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Volume 103(4);  January 24, 2006
In This Issue
This Week in PNAS
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 827–828. doi: 10.1073/iti0406103.
PMCID: PMC1347962
Commentary
Up, down, and all around: How plants sense and respond to environmental stimuli
John Z. Kiss
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 829–830. Published online 2006 January 17. doi: 10.1073/pnas.0510471102.
PMCID: PMC1348016
Physical Sciences
Chemistry
Heterogeneity in a room-temperature ionic liquid: Persistent local environments and the red-edge effect
Zhonghan Hu and Claudio J. Margulis
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 831–836. Published online 2006 January 17. doi: 10.1073/pnas.0507364103.
PMCID: PMC1347981
Consistent simulations of multiple proxy responses to an abrupt climate change event
A. N. LeGrande, G. A. Schmidt, D. T. Shindell, C. V. Field, R. L. Miller, D. M. Koch, G. Faluvegi, and G. Hoffmann
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 837–842. Published online 2006 January 13. doi: 10.1073/pnas.0510095103.
PMCID: PMC1348000
Biological Sciences
Anthropology
A prehistory of Indian Y chromosomes: Evaluating demic diffusion scenarios
Sanghamitra Sahoo, Anamika Singh, G. Himabindu, Jheelam Banerjee, T. Sitalaximi, Sonali Gaikwad, R. Trivedi, Phillip Endicott, Toomas Kivisild, Mait Metspalu, Richard Villems, and V. K. Kashyap
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 843–848. Published online 2006 January 13. doi: 10.1073/pnas.0507714103.
PMCID: PMC1347984
Applied Biological Sciences
Detachment of affinity-captured bioparticles by elastic deformation of a macroporous hydrogel
Maria B. Dainiak, Ashok Kumar, Igor Yu. Galaev, and Bo Mattiasson
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 849–854. Published online 2006 January 17. doi: 10.1073/pnas.0508432103.
PMCID: PMC1347990
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage
Janka Kisucka, Catherine E. Butterfield, Dan G. Duda, Sarah C. Eichenberger, Simin Saffaripour, Jerry Ware, Zaverio M. Ruggeri, Rakesh K. Jain, Judah Folkman, and Denisa D. Wagner
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 855–860. Published online 2006 January 17. doi: 10.1073/pnas.0510412103.
PMCID: PMC1348013
Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system
Luca Santi, Anatoli Giritch, Chad J. Roy, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba, Robert Webb, Charles J. Arntzen, and Hugh S. Mason
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 861–866. Published online 2006 January 12. doi: 10.1073/pnas.0510014103.
PMCID: PMC1326254
Defining the sequence-recognition profile of DNA-binding molecules
Christopher L. Warren, Natasha C. S. Kratochvil, Karl E. Hauschild, Shane Foister, Mary L. Brezinski, Peter B. Dervan, George N. Phillips, Jr., and Aseem Z. Ansari
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 867–872. Published online 2006 January 17. doi: 10.1073/pnas.0509843102.
PMCID: PMC1347994
Biochemistry
Structure of Pfu Pop5, an archaeal RNase P protein
Ross C. Wilson, Christopher J. Bohlen, Mark P. Foster, and Charles E. Bell
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 873–878. Published online 2006 January 17. doi: 10.1073/pnas.0508004103.
PMCID: PMC1347986
Activation of protein C by the thrombin–thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C
Likui Yang, Chandrashekhara Manithody, and Alireza R. Rezaie
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 879–884. Published online 2006 January 17. doi: 10.1073/pnas.0507700103.
PMCID: PMC1347983
IA-2β, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion
Asako Doi, Takeshi Shono, Masahiro Nishi, Hiroto Furuta, Hideyuki Sasaki, and Kishio Nanjo
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 885–890. Published online 2006 January 17. doi: 10.1073/pnas.0502470102.
PMCID: PMC1347964
Unexpected NO-dependent DNA binding by the CooA homolog from Carboxydothermus hydrogenoformans
Robert W. Clark, Nicholas D. Lanz, Andrea J. Lee, Robert L. Kerby, Gary P. Roberts, and Judith N. Burstyn
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 891–896. Published online 2006 January 12. doi: 10.1073/pnas.0505919103.
PMCID: PMC1347970
The Tof1p–Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae
Bidyut K. Mohanty, Narendra K. Bairwa, and Deepak Bastia
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 897–902. Published online 2006 January 17. doi: 10.1073/pnas.0506540103.
PMCID: PMC1347974
From the Cover:
Polyphosphate modulates blood coagulation and fibrinolysis
Stephanie A. Smith, Nicola J. Mutch, Deepak Baskar, Peter Rohloff, Roberto Docampo, and James H. Morrissey
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 903–908. Published online 2006 January 12. doi: 10.1073/pnas.0507195103.
PMCID: PMC1347979
Two peptide sequences can function cooperatively to facilitate binding and unfolding by ClpA and degradation by ClpAP
Joel R. Hoskins and Sue Wickner
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 909–914. Published online 2006 January 12. doi: 10.1073/pnas.0509154103.
PMCID: PMC1347992
Biophysics
HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations
Viktor Hornak, Asim Okur, Robert C. Rizzo, and Carlos Simmerling
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 915–920. Published online 2006 January 17. doi: 10.1073/pnas.0508452103.
PMCID: PMC1347991
Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors
Alexander Star, Eugene Tu, Joseph Niemann, Jean-Christophe P. Gabriel, C. Steve Joiner, and Christian Valcke
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 921–926. Published online 2006 January 17. doi: 10.1073/pnas.0504146103.
PMCID: PMC1347966
Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase
Michael J. Begley, Gregory S. Taylor, Melissa A. Brock, Partho Ghosh, Virgil L. Woods, and Jack E. Dixon
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 927–932. Published online 2006 January 12. doi: 10.1073/pnas.0510006103.
PMCID: PMC1347996
Cell Biology
ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable
Tobias Brambrink, Konrad Hochedlinger, George Bell, and Rudolf Jaenisch
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 933–938. Published online 2006 January 17. doi: 10.1073/pnas.0510485103.
PMCID: PMC1348019
Pbn1p: An essential endoplasmic reticulum membrane protein required for protein processing in the endoplasmic reticulum of budding yeast
Shoba Subramanian, Carol A. Woolford, Emily Drill, Meng Lu, and Elizabeth W. Jones
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 939–944. Published online 2006 January 17. doi: 10.1073/pnas.0505570103.
PMCID: PMC1347969
Developmental Biology
Somitic origin of limb muscle satellite and side population cells
Jaclyn Schienda, Kurt A. Engleka, Susan Jun, Mark S. Hansen, Jonathan A. Epstein, Clifford J. Tabin, Louis M. Kunkel, and Gabrielle Kardon
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 945–950. Published online 2006 January 17. doi: 10.1073/pnas.0510164103.
PMCID: PMC1348004
Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia
Zhicao Yue, Ting-Xin Jiang, Randall Bruce Widelitz, and Cheng-Ming Chuong
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 951–955. Published online 2006 January 17. doi: 10.1073/pnas.0506894103.
PMCID: PMC1347975
Ecology
Pollination decays in biodiversity hotspots
Jana C. Vamosi, Tiffany M. Knight, Janette A. Steets, Susan J. Mazer, Martin Burd, and Tia-Lynn Ashman
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 956–961. Published online 2006 January 17. doi: 10.1073/pnas.0507165103.
PMCID: PMC1347978
Evolution
From the Cover:
Reproductive protein protects functionally sterile honey bee workers from oxidative stress
Siri-Christine Seehuus, Kari Norberg, Ulrike Gimsa, Trygve Krekling, and Gro V. Amdam
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 962–967. Published online 2006 January 17. doi: 10.1073/pnas.0502681103.
PMCID: PMC1347965
From the Cover:
DNA barcodes distinguish species of tropical Lepidoptera
Mehrdad Hajibabaei, Daniel H. Janzen, John M. Burns, Winnie Hallwachs, and Paul D. N. Hebert
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 968–971. Published online 2006 January 17. doi: 10.1073/pnas.0510466103.
PMCID: PMC1327734
High biological species diversity in the arctic flora
Hanne Hegre Grundt, Siri Kjølner, Liv Borgen, Loren H. Rieseberg, and Christian Brochmann
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 972–975. Published online 2006 January 17. doi: 10.1073/pnas.0510270103.
PMCID: PMC1348009
Genetics
From the Cover:
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines
Ying Liu and Walter F. Bodmer
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 976–981. Published online 2006 January 17. doi: 10.1073/pnas.0510146103.
PMCID: PMC1327731
Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer
Laura T. Smith, Mauting Lin, Romulo M. Brena, James C. Lang, David E. Schuller, Gregory A. Otterson, Carl D. Morrison, Dominic J. Smiraglia, and Christoph Plass
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 982–987. Published online 2006 January 13. doi: 10.1073/pnas.0510171102.
PMCID: PMC1348006
Immunology
Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-κB activation
Almut Dufner, Scott Pownall, and Tak W. Mak
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 988–993. Published online 2006 January 17. doi: 10.1073/pnas.0510380103.
PMCID: PMC1327733
A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies
Nicole L. La Gruta, Katherine Kedzierska, Ken Pang, Richard Webby, Miles Davenport, Weisan Chen, Stephen J. Turner, and Peter C. Doherty
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 994–999. Published online 2006 January 17. doi: 10.1073/pnas.0510429103.
PMCID: PMC1348014
Stat5a/b are essential for normal lymphoid development and differentiation
Zhengju Yao, Yongzhi Cui, Wendy T. Watford, Jay H. Bream, Kunihiro Yamaoka, Bruce D. Hissong, Denise Li, Scott K. Durum, Qiong Jiang, Avinash Bhandoola, Lothar Hennighausen, and John J. O'Shea
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1000–1005. Published online 2006 January 17. doi: 10.1073/pnas.0507350103.
PMCID: PMC1327727
Medical Sciences
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
Yanqiao Zhang, Florence Ying Lee, Gabriel Barrera, Hans Lee, Charisse Vales, Frank J. Gonzalez, Timothy M. Willson, and Peter A. Edwards
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1006–1011. Published online 2006 January 12. doi: 10.1073/pnas.0506982103.
PMCID: PMC1347977
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures
Gang Hao, Behrad Derakhshan, Lei Shi, Fabien Campagne, and Steven S. Gross
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1012–1017. Published online 2006 January 17. doi: 10.1073/pnas.0508412103.
PMCID: PMC1347989
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression
Ya-Xiong Chen, Jizhou Yan, Karen Keeshan, Anthony T. Tubbs, Haoren Wang, Albert Silva, Eric J. Brown, Jay L. Hess, Warren S. Pear, and Xianxin Hua
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1018–1023. Published online 2006 January 13. doi: 10.1073/pnas.0510347103.
PMCID: PMC1326489
(–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
Hagen Schroeter, Christian Heiss, Jan Balzer, Petra Kleinbongard, Carl L. Keen, Norman K. Hollenberg, Helmut Sies, Catherine Kwik-Uribe, Harold H. Schmitz, and Malte Kelm
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1024–1029. Published online 2006 January 17. doi: 10.1073/pnas.0510168103.
PMCID: PMC1327732
Gene expression profiles in acute myeloid leukemia with common translocations using SAGE
Sanggyu Lee, Jianjun Chen, Guolin Zhou, Run Zhang Shi, Gerard G. Bouffard, Masha Kocherginsky, Xijin Ge, Miao Sun, Nimanthi Jayathilaka, Yeong Cheol Kim, Neelmini Emmanuel, Stefan K. Bohlander, Mark Minden, Justin Kline, Ozden Ozer, Richard A. Larson, Michelle M. LeBeau, Eric D. Green, Jeffery Trent, Theodore Karrison, Piu Paul Liu, San Ming Wang, and Janet D. Rowley
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1030–1035. Published online 2006 January 17. doi: 10.1073/pnas.0509878103.
PMCID: PMC1347995
Correction of the sickle cell mutation in embryonic stem cells
Judy C. Chang, Lin Ye, and Yuet Wai Kan
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1036–1040. Published online 2006 January 11. doi: 10.1073/pnas.0510177103.
PMCID: PMC1326143
Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation
John R. McWhirter, Anke Kretz-Rommel, Alan Saven, Toshiaki Maruyama, Kathleen N. Potter, C. Ian Mockridge, E. Prenn Ravey, Fenghua Qin, and Katherine S. Bowdish
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1041–1046. Published online 2006 January 17. doi: 10.1073/pnas.0510081103.
PMCID: PMC1327729
Microbiology
Variations in the association of papillomavirus E2 proteins with mitotic chromosomes
Jaquelline G. Oliveira, Leremy A. Colf, and Alison A. McBride
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1047–1052. Published online 2006 January 13. doi: 10.1073/pnas.0507624103.
PMCID: PMC1326487
Neuroscience
Direct neurophysiological evidence for spatial suppression surrounding the focus of attention in vision
J.-M. Hopf, C. N. Boehler, S. J. Luck, J. K. Tsotsos, H.-J. Heinze, and M. A. Schoenfeld
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1053–1058. Published online 2006 January 12. doi: 10.1073/pnas.0507746103.
PMCID: PMC1347985
Serotonergic neuron diversity: Identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm
Bernat Kocsis, Viktor Varga, Lionel Dahan, and Attila Sik
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1059–1064. Published online 2006 January 17. doi: 10.1073/pnas.0508360103.
PMCID: PMC1347988
Dissociation of face-selective cortical responses by attention
Maura L. Furey, Topi Tanskanen, Michael S. Beauchamp, Sari Avikainen, Kimmo Uutela, Riitta Hari, and James V. Haxby
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1065–1070. Published online 2006 January 13. doi: 10.1073/pnas.0510124103.
PMCID: PMC1348001
Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus
Sridhara Chakravarthy, M. Hadi Saiepour, Matthew Bence, Sean Perry, Robin Hartman, Jonathan J. Couey, Huibert D. Mansvelder, and Christiaan N. Levelt
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1071–1076. Published online 2006 January 17. doi: 10.1073/pnas.0506305103.
PMCID: PMC1347973
Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons
John F. Guzowski, Teiko Miyashita, Monica K. Chawla, Jennifer Sanderson, Levi I. Maes, Frank P. Houston, Peter Lipa, Bruce L. McNaughton, Paul F. Worley, and Carol A. Barnes
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1077–1082. Published online 2006 January 13. doi: 10.1073/pnas.0505519103.
PMCID: PMC1347968
Intrinsic kinetics determine the time course of neuronal synaptic transporter currents
Jacques I. Wadiche, Anastassios V. Tzingounis, and Craig E. Jahr
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1083–1087. Published online 2006 January 17. doi: 10.1073/pnas.0510476103.
PMCID: PMC1348018
Early auditory experience generates long-lasting memories that may subserve vocal learning in songbirds
Mimi L. Phan, Carolyn L. Pytte, and David S. Vicario
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1088–1093. Published online 2006 January 17. doi: 10.1073/pnas.0510136103.
PMCID: PMC1327730
Cellular identification of water gustatory receptor neurons and their central projection pattern in Drosophila
Tsuyoshi Inoshita and Teiichi Tanimura
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1094–1099. Published online 2006 January 13. doi: 10.1073/pnas.0502376103.
PMCID: PMC1347963
SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis elegans
Yi Zheng, Penelope J. Brockie, Jerry E. Mellem, David M. Madsen, Craig S. Walker, Michael M. Francis, and Andres V. Maricq
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1100–1105. Published online 2006 January 17. doi: 10.1073/pnas.0504612103.
PMCID: PMC1347967
A neurocomputational hypothesis for nicotine addiction
Boris S. Gutkin, Stanislas Dehaene, and Jean-Pierre Changeux
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1106–1111. Published online 2006 January 13. doi: 10.1073/pnas.0510220103.
PMCID: PMC1348008
Goα regulates olfactory adaptation by antagonizing Gqα-DAG signaling in Caenorhabditis elegans
Masahiro Matsuki, Hirofumi Kunitomo, and Yuichi Iino
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1112–1117. Published online 2006 January 17. doi: 10.1073/pnas.0506954103.
PMCID: PMC1347976
Pharmacology
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties
Domenico Tricarico, Antonietta Mele, Andrew L. Lundquist, Reshma R. Desai, Alfred L. George, Jr., and Diana Conte Camerino
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1118–1123. Published online 2006 January 17. doi: 10.1073/pnas.0505974103.
PMCID: PMC1347972
Physiology
Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1α
Michihiro Tateyama and Yoshihiro Kubo
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1124–1128. Published online 2006 January 12. doi: 10.1073/pnas.0505925103.
PMCID: PMC1347971
Plant Biology
The products of a single maize sesquiterpene synthase form a volatile defense signal that attracts natural enemies of maize herbivores
Christiane Schnee, Tobias G. Köllner, Matthias Held, Ted C. J. Turlings, Jonathan Gershenzon, and Jörg Degenhardt
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1129–1134. Published online 2006 January 17. doi: 10.1073/pnas.0508027103.
PMCID: PMC1347987
From the Cover:
Osmotic effects on vacuolar ion release in guard cells
Enid A. C. MacRobbie
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1135–1140. Published online 2006 January 17. doi: 10.1073/pnas.0510023103.
PMCID: PMC1347998
Psychology
A gain-control theory of binocular combination
Jian Ding and George Sperling
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1141–1146. Published online 2006 January 12. doi: 10.1073/pnas.0509629103.
PMCID: PMC1347993
Social Sciences
Environmental Sciences
Early maize (Zea mays L.) cultivation in Mexico: Dating sedimentary pollen records and its implications
Andrew Sluyter and Gabriela Dominguez
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1147–1151. Published online 2006 January 17. doi: 10.1073/pnas.0510473103.
PMCID: PMC1348017
Corrections
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1152–1153. doi: 10.1073/pnas.0510844103.
PMCID: PMC1348020
Corrects: I. M. Held, et al. Simulation of Sahel drought in the 20th and 21st centuries. Proc Natl Acad Sci U S A. 2005 December 13; 102(50): 17891–17896.
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1153. doi: 10.1073/pnas.0510409102.
PMCID: PMC1348012
Corrects: Guangtao Li, et al. Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome. Proc Natl Acad Sci U S A. 2005 November 1; 102(44): 15809–15814.
Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1153. doi: 10.1073/pnas.0511236103.
PMCID: PMC1348021
Corrects: Jean-Marie Peloponese, Jr., et al. Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein. Proc Natl Acad Sci U S A. 2005 December 27; 102(52): 18974–18979.
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