| | This journal provides immediate access to some articles. Interview Ready for Her Close-Up: An Interview with Elaine Strass Jane Gitschier PMCID: PMC2265527 Review What Can Genome-Wide Association Studies Tell Us about the Genetics of Common Disease Mark M Iles PMCID: PMC2323402 Research Articles ER Stress-Mediated Apoptosis in a New Mouse Model of Osteogenesis imperfecta Thomas S Lisse, Frank Thiele, Helmut Fuchs, Wolfgang Hans, Gerhard K. H Przemeck, Koichiro Abe, Birgit Rathkolb, Leticia Quintanilla-Martinez, Gabriele Hoelzlwimmer, Miep Helfrich, Eckhard Wolf, Stuart H Ralston, and Martin Hrabé de Angelis PMCID: PMC2222924 Network Discovery Pipeline Elucidates Conserved Time-of-Day–Specific cis-Regulatory Modules Todd P Michael, Todd C Mockler, Ghislain Breton, Connor McEntee, Amanda Byer, Jonathan D Trout, Samuel P Hazen, Rongkun Shen, Henry D Priest, Christopher M Sullivan, Scott A Givan, Marcelo Yanovsky, Fangxin Hong, Steve A Kay, and Joanne Chory PMCID: PMC2222925 Notch Signalling Synchronizes the Zebrafish Segmentation Clock but Is Not Needed To Create Somite Boundaries Ertuğrul M Özbudak and Julian Lewis PMCID: PMC2222926 Comparing Patterns of Natural Selection across Species Using Selective Signatures B. Jesse Shapiro and Eric J Alm PMCID: PMC2233676 A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, and Cynthia Kenyon PMCID: PMC2242811 The Evolution of Spinnable Cotton Fiber Entailed Prolonged Development and a Novel Metabolism Ran Hovav, Joshua A Udall, Bhupendra Chaudhary, Einat Hovav, Lex Flagel, Guanjing Hu, and Jonathan F Wendel PMCID: PMC2222923 Genome-Wide Expression of Azoospermia Testes Demonstrates a Specific Profile and Implicates ART3 in Genetic Susceptibility Hiroyuki Okada, Atsushi Tajima, Kazuyoshi Shichiri, Atsushi Tanaka, Kenichi Tanaka, and Ituro Inoue PMCID: PMC2233677 Dynamic Regulation of ARGONAUTE4 within Multiple Nuclear Bodies in Arabidopsis thaliana Carey F Li, Ian R Henderson, Liang Song, Nina Fedoroff, Thierry Lagrange, and Steven E Jacobsen PMCID: PMC2233678 Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women Sagiv Shifman, Martina Johannesson, Michal Bronstein, Sam X Chen, David A Collier, Nicholas J Craddock, Kenneth S Kendler, Tao Li, Michael O'Donovan, F. Anthony O'Neill, Michael J Owen, Dermot Walsh, Daniel R Weinberger, Cuie Sun, Jonathan Flint, and Ariel Darvasi PMCID: PMC2242812 Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence Dirk A Kleinjan, Ruth M Bancewicz, Philippe Gautier, Ralf Dahm, Helia B Schonthaler, Giuseppe Damante, Anne Seawright, Ann M Hever, Patricia L Yeyati, Veronica van Heyningen, and Pedro Coutinho PMCID: PMC2242813 X Chromosome Activity in Mouse XX Primordial Germ Cells Susana M Chuva de Sousa Lopes, Katsuhiko Hayashi, Tanya C Shovlin, Will Mifsud, M. Azim Surani, and Anne McLaren†† PMCID: PMC2233679 Drosophila brca2 Is Required for Mitotic and Meiotic DNA Repair and Efficient Activation of the Meiotic Recombination Checkpoint Martha Klovstad, Uri Abdu, and Trudi Schüpbach PMCID: PMC2233675 Adaptations to Climate in Candidate Genes for Common Metabolic Disorders Angela M Hancock, David B Witonsky, Adam S Gordon, Gidon Eshel, Jonathan K Pritchard, Graham Coop, and Anna Di Rienzo PMCID: PMC2242814 Unintentional miRNA Ablation Is a Risk Factor in Gene Knockout Studies: A Short Report Ivan Osokine, Ruby Hsu, Gabriel B Loeb, and Michael T McManus PMCID: PMC2242815 Expression Profiles Reveal Parallel Evolution of Epistatic Interactions Involving the CRP Regulon in Escherichia coli Tim F Cooper, Susanna K Remold, Richard E Lenski, and Dominique Schneider PMCID: PMC2242816 Motility Screen Identifies Drosophila IGF-II mRNA-Binding Protein—Zipcode-Binding Protein Acting in Oogenesis and Synaptogenesis Kristin L. M Boylan, Sarah Mische, Mingang Li, Guillermo Marqués, Xavier Morin, William Chia, and Thomas S Hays PMCID: PMC2242817 Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm Masayuki Kimura, Lynn F Cherkas, Bernet S Kato, Serkalem Demissie, Jacob B Hjelmborg, Michael Brimacombe, Adrienne Cupples, Janice L Hunkin, Jefferey P Gardner, Xiaobin Lu, Xiaojian Cao, Malinee Sastrasinh, Michael A Province, Steven C Hunt, Kaare Christensen, Daniel Levy, Tim D Spector, and Abraham Aviv PMCID: PMC2242810 Alternative Splicing Regulation During C. elegans Development: Splicing Factors as Regulated Targets Sergio Barberan-Soler and Alan M. Zahler PMCID: PMC2265522 The Secreted Metalloprotease ADAMTS20 Is Required for Melanoblast Survival Debra L. Silver, Ling Hou, Robert Somerville, Mary E. Young, Suneel S. Apte, and William J. Pavan PMCID: PMC2265537 Variation in Molybdenum Content Across Broadly Distributed Populations of Arabidopsis thaliana Is Controlled by a Mitochondrial Molybdenum Transporter (MOT1) Ivan Baxter, Balasubramaniam Muthukumar, Hyeong Cheol Park, Peter Buchner, Brett Lahner, John Danku, Keyan Zhao, Joohyun Lee, Malcolm J. Hawkesford, Mary Lou Guerinot, and David E. Salt PMCID: PMC2265440 Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen Anthony Arnoldo, Jasna Curak, Saranya Kittanakom, Igor Chevelev, Vincent T. Lee, Mehdi Sahebol-Amri, Becky Koscik, Lana Ljuma, Peter J. Roy, Antonio Bedalov, Guri Giaever, Corey Nislow, Rod A. Merrill, Stephen Lory, and Igor Stagljar PMCID: PMC2265467 Differential Allelic Expression in the Human Genome: A Robust Approach To Identify Genetic and Epigenetic Cis-Acting Mechanisms Regulating Gene Expression David Serre, Scott Gurd, Bing Ge, Robert Sladek, Donna Sinnett, Eef Harmsen, Marina Bibikova, Eugene Chudin, David L. Barker, Todd Dickinson, Jian-Bing Fan, and Thomas J. Hudson PMCID: PMC2265535 Genome-Wide Assessments Reveal Extremely High Levels of Polymorphism of Two Active Families of Mouse Endogenous Retroviral Elements Ying Zhang, Irina A. Maksakova, Liane Gagnier, Louie N. van de Lagemaat, and Dixie L. Mager PMCID: PMC2265474 Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits William G. Hill, Michael E. Goddard, and Peter M. Visscher PMCID: PMC2265475 Drosophila Histone Deacetylase-3 Controls Imaginal Disc Size through Suppression of Apoptosis Changqi C. Zhu, Douglas J. Bornemann, David Zhitomirsky, Ellen L. Miller, Michael B. O'Connor, and Jeffrey A. Simon PMCID: PMC2265479 Identification of the Yellow Skin Gene Reveals a Hybrid Origin of the Domestic Chicken Jonas Eriksson, Greger Larson, Ulrika Gunnarsson, Bertrand Bed'hom, Michele Tixier-Boichard, Lina Strömstedt, Dominic Wright, Annemieke Jungerius, Addie Vereijken, Ettore Randi, Per Jensen, and Leif Andersson PMCID: PMC2265484 RSF Governs Silent Chromatin Formation via Histone H2Av Replacement Kazuma Hanai, Hirofumi Furuhashi, Takashi Yamamoto, Koji Akasaka, and Susumu Hirose PMCID: PMC2265536 DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore Eun Mi Kim and Daniel J. Burke PMCID: PMC2265443 Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death Kelly N. Owens, Felipe Santos, Brock Roberts, Tor Linbo, Allison B. Coffin, Anna J. Knisely, Julian A. Simon, Edwin W. Rubel, and David W. Raible PMCID: PMC2265478 The Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material Stefan Taubert, Malene Hansen, Marc R. Van Gilst, Samantha B. Cooper, and Keith R. Yamamoto PMCID: PMC2265483 The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals Takayuki Kanazawa, Mauro D. Zappaterra, Ayako Hasegawa, Ashley P. Wright, Erin D. Newman-Smith, Karolyn F. Buttle, Kent McDonald, Carmen A. Mannella, and Alexander M. van der Bliek PMCID: PMC2265488 Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms Andrew C. Liu, Hien G. Tran, Eric E. Zhang, Aaron A. Priest, David K. Welsh, and Steve A. Kay PMCID: PMC2265523 |
