| | This journal provides immediate access to some articles. Commentaries Stepwise helix formation and chain compaction during protein folding Heinrich Roder PMCID: PMC357004 Slow-wave sleep, acetylcholine, and memory consolidation Ann E. Power PMCID: PMC357005 Biography INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Karl Hess Christen Brownlee PMCID: PMC383292 Physical Sciences Applied Mathematics The elements of draping E. Cerda, L. Mahadevan, and J. M. Pasini PMCID: PMC357008 Mathematics INAUGURAL ARTICLE by a Recently Elected Academy Member: Breakdown of Bell's theorem for certain objective local parameter spaces Karl Hess and Walter Philipp PMCID: PMC357007 Physics From the Cover:
Molecular modulation of calcium oxalate crystallization by osteopontin and citrate S. R. Qiu, A. Wierzbicki, C. A. Orme, A. M. Cody, J. R. Hoyer, G. H. Nancollas, S. Zepeda, and J. J. De Yoreo PMCID: PMC357009 Biological Sciences Biochemistry Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment Michael D. Feese, Taro Tamada, Yoichi Kato, Yoshitake Maeda, Masako Hirose, Yasuko Matsukura, Hideki Shigematsu, Takanori Muto, Atsushi Matsumoto, Hiroshi Watarai, Kinya Ogami, Tomoyuki Tahara, Takashi Kato, Hiroshi Miyazaki, and Ryota Kuroki PMCID: PMC357010 Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems David Angeli, James E. Ferrell, Jr., and Eduardo D. Sontag PMCID: PMC357011 From the Cover:
Computational design of water-soluble analogues of the potassium channel KcsA Avram M. Slovic, Hidetoshi Kono, James D. Lear, Jeffery G. Saven, and William F. DeGrado PMCID: PMC357012 The role of protein tyrosine phosphatase 1B in Ras signaling Nadia Dubé, Alan Cheng, and Michel L. Tremblay PMCID: PMC357013 The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells Chaitanya S. Nirodi, Brenda C. Crews, Kevin R. Kozak, Jason D. Morrow, and Lawrence J. Marnett PMCID: PMC357014 Cholesterol feeding of mice expressing cholesterol 7α-hydroxylase increases bile acid pool size despite decreased enzyme activity Michaela Tiemann, Zhihua Han, Raymond Soccio, Jaya Bollineni, Sarah Shefer, Ephraim Sehayek, and Jan L. Breslow PMCID: PMC357015 Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins Klas Jönsson, Betty P. Guo, Hans-Jürg Monstein, John J. Mekalanos, and Göran Kronvall PMCID: PMC357016 Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex Ed Hurt, Ming-juan Luo, Susanne Röther, Robin Reed, and Katja Sträßer PMCID: PMC357017 Replication of plant RNA virus genomes in a cell-free extract of evacuolated plant protoplasts Keisuke Komoda, Satoshi Naito, and Masayuki Ishikawa PMCID: PMC357018 Cell Biology From the Cover:
Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic D. William Provance, Jr., Christopher R. Gourley, Colleen M. Silan, L. C. Cameron, Kevan M. Shokat, James R. Goldenring, Kavita Shah, Peter G. Gillespie, and John A. Mercer PMCID: PMC357019 Rho activity critically and selectively regulates endothelial cell organization during angiogenesis Mien V. Hoang, Mary C. Whelan, and Donald R. Senger PMCID: PMC357020 Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro I. Zucchi, A. Prinetti, M. Scotti, V. Valsecchi, R. Valaperta, E. Mento, R. Reinbold, P. Vezzoni, S. Sonnino, A. Albertini, and R. Dulbecco PMCID: PMC357021 Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases Camilla Persson, Tobias Sjöblom, Arnoud Groen, Kai Kappert, Ulla Engström, Ulf Hellman, Carl-Henrik Heldin, Jeroen den Hertog, and Arne Östman PMCID: PMC357022 Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells Peter C. Scacheri, Orit Rozenblatt-Rosen, Natasha J. Caplen, Tyra G. Wolfsberg, Lowell Umayam, Jeffrey C. Lee, Christina M. Hughes, Kalai Selvi Shanmugam, Arindam Bhattacharjee, Matthew Meyerson, and Francis S. Collins PMCID: PMC357023 The promyelocytic leukemia zinc finger protein down-regulates apoptosis and expression of the proapoptotic BID protein in lymphocytes Antonio Parrado, Macarena Robledo, M. Rosa Moya-Quiles, Luis A. Marín, Christine Chomienne, Rose Ann Padua, and M. Rocío Álvarez-López PMCID: PMC357024 Evolution Darwin's abominable mystery: Insights from a supertree of the angiosperms T. Jonathan Davies, Timothy G. Barraclough, Mark W. Chase, Pamela S. Soltis, Douglas E. Soltis, and Vincent Savolainen PMCID: PMC357025 Type I MADS-box genes have experienced faster birth-and-death evolution than type II MADS-box genes in angiosperms Jongmin Nam, Joonyul Kim, Shinyoung Lee, Gynheung An, Hong Ma, and Masatoshi Nei PMCID: PMC357026 Genetics Whole-genome shotgun assembly and comparison of human genome assemblies Sorin Istrail, Granger G. Sutton, Liliana Florea, Aaron L. Halpern, Clark M. Mobarry, Ross Lippert, Brian Walenz, Hagit Shatkay, Ian Dew, Jason R. Miller, Michael J. Flanigan, Nathan J. Edwards, Randall Bolanos, Daniel Fasulo, Bjarni V. Halldorsson, Sridhar Hannenhalli, Russell Turner, Shibu Yooseph, Fu Lu, Deborah R. Nusskern, Bixiong Chris Shue, Xiangqun Holly Zheng, Fei Zhong, Arthur L. Delcher, Daniel H. Huson, Saul A. Kravitz, Laurent Mouchard, Knut Reinert, Karin A. Remington, Andrew G. Clark, Michael S. Waterman, Evan E. Eichler, Mark D. Adams, Michael W. Hunkapiller, Eugene W. Myers, and J. Craig Venter PMCID: PMC357027 Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors Usha Acharya, Michael Beth Mowen, Kunio Nagashima, and Jairaj K. Acharya PMCID: PMC357028 From the Cover:
Inducible, reversible, and stable RNA interference in mammalian cells Sunita Gupta, Rebecca A. Schoer, James E. Egan, Gregory J. Hannon, and Vivek Mittal PMCID: PMC357029 Linear-After-The-Exponential (LATE)–PCR: An advanced method of asymmetric PCR and its uses in quantitative real-time analysis J. Aquiles Sanchez, Kenneth E. Pierce, John E. Rice, and Lawrence J. Wangh PMCID: PMC357030 Identification of a prostate cancer susceptibility locus on chromosome 7q11–21 in Jewish families Danielle M. Friedrichsen, Janet L. Stanford, Sarah D. Isaacs, Marta Janer, Bao-li Chang, Kerry Deutsch, Elizabeth Gillanders, Suzanne Kolb, Katherine E. Wiley, Michael D. Badzioch, S. Lilly Zheng, Patrick C. Walsh, Gail P. Jarvik, Leroy Hood, Jeffrey M. Trent, William B. Isaacs, Elaine A. Ostrander, and Jianfeng Xu PMCID: PMC357031 Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C B. H. Collins, E. Rosato, and C. P. Kyriacou PMCID: PMC357032 Immunology Mimicking live flavivirus immunization with a noninfectious RNA vaccine Regina M. Kofler, Judith H. Aberle, Stephan W. Aberle, Steven L. Allison, Franz X. Heinz, and Christian W. Mandl PMCID: PMC357033 Cofilin peptide homologs interfere with immunological synapse formation and T cell activation Sybille M. Eibert, Kyeong-Hee Lee, Rüdiger Pipkorn, Urban Sester, Guido H. Wabnitz, Thomas Giese, Stefan C. Meuer, and Yvonne Samstag PMCID: PMC357034 Development of a specific system for targeting protein to metallophilic macrophages Philip R. Taylor, Susanne Zamze, Richard J. Stillion, Simon Y. C. Wong, Siamon Gordon, and Luisa Martinez-Pomares PMCID: PMC357035 IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells Christopher A. Klebanoff, Steven E. Finkelstein, Deborah R. Surman, Michael K. Lichtman, Luca Gattinoni, Marc R. Theoret, Navrose Grewal, Paul J. Spiess, Paul A. Antony, Douglas C. Palmer, Yutaka Tagaya, Steven A. Rosenberg, Thomas A. Waldmann, and Nicholas P. Restifo PMCID: PMC357036 Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1 Satomi Ito, Hitoshi Nagaoka, Reiko Shinkura, Nasim Begum, Masamichi Muramatsu, Mikiyo Nakata, and Tasuku Honjo PMCID: PMC357037 Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut Keiichiro Suzuki, Bob Meek, Yasuko Doi, Masamichi Muramatsu, Tsutomu Chiba, Tasuku Honjo, and Sidonia Fagarasan PMCID: PMC357038 Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-γ (Mig, CXCL9) Patricia C. Fulkerson, Nives Zimmermann, Eric B. Brandt, Emily E. Muntel, Matthew P. Doepker, Jessica L. Kavanaugh, Anil Mishra, David P. Witte, Hongwei Zhang, Joshua M. Farber, Ming Yang, Paul S. Foster, and Marc E. Rothenberg PMCID: PMC357039 GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells Sung-Yun Pai, Morgan L. Truitt, and I-Cheng Ho PMCID: PMC357040 Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy Christian Siebold, Bjarke E. Hansen, Jessica R. Wyer, Karl Harlos, Robert E. Esnouf, Arne Svejgaard, John I. Bell, Jack L. Strominger, E. Yvonne Jones, and Lars Fugger PMCID: PMC357041 B cell development and immunoglobulin transcription in Oct-1-deficient mice Victoria E. H. Wang, Dean Tantin, Jianzhu Chen, and Phillip A. Sharp PMCID: PMC357042 Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor α, cyclooxygenase 2, and inflammatory arthritis Kristine Phillips, Nancy Kedersha, Lily Shen, Perry J. Blackshear, and Paul Anderson PMCID: PMC357043 The limits of protection by “memory” T cells in Ig–/– mice persistently infected with a γ-herpesvirus Samita Andreansky, Haiyan Liu, Heiko Adler, Ulrich H. Koszinowski, Stacey Efstathiou, and Peter C. Doherty PMCID: PMC357044 Medical Sciences A germ-line insertion in the Birt–Hogg–Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer Kazuo Okimoto, Junko Sakurai, Toshiyuki Kobayashi, Hiroaki Mitani, Youko Hirayama, Michael L. Nickerson, Michelle B. Warren, Berton Zbar, Laura S. Schmidt, and Okio Hino PMCID: PMC357045 Identification of a human NF-κB-activating protein, TAB3 Ge Jin, Alison Klika, Michelle Callahan, Ben Faga, Joel Danzig, Zhengfan Jiang, Xiaoxia Li, George R. Stark, John Harrington, and Bruce Sherf PMCID: PMC357046 A 9,000-year record of Chagas' disease Arthur C. Aufderheide, Wilmar Salo, Michael Madden, John Streitz, Jane Buikstra, Felipe Guhl, Bernardo Arriaza, Colleen Renier, Lorentz E. Wittmers, Jr., Gino Fornaciari, and Marvin Allison PMCID: PMC357047 Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers Nobunao Wakabayashi, Albena T. Dinkova-Kostova, W. David Holtzclaw, Moon-Il Kang, Akira Kobayashi, Masayuki Yamamoto, Thomas W. Kensler, and Paul Talalay PMCID: PMC357048 Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes Moon-Il Kang, Akira Kobayashi, Nobunao Wakabayashi, Sang-Geon Kim, and Masayuki Yamamoto PMCID: PMC357049 DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen Toshiki Itoh, Dragana Cado, Ryoichi Kamide, and Stuart Linn PMCID: PMC357050 Rapid transformation of white adipocytes into fat-oxidizing machines Lelio Orci, William S. Cook, Mariella Ravazzola, May-yun Wang, Byung-Hyun Park, Roberto Montesano, and Roger H. Unger PMCID: PMC357051 WNK4 regulates apical and basolateral Cl– flux in extrarenal epithelia Kristopher T. Kahle, Ignacio Gimenez, Hatim Hassan, Frederick H. Wilson, Robert D. Wong, Biff Forbush, Peter S. Aronson, and Richard P. Lifton PMCID: PMC357052 Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease Roy G. Cutler, Jeremiah Kelly, Kristin Storie, Ward A. Pedersen, Anita Tammara, Kimmo Hatanpaa, Juan C. Troncoso, and Mark P. Mattson PMCID: PMC357053 The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor α to the plasma membrane Robert X. Song, Christopher J. Barnes, Zhenguo Zhang, Yongde Bao, Rakesh Kumar, and Richard J. Santen PMCID: PMC357054 Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity Bangyan Stiles, Ying Wang, Andreas Stahl, Sara Bassilian, W. Paul Lee, Yoon-Jung Kim, Robert Sherwin, Sherin Devaskar, Ralf Lesche, Mark A. Magnuson, and Hong Wu PMCID: PMC357055 Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy Ralph V. Shohet, Yaz Y. Kisanuki, Xiao-Song Zhao, Zakir Siddiquee, Fatima Franco, and Masashi Yanagisawa PMCID: PMC357056 Microbiology Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism John H. Lee, Su Min P. Yi, Mary E. Anderson, Kristi L. Berger, Michael J. Welsh, Aloysius J. Klingelhutz, and Michelle A. Ozbun PMCID: PMC357057 A capsid protein of nonenveloped Bluetongue virus exhibits membrane fusion activity Mario Forzan, Christoph Wirblich, and Polly Roy PMCID: PMC357058 Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques Jay V. Solnick, Lori M. Hansen, Nina R. Salama, Jenni K. Boonjakuakul, and Michael Syvanen PMCID: PMC357059 DNA-dependent PK inhibits adeno-associated virus DNA integration Sihong Song, Yuanqing Lu, Young-Kook Choi, Yinong Han, Qiushi Tang, Ge Zhao, Kenneth I. Berns, and Terence R. Flotte PMCID: PMC357060 Crosslinking snapshots of bacterial chemoreceptor squads Claudia A. Studdert and John S. Parkinson PMCID: PMC357061 Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area Shah M. Faruque, Nityananda Chowdhury, M. Kamruzzaman, Michelle Dziejman, M. Hasibur Rahman, David A. Sack, G. Balakrish Nair, and John J. Mekalanos PMCID: PMC357062 Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees Stefan F. Wieland, Hans Christian Spangenberg, Robert Thimme, Robert H. Purcell, and Francis V. Chisari PMCID: PMC357063 The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase Russell E. Vance, Song Hong, Karsten Gronert, Charles N. Serhan, and John J. Mekalanos PMCID: PMC357064 Neuroscience From the Cover:
Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation Steffen Gais and Jan Born PMCID: PMC357065 Identification and analysis of plasticity-induced late-response genes Suk Jin Hong, Huiwu Li, Kevin G. Becker, Valina L. Dawson, and Ted M. Dawson PMCID: PMC357066 Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk Richard Piet, Lydia Vargová, Eva Syková, Dominique A. Poulain, and Stéphane H. R. Oliet PMCID: PMC357067 The mouse olfactory receptor gene family Paul A. Godfrey, Bettina Malnic, and Linda B. Buck PMCID: PMC357068 LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord J. G. Boyd, J. Lee, V. Skihar, R. Doucette, and M. D. Kawaja PMCID: PMC357069 A revised view of sensory cortical parcellation Mark T. Wallace, Ramnarayan Ramachandran, and Barry E. Stein PMCID: PMC357070 Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses Eric M. Blalock, James W. Geddes, Kuey Chu Chen, Nada M. Porter, William R. Markesbery, and Philip W. Landfield PMCID: PMC357071 Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine Lawrence P. Reagan, Daniel R. Rosell, Gwendolyn E. Wood, Michael Spedding, Carmen Muñoz, Jeffrey Rothstein, and Bruce S. McEwen PMCID: PMC357072 Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice Chenjian Li, Wayne G. Brake, Russell D. Romeo, John C. Dunlop, Marisa Gordon, Rodica Buzescu, Ana Maria Magarinos, Patrick B. Allen, Paul Greengard, Victoria Luine, and Bruce S. McEwen PMCID: PMC357073 Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum Karima Chergui, Per Svenningsson, and Paul Greengard PMCID: PMC357074 Plant Biology Identification of plastid envelope proteins required for import of protochlorophyllide oxidoreductase A into the chloroplast of barley Steffen Reinbothe, Françoise Quigley, John Gray, Andreas Schemenewitz, and Christiane Reinbothe PMCID: PMC380236 The outer plastid envelope protein Oep16: Role as precursor translocase in import of protochlorophyllide oxidoreductase A Steffen Reinbothe, Françoise Quigley, Armin Springer, Andreas Schemenewitz, and Christiane Reinbothe PMCID: PMC357075 The 4-coumarate:CoA ligase gene family in Arabidopsis thaliana comprises one rare, sinapate-activating and three commonly occurring isoenzymes Björn Hamberger and Klaus Hahlbrock PMCID: PMC357076 Starch granule initiation is controlled by a heteromultimeric isoamylase in potato tubers Regla Bustos, Brendan Fahy, Christopher M. Hylton, Robert Seale, N. Miranda Nebane, Anne Edwards, Cathie Martin, and Alison M. Smith PMCID: PMC357077 |
