| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 October 18; 102(42): 14937–14938. doi: 10.1073/iti4205102.PMCID: PMC1257748 Commentaries The opened processivity clamp slides into view David Jeruzalmi PMCID: PMC1257719 A multifunctional enzyme adds to its repertoire Timothy F. Walseth PMCID: PMC1257722 Perspective Antibody vs. HIV in a clash of evolutionary titans Dennis R. Burton, Robyn L. Stanfield, and Ian A. Wilson PMCID: PMC1257708 Profile Profile of Akira Tonomura Philip Downey PMCID: PMC1257714 Physical Sciences Applied Physical Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: Direct observation of thitherto unobservable quantum phenomena by using electrons Akira Tonomura PMCID: PMC1198996 Microfluidic gas-flow profiling using remote-detection NMR Christian Hilty, Erin E. McDonnell, Josef Granwehr, Kimberly L. Pierce, Song-I Han, and Alexander Pines PMCID: PMC1257736 Geology Cenozoic continental climatic evolution of Central Europe Volker Mosbrugger, Torsten Utescher, and David L. Dilcher PMCID: PMC1257711 Geophysics From the Cover:
Tectonic implications of Mars crustal magnetism J. E. P. Connerney, M. H. Acuña, N. F. Ness, G. Kletetschka, D. L. Mitchell, R. P. Lin, and H. Reme PMCID: PMC1250232 Physics Visible and UV coherent Raman spectroscopy of dipicolinic acid Dmitry Pestov, Miaochan Zhi, Zoe-Elizabeth Sariyanni, Nikolai G. Kalugin, Alexandre A. Kolomenskii, Robert Murawski, Gerhard G. Paulus, Vladimir A. Sautenkov, Hans Schuessler, Alexei V. Sokolov, George R. Welch, Yuri V. Rostovtsev, Torsten Siebert, Denis A. Akimov, Stefanie Graefe, Wolfgang Kiefer, and Marlan O. Scully PMCID: PMC1257716 Biological Sciences Applied Biological Sciences Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway Shu-ichi Matsuzawa, Michael Cuddy, Toru Fukushima, and John C. Reed PMCID: PMC1257734 Biochemistry Massive sequence perturbation of a small protein F.-X. Campbell-Valois, K. Tarassov, and S. W. Michnick PMCID: PMC1257691 Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus Susana L. A. Andrade, Antje Dickmanns, Ralf Ficner, and Oliver Einsle PMCID: PMC1257715 Aldosterone acts via an ATP autocrine/paracrine system: The Edelman ATP hypothesis revisited Julia Gorelik, Yanjun Zhang, Daniel Sánchez, Andrew Shevchuk, Gregory Frolenkov, Max Lab, David Klenerman, Christopher Edwards, and Yuri Korchev PMCID: PMC1257717 Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission Gareth M. Thomas, Gavin R. Rumbaugh, Dana B. Harrar, and Richard L. Huganir PMCID: PMC1257731 Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the β-globin locus control region Milind C. Mahajan, Geeta J. Narlikar, Gokul Boyapaty, Robert E. Kingston, and Sherman M. Weissman PMCID: PMC1257739 Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism Ekaterina I. Biterova, Anton A. Turanov, Vadim N. Gladyshev, and Joseph J. Barycki PMCID: PMC1257698 The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand Samuel Bouyain, Patti A. Longo, Shiqing Li, Kathryn M. Ferguson, and Daniel J. Leahy PMCID: PMC1257738 RGS4 and RGS5 are in vivo substrates of the N-end rule pathway Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V. Davydov, and Yong Tae Kwon PMCID: PMC1257735 A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS Murali Palangat, Dan B. Renner, David H. Price, and Robert Landick PMCID: PMC1257689 Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor Jeremy R. Sanford, Jonathan D. Ellis, Demian Cazalla, and Javier F. Cáceres PMCID: PMC1257746 DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression Korry J. Hintze and Elizabeth C. Theil PMCID: PMC1257710 Proximity-induced activation of human Cdc34 through heterologous dimerization Stefan Gazdoiu, Kosj Yamoah, Kenneth Wu, Carlos R. Escalante, Inger Tappin, Vladimir Bermudez, Aneel K. Aggarwal, Jerard Hurwitz, and Zhen-Qiang Pan PMCID: PMC1242854 Biophysics From the Cover:
Interface connections of a transmembrane voltage sensor J. Alfredo Freites, Douglas J. Tobias, Gunnar von Heijne, and Stephen H. White PMCID: PMC1250233 Predicting the energetics of osmolyte-induced protein folding/unfolding Matthew Auton and D. Wayne Bolen PMCID: PMC1257718 Dynamics of the acetylcholine receptor pore at the gating transition state Ananya Mitra, Gisela D. Cymes, and Anthony Auerbach PMCID: PMC1257706 Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design Vladimir A. Karginov, Ekaterina M. Nestorovich, Mahtab Moayeri, Stephen H. Leppla, and Sergey M. Bezrukov PMCID: PMC1257733 Cell Biology Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity Bharath Ananthanarayanan, Qiang Ni, and Jin Zhang PMCID: PMC1257695 Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells Yoshiyuki Wakabayashi, Parmesh Dutt, Jennifer Lippincott-Schwartz, and Irwin M. Arias PMCID: PMC1257697 From the Cover:
p600, a unique protein required for membrane morphogenesis and cell survival Yoshihiro Nakatani, Hiroaki Konishi, Alex Vassilev, Hisanori Kurooka, Keiichiro Ishiguro, Jun-ichi Sawada, Tsuyoshi Ikura, Stanley J. Korsmeyer, Jun Qin, and Anna M. Herlitz PMCID: PMC1247991 Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages Harald Bär, Norbert Mücke, Anna Kostareva, Gunnar Sjöberg, Ueli Aebi, and Harald Herrmann PMCID: PMC1250230 BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly Shiaw-Yih Lin, Rekha Rai, Kaiyi Li, Zhi-Xiang Xu, and Stephen J. Elledge PMCID: PMC1257745 Single-particle tracking of murine polyoma virus-like particles on live cells and artificial membranes Helge Ewers, Alicia E. Smith, Ivo F. Sbalzarini, Hauke Lilie, Petros Koumoutsakos, and Ari Helenius PMCID: PMC1257700 Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells Kohtaro Minami, Masaaki Okuno, Kazumasa Miyawaki, Akinori Okumachi, Katsuhiko Ishizaki, Kazunobu Oyama, Miho Kawaguchi, Nobuko Ishizuka, Toshihiko Iwanaga, and Susumu Seino PMCID: PMC1257737 Developmental Biology Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation Jiyeon Oh, James A. Richardson, and Eric N. Olson PMCID: PMC1257726 The Ca2+-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo Julie Batut, Laurence Vandel, Catherine Leclerc, Christiane Daguzan, Marc Moreau, and Isabelle Néant PMCID: PMC1257693 Transposon-mediated insertional mutagenesis revealed the functions of animal cellulose synthase in the ascidian Ciona intestinalis Yasunori Sasakura, Keisuke Nakashima, Satoko Awazu, Terumi Matsuoka, Akie Nakayama, Jun-ichi Azuma, and Nori Satoh PMCID: PMC1257696 Ecology Measuring the transmission dynamics of a sexually transmitted disease Jonathan J. Ryder, K. Mary Webberley, Michael Boots, and Robert J. Knell PMCID: PMC1257709 Environmental Sciences Regional vegetation die-off in response to global-change-type drought David D. Breshears, Neil S. Cobb, Paul M. Rich, Kevin P. Price, Craig D. Allen, Randy G. Balice, William H. Romme, Jude H. Kastens, M. Lisa Floyd, Jayne Belnap, Jesse J. Anderson, Orrin B. Myers, and Clifton W. Meyer PMCID: PMC1250231 Evolution The evolutionary origin of a complex scrambled gene Wei-Jen Chang, Paul D. Bryson, Han Liang, Mann Kyoon Shin, and Laura F. Landweber PMCID: PMC1257744 A spider that feeds indirectly on vertebrate blood by choosing female mosquitoes as prey Robert R. Jackson, Ximena J. Nelson, and Godfrey O. Sune PMCID: PMC1257728 Adaptive evolution of heparanase in hypoxia-tolerant Spalax: Gene cloning and identification of a unique splice variant Nicola J. Nasser, Eviatar Nevo, Itay Shafat, Neta Ilan, Israel Vlodavsky, and Aaron Avivi PMCID: PMC1257723 Genetics Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance Xiaolin Bi, Deepa Srikanta, Laura Fanti, Sergio Pimpinelli, RamaKrishna Badugu, Rebecca Kellum, and Yikang S. Rong PMCID: PMC1257705 Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2 Courtney T. Griffin, JoAnn Trejo, and Terry Magnuson PMCID: PMC1257690 Immunology Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease Norihito Yazawa, Yasuhito Hamaguchi, Jonathan C. Poe, and Thomas F. Tedder PMCID: PMC1257712 Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness Daniel R. Johnson, Jason C. O'Connor, Robert Dantzer, and Gregory G. Freund PMCID: PMC1257721 HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates Ulrike Wille-Reece, Barbara J. Flynn, Karin Loré, Richard A. Koup, Ross M. Kedl, Joseph J. Mattapallil, Walter R. Weiss, Mario Roederer, and Robert A. Seder PMCID: PMC1257732 Medical Sciences From the Cover:
A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3β/FBW7 loss of function Sabine Rottmann, Yan Wang, Marc Nasoff, Quinn L. Deveraux, and Kim C. Quon PMCID: PMC1257707 Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions Yanping Zhang, Wenxue Tang, Shoab Ahmad, James A. Sipp, Ping Chen, and Xi Lin PMCID: PMC1257692 Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity Thomas Ho-Yin Leung, Yick-Pang Ching, Judy Wai Ping Yam, Chun-Ming Wong, Tai-On Yau, Dong-Yan Jin, and Irene Oi-Lin Ng PMCID: PMC1250229 Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL) Ryu-ichi Fukuda, Ayako Hayashi, Atae Utsunomiya, Yuko Nukada, Rie Fukui, Katsuhiko Itoh, Katsunari Tezuka, Kazumasa Ohashi, Kensaku Mizuno, Manabu Sakamoto, Masahiro Hamanoue, and Takashi Tsuji PMCID: PMC1257720 Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy D. Ragozzino, E. Palma, S. Di Angelantonio, M. Amici, A. Mascia, A. Arcella, F. Giangaspero, G. Cantore, G. Di Gennaro, M. Manfredi, V. Esposito, P. P. Quarato, R. Miledi, and F. Eusebi PMCID: PMC1257725 Neuroscience Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice Amy K. Y. Fu, Fanny C. F. Ip, Wing-Yu Fu, Janet Cheung, Jerry H. Wang, Wing-Ho Yung, and Nancy Y. Ip PMCID: PMC1257743 Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling Chay T. Kuo, Lily Y. Jan, and Yuh Nung Jan PMCID: PMC1242853 Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain J. Gotman, C. Grova, A. Bagshaw, E. Kobayashi, Y. Aghakhani, and F. Dubeau PMCID: PMC1257704 Physiology Low mobility of phosphatidylinositol 4,5-bisphosphate underlies receptor specificity of Gq-mediated ion channel regulation in atrial myocytes Hana Cho, Yeon A. Kim, Jin-Young Yoon, Doyun Lee, Jae Ho Kim, Suk Ho Lee, and Won-Kyung Ho PMCID: PMC1257688 Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2 Mari Leppilampi, Seppo Parkkila, Tuomo Karttunen, Marta Ortova Gut, Gerolf Gros, and Markus Sjöblom PMCID: PMC1257747 Plant Biology From the Cover:
The UGT73C5 of Arabidopsis thaliana glucosylates brassinosteroids Brigitte Poppenberger, Shozo Fujioka, Kazuo Soeno, Gilu L. George, Fabián E. Vaistij, Sayoko Hiranuma, Hideharu Seto, Suguru Takatsuto, Gerhard Adam, Shigeo Yoshida, and Dianna Bowles PMCID: PMC1257699 Population Biology Dynamic effects of antibody-dependent enhancement on the fitness of viruses Derek A. T. Cummings, Ira B. Schwartz, Lora Billings, Leah B. Shaw, and Donald S. Burke PMCID: PMC1257724 Human infection patterns and heterogeneous exposure in river blindness João A. N. Filipe, Michel Boussinesq, Alfons Renz, Richard C. Collins, Sarai Vivas-Martinez, María-Eugenia Grillet, Mark P. Little, and María-Gloria Basáñez PMCID: PMC1257694 Social Sciences Psychology Oscillatory activity in the infant brain reflects object maintenance Jordy Kaufman, Gergely Csibra, and Mark H. Johnson PMCID: PMC1257741 |
