ELIGIBILITY CRITERIA:
No one will be excluded from this study based on race, gender, or ethnicity.
A. General Inclusion Criteria:
-Age greater than or equal to 18 (children are excluded because coronary disease is rare in this population).
-Capable of giving informed consent.
B. General Exclusion Criteria (for all arms):
-Pregnant women (uncertain patients will have urine or blood testing).
-Decompensated heart failure (unable to lie flat in bed).
Test Specific Exclusion Criteria:
A. CT Exclusion Criteria (excludes contrast enhanced CT scan only):
-Allergy to iodinated contrast agent excludes contrast enhanced CT research studies.
-Multiple myeloma.
-Patients with severe kidney disease (eGFR less than 30 mL/min/1.73 m(2).
B. Beta Antagonist Exclusions (excluded the use of beta blocker only):
-Asthma or severe chronic lung disease/emphysema with regular use of inhaler.
-Decompensated heart failure.
C. MRI Exclusion Criteria (excludes MRI scan only):
-Cardiac pacemaker or implantable defibrillator.
-Cerebral aneurysm clip.
-Neural stimulator (e.g. TENS-Unit).
-Any type of ear implant.
-Metal in eye (e.g. from machining).
-Any implanted device (e.g. insulin pump, drug infusion device).
D. Exclusions from MRI contrast agents:
-Lacting women unless they are willing to discard breast milk for 24 hours.
-Severe kidney disease (mL/min/1.73 m(2).
E. Vasodilator Exclusions (excludes some vasodilator stress testing):
-Asthma or chronic obstructive pulmonary disease (emphysema) actively treated with bronchodilators or leukotriene receptor antagonists (albuterol, seravent, atrovent, montelukast singulair (® (Registered Trademark)), zafirlukast Accolate® (Registered Trademark). These conditions only exclude adenosine and dipyridamole.
-Second degree (Type II) and third degree atrioventricular heart block.
F. Exclusions from Dobutamine stress MRI only:
-Severe problems with heart rhythms.
-Severe high blood pressure.
G. Exclusion criteria for atropine (given during dobutamine stress echocardiography when target heart rate not achievable with dobutamine alone).
-Narrow angle glaucoma.
-Known or suspected severe bladder outlet obstruction due to prostatic hypertrophy.