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Volume 2(6);  June 2004
Synopses
A Gene Responsible for Hybrid Incompatibility in Drosophila
PLoS Biol. 2004 June; 2(6): e165. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020165.
PMCID: PMC423140
Annotation Marathon Validates 21,037 Human Genes
PLoS Biol. 2004 June; 2(6): e166. Published online 2004 April 20. doi: 10.1371/journal.pbio.0020166.
PMCID: PMC393293
Information Transport across a Membrane
PLoS Biol. 2004 June; 2(6): e168. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020168.
PMCID: PMC423142
Deconstructing Brain Waves: Background, Cue, and Response
PLoS Biol. 2004 June; 2(6): e180. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020180.
PMCID: PMC423148
Initiation of DNA Replication: The Genomic Context
PLoS Biol. 2004 June; 2(6): e184. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020184.
PMCID: PMC423152
Computation Approach Shows Robustness of the Striped Pattern of Fruitfly Embryos
PLoS Biol. 2004 June; 2(6): e185. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020185.
PMCID: PMC423153
Ecology Drives the Global Distribution of Human Diseases
PLoS Biol. 2004 June; 2(6): e186. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020186.
PMCID: PMC423154
Turning Down the Volume: Why Some Genes Tolerate Less Noise
PLoS Biol. 2004 June; 2(6): e191. Published online 2004 April 27. doi: 10.1371/journal.pbio.0020191.
PMCID: PMC406520
A DNA Recombination “Hotspot” in Humans Is Missing in Chimps
PLoS Biol. 2004 June; 2(6): e192. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020192.
PMCID: PMC423159
Combining Measures to Characterize Subcellular Machinery
PLoS Biol. 2004 June; 2(6): e193. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020193.
PMCID: PMC423160
A Protein's Role in Progressive Renal Disease
PLoS Biol. 2004 June; 2(6): e194. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020194.
PMCID: PMC423161
A Method for Studying Calcium Dynamics in Transgenic Mice
PLoS Biol. 2004 June; 2(6): e195. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020195.
PMCID: PMC423162
Essay
A Calculus of Purpose
Arthur D Lander
PLoS Biol. 2004 June; 2(6): e164. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020164.
PMCID: PMC423139
Features
fMRI Beyond the Clinic: Will It Ever Be Ready for Prime Time?
Richard Robinson
PLoS Biol. 2004 June; 2(6): e150. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020150.
PMCID: PMC423132
Everything You Always Wanted to Know about Sexes
John Whitfield
PLoS Biol. 2004 June; 2(6): e183. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020183.
PMCID: PMC423151
Book Review/Science in the Media
Escape Velocity: Why the Prospect of Extreme Human Life Extension Matters Now
Aubrey D. N. J de Grey
PLoS Biol. 2004 June; 2(6): e187. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020187.
PMCID: PMC423155
Obituary
Choices: The Science of Bela Julesz
Ralph M Siegel
PLoS Biol. 2004 June; 2(6): e172. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020172.
PMCID: PMC423145
Primer
Integrin Bidirectional Signaling: A Molecular View
Jun Qin, Olga Vinogradova, and Edward F Plow
PLoS Biol. 2004 June; 2(6): e169. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020169.
PMCID: PMC423143
What's So Hot about Recombination Hotspots?
Jody Hey
PLoS Biol. 2004 June; 2(6): e190. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020190.
PMCID: PMC423158
Community Page
Virtual Labs: E-Learning for Tomorrow
Camillan Huang
PLoS Biol. 2004 June; 2(6): e157. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020157.
PMCID: PMC423136
Correspondence and Other Communications
Ethics as Our Guide
Michael Cook
PLoS Biol. 2004 June; 2(6): e170. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020170.
PMCID: PMC423144
Scientists and Bioethics Councils
Anne McLaren
PLoS Biol. 2004 June; 2(6): e177. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020177.
PMCID: PMC423147
Beyond Therapy …
Robert Sinsheimer
PLoS Biol. 2004 June; 2(6): e181. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020181.
PMCID: PMC423149
A Voice for Research, a Voice for Patients
Daniel Perry
PLoS Biol. 2004 June; 2(6): e182. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020182.
PMCID: PMC423150
Taking the Stem Cell Debate to the Public
Leonard I Zon, Laurie Zoloth, and Suzanne Kadereit
PLoS Biol. 2004 June; 2(6): e188. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020188.
PMCID: PMC423156
Ethereal Ethics
Robin Lovell-Badge
PLoS Biol. 2004 June; 2(6): e189. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020189.
PMCID: PMC423157
Research Articles
Topology and Robustness in the Drosophila Segment Polarity Network
Nicholas T Ingolia
PLoS Biol. 2004 June; 2(6): e123. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020123.
PMCID: PMC423129
Noise Minimization in Eukaryotic Gene Expression
Hunter B Fraser, Aaron E Hirsh, Guri Giaever, Jochen Kumm, and Michael B Eisen
PLoS Biol. 2004 June; 2(6): e137. Published online 2004 April 27. doi: 10.1371/journal.pbio.0020137.
PMCID: PMC400249
Ecology Drives the Worldwide Distribution of Human Diseases
Vanina Guernier, Michael E Hochberg, and Jean-François Guégan
PLoS Biol. 2004 June; 2(6): e141. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020141.
PMCID: PMC423130
Functional Divergence Caused by Ancient Positive Selection of a Drosophila Hybrid Incompatibility Locus
Daniel A Barbash, Philip Awadalla, and Aaron M Tarone
PLoS Biol. 2004 June; 2(6): e142. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020142.
PMCID: PMC423131
Plasticity of DNA Replication Initiation in Epstein-Barr Virus Episomes
Paolo Norio and Carl L Schildkraut
PLoS Biol. 2004 June; 2(6): e152. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020152.
PMCID: PMC423133
A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand
Bing-Hao Luo, Timothy A Springer, and Junichi Takagi
PLoS Biol. 2004 June; 2(6): e153. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020153.
PMCID: PMC423134
Absence of the TAP2 Human Recombination Hotspot in Chimpanzees
Susan E Ptak, Amy D Roeder, Matthew Stephens, Yoav Gilad, Svante Pääbo, and Molly Przeworski
PLoS Biol. 2004 June; 2(6): e155. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020155.
PMCID: PMC423135
Integrative Analysis of the Mitochondrial Proteome in Yeast
Holger Prokisch, Curt Scharfe, David G Camp, II, Wenzhong Xiao, Lior David, Christophe Andreoli, Matthew E Monroe, Ronald J Moore, Marina A Gritsenko, Christian Kozany, Kim K Hixson, Heather M Mottaz, Hans Zischka, Marius Ueffing, Zelek S Herman, Ronald W Davis, Thomas Meitinger, Peter J Oefner, Richard D Smith, and Lars M Steinmetz
PLoS Biol. 2004 June; 2(6): e160. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020160.
PMCID: PMC423137
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O Koyanagi, Roberto A Barrero, Takuro Tamura, Yumi Yamaguchi-Kabata, Motohiko Tanino, Kei Yura, Satoru Miyazaki, Kazuho Ikeo, Keiichi Homma, Arek Kasprzyk, Tetsuo Nishikawa, Mika Hirakawa, Jean Thierry-Mieg, Danielle Thierry-Mieg, Jennifer Ashurst, Libin Jia, Mitsuteru Nakao, Michael A Thomas, Nicola Mulder, Youla Karavidopoulou, Lihua Jin, Sangsoo Kim, Tomohiro Yasuda, Boris Lenhard, Eric Eveno, Yoshiyuki Suzuki, Chisato Yamasaki, Jun-ichi Takeda, Craig Gough, Phillip Hilton, Yasuyuki Fujii, Hiroaki Sakai, Susumu Tanaka, Clara Amid, Matthew Bellgard, Maria de Fatima Bonaldo, Hidemasa Bono, Susan K Bromberg, Anthony J Brookes, Elspeth Bruford, Piero Carninci, Claude Chelala, Christine Couillault, Sandro J. de Souza, Marie-Anne Debily, Marie-Dominique Devignes, Inna Dubchak, Toshinori Endo, Anne Estreicher, Eduardo Eyras, Kaoru Fukami-Kobayashi, Gopal R. Gopinath, Esther Graudens, Yoonsoo Hahn, Michael Han, Ze-Guang Han, Kousuke Hanada, Hideki Hanaoka, Erimi Harada, Katsuyuki Hashimoto, Ursula Hinz, Momoki Hirai, Teruyoshi Hishiki, Ian Hopkinson, Sandrine Imbeaud, Hidetoshi Inoko, Alexander Kanapin, Yayoi Kaneko, Takeya Kasukawa, Janet Kelso, Paul Kersey, Reiko Kikuno, Kouichi Kimura, Bernhard Korn, Vladimir Kuryshev, Izabela Makalowska, Takashi Makino, Shuhei Mano, Regine Mariage-Samson, Jun Mashima, Hideo Matsuda, Hans-Werner Mewes, Shinsei Minoshima, Keiichi Nagai, Hideki Nagasaki, Naoki Nagata, Rajni Nigam, Osamu Ogasawara, Osamu Ohara, Masafumi Ohtsubo, Norihiro Okada, Toshihisa Okido, Satoshi Oota, Motonori Ota, Toshio Ota, Tetsuji Otsuki, Dominique Piatier-Tonneau, Annemarie Poustka, Shuang-Xi Ren, Naruya Saitou, Katsunaga Sakai, Shigetaka Sakamoto, Ryuichi Sakate, Ingo Schupp, Florence Servant, Stephen Sherry, Rie Shiba, Nobuyoshi Shimizu, Mary Shimoyama, Andrew J Simpson, Bento Soares, Charles Steward, Makiko Suwa, Mami Suzuki, Aiko Takahashi, Gen Tamiya, Hiroshi Tanaka, Todd Taylor, Joseph D Terwilliger, Per Unneberg, Vamsi Veeramachaneni, Shinya Watanabe, Laurens Wilming, Norikazu Yasuda, Hyang-Sook Yoo, Marvin Stodolsky, Wojciech Makalowski, Mitiko Go, Kenta Nakai, Toshihisa Takagi, Minoru Kanehisa, Yoshiyuki Sakaki, John Quackenbush, Yasushi Okazaki, Yoshihide Hayashizaki, Winston Hide, Ranajit Chakraborty, Ken Nishikawa, Hideaki Sugawara, Yoshio Tateno, Zhu Chen, Michio Oishi, Peter Tonellato, Rolf Apweiler, Kousaku Okubo, Lukas Wagner, Stefan Wiemann, Robert L Strausberg, Takao Isogai, Charles Auffray, Nobuo Nomura, Takashi Gojobori, and Sumio Sugano
PLoS Biol. 2004 June; 2(6): e162. Published online 2004 April 20. doi: 10.1371/journal.pbio.0020162.
PMCID: PMC393292
Functional Fluorescent Ca2+ Indicator Proteins in Transgenic Mice under TET Control
Mazahir T Hasan, Rainer W Friedrich, Thomas Euler, Matthew E Larkum, Günter Giese, Matthias Both, Jens Duebel, Jack Waters, Hermann Bujard, Oliver Griesbeck, Roger Y Tsien, Takeharu Nagai, Atsushi Miyawaki, and Winfried Denk
PLoS Biol. 2004 June; 2(6): e163. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020163.
PMCID: PMC423138
α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein
June Yao, Tu Cam Le, Claudine H Kos, Joel M Henderson, Phillip G Allen, Bradley M Denker, and Martin R Pollak
PLoS Biol. 2004 June; 2(6): e167. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020167.
PMCID: PMC423141
Electroencephalographic Brain Dynamics Following Manually Responded Visual Targets
Scott Makeig, Arnaud Delorme, Marissa Westerfield, Tzyy-Ping Jung, Jeanne Townsend, Eric Courchesne, and Terrence J Sejnowski
PLoS Biol. 2004 June; 2(6): e176. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020176.
PMCID: PMC423146
Correction
Correction: Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes
PLoS Biol. 2004 June; 2(6): e229. Published online 2004 June 15. doi: 10.1371/journal.pbio.0020229.
PMCID: PMC423163
Corrects: Vincenzo Costanzo, et al. Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes. PLoS Biol. 2004 May; 2(5): e110.
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