| Laboratory of Cellular and Molecular Biology |
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| Ranjan Sen, Ph.D., Chief Senior Investigator |
| Overview |
| The Laboratory of Cellular and Molecular Biology (LCMB) is currently comprised of six independent research programs headed by either a tenured scientist or senior investigator. These programs include the Gene Regulation Section, the Chromatin Structure and Function Unit, the DNA Repair Unit, the Molecular Immunology Unit, the Cancer Genomics and Signaling Section, and the RNA Regulation Section. |
| Major areas of emphasis common to the individual programs include: 1) the elucidation of signal transduction processes and genes involved in regulating cellular responses to environmental signals such as growth factors, cytokines, and stress stimuli; 2) the determination of mechanisms contributing to the maintenance of cellular homeostasis and cell cycle control, and 3) the contribution of dysregulated gene expression or loss of critical gene functions to the development of cancer. As described below for the individual programs, a wide variety of in vitro and in vivo models are being employed to approach these issues. These processes have direct relevance to our understanding of critical events associated with various age-related deficits and/or development of age-related diseases including cancer and Alzheimer's disease. The ultimate goal of the programs is to uncover knowledge that can be applied to prevent or delay the onset of age-related disabilities and disease processes, and/or provide new strategies for their treatment. |
| While the individual research programs within the LCMB generally function as independent groups, they are highly interactive, conduct biweekly joint meetings, and engage in collaborative projects. Combined, the programs within the LCMB provide extensive and broad expertise in the areas of biochemistry, cellular and molecular biology and genetics. Specialized expertise in a variety of approaches used to analyze or manipulate gene expression is also available within the LCMB. The LCMB is equipped with state-of-the-art instrumentation and an extensive computer network. |
| Research Programs |
| The Laboratory of Cellular and Molecular Biology periodically has openings for outstanding post-doctoral fellows. Direct inquiries to: |
| National Institute on Aging Intramural Research Program Laboratory of Cellular and Molecular Biology Biomedical Research Center 251 Bayview Boulevard, Suite 100 Baltimore, MD 21224 Phone: 410-558-8630 Fax: 410-558-8386 |
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