/journal.ppat.0040022.
PMCID: PMC2233672
Persistent Coxiella burnetii Infection in Mice Overexpressing IL-10: An Efficient Model for Chronic Q Fever Pathogenesis
Soraya Meghari, Yassina Bechah, Christian Capo, Hubert Lepidi, Didier Raoult, Peter J Murray, and Jean-Louis Mege
PLoS Pathog. 2008 February; 4(2): e23. Published online 2008 February 1. doi: 10.1371/journal.ppat.0040023.
PMCID: PMC2222951
A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity
Duangjit Kanistanon, Adeline M Hajjar, Mark R Pelletier, Larry A Gallagher, Thomas Kalhorn, Scott A Shaffer, David R Goodlett, Laurence Rohmer, Mitchell J Brittnacher, Shawn J Skerrett, and Robert K Ernst
PLoS Pathog. 2008 February; 4(2): e24. Published online 2008 February 8. doi: 10.1371/journal.ppat.0040024.
PMCID: PMC2233673
Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68
Bonsu Ku, Jae-Sung Woo, Chengyu Liang, Kwang-Hoon Lee, Hyang-Suk Hong, Xiaofei E, Key-Sun Kim, Jae U Jung, and Byung-Ha Oh
PLoS Pathog. 2008 February; 4(2): e25. Published online 2008 February 1. doi: 10.1371/journal.ppat.0040025.
PMCID: PMC2222952
NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens
Anthony L Keyburn, John D Boyce, Paola Vaz, Trudi L Bannam, Mark E Ford, Dane Parker, Antonio Di Rubbo, Julian I Rood, and Robert J Moore
PLoS Pathog. 2008 February; 4(2): e26. Published online 2008 February 8. doi: 10.1371/journal.ppat.0040026.
PMCID: PMC2233674
Tonsilar NK Cells Restrict B Cell Transformation by the Epstein-Barr Virus via IFN-γ
Till Strowig, Fabienne Brilot, Frida Arrey, Gwenola Bougras, Dolca Thomas, William A Muller, and Christian Münz
PLoS Pathog. 2008 February; 4(2): e27. Published online 2008 February 8. doi: 10.1371/journal.ppat.0040027.
PMCID: PMC2233668
Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis
Zsolt Tallóczy, Jose Martinez, Danielle Joset, Yonaton Ray, Attila Gácser, Sima Toussi, Noboru Mizushima, Josh Nosanchuk, Harris Goldstein, John Loike, David Sulzer, and Laura Santambrogio
PLoS Pathog. 2008 February; 4(2): e28. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040028.
PMCID: PMC2242831
A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease
Thérèse Couderc, Fabrice Chrétien, Clémentine Schilte, Olivier Disson, Madly Brigitte, Florence Guivel-Benhassine, Yasmina Touret, Georges Barau, Nadège Cayet, Isabelle Schuffenecker, Philippe Desprès, Fernando Arenzana-Seisdedos, Alain Michault, Matthew L Albert, and Marc Lecuit
PLoS Pathog. 2008 February; 4(2): e29. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040029.
PMCID: PMC2242832
A Role for NKG2D in NK Cell–Mediated Resistance to Poxvirus Disease
Min Fang, Lewis L Lanier, and Luis J Sigal
PLoS Pathog. 2008 February; 4(2): e30. Published online 2008 February 8. doi: 10.1371/journal.ppat.0040030.
PMCID: PMC2233669
Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization
Joppe W. R Hovius, Marein A. W. P de Jong, Jeroen den Dunnen, Manja Litjens, Erol Fikrig, Tom van der Poll, Sonja I Gringhuis, and Teunis B. H Geijtenbeek
PLoS Pathog. 2008 February; 4(2): e31. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040031.
PMCID: PMC2242833
The Landscape of Human Proteins Interacting with Viruses and Other Pathogens
Matthew D Dyer, T. M Murali, and Bruno W Sobral
PLoS Pathog. 2008 February; 4(2): e32. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040032.
PMCID: PMC2242834
Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP
Wafa Frigui, Daria Bottai, Laleh Majlessi, Marc Monot, Emmanuelle Josselin, Priscille Brodin, Thierry Garnier, Brigitte Gicquel, Carlos Martin, Claude Leclerc, Stewart T Cole, and Roland Brosch
PLoS Pathog. 2008 February; 4(2): e33. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040033.
PMCID: PMC2242835
Mucosal Damage and Neutropenia Are Required for Candida albicans Dissemination
Andrew Y Koh, Julia R Köhler, Kathleen T Coggshall, Nico Van Rooijen, and Gerald B Pier
PLoS Pathog. 2008 February; 4(2): e35. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040035.
PMCID: PMC2242836
Forward Genetic Analysis of the Apicomplexan Cell Division Cycle in Toxoplasma gondii
Marc-Jan Gubbels, Margaret Lehmann, Mani Muthalagi, Maria E Jerome, Carrie F Brooks, Tomasz Szatanek, Jayme Flynn, Ben Parrot, Josh Radke, Boris Striepen, and Michael W White
PLoS Pathog. 2008 February; 4(2): e36. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040036.
PMCID: PMC2242837
Nucleotide Biosynthesis Is Critical for Growth of Bacteria in Human Blood
Shalaka Samant, Hyunwoo Lee, Mahmood Ghassemi, Juan Chen, James L Cook, Alexander S Mankin, and Alexander A Neyfakh
PLoS Pathog. 2008 February; 4(2): e37. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040037.
PMCID: PMC2242838
Human Innate Mycobacterium tuberculosis–Reactive αβTCR+ Thymocytes
Marielle C Gold, Heather D Ehlinger, Matthew S Cook, Susan K Smyk-Pearson, Paul T Wille, Ross M Ungerleider, Deborah A Lewinsohn, and David M Lewinsohn
PLoS Pathog. 2008 February; 4(2): e39. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040039.
PMCID: PMC2242840
Nanobacteria Are Mineralo Fetuin Complexes
Didier Raoult, Michel Drancourt, Saïd Azza, Claude Nappez, Régis Guieu, Jean-Marc Rolain, Patrick Fourquet, Bernard Campagna, Bernard La Scola, Jean-Louis Mege, Pascal Mansuelle, Eric Lechevalier, Yvon Berland, Jean-Pierre Gorvel, and Patricia Renesto
PLoS Pathog. 2008 February; 4(2): e41. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040041.
PMCID: PMC2242841
Structural Insight into Epitopes in the Pregnancy-Associated Malaria Protein VAR2CSA
Pernille Andersen, Morten A Nielsen, Mafalda Resende, Thomas S Rask, Madeleine Dahlbäck, Thor Theander, Ole Lund, and Ali Salanti
PLoS Pathog. 2008 February; 4(2): e42. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040042.
PMCID: PMC2242842
Structure–Function Aspects of PstS in Multi-Drug–Resistant Pseudomonas aeruginosa
Olga Zaborina, Christopher Holbrook, Yimei Chen, Jason Long, Alexander Zaborin, Irina Morozova, Hoylan Fernandez, Yingmin Wang, Jerrold R Turner, and John C Alverdy
PLoS Pathog. 2008 February; 4(2): e43. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040043.
PMCID: PMC2242829
Iron Source Preference and Regulation of Iron Uptake in Cryptococcus neoformans
Won Hee Jung, Anita Sham, Tianshun Lian, Arvinder Singh, Daniel J Kosman, and James W Kronstad
PLoS Pathog. 2008 February; 4(2): e45. Published online 2008 February 15. doi: 10.1371/journal.ppat.0040045.
PMCID: PMC2242830
A Mycobacterial Enzyme Essential for Cell Division Synergizes with Resuscitation-Promoting Factor
Erik C. Hett, Michael C. Chao, Lynn L. Deng, and Eric J. Rubin
PLoS Pathog. 2008 February; 4(2): e1000001. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000001.
PMCID: PMC2262848
Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys
Ruchi M. Newman, Laura Hall, Andrea Kirmaier, Lu-Ann Pozzi, Erez Pery, Michael Farzan, Shawn P. O'Neil, and Welkin Johnson
PLoS Pathog. 2008 February; 4(2): e1000003. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000003.
PMCID: PMC2279257
IL-10 from CD4+CD25Foxp3CD127 Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection
Kevin N. Couper, Daniel G. Blount, Mark S. Wilson, Julius C. Hafalla, Yasmine Belkaid, Masahito Kamanaka, Richard A. Flavell, J. Brian de Souza, and Eleanor M. Riley
PLoS Pathog. 2008 February; 4(2): e1000004. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000004.
PMCID: PMC2291447
Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T Cells
Maria Paula Longhi, Kate Wright, Sarah N. Lauder, Mari A. Nowell, Gareth W. Jones, Andrew J. Godkin, Simon A. Jones, and Awen M. Gallimore
PLoS Pathog. 2008 February; 4(2): e1000006. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000006.
PMCID: PMC2279258
The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22
Stephen D. Barr, James R. Smiley, and Frederic D. Bushman
PLoS Pathog. 2008 February; 4(2): e1000007. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000007.
PMCID: PMC2279259
Adenylyl Cyclase α and cAMP Signaling Mediate Plasmodium Sporozoite Apical Regulated Exocytosis and Hepatocyte Infection
Takeshi Ono, Laura Cabrita-Santos, Ricardo Leitao, Esther Bettiol, Lisa A. Purcell, Olga Diaz-Pulido, Lucy B. Andrews, Takushi Tadakuma, Purnima Bhanot, Maria M. Mota, and Ana Rodriguez
PLoS Pathog. 2008 February; 4(2): e1000008. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000008.
PMCID: PMC2279260
An RND-Type Efflux System in Borrelia burgdorferi Is Involved in Virulence and Resistance to Antimicrobial Compounds
Ignas Bunikis, Katrin Denker, Yngve Östberg, Christian Andersen, Roland Benz, and Sven Bergström
PLoS Pathog. 2008 February; 4(2): e1000009. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000009.
PMCID: PMC2279261
Hepatocyte Permissiveness to Plasmodium Infection Is Conveyed by a Short and Structurally Conserved Region of the CD81 Large Extracellular Domain
Samir Yalaoui, Sergine Zougbédé, Stéphanie Charrin, Olivier Silvie, Cécile Arduise, Khemais Farhati, Claude Boucheix, Dominique Mazier, Eric Rubinstein, and Patrick Froissard
PLoS Pathog. 2008 February; 4(2): e1000010. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000010.
PMCID: PMC2279262
Metagenomic Analysis of Human Diarrhea: Viral Detection and Discovery
Stacy R. Finkbeiner, Adam F. Allred, Phillip I. Tarr, Eileen J. Klein, Carl D. Kirkwood, and David Wang
PLoS Pathog. 2008 February; 4(2): e1000011. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000011.
PMCID: PMC2290972
Multiple Reassortment Events in the Evolutionary History of H1N1 Influenza A Virus Since 1918
Martha I. Nelson, Cécile Viboud, Lone Simonsen, Ryan T. Bennett, Sara B. Griesemer, Kirsten St. George, Jill Taylor, David J. Spiro, Naomi A. Sengamalay, Elodie Ghedin, Jeffery K. Taubenberger, and Edward C. Holmes
PLoS Pathog. 2008 February; 4(2): e1000012. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000012.
PMCID: PMC2262849
Activation of Invariant NKT Cells Exacerbates Experimental Visceral Leishmaniasis
Amanda C. Stanley, Yonghong Zhou, Fiona H. Amante, Louise M. Randall, Ashraful Haque, Daniel G. Pellicci, Geoff R. Hill, Mark J. Smyth, Dale I. Godfrey, and Christian R. Engwerda
PLoS Pathog. 2008 February; 4(2): e1000028. Published online 2008 February 29. doi: 10.1371/journal.ppat.1000028.
PMCID: PMC2265425
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