Do basic region-leucine zipper proteins bend their DNA targets ... does it matter?

Coordinating DNA replication with cell division: current status of the licensing concept.

The yeast two-hybrid system: forward and reverse.

The minimal cell genome: "on being the right size".

A modified gambler's ruin model of polyethylene chains in the amorphous region.

Dendrimer-supported combinatorial chemistry.

On the mechanism of action of ribonuclease A: relevance of enzymatic studies with a p-nitrophenylphosphate ester and a thiophosphate ester.

Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice.

Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex.

Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.

Dependence of agonist activation on a conserved apolar residue in the third intracellular loop of the AT1 angiotensin receptor.

Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase.

ATPase activity of Escherichia coli Rep helicase crosslinked to single-stranded DNA: implications for ATP driven helicase translocation.

Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible system.

Initiation of (-) strand DNA synthesis from tRNA(3Lys) on lentiviral RNAs: implications of specific HIV-1 RNA-tRNA(3Lys) interactions inhibiting primer utilization by retroviral reverse transcriptases.

Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator.

Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein.

Ultrasensitivity in the mitogen-activated protein kinase cascade.

Behavioral responses of Escherichia coli to changes in redox potential.

Signal termination in bacterial chemotaxis: CheZ mediates dephosphorylation of free rather than switch-bound CheY.

SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form.

Newly identified stress-responsive protein kinases, Krs-1 and Krs-2.

Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor.

Alpha-lactalbumin affects the acceptor specificity of Lymnaea stagnalis albumen gland UDP-GalNAc:GlcNAc beta-R beta 1-->4-N-acetylgalactosaminyltransferase: synthesis of GalNAc beta 1-->4Glc.

Fos and Jun bend the AP-1 site: effects of probe geometry on the detection of protein-induced DNA bending.

Site-directed spin labeling and chemical crosslinking demonstrate that helix V is close to helices VII and VIII in the lactose permease of Escherichia coli.

Interaction between human tRNA synthetases involves repeated sequence elements.

Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.

Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin.

Phosducin is a ubiquitous G-protein regulator.

Dual-function regulators: the cAMP receptor protein and the CytR regulator can act either to repress or to activate transcription depending on the context.

Mismatch repair in Xenopus egg extracts: DNA strand breaks act as signals rather than excision points.

Determinants of RNA polymerase alpha subunit for interaction with beta, beta', and sigma subunits: hydroxyl-radical protein footprinting.

Packing at the protein-water interface.

Glass transition in DNA from molecular dynamics simulations.

The fifth epidermal growth factor-like domain of thrombomodulin does not have an epidermal growth factor-like disulfide bonding pattern.

Circadian gating of cell division in cyanobacteria growing with average doubling times of less than 24 hours.

XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication.

Translocation of PKN from the cytosol to the nucleus induced by stresses.

Ordered tandem arrangement of chromosomes in the sperm heads of monotreme mammals.

Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells.

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleus.

Rad51 expression and localization in B cells carrying out class switch recombination.

Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.

Cellular expression of human centromere protein C demonstrates a cyclic behavior with highest abundance in the G1 phase.

Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

Fibroblast growth factor 2 can replace ectodermal signaling for feather development.

Histone H1 overexpressed to high level in tobacco affects certain developmental programs but has limited effect on basal cellular functions.

Selective constraints on the activation domain of transcription factor Pit-1.

Female mating preference for bold males in the guppy, Poecilia reticulata.

A minimal gene set for cellular life derived by comparison of complete bacterial genomes.

Substitution rate comparisons between grasses and palms: synonymous rate differences at the nuclear gene Adh parallel rate differences at the plastid gene rbcL.

Plant virus DNA replication processes in Agrobacterium: insight into the origins of geminiviruses?

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Regulation of SOS mutagenesis by proteolysis.

Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.

Highly plastic chromosomal organization in Salmonella typhi.

Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.

Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.

Identification of novel genes in Drosophila reveals the complex regulation of early gene activity in the mesoderm.

Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects.

Shared fine specificity between T-cell receptors and an antibody recognizing a peptide/major histocompatibility class I complex.

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.

Interleukin 7 independent development of human B cells.

Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes.

The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

Clonal analysis of stably transduced human epidermal stem cells in culture.

A novel nonneuronal catecholaminergic system: exocrine pancreas synthesizes and releases dopamine.

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.

Relationship between psychostimulant-induced "high" and dopamine transporter occupancy.

Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.

Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.

Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity.

c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1.

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

Open reading frame P--a herpes simplex virus gene repressed during productive infection encodes a protein that binds a splicing factor and reduces synthesis of viral proteins made from spliced mRNA.

Propagation of an attenuated virus by design: engineering a novel receptor for a noninfectious foot-and-mouth disease virus.

Large-scale isolation of candidate virulence genes of Pseudomonas aeruginosa by in vivo selection.

Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: novel targets for cAMP/cGMP function.

Influence of general anesthetics on a specific neural pathway in Drosophila melanogaster.

Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation.

Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo.

Two new forms of gonadotropin-releasing hormone in a protochordate and the evolutionary implications.

P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.

SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis.

CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice.

NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels.

Nonlinear dynamics in ventricular fibrillation.

Rapid activation of Na+/H+ exchange by aldosterone in renal epithelial cells requires Ca2+ and stimulation of a plasma membrane proton conductance.

A biologic function for an "orphan" messenger: D-myo-inositol 3,4,5,6-tetrakisphosphate selectively blocks epithelial calcium-activated chloride channels.

Potassium homeostasis in vacuolate plant cells.

The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway.

Phosphate transporters from the higher plant Arabidopsis thaliana.

Immunocytochemical localization of acyl-lipid desaturases in cyanobacterial cells: evidence that both thylakoid membranes and cytoplasmic membranes are sites of lipid desaturation.

Measurement of genetic structure within populations using Moran's spatial autocorrelation statistics.

Mnemonic neuronal activity in somatosensory cortex.

Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH