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Volume 102(28);  July 12, 2005
From the Academy
Modeling attacks on the food supply
Bruce Alberts
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9737–9738. Published online 2005 June 28. doi: 10.1073/pnas.0504944102.
PMCID: PMC1175018
In This Issue
This Week in PNAS
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9735–9736. doi: 10.1073/iti2805102.
PMCID: PMC1175019
Commentary
Efficient hepatitis C virus cell culture system: What a difference the host cell makes
Ralf Bartenschlager and Thomas Pietschmann
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9739–9740. Published online 2005 July 5. doi: 10.1073/pnas.0504296102.
PMCID: PMC1175013
Physical Sciences
Chemistry
Initial synthesis and structure of an all-ferrous analogue of the fully reduced [Fe4S4]0 cluster of the nitrogenase iron protein
Thomas A. Scott, Curtis P. Berlinguette, Richard H. Holm, and Hong-Cai Zhou
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9741–9744. Published online 2005 June 28. doi: 10.1073/pnas.0504258102.
PMCID: PMC1175011
Fisher's theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics
Marcel O. Vlad, Stefan E. Szedlacsek, Nader Pourmand, L. Luca Cavalli-Sforza, Peter Oefner, and John Ross
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9848–9853. Published online 2005 June 30. doi: 10.1073/pnas.0504073102.
PMCID: PMC1175005
Engineering
A modular microfluidic architecture for integrated biochemical analysis
Kashan A. Shaikh, Kee Suk Ryu, Edgar D. Goluch, Jwa-Min Nam, Juewen Liu, C. Shad Thaxton, Thomas N. Chiesl, Annelise E. Barron, Yi Lu, Chad A. Mirkin, and Chang Liu
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9745–9750. Published online 2005 June 28. doi: 10.1073/pnas.0504082102.
PMCID: PMC1161008
Geophysics
Iron-rich silicates in the Earth's D″ layer
Wendy L. Mao, Yue Meng, Guoyin Shen, Vitali B. Prakapenka, Andrew J. Campbell, Dion L. Heinz, Jinfu Shu, Razvan Caracas, Ronald E. Cohen, Yingwei Fei, Russell J. Hemley, and Ho-kwang Mao
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9751–9753. Published online 2005 June 30. doi: 10.1073/pnas.0503737102.
PMCID: PMC1174998
Biological Sciences
Biochemistry
Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants
Mikael J. Lindberg, Roberth Byström, Niklas Boknäs, Peter M. Andersen, and Mikael Oliveberg
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9754–9759. Published online 2005 June 29. doi: 10.1073/pnas.0501957102.
PMCID: PMC1174986
Isolation and functional expression of an animal geranyl diphosphate synthase and its role in bark beetle pheromone biosynthesis
Anna B. Gilg, Jeremy C. Bearfield, Claus Tittiger, William H. Welch, and Gary J. Blomquist
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9760–9765. Published online 2005 June 27. doi: 10.1073/pnas.0503277102.
PMCID: PMC1174994
Sequential phosphorylation of CCAAT enhancer-binding protein β by MAPK and glycogen synthase kinase 3β is required for adipogenesis
Qi-Qun Tang, Mads Grønborg, Haiyan Huang, Jae-Woo Kim, Tamara C. Otto, Akhilesh Pandey, and M. Daniel Lane
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9766–9771. Published online 2005 June 28. doi: 10.1073/pnas.0503891102.
PMCID: PMC1175002
Soluble epoxide hydrolase is a therapeutic target for acute inflammation
Kara R. Schmelzer, Lukas Kubala, John W. Newman, In-Hae Kim, Jason P. Eiserich, and Bruce D. Hammock
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9772–9777. Published online 2005 June 30. doi: 10.1073/pnas.0503279102.
PMCID: PMC1168955
Telomerase can act as a template- and RNA-independent terminal transferase
Neal F. Lue, Dimitry Bosoy, Tara J. Moriarty, Chantal Autexier, Brian Altman, and Siyang Leng
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9778–9783. Published online 2005 June 30. doi: 10.1073/pnas.0502252102.
PMCID: PMC1174988
From the Cover:
Evolution of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae
Kerstin Helmstaedt, Axel Strittmatter, William N. Lipscomb, and Gerhard H. Braus
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9784–9789. Published online 2005 June 29. doi: 10.1073/pnas.0504238102.
PMCID: PMC1175010
Biophysics
On soliton propagation in biomembranes and nerves
Thomas Heimburg and Andrew D. Jackson
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9790–9795. Published online 2005 July 1. doi: 10.1073/pnas.0503823102.
PMCID: PMC1175000
Single-molecule studies of repressor–DNA interactions show long-range interactions
Y. M. Wang, Jonas O. Tegenfeldt, W. Reisner, R. Riehn, Xiao-Juan Guan, Ling Guo, Ido Golding, Edward C. Cox, James Sturm, and Robert H. Austin
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9796–9801. Published online 2005 June 30. doi: 10.1073/pnas.0502917102.
PMCID: PMC1168954
Cell Biology
The structural basis of androgen receptor activation: Intramolecular and intermolecular amino–carboxy interactions
Fred Schaufele, Xavier Carbonell, Martin Guerbadot, Sabine Borngraeber, Mark S. Chapman, Aye Aye K. Ma, Jeffrey N. Miner, and Marc I. Diamond
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9802–9807. Published online 2005 July 1. doi: 10.1073/pnas.0408819102.
PMCID: PMC1168953
Stochastic model for Soj relocation dynamics in Bacillus subtilis
Konstantin Doubrovinski and Martin Howard
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9808–9813. Published online 2005 July 5. doi: 10.1073/pnas.0500529102.
PMCID: PMC1174977
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and α-actinin are components of the nephrin multiprotein complex
Sanna Lehtonen, Jennifer J. Ryan, Krystyna Kudlicka, Noriaki Iino, Huilin Zhou, and Marilyn G. Farquhar
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9814–9819. Published online 2005 July 1. doi: 10.1073/pnas.0504166102.
PMCID: PMC1175008
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets
Nicolas Prévost, Donna S. Woulfe, Hong Jiang, Timothy J. Stalker, Patrizia Marchese, Zaverio M. Ruggeri, and Lawrence F. Brass
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9820–9825. Published online 2005 July 1. doi: 10.1073/pnas.0404065102.
PMCID: PMC1174973
Ecology
Estimating the total genetic diversity of a spatial field population from a sample and implications of its dependence on habitat area
Erik M. Rauch and Yaneer Bar-Yam
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9826–9829. Published online 2005 July 5. doi: 10.1073/pnas.0408471102.
PMCID: PMC1174974
Evolution
Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences
Jim R. Hughes, Jan-Fang Cheng, Nicki Ventress, Shyam Prabhakar, Kevin Clark, Eduardo Anguita, Marco De Gobbi, Pieter de Jong, Eddy Rubin, and Douglas R. Higgs
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9830–9835. doi: 10.1073/pnas.0503401102.
PMCID: PMC1174996
Replication-associated strand asymmetries in mammalian genomes: Toward detection of replication origins
Marie Touchon, Samuel Nicolay, Benjamin Audit, Edward-Benedict Brodie of Brodie, Yves d'Aubenton-Carafa, Alain Arneodo, and Claude Thermes
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9836–9841. Published online 2005 June 28. doi: 10.1073/pnas.0500577102.
PMCID: PMC1174978
Genetics
Stable barley chromosomes without centromeric repeats
S. Nasuda, S. Hudakova, I. Schubert, A. Houben, and T. R. Endo
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9842–9847. Published online 2005 July 5. doi: 10.1073/pnas.0504235102.
PMCID: PMC1175009
Fisher's theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics
Marcel O. Vlad, Stefan E. Szedlacsek, Nader Pourmand, L. Luca Cavalli-Sforza, Peter Oefner, and John Ross
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9848–9853. Published online 2005 June 30. doi: 10.1073/pnas.0504073102.
PMCID: PMC1175005
APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast
April J. Schumacher, Dwight V. Nissley, and Reuben S. Harris
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9854–9859. Published online 2005 July 6. doi: 10.1073/pnas.0501694102.
PMCID: PMC1172225
Immunology
Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors
Sumathi Sankaran, Moraima Guadalupe, Elizabeth Reay, Michael D. George, Jason Flamm, Thomas Prindiville, and Satya Dandekar
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9860–9865. Published online 2005 June 24. doi: 10.1073/pnas.0503463102.
PMCID: PMC1159164
Control of T helper 2 cell function and allergic airway inflammation by PKCζ
Pilar Martin, Ricardo Villares, Sandra Rodriguez-Mascarenhas, Angel Zaballos, Michael Leitges, Judit Kovac, Irene Sizing, Paul Rennert, Gabriel Márquez, Carlos Martínez-A, María T. Diaz-Meco, and Jorge Moscat
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9866–9871. Published online 2005 June 29. doi: 10.1073/pnas.0501202102.
PMCID: PMC1174981
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
P'ng Loke, Xingxing Zang, Lisa Hsuan, Rebecca Waitz, Richard M. Locksley, Judith E. Allen, and James P. Allison
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9872–9877. Published online 2005 July 1. doi: 10.1073/pnas.0503961102.
PMCID: PMC1175004
Medical Sciences
From the Cover:
Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer
Dulal Panda, K. Rathinasamy, Manas K. Santra, and Leslie Wilson
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9878–9883. Published online 2005 June 28. doi: 10.1073/pnas.0501821102.
PMCID: PMC1174985
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice
Timothy R. Carlson, Yibing Yan, Xiaoqing Wu, Michael T. Lam, Gale L. Tang, Levi J. Beverly, Louis M. Messina, Anthony J. Capobianco, Zena Werb, and Rong Wang
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9884–9889. Published online 2005 June 30. doi: 10.1073/pnas.0504391102.
PMCID: PMC1175015
The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells
Yuexing Zhang, Xin-Wei Wang, Danijela Jelovac, Takeo Nakanishi, Myoung-hee Yu, Damilola Akinmade, Olga Goloubeva, Douglas D. Ross, Angela Brodie, and Anne W. Hamburger
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9890–9895. Published online 2005 June 30. doi: 10.1073/pnas.0503829102.
PMCID: PMC1175001
The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of β-like globin genes
Dongxiao Feng and Yuet Wai Kan
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9896–9900. Published online 2005 July 5. doi: 10.1073/pnas.0502041102.
PMCID: PMC1174987
An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers
Joseph E. Ippolito, Jian Xu, Sanjay Jain, Krista Moulder, Steven Mennerick, Jan R. Crowley, R. Reid Townsend, and Jeffrey I. Gordon
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9901–9906. Published online 2005 July 5. doi: 10.1073/pnas.0500756102.
PMCID: PMC1169236
Microbiology
From the Cover:
Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120
Sophie Laurent, Han Chen, Sylvie Bédu, Fabio Ziarelli, Ling Peng, and Cheng-Cai Zhang
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9907–9912. Published online 2005 June 28. doi: 10.1073/pnas.0502337102.
PMCID: PMC1174989
Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids
Stefan F. Wieland, Angelina Eustaquio, Christina Whitten-Bauer, Bryan Boyd, and Francis V. Chisari
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9913–9917. Published online 2005 July 1. doi: 10.1073/pnas.0504273102.
PMCID: PMC1175012
A tumor necrosis factor receptor family protein serves as a cellular receptor for the macrophage-tropic equine lentivirus
Baoshan Zhang, Sha Jin, Jing Jin, Feng Li, and Ronald C. Montelaro
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9918–9923. Published online 2005 June 28. doi: 10.1073/pnas.0501560102.
PMCID: PMC1174982
The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages
John-Demian Sauer, Michael A. Bachman, and Michele S. Swanson
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9924–9929. Published online 2005 July 5. doi: 10.1073/pnas.0502767102.
PMCID: PMC1174991
A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system
Mark L. Urbanowski, Guinevere L. Lykken, and Timothy L. Yahr
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9930–9935. Published online 2005 June 28. doi: 10.1073/pnas.0504405102.
PMCID: PMC1175016
Neuroscience
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
Jianrong Li, Olivier Baud, Timothy Vartanian, Joseph J. Volpe, and Paul A. Rosenberg
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9936–9941. Published online 2005 July 5. doi: 10.1073/pnas.0502552102.
PMCID: PMC1174990
From the Cover:
Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain
Michele A. Kelly, Carsten T. Beuckmann, S. Clay Williams, Christopher M. Sinton, Toshiyuki Motoike, James A. Richardson, Robert E. Hammer, Mary G. Garry, and Masashi Yanagisawa
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9942–9947. Published online 2005 June 27. doi: 10.1073/pnas.0503795102.
PMCID: PMC1174999
Synchronous neural activity in scale-free network models versus random network models
Geoffrey Grinstein and Ralph Linsker
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9948–9953. Published online 2005 July 5. doi: 10.1073/pnas.0504127102.
PMCID: PMC1175007
Physiology
Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK)
Anthony D. O'Connell, Qiang Leng, Ke Dong, Gordon G. MacGregor, Gerhard Giebisch, and Steven C. Hebert
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9954–9959. Published online 2005 June 29. doi: 10.1073/pnas.0504332102.
PMCID: PMC1175014
Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus
Haibin Wang, Susanne Tranguch, Huirong Xie, Gregory Hanley, Sanjoy K. Das, and Sudhansu K. Dey
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9960–9965. Published online 2005 June 29. doi: 10.1073/pnas.0501632102.
PMCID: PMC1174983
Plant Biology
HOS10 encodes an R2R3-type MYB transcription factor essential for cold acclimation in plants
Jianhua Zhu, Paul E. Verslues, Xianwu Zheng, Byeong-ha Lee, Xiangqiang Zhan, Yuzuki Manabe, Irina Sokolchik, Yanmei Zhu, Chun-Hai Dong, Jian-Kang Zhu, Paul M. Hasegawa, and Ray A. Bressan
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9966–9971. Published online 2005 July 1. doi: 10.1073/pnas.0503960102.
PMCID: PMC1175003
Agrobacterium tumefaciens increases cytokinin production in plastids by modifying the biosynthetic pathway in the host plant
Hitoshi Sakakibara, Hiroyuki Kasahara, Nanae Ueda, Mikiko Kojima, Kentaro Takei, Shojiro Hishiyama, Tadao Asami, Kazunori Okada, Yuji Kamiya, Tomoyuki Yamaya, and Shinjiro Yamaguchi
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9972–9977. Published online 2005 July 5. doi: 10.1073/pnas.0500793102.
PMCID: PMC1174980
Psychology
Hypnotic suggestion reduces conflict in the human brain
Amir Raz, Jin Fan, and Michael I. Posner
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9978–9983. Published online 2005 June 30. doi: 10.1073/pnas.0503064102.
PMCID: PMC1174993
Social Sciences
Social Sciences
Analyzing a bioterror attack on the food supply: The case of botulinum toxin in milk
Lawrence M. Wein and Yifan Liu
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9984–9989. Published online 2005 June 28. doi: 10.1073/pnas.0408526102.
PMCID: PMC1161865
Correction
Proc Natl Acad Sci U S A. 2005 July 12; 102(28): 9990. doi: 10.1073/pnas.0504835102.
PMCID: PMC1175017
Corrects: Jonathan M. Jeschke, et al. From the Cover:
Invasion success of vertebrates in Europe and North America.
Proc Natl Acad Sci U S A. 2005 May 17; 102(20): 7198–7202.
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