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Yue Wang, M.D., Ph.D., Head Electrophysiology Facility Laboratory of Neurosciences

Overview: The Neuroscience Electrophysiology Facility provides services and technical support for all research sections in the Laboratory of Neurosciences. State-of-the-art electrophysiological technologies (multi-electrode field potential and patch-clamp recording) in brain slices and cultured neurons from mice and rats are employed to investigate the molecular and biophysical mechanisms of synaptic function and plasticity. These methods are applied to elucidate mechanisms of learning and memory in the contexts of normal brain aging and age-related neurological disorders such as Alzheimer's disease. In addition, electrophysiological analyses of synaptic function are used to evaluate the efficacy of novel pharmacological and dietary interventions for the prevention and treatment of neurodegenerative disorders.

Biography: Dr. Wang received his M.D. degree from the University of Zurich and Ph.D. from Trinity College in Dublin. His postdoctoral research in the areas of neurophysiology and synaptic plasticity was performed at the University of Maryland and the National Institute on Aging. Dr. Wang was appointed as the manager of the Electrophysiology Facility in 2005. He can be reached at: wangyu@grc.nia.nih.gov, Phone: 410-558-8283, and Fax: 410-558-8323.

Recent Publications:

Szklarczyk A, Ewaleifoh O, Beique JC, Wang Y, Knorr D, Haughey N, Malpica T, Mattson MP, Huganir R, Conant K. (2008) MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function. FASEB J. 2008 August. [Epub ahead of print]. [Abs] Wang Y., Chandran JS., Cai H., Mattson MP. (2008) DJ-1 is essential for long-term depression at hippocampal CA1 synapses. Neuromolecular Med. 10(1): 40-45. [Abs] Wang Y., Greig NG., Yu QS., Mattson MP. (2007) Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices. Neurobiol. Aging. [Epub ahead of print]. [Abs] Greig NG., Utsuki T., Ingram DK. Wang Y, Pepeu G., Scali C., Yu QS., Mamczarz J., Holloway HW., Giordano T., Chen D., Furukawa K., Sambamurti K., Brossi A., Lahiri DK. (2005) Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers amyloid-b peptide in rodents. Proc. Natl. Acad. Sci. USA. 102: 17213-17218. [Abs] Wang Y., Chan SL., Miele L., Yao PJ., Mackes J., Ingram DK., Mattson MP., Furukawa K. (2004) Involvement of Notch signaling in hippocampal synaptic plasticity. Proc. Natl. Acad. Sci. USA. 101: 9458-9462. [Abs] Carlson G., Wang Y., Alger BE. (2002) Endocannabinoids facilitate the induction of LTP in the hippocampus. Nat. Neurosci. 5: 723-724. [Abs]

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Updated: Tuesday August 19, 2008