Progress and Innovation

The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.

The molecular mechanism for the tetrameric association of glycogen phosphorylase promoted by protein phosphorylation.

Design, synthesis, and characterization of a protein sequencing reagent yielding amino acid derivatives with enhanced detectability by mass spectrometry.

Structural analysis of wild-type and mutant yeast calmodulins by limited proteolysis and electrospray ionization mass spectrometry.

Guanidine derivatives restore activity to carboxypeptidase lacking arginine-127.

Renaturation of citrate synthase: influence of denaturant and folding assistants.

Dissociation of peripheral protein-membrane complexes by high pressure.

Extreme pKa displacements at the active sites of FMN-dependent alpha-hydroxy acid-oxidizing enzymes.

Characterization of EntF as a serine-activating enzyme.