| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 March 21; 103(12): 4331–4332. doi: 10.1073/iti1206103.PMCID: PMC1450167 Commentaries How bile acids confer gut mucosal protection against bacteria Alan F. Hofmann and Lars Eckmann PMCID: PMC1450168 T cells like a firm molecular handshake Michael L. Dustin and Cheng Zhu PMCID: PMC1450169 Nitric oxide and cisplatin resistance: NO easy answers John J. Turchi PMCID: PMC1450170 Structural insight into the role of myelin basic protein in multiple sclerosis Cynthia Husted PMCID: PMC1450171 Profile Profile of Richard L. Huganir Tinsley H. Davis PMCID: PMC1450172 Physical Sciences Applied Mathematics On the existence and scaling of structure functions in turbulence according to the data Alexandre Arenas and Alexandre J. Chorin PMCID: PMC1450174 Chemistry Enzymatic aminoacylation of tRNA with unnatural amino acids Matthew C. T. Hartman, Kristopher Josephson, and Jack W. Szostak PMCID: PMC1450175 Suppressing Brownian motion of individual biomolecules in solution Adam E. Cohen and W. E. Moerner PMCID: PMC1450176 Engineering Beyond Rayleigh's criterion: A resolution measure with application to single-molecule microscopy Sripad Ram, E. Sally Ward, and Raimund J. Ober PMCID: PMC1450193 Environmental Sciences Impact of aerosol indirect effect on surface temperature over East Asia Yan Huang, Robert E. Dickinson, and William L. Chameides PMCID: PMC1450178 Geology The Avellino 3780-yr-B.P. catastrophe as a worst-case scenario for a future eruption at Vesuvius Giuseppe Mastrolorenzo, Pierpaolo Petrone, Lucia Pappalardo, and Michael F. Sheridan PMCID: PMC1450177 Geophysics Impact of aerosol indirect effect on surface temperature over East Asia Yan Huang, Robert E. Dickinson, and William L. Chameides PMCID: PMC1450178 Cross influences of ozone and sulfate precursor emissions changes on air quality and climate Nadine Unger, Drew T. Shindell, Dorothy M. Koch, and David G. Streets PMCID: PMC1397797 Statistics Surprising contribution to aminoacylation and translation of non-Watson–Crick pairs in tRNA William H. McClain PMCID: PMC1450212 Biological Sciences Anthropology From the Cover:
Cranial remains of an Eocene tarsier James B. Rossie, Xijun Ni, and K. Christopher Beard PMCID: PMC1450180 Biochemistry Enzymatic aminoacylation of tRNA with unnatural amino acids Matthew C. T. Hartman, Kristopher Josephson, and Jack W. Szostak PMCID: PMC1450175 Structural basis for mammalian vitamin B12 transport by transcobalamin Jochen Wuerges, Gianpiero Garau, Silvano Geremia, Sergey N. Fedosov, Torben E. Petersen, and Lucio Randaccio PMCID: PMC1450181 Self-catalyzed site-specific depurination of guanine residues within gene sequences Olga Amosova, Richard Coulter, and Jacques R. Fresco PMCID: PMC1450182 Targeted disruption of genes in the Bombyx mori sex pheromone biosynthetic pathway Atsushi Ohnishi, J. Joe Hull, and Shogo Matsumoto PMCID: PMC1450183 Three-dimensional structure of the bacterial cell wall peptidoglycan Samy O. Meroueh, Krisztina Z. Bencze, Dusan Hesek, Mijoon Lee, Jed F. Fisher, Timothy L. Stemmler, and Shahriar Mobashery PMCID: PMC1450184 Biophysics Suppressing Brownian motion of individual biomolecules in solution Adam E. Cohen and W. E. Moerner PMCID: PMC1450176 Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation Christopher L. Colbert, Qiong Wu, Paul J. A. Erbel, Kevin H. Gardner, and Johann Deisenhofer PMCID: PMC1400588 From the Cover:
Molecular flexibility can influence the stimulatory ability of receptor–ligand interactions at cell–cell junctions Shuyan Qi, Michelle Krogsgaard, Mark M. Davis, and Arup K. Chakraborty PMCID: PMC1450186 From the Cover:
Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope Abdiwahab A. Musse, Joan M. Boggs, and George Harauz PMCID: PMC1450187 A method for evaluating the structural quality of protein models by using higher-order ![[var phi]](corehtml/pmc/pmcents/x03C6.gif) –ψ pairs scoring Gregory E. Sims and Sung-Hou Kim PMCID: PMC1401231 Residues in substrate proteins that interact with GroEL in the capture process are buried in the native state George Stan, Bernard R. Brooks, George H. Lorimer, and D. Thirumalai PMCID: PMC1450189 Thermodynamic and kinetic modeling of transcriptional pausing Vasisht R. Tadigotla, Dáibhid Ó Maoiléidigh, Anirvan M. Sengupta, Vitaly Epshtein, Richard H. Ebright, Evgeny Nudler, and Andrei E. Ruckenstein PMCID: PMC1450190 Automated local bright feature image analysis of nuclear protein distribution identifies changes in tissue phenotype David W. Knowles, Damir Sudar, Carol Bator-Kelly, Mina J. Bissell, and Sophie A. Lelièvre PMCID: PMC1450191 The molecular elasticity of the insect flight muscle proteins projectin and kettin Belinda Bullard, Tzintzuni Garcia, Vladimir Benes, Mark C. Leake, Wolfgang A. Linke, and Andres F. Oberhauser PMCID: PMC1450192 Beyond Rayleigh's criterion: A resolution measure with application to single-molecule microscopy Sripad Ram, E. Sally Ward, and Raimund J. Ober PMCID: PMC1450193 Cell Biology Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein Deborah N. Chadee, Dazhong Xu, Gene Hung, Ali Andalibi, David J. Lim, Zhijun Luo, David H. Gutmann, and John M. Kyriakis PMCID: PMC1450194 Circadian clock genes frequency and white collar-1 are not essential for entrainment to temperature cycles in Neurospora crassa Patricia L. Lakin-Thomas PMCID: PMC1450195 S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents Mauricio A. Retamal, Constanza J. Cortés, Luis Reuss, Michael V. L. Bennett, and Juan C. Sáez PMCID: PMC1450196 Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level Jacob Ilany, Philip J. Bilan, Sonia Kapur, James S. Caldwell, Mary-Elizabeth Patti, Andre Marette, and C. Ronald Kahn PMCID: PMC1450197 Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster André P. Gerber, Stefan Luschnig, Mark A. Krasnow, Patrick O. Brown, and Daniel Herschlag PMCID: PMC1400586 Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin Bedrick B. Gadea and Joan V. Ruderman PMCID: PMC1401233 Developmental Biology Social exploitation of hexamerin: RNAi reveals a major caste-regulatory factor in termites Xuguo Zhou, Faith M. Oi, and Michael E. Scharf PMCID: PMC1450200 Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling Natalia A. Riobó, Ke Lu, Xingbin Ai, Gwendolyn M. Haines, and Charles P. Emerson, Jr. PMCID: PMC1450201 A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development John Cobb, Andrée Dierich, Yolande Huss-Garcia, and Denis Duboule PMCID: PMC1450202 Serum response factor MADS box serine -162 phosphorylation switches proliferation and myogenic gene programs Dinakar Iyer, David Chang, Joe Marx, Lei Wei, Eric N. Olson, Michael S. Parmacek, Ashok Balasubramanyam, and Robert J. Schwartz PMCID: PMC1450203 Ecology Reduced nitrate leaching and enhanced denitrifier activity and efficiency in organically fertilized soils Sasha B. Kramer, John P. Reganold, Jerry D. Glover, Brendan J. M. Bohannan, and Harold A. Mooney PMCID: PMC1450204 Evolution Recombination between elongation factor 1α genes from distantly related archaeal lineages Yuji Inagaki, Edward Susko, and Andrew J. Roger PMCID: PMC1450205 Genetics High-resolution mapping of DNA copy alterations in human chromosome 22 using high-density tiling oligonucleotide arrays Alexander Eckehart Urban, Jan O. Korbel, Rebecca Selzer, Todd Richmond, April Hacker, George V. Popescu, Joseph F. Cubells, Roland Green, Beverly S. Emanuel, Mark B. Gerstein, Sherman M. Weissman, and Michael Snyder PMCID: PMC1450206 Self-synthesizing DNA transposons in eukaryotes Vladimir V. Kapitonov and Jerzy Jurka PMCID: PMC1450207 From the Cover:
The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses Alexander Idnurm, Julio Rodríguez-Romero, Luis M. Corrochano, Catalina Sanz, Enrique A. Iturriaga, Arturo P. Eslava, and Joseph Heitman PMCID: PMC1450208 A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample Camila Guindalini, Mark Howard, Kate Haddley, Ronaldo Laranjeira, David Collier, Nik Ammar, Ian Craig, Colin O’Gara, Vivian J. Bubb, Tiffany Greenwood, John Kelsoe, Phil Asherson, Robin M. Murray, Adauto Castelo, John P. Quinn, Homero Vallada, and Gerome Breen PMCID: PMC1450209 Role of the lytic repressor in prophage induction of phage λ as analyzed by a module-replacement approach Shota Atsumi and John W. Little PMCID: PMC1450210 Interplay between replication and recombination in Escherichia coli: Impact of the alternative DNA polymerases Stéphane Delmas and Ivan Matic PMCID: PMC1450211 Surprising contribution to aminoacylation and translation of non-Watson–Crick pairs in tRNA William H. McClain PMCID: PMC1450212 Immunology From the Cover:
Molecular flexibility can influence the stimulatory ability of receptor–ligand interactions at cell–cell junctions Shuyan Qi, Michelle Krogsgaard, Mark M. Davis, and Arup K. Chakraborty PMCID: PMC1450186 Inhibitor-binding mode of homobelactosin C to proteasomes: New insights into class I MHC ligand generation Michael Groll, Oleg V. Larionov, Robert Huber, and Armin de Meijere PMCID: PMC1450213 Gestation stage-dependent mechanisms of invariant natural killer T cell-mediated pregnancy loss Jonathan E. Boyson, Nisha Nagarkatti, Leena Nizam, Mark A. Exley, and Jack L. Strominger PMCID: PMC1450214 Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies Erwin De Genst, Karen Silence, Klaas Decanniere, Katja Conrath, Remy Loris, Jörg Kinne, Serge Muyldermans, and Lode Wyns PMCID: PMC1450215 Medical Sciences Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells Eric Dobrzynski, Julie C. Fitzgerald, Ou Cao, Federico Mingozzi, Lixin Wang, and Roland W. Herzog PMCID: PMC1450216 Kupffer cell-dependent TNF-α signaling mediates injury in the arterialized small-for-size liver transplantation in the mouse Yinghua Tian, Wolfram Jochum, Panco Georgiev, Wolfgang Moritz, Rolf Graf, and Pierre-Alain Clavien PMCID: PMC1400589 Proapoptotic Bid is required for pulmonary fibrosis G. R. Scott Budinger, Gökhan M. Mutlu, James Eisenbart, Alyson C. Fuller, Amy A. Bellmeyer, Christina M. Baker, Mindy Wilson, Karen Ridge, Terrence A. Barrett, Vivian Y. Lee, and Navdeep S. Chandel PMCID: PMC1401229 Lipopeptide antagonists of growth hormone-releasing hormone with improved antitumor activities Marta Zarandi, Jozsef L. Varga, Andrew V. Schally, Judit E. Horvath, Gabor L. Toller, Magdolna Kovacs, Markus Letsch, Kate Groot, Patricia Armatis, and Gabor Halmos PMCID: PMC1450219 Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin Kozo Nakai, Maria B. Kadiiska, Jin-Jie Jiang, Krisztian Stadler, and Ronald P. Mason PMCID: PMC1450220 The DNA repair genes XPB and XPD defend cells from retroviral infection Kristine Yoder, Alain Sarasin, Kenneth Kraemer, Michael McIlhatton, Frederic Bushman, and Richard Fishel PMCID: PMC1450221 High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis Rabindra Tirouvanziam, Carol K. Conrad, Teodoro Bottiglieri, Leonore A. Herzenberg, Richard B. Moss, and Leonard A. Herzenberg PMCID: PMC1450222 Microbiology Sinorhizobium meliloti bluB is necessary for production of 5,6-dimethylbenzimidazole, the lower ligand of B12 Gordon R. O. Campbell, Michiko E. Taga, Kavita Mistry, Javier Lloret, Peter J. Anderson, John R. Roth, and Graham C. Walker PMCID: PMC1450223 Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor Gen Wang, John W. Barrett, Marianne Stanford, Steven J. Werden, James B. Johnston, Xiujuan Gao, Mei Sun, Jin Q. Cheng, and Grant McFadden PMCID: PMC1450224 Reverse genetics system for introduction of site-specific mutations into the double-stranded RNA genome of infectious rotavirus Satoshi Komoto, Jun Sasaki, and Koki Taniguchi PMCID: PMC1450225 Modeling the role of bacteriophage in the control of cholera outbreaks Mark A. Jensen, Shah M. Faruque, John J. Mekalanos, and Bruce R. Levin PMCID: PMC1450226 Indoleacetic acid, a product of transferred DNA, inhibits vir gene expression and growth of Agrobacterium tumefaciens C58 Pu Liu and Eugene W. Nester PMCID: PMC1450227 Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA Lukas Flatz, Andreas Bergthaler, Juan Carlos de la Torre, and Daniel D. Pinschewer PMCID: PMC1450228 Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1 Jeffrey A. Gralnick, Hojatollah Vali, Douglas P. Lies, and Dianne K. Newman PMCID: PMC1450229 Neuroscience INAUGURAL ARTICLE by a Recently Elected Academy Member: SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons Gavin Rumbaugh, J. Paige Adams, Jee H. Kim, and Richard L. Huganir PMCID: PMC1450173 Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1 Chittaranjan Das, Quyen Q. Hoang, Cheryl A. Kreinbring, Sarah J. Luchansky, Robin K. Meray, Soumya S. Ray, Peter T. Lansbury, Dagmar Ringe, and Gregory A. Petsko PMCID: PMC1450230 Form deprivation modulates retinal neurogenesis in primate experimental myopia Andrei V. Tkatchenko, Pamela A. Walsh, Tatiana V. Tkatchenko, Stefano Gustincich, and Elio Raviola PMCID: PMC1400590 Altered sleep–wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice Zhi-Li Huang, Takatoshi Mochizuki, Wei-Min Qu, Zong-Yuan Hong, Takeshi Watanabe, Yoshihiro Urade, and Osamu Hayaishi PMCID: PMC1450232 Discrete and analogue quantity processing in the parietal lobe: A functional MRI study Fulvia Castelli, Daniel E. Glaser, and Brian Butterworth PMCID: PMC1450233 Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways Amalia Di Castro, Liam J. Drew, John N. Wood, and Paolo Cesare PMCID: PMC1450234 Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats Alexandre Mouravlev, Jane Dunning, Deborah Young, and Matthew J. During PMCID: PMC1401230 Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor Virginie Fontaine-Lenoir, Béatrice Chambraud, Arlette Fellous, Sébastien David, Yann Duchossoy, Etienne-Emile Baulieu, and Paul Robel PMCID: PMC1450236 p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling Douglas J. Sheffler, Wesley K. Kroeze, Bonnie G. Garcia, Ariel Y. Deutch, Sandra J. Hufeisen, Patrick Leahy, Jens C. Brüning, and Bryan L. Roth PMCID: PMC1450237 Wiring optimization can relate neuronal structure and function Beth L. Chen, David H. Hall, and Dmitri B. Chklovskii PMCID: PMC1550972 Pharmacology Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts Je-Tae Woo, Makoto Kawatani, Masanori Kato, Toshimasa Shinki, Takayuki Yonezawa, Naoki Kanoh, Hiroshi Nakagawa, Masamichi Takami, Kun Hyung Lee, Paula H. Stern, Kazuo Nagai, and Hiroyuki Osada PMCID: PMC1450238 Physiology Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B Thomas H. Langenickel, Jens Buttgereit, Ines Pagel-Langenickel, Maren Lindner, Jan Monti, Knut Beuerlein, Nidal Al-Saadi, Ralph Plehm, Elena Popova, Jens Tank, Rainer Dietz, Roland Willenbrock, and Michael Bader PMCID: PMC1450239 The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle T. A. Hornberger, W. K. Chu, Y. W. Mak, J. W. Hsiung, S. A. Huang, and S. Chien PMCID: PMC1450240 Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions Venkataramana K. Sidhaye, Ali D. Güler, Kelly S. Schweitzer, Franco D’Alessio, Michael J. Caterina, and Landon S. King PMCID: PMC1450241 Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2 Yvonne N. Tallini, Masamichi Ohkura, Bum-Rak Choi, Guangju Ji, Keiji Imoto, Robert Doran, Jane Lee, Patricia Plan, Jason Wilson, Hong-Bo Xin, Atsushi Sanbe, James Gulick, John Mathai, Jeffrey Robbins, Guy Salama, Junichi Nakai, and Michael I. Kotlikoff PMCID: PMC1450242 Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism Jochen Steppan, Sungwoo Ryoo, Karl H. Schuleri, Chris Gregg, Rani K. Hasan, A. Ron White, Lukasz J. Bugaj, Mehnaz Khan, Lakshmi Santhanam, Daniel Nyhan, Artin A. Shoukas, Joshua M. Hare, and Dan E. Berkowitz PMCID: PMC1450243 Plant Biology Differential recognition of plant cell walls by microbial xylan-specific carbohydrate-binding modules Lesley McCartney, Anthony W. Blake, James Flint, David N. Bolam, Alisdair B. Boraston, Harry J. Gilbert, and J. Paul Knox PMCID: PMC1450244 High-efficiency biolistic transformation of Chlamydomonas mitochondria can be used to insert mutations in complex I genes Claire Remacle, Pierre Cardol, Nadine Coosemans, Mauricette Gaisne, and Nathalie Bonnefoy PMCID: PMC1450245 A role for chlorophyllide a oxygenase in the regulated import and stabilization of light-harvesting chlorophyll a/b proteins Christiane Reinbothe, Sandra Bartsch, Laura L. Eggink, J. Kenneth Hoober, Judy Brusslan, Ricardo Andrade-Paz, Julie Monnet, and Steffen Reinbothe PMCID: PMC1450246 Psychology Strength of early visual adaptation depends on visual awareness Randolph Blake, Duje Tadin, Kenith V. Sobel, Tony A. Raissian, and Sang Chul Chong PMCID: PMC1400587 Seeing the content of the mind: Enhanced awareness through working memory in patients with visual extinction David Soto and Glyn W. Humphreys PMCID: PMC1450248 Sustainability Science Reduced nitrate leaching and enhanced denitrifier activity and efficiency in organically fertilized soils Sasha B. Kramer, John P. Reganold, Jerry D. Glover, Brendan J. M. Bohannan, and Harold A. Mooney PMCID: PMC1450204 Correction Correction for Collins et al., Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation PMCID: PMC1450249 Corrects: Marcus D. Collins, et al. Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation. Proc Natl Acad Sci U S A. 2005 November 15; 102(46): 16668–16671. |
