| | This journal provides immediate access to some articles. In This Issue J Clin Invest. 2004 April 15; 113(8): 1071. doi: 10.1172/JCI119997.PMCID: PMC385421 Editorial When did everyone become so naughty? Ushma Savla PMCID: PMC385420 News Getting under your skin Laurie Goodman PMCID: PMC385419 Book Review In the beginning was the worm: Finding the secrets of life in a tiny hermaphrodite Catherine A. Wolkow and Mark P. Mattson PMCID: PMC385416 Science in Medicine Salt handling and hypertension Kevin M. O’Shaughnessy and Fiona E. Karet PMCID: PMC385413 Review Series Antimalarial drug resistance Nicholas J. White PMCID: PMC385418 The emergence of Lyme disease Allen C. Steere, Jenifer Coburn, and Lisa Glickstein PMCID: PMC385417 West Nile virus: a growing concern? L. Hannah Gould and Erol Fikrig PMCID: PMC385414 Commentaries Blood to brain to the rescue Richard L. Proia and Yun-Ping Wu PMCID: PMC385411 Undermining the endothelium by ablation of MAPK-MEF2 signaling Eric N. Olson PMCID: PMC385412 Insig: a significant integrator of nutrient and hormonal signals Alan D. Attie PMCID: PMC385410 Experimental autoimmune hearing loss Peter Billings PMCID: PMC385415 Articles Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells Alessandra Biffi, Michele De Palma, Angelo Quattrini, Ubaldo Del Carro, Stefano Amadio, Ilaria Visigalli, Maria Sessa, Stefania Fasano, Riccardo Brambilla, Sergio Marchesini, Claudio Bordignon, and Luigi Naldini PMCID: PMC385395 Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system Patrick Y. Jay, Brett S. Harris, Colin T. Maguire, Antje Buerger, Hiroko Wakimoto, Makoto Tanaka, Sabina Kupershmidt, Dan M. Roden, Thomas M. Schultheiss, Terrence X. O’Brien, Robert G. Gourdie, Charles I. Berul, and Seigo Izumo PMCID: PMC385399 Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure Masaaki Hayashi, Sung-Woo Kim, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, E. Dale Abel, Brian Eliceiri, Young Yang, Richard J. Ulevitch, and Jiing-Dwan Lee PMCID: PMC385403 Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease Jesús Ruberte, Eduard Ayuso, Marc Navarro, Ana Carretero, Víctor Nacher, Virginia Haurigot, Mónica George, Cristina Llombart, Alba Casellas, Cristina Costa, Assumpció Bosch, and Fatima Bosch PMCID: PMC385397 MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs Giovanni Sitia, Masanori Isogawa, Matteo Iannacone, Iain L. Campbell, Francis V. Chisari, and Luca G. Guidotti PMCID: PMC385409 Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis Luke J. Engelking, Hiroshi Kuriyama, Robert E. Hammer, Jay D. Horton, Michael S. Brown, Joseph L. Goldstein, and Guosheng Liang PMCID: PMC385408 Altered lipid raft–associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus Elizabeth C. Jury, Panagiotis S. Kabouridis, Fabian Flores-Borja, Rizgar A. Mageed, and David A. Isenberg PMCID: PMC385405 Human immunoglobulin selection associated with class switch and possible tolerogenic origins for Cδ class-switched B cells Nai-Ying Zheng, Kenneth Wilson, Xiaojian Wang, Angela Boston, Grant Kolar, Stephen M. Jackson, Yong-Jun Liu, Virginia Pascual, J. Donald Capra, and Patrick C. Wilson PMCID: PMC385404 The endogenous cannabinoid system protects against colonic inflammation Federico Massa, Giovanni Marsicano, Heike Hermann, Astrid Cannich, Krisztina Monory, Benjamin F. Cravatt, Gian-Luca Ferri, Andrei Sibaev, Martin Storr, and Beat Lutz PMCID: PMC385396 Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides C. Arturo Solares, Andrea E. Edling, Justin M. Johnson, Moo-Jin Baek, Keiko Hirose, Gordon B. Hughes, and Vincent K. Tuohy PMCID: PMC385394 Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes Vily Panoutsakopoulou, Katharina M. Huster, Nami McCarty, Evan Feinberg, Rijian Wang, Kai W. Wucherpfennig, and Harvey Cantor PMCID: PMC385407 An immunodominant SSX-2–derived epitope recognized by CD4+ T cells in association with HLA-DR Maha Ayyoub, Charles S. Hesdorffer, Monica Montes, Andrea Merlo, Daniel Speiser, Donata Rimoldi, Jean-Charles Cerottini, Gerd Ritter, Matthew Scanlan, Lloyd J. Old, and Danila Valmori PMCID: PMC385406 A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression Janete M. Cerutti, Rosana Delcelo, Marcelo João Amadei, Claudia Nakabashi, Rui M.B. Maciel, Bercedis Peterson, Jennifer Shoemaker, and Gregory J. Riggins PMCID: PMC385398 |
