| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 December 27; 102(52): 18765–18766. doi: 10.1073/iti5205102.PMCID: PMC1323143 Commentaries Integrity matters: Linking nuclear architecture to lifespan Katherine L. Wilson PMCID: PMC1323184 The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations Lawrence A. Loeb, Douglas C. Wallace, and George M. Martin PMCID: PMC1323222 Indigestion is a plant's best defense Gary W. Felton PMCID: PMC1323224 Physical Sciences Applied Physical Sciences From the Cover:
The growth of business firms: Theoretical framework and empirical evidence Dongfeng Fu, Fabio Pammolli, S. V. Buldyrev, Massimo Riccaboni, Kaushik Matia, Kazuko Yamasaki, and H. Eugene Stanley PMCID: PMC1323202 Chemistry Femtochemistry of orange II in solution and in chemical and biological nanocavities Abderrazzak Douhal, Mikel Sanz, and Laura Tormo PMCID: PMC1345726 Absolute rate theories of epigenetic stability Aleksandra M. Walczak, José N. Onuchic, and Peter G. Wolynes PMCID: PMC1323203 Engineering TGF-β regulates the mechanical properties and composition of bone matrix Guive Balooch, Mehdi Balooch, Ravi K. Nalla, Stephen Schilling, Ellen H. Filvaroff, Grayson W. Marshall, Sally J. Marshall, Robert O. Ritchie, Rik Derynck, and Tamara Alliston PMCID: PMC1323171 Environmental Sciences Processes conducive to the release and transport of arsenic into aquifers of Bangladesh Matthew L. Polizzotto, Charles F. Harvey, Steve R. Sutton, and Scott Fendorf PMCID: PMC1323201 Physics Quantum criticality in ferromagnetic single-electron transistors Stefan Kirchner, Lijun Zhu, Qimiao Si, and D. Natelson PMCID: PMC1323197 Biological Sciences Agricultural Sciences Up-regulation of a H+-pyrophosphatase (H+-PPase) as a strategy to engineer drought-resistant crop plants Sunghun Park, Jisheng Li, Jon K. Pittman, Gerald A. Berkowitz, Haibing Yang, Soledad Undurraga, Jay Morris, Kendal D. Hirschi, and Roberto A. Gaxiola PMCID: PMC1323196 Anthropology Morphological affinities of the Sahelanthropus tchadensis (Late Miocene hominid from Chad) cranium Franck Guy, Daniel E. Lieberman, David Pilbeam, Marcia Ponce de León, Andossa Likius, Hassane T. Mackaye, Patrick Vignaud, Christoph Zollikofer, and Michel Brunet PMCID: PMC1323204 Placing confidence limits on the molecular age of the human–chimpanzee divergence Sudhir Kumar, Alan Filipski, Vinod Swarna, Alan Walker, and S. Blair Hedges PMCID: PMC1316887 Biochemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: On the mechanism of sensing unfolded protein in the endoplasmic reticulum Joel J. Credle, Janet S. Finer-Moore, Feroz R. Papa, Robert M. Stroud, and Peter Walter PMCID: PMC1316886 A papain-like enzyme at work: Native and acyl–enzyme intermediate structures in phytochelatin synthesis Denis Vivares, Pascal Arnoux, and David Pignol PMCID: PMC1310510 The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases Alexander Ungewickell, Christopher Hugge, Marina Kisseleva, Shao-Chun Chang, Jun Zou, Yucheng Feng, Edouard E. Galyov, Monita Wilson, and Philip W. Majerus PMCID: PMC1323219 Experimental support for the “E pathway hypothesis” of coupled transmembrane e– and H+ transfer in dihemic quinol:fumarate reductase C. Roy D. Lancaster, Ursula S. Sauer, Roland Groß, Alexander H. Haas, Jürgen Graf, Harald Schwalbe, Werner Mäntele, Jörg Simon, and M. Gregor Madej PMCID: PMC1323215 Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains Hideyuki Yokote, Koji Fujita, Xuefeng Jing, Takahiro Sawada, Sitai Liang, Li Yao, Xiaomei Yan, Yueqiang Zhang, Joseph Schlessinger, and Kazushige Sakaguchi PMCID: PMC1323220 From the Cover:
A selection for mutants that interfere with folding of Escherichia coli thioredoxin-1 in vivo Damon Huber, Myoung-il Cha, Laurent Debarbieux, Anne-Gaëlle Planson, Nelly Cruz, Gary López, María Luisa Tasayco, Alain Chaffotte, and Jon Beckwith PMCID: PMC1323206 Structure of the mid-region of tropomyosin: Bending and binding sites for actin Jerry H. Brown, Zhaocai Zhou, Ludmilla Reshetnikova, Howard Robinson, Rama D. Yammani, Larry S. Tobacman, and Carolyn Cohen PMCID: PMC1323185 Enhancer-independent Mu transposition from two topologically distinct synapses Zhiqi Yin and Rasika M. Harshey PMCID: PMC1323169 Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases Engin Özkan, Hongtao Yu, and Johann Deisenhofer PMCID: PMC1316884 Evidence for an essential function of the N terminus of a small heat shock protein in vivo, independent of in vitro chaperone activity Kim C. Giese, Eman Basha, Belmund Y. Catague, and Elizabeth Vierling PMCID: PMC1323161 A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165 Joon-Hwa Lee, Marella D. Canny, Andrea De Erkenez, Dominik Krilleke, Yin-Shan Ng, David T. Shima, Arthur Pardi, and Fiona Jucker PMCID: PMC1323181 Biophysics Structural changes involved in protein binding correlate with intrinsic motions of proteins in the unbound state Dror Tobi and Ivet Bahar PMCID: PMC1323175 High-resolution protein folding with a transferable potential Isaac A. Hubner, Eric J. Deeds, and Eugene I. Shakhnovich PMCID: PMC1323145 Structural genomics analysis of alternative splicing and application to isoform structure modeling Peng Wang, Bo Yan, Jun-tao Guo, Chindo Hicks, and Ying Xu PMCID: PMC1323168 Absolute rate theories of epigenetic stability Aleksandra M. Walczak, José N. Onuchic, and Peter G. Wolynes PMCID: PMC1323203 Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 Å John K. Lee, David Kozono, Jonathan Remis, Yoshichika Kitagawa, Peter Agre, and Robert M. Stroud PMCID: PMC1323191 Extreme conformational diversity in human telomeric DNA J. Y. Lee, Burak Okumus, D. S. Kim, and Taekjip Ha PMCID: PMC1316883 From the Cover:
Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses Reza Khayat, Liang Tang, Eric T. Larson, C. Martin Lawrence, Mark Young, and John E. Johnson PMCID: PMC1323162 Correlation between evolutionary structural development and protein folding Chioko Nagao, Tomoki P. Terada, Tetsuya Yomo, and Masaki Sasai PMCID: PMC1323182 Ribosome exit tunnel can entropically stabilize α-helices Guy Ziv, Gilad Haran, and D. Thirumalai PMCID: PMC1323178 Cell Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: How to make a curved Drosophila bristle using straight actin bundles Lewis G. Tilney and David J. DeRosier PMCID: PMC1323189 Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation Xiaohui Lu, Ross Levine, Wei Tong, Gerlinde Wernig, Yana Pikman, Sara Zarnegar, D. Gary Gilliland, and Harvey Lodish PMCID: PMC1323216 Deregulation of common genes by c-Myc and its direct target, MT-MC1 Kenneth R. Rogulski, Debra E. Cohen, David L. Corcoran, Panayiotis V. Benos, and Edward V. Prochownik PMCID: PMC1323176 Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein Jean-Marie Peloponese, Jr., Kerstin Haller, Akiko Miyazato, and Kuan-Teh Jeang PMCID: PMC1323167 Epidermal transit of replication-arrested, undifferentiated keratinocytes in UV-exposed XPC mice: An alternative to in situ apoptosis Gerdine J. Stout, Daniel Westdijk, Dennis M. Calkhoven, Olaf Pijper, Claude M. P. Backendorf, Rein Willemze, Leon H. F. Mullenders, and Frank R. de Gruijl PMCID: PMC1323157 Developmental Biology MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling Chulan Kwon, Zhe Han, Eric N. Olson, and Deepak Srivastava PMCID: PMC1315275 Evolution A MAPK gene from Dead Sea fungus confers stress tolerance to lithium salt and freezing–thawing: Prospects for saline agriculture Yan Jin, Song Weining, and Eviatar Nevo PMCID: PMC1323214 From the Cover:
Discovery of an ornithurine bird and its implication for Early Cretaceous avian radiation Zhonghe Zhou and Fucheng Zhang PMCID: PMC1323170 The evolutionary history of Cys-tRNACys formation Patrick O'Donoghue, Anurag Sethi, Carl R. Woese, and Zaida A. Luthey-Schulten PMCID: PMC1323144 Widespread genetic exchange among terrestrial bacteriophages Olin K. Silander, Daniel M. Weinreich, Kevin M. Wright, Kara J. O'Keefe, Camilla U. Rang, Paul E. Turner, and Lin Chao PMCID: PMC1323146 Genetics High-dimensional and large-scale phenotyping of yeast mutants Yoshikazu Ohya, Jun Sese, Masashi Yukawa, Fumi Sano, Yoichiro Nakatani, Taro L. Saito, Ayaka Saka, Tomoyuki Fukuda, Satoru Ishihara, Satomi Oka, Genjiro Suzuki, Machika Watanabe, Aiko Hirata, Miwaka Ohtani, Hiroshi Sawai, Nicolas Fraysse, Jean-Paul Latgé, Jean M. François, Markus Aebi, Seiji Tanaka, Sachiko Muramatsu, Hiroyuki Araki, Kintake Sonoike, Satoru Nogami, and Shinichi Morishita PMCID: PMC1316885 Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila Ben H. Collins, Stephane Dissel, Edward Gaten, Ezio Rosato, and Charalambos P. Kyriacou PMCID: PMC1323156 Stereotypic and random patterns of connectivity in the larval mushroom body calyx of Drosophila Liria M. Masuda-Nakagawa, Nobuaki K. Tanaka, and Cahir J. O'Kane PMCID: PMC1323213 Immunology Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function K. Scott Weber, David L. Donermeyer, Paul M. Allen, and David M. Kranz PMCID: PMC1323173 Network of dendritic cells within the muscular layer of the mouse intestine Adriana Flores-Langarica, Selene Meza-Perez, Juana Calderon-Amador, Teresa Estrada-Garcia, Gordon MacPherson, Serge Lebecque, Sem Saeland, Ralph M. Steinman, and Leopoldo Flores-Romo PMCID: PMC1316057 The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice Rina Aharoni, Raya Eilam, Hagit Domev, Galya Labunskay, Michael Sela, and Ruth Arnon PMCID: PMC1323190 Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice Jennifer A. Westwood, Mark J. Smyth, Michele W. L. Teng, Maria Moeller, Joseph A. Trapani, Andrew M. Scott, Fiona E. Smyth, Glenn A. Cartwright, Barbara E. Power, Dirk Hönemann, H. Miles Prince, Phillip K. Darcy, and Michael H. Kershaw PMCID: PMC1323148 Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a) Michelle A. Lowes, Francesca Chamian, Maria Veronica Abello, Judilyn Fuentes-Duculan, Shao-Lee Lin, Rachel Nussbaum, Inna Novitskaya, Henrietta Carbonaro, Irma Cardinale, Toyoko Kikuchi, Patricia Gilleaudeau, Mary Sullivan-Whalen, Knut M. Wittkowski, Kim Papp, Marvin Garovoy, Wolfgang Dummer, Ralph M. Steinman, and James G. Krueger PMCID: PMC1323218 A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function Lalit Kumar, Stefan Feske, Anjana Rao, and Raif S. Geha PMCID: PMC1323183 Medical Sciences Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations Anna Andersson, Tor Olofsson, David Lindgren, Björn Nilsson, Cecilia Ritz, Patrik Edén, Carin Lassen, Johan Råde, Magnus Fontes, Helena Mörse, Jesper Heldrup, Mikael Behrendtz, Felix Mitelman, Mattias Höglund, Bertil Johansson, and Thoas Fioretos PMCID: PMC1323166 The role of microRNA genes in papillary thyroid carcinoma Huiling He, Krystian Jazdzewski, Wei Li, Sandya Liyanarachchi, Rebecca Nagy, Stefano Volinia, George A. Calin, Chang-gong Liu, Kaarle Franssila, Saul Suster, Richard T. Kloos, Carlo M. Croce, and Albert de la Chapelle PMCID: PMC1323209 Embryonic stem cell-derived hematopoietic stem cells Yuan Wang, Frank Yates, Olaia Naveiras, Patricia Ernst, and George Q. Daley PMCID: PMC1323159 The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer Olga Kovbasnjuk, Rakhilya Mourtazina, Boris Baibakov, Thomas Wang, Christian Elowsky, Michael A. Choti, Anne Kane, and Mark Donowitz PMCID: PMC1323164 A cancer DNA phenotype in healthy prostates, conserved in tumors and adjacent normal cells, implies a relationship to carcinogenesis Donald C. Malins, Naomi K. Gilman, Virginia M. Green, Thomas M. Wheeler, Edward A. Barker, and Katie M. Anderson PMCID: PMC1323211 Evidence by molecular profiling for a placental origin of infantile hemangioma Carmen M. Barnés, Sui Huang, Arja Kaipainen, Despina Sanoudou, Emy J. Chen, Gabriel S. Eichler, Yuchun Guo, Ying Yu, Donald E. Ingber, John B. Mulliken, Alan H. Beggs, Judah Folkman, and Steven J. Fishman PMCID: PMC1323205 Microbiology The global transcriptional regulatory network for metabolism in Escherichia coli exhibits few dominant functional states Christian L. Barrett, Christopher D. Herring, Jennifer L. Reed, and Bernhard O. Palsson PMCID: PMC1323155 Microarray-based detection of genetic heterogeneity, antimicrobial resistance, and the viable but nonculturable state in human pathogenic Vibrio spp. Gary J. Vora, Carolyn E. Meador, Michele M. Bird, Cheryl A. Bopp, Joanne D. Andreadis, and David A. Stenger PMCID: PMC1323153 Neuroscience INAUGURAL ARTICLE by a Recently Elected Academy Member: Modeling the spatiotemporal cortical activity associated with the line-motion illusion in primary visual cortex Aaditya V. Rangan, David Cai, and David W. McLaughlin PMCID: PMC1323193 Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor Paul Berghuis, Marton B. Dobszay, Xinyu Wang, Sabrina Spano, Fernanda Ledda, Kyle M. Sousa, Gunnar Schulte, Patrik Ernfors, Ken Mackie, Gustavo Paratcha, Yasmin L. Hurd, and Tibor Harkany PMCID: PMC1323195 Increasing Ca2+ transients by broadening postsynaptic action potentials enhances timing-dependent synaptic depression Yu-Dong Zhou, Corey D. Acker, Theoden I. Netoff, Kamal Sen, and John A. White PMCID: PMC1323223 Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage Celine Perier, Kim Tieu, Christelle Guégan, Casper Caspersen, Vernice Jackson-Lewis, Valerio Carelli, Andrea Martinuzzi, Michio Hirano, Serge Przedborski, and Miquel Vila PMCID: PMC1323177 A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice Noboru Hiroi, Hongwen Zhu, MoonSook Lee, Birgit Funke, Makoto Arai, Masanari Itokawa, Raju Kucherlapati, Bernice Morrow, Takehito Sawamura, and Soh Agatsuma PMCID: PMC1323212 P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation David B. Arthur, Katerina Akassoglou, and Paul A. Insel PMCID: PMC1323158 The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins Jane E. Lauckner, Bertil Hille, and Ken Mackie PMCID: PMC1323208 Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: Implications for intracranial self-stimulation Joseph F. Cheer, Michael L. A. V. Heien, Paul A. Garris, Regina M. Carelli, and R. Mark Wightman PMCID: PMC1323210 Perinatal anoxia degrades auditory system function in rats F. Strata, A. R. deIpolyi, B. H. Bonham, E. F. Chang, R. C. Liu, H. Nakahara, and M. M. Merzenich PMCID: PMC1323198 Asymmetry in corticofugal modulation of frequency-tuning in mustached bat auditory system Zhongju Xiao and Nobuo Suga PMCID: PMC1323221 Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior Benjamin Boutrel, Paul J. Kenny, Sheila E. Specio, Rémi Martin-Fardon, Athina Markou, George F. Koob, and Luis de Lecea PMCID: PMC1323172 Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate J.-C. Platel, S. Boisseau, A. Dupuis, J. Brocard, A. Poupard, M. Savasta, M. Villaz, and M. Albrieux PMCID: PMC1323152 Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain Sho Kakizawa, Taisuke Miyazaki, Dai Yanagihara, Masamitsu Iino, Masahiko Watanabe, and Masanobu Kano PMCID: PMC1323150 CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum Amir A. Levine, Zhonghui Guan, Angel Barco, Shiqin Xu, Eric R. Kandel, and James H. Schwartz PMCID: PMC1323217 The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes Benoît Zuber, Irina Nikonenko, Paul Klauser, Dominique Muller, and Jacques Dubochet PMCID: PMC1323199 Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model Xu Yue, Melissa Lu, Techie Lancaster, Phillip Cao, Shin-Ichiro Honda, Matthias Staufenbiel, Nobuhiro Harada, Zhenyu Zhong, Yong Shen, and Rena Li PMCID: PMC1323154 Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone Henk Karst, Stefan Berger, Marc Turiault, Francois Tronche, Günther Schütz, and Marian Joëls PMCID: PMC1323174 Pharmacology Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series David J. Daniels, Natalie R. Lenard, Chris L. Etienne, Ping-Yee Law, Sandra C. Roerig, and Philip S. Portoghese PMCID: PMC1323165 Physiology TGF-β regulates the mechanical properties and composition of bone matrix Guive Balooch, Mehdi Balooch, Ravi K. Nalla, Stephen Schilling, Ellen H. Filvaroff, Grayson W. Marshall, Sally J. Marshall, Robert O. Ritchie, Rik Derynck, and Tamara Alliston PMCID: PMC1323171 A dynamic switch between inhibitory and excitatory currents in a neuronal glutamate transporter Nico Melzer, Delany Torres-Salazar, and Christoph Fahlke PMCID: PMC1323179 Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems Miguel Constância, Emily Angiolini, Ionel Sandovici, Paul Smith, Rachel Smith, Gavin Kelsey, Wendy Dean, Anne Ferguson-Smith, Colin P. Sibley, Wolf Reik, and Abigail Fowden PMCID: PMC1316882 Interaction between the dihydropyridine receptor Ca2+ channel β-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling Weijun Cheng, Xavier Altafaj, Michel Ronjat, and Roberto Coronado PMCID: PMC1323149 Plant Biology Involvement of KU80 in T-DNA integration in plant cells Jianxiong Li, Manjusha Vaidya, Charles White, Alexander Vainstein, Vitaly Citovsky, and Tzvi Tzfira PMCID: PMC1323163 From the Cover:
Jasmonate-inducible plant enzymes degrade essential amino acids in the herbivore midgut Hui Chen, Curtis G. Wilkerson, Jason A. Kuchar, Brett S. Phinney, and Gregg A. Howe PMCID: PMC1323180 Analysis and mapping of randomly chosen bacterial artificial chromosome clones from hexaploid bread wheat Katrien M. Devos, Jianxin Ma, Ana C. Pontaroli, Lee H. Pratt, and Jeffrey L. Bennetzen PMCID: PMC1323192 Social Sciences Economic Sciences From the Cover:
The growth of business firms: Theoretical framework and empirical evidence Dongfeng Fu, Fabio Pammolli, S. V. Buldyrev, Massimo Riccaboni, Kaushik Matia, Kazuko Yamasaki, and H. Eugene Stanley PMCID: PMC1323202 Psychology Grammatical Subjects in home sign: Abstract linguistic structure in adult primary gesture systems without linguistic input Marie Coppola and Elissa L. Newport PMCID: PMC1315276 |
