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Volume 37(6);  April 2009
Chemistry and Synthetic Biology
A synthetic snRNA m3G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids
Pedro M. D. Moreno, Malgorzata Wenska, Karin E. Lundin, Örjan Wrange, Roger Strömberg, and C. I. Edvard Smith
Nucleic Acids Res. 2009 April; 37(6): 1925–1935. Published online 2009 April. doi: 10.1093/nar/gkp048.
PMCID: PMC2665231
Front-Matter/Back-Matter
Nucleic Acids Research: VOLUME 37 ISSUE 6 2009
Nucleic Acids Res. 2009 April; 37(6): i. Published online 2009 April. doi: 10.1093/nar/gkp246.
PMCID: PMC2665247
Nucleic Acids Research
Nucleic Acids Res. 2009 April; 37(6): ii. Published online 2009 April. doi: 10.1093/nar/gkp245.
PMCID: PMC2665246
Subscriptions
Nucleic Acids Res. 2009 April; 37(6): iii. Published online 2009 April. doi: 10.1093/nar/gkp247.
PMCID: PMC2665248
Gene Regulation, Chromatin and Epigenetics
Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation
Song Qin, Qien Wang, Alo Ray, Gulzar Wani, Qun Zhao, Sukesh R. Bhaumik, and Altaf A. Wani
Nucleic Acids Res. 2009 April; 37(6): 1843–1853. Published online 2009 April. doi: 10.1093/nar/gkn1049.
PMCID: PMC2665209
JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks
Shouyu Wang, Zhenghua Gong, Rui Chen, Yunru Liu, Aiping Li, Gang Li, and Jianwei Zhou
Nucleic Acids Res. 2009 April; 37(6): 1936–1950. Published online 2009 April. doi: 10.1093/nar/gkp054.
PMCID: PMC2665235
Genome Integrity, Repair and Replication
A role for monoubiquitinated FANCD2 at telomeres in ALT cells
Qiang Fan, Fan Zhang, Briana Barrett, Keqin Ren, and Paul R. Andreassen
Nucleic Acids Res. 2009 April; 37(6): 1740–1754. Published online 2009 April. doi: 10.1093/nar/gkn995.
PMCID: PMC2665210
The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells
Stanislav G. Kozmin, Yuliya Sedletska, Anne Reynaud-Angelin, Didier Gasparutto, and Evelyne Sage
Nucleic Acids Res. 2009 April; 37(6): 1767–1777. Published online 2009 April. doi: 10.1093/nar/gkp010.
PMCID: PMC2665211
Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions
Reto Brem, Feng Li, and Peter Karran
Nucleic Acids Res. 2009 April; 37(6): 1951–1961. Published online 2009 April. doi: 10.1093/nar/gkp070.
PMCID: PMC2665240
Single-molecule analysis reveals two separate DNA-binding domains in the Escherichia coli UvrA dimer
Koen Wagner, Geri Moolenaar, John van Noort, and Nora Goosen
Nucleic Acids Res. 2009 April; 37(6): 1962–1972. Published online 2009 April. doi: 10.1093/nar/gkp071.
PMCID: PMC2665241
Molecular Biology
Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein
Klara Post, Besik Kankia, Swathi Gopalakrishnan, Victoria Yang, Elizabeth Cramer, Pilar Saladores, Robert J. Gorelick, Jianhui Guo, Karin Musier-Forsyth, and Judith G. Levin
Nucleic Acids Res. 2009 April; 37(6): 1755–1766. Published online 2009 April. doi: 10.1093/nar/gkn1045.
PMCID: PMC2665208
Improved tetracycline repressors for gene silencing in mycobacteria
Marcus Klotzsche, Sabine Ehrt, and Dirk Schnappinger
Nucleic Acids Res. 2009 April; 37(6): 1778–1788. Published online 2009 April. doi: 10.1093/nar/gkp015.
PMCID: PMC2665214
Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development
Ivana Bratic, Jürgen Hench, Johan Henriksson, Adam Antebi, Thomas R Bürglin, and Aleksandra Trifunovic
Nucleic Acids Res. 2009 April; 37(6): 1817–1828. Published online 2009 April. doi: 10.1093/nar/gkp018.
PMCID: PMC2665216
AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity
Donna A. MacDuff, Zachary L. Demorest, and Reuben S. Harris
Nucleic Acids Res. 2009 April; 37(6): 1854–1867. Published online 2009 April. doi: 10.1093/nar/gkp030.
PMCID: PMC2665220
Borrelia burgdorferi EbfC defines a newly-identified, widespread family of bacterial DNA-binding proteins
Sean P. Riley, Tomasz Bykowski, Anne E. Cooley, Logan H. Burns, Kelly Babb, Catherine A. Brissette, Amy Bowman, Matthew Rotondi, M. Clarke Miller, Edward DeMoll, Kap Lim, Michael G. Fried, and Brian Stevenson
Nucleic Acids Res. 2009 April; 37(6): 1973–1983. Published online 2009 April. doi: 10.1093/nar/gkp027.
PMCID: PMC2665219
Functional four-base A/T gap core sequence CATTAG of P53 response elements specifically bound tetrameric P53 differently than two-base A/T gap core sequence CATG bound both dimeric and tetrameric P53
Bi-He Cai, Jang-Yi Chen, Mei-Hua Lu, Li-Tze Chang, Hwang-Chi Lin, Yu-Ming Chang, and Chung-Faye Chao
Nucleic Acids Res. 2009 April; 37(6): 1984–1990. Published online 2009 April. doi: 10.1093/nar/gkp033.
PMCID: PMC2665222
The replication of plastid minicircles involves rolling circle intermediates
Siu Kai Leung and Joseph T. Y. Wong
Nucleic Acids Res. 2009 April; 37(6): 1991–2002. Published online 2009 April. doi: 10.1093/nar/gkp063.
PMCID: PMC2665238
Evolutionary Conserved Motif Finder (ECMFinder) for genome-wide identification of clustered YY1- and CTCF-binding sites
Keunsoo Kang, Jae Hoon Chung, and Joomyeong Kim
Nucleic Acids Res. 2009 April; 37(6): 2003–2013. Published online 2009 April. doi: 10.1093/nar/gkp077.
PMCID: PMC2665242
RNA
Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1
Isabelle Hatin, Celine Fabret, Jean-Pierre Rousset, and Olivier Namy
Nucleic Acids Res. 2009 April; 37(6): 1789–1798. Published online 2009 April. doi: 10.1093/nar/gkp012.
PMCID: PMC2665212
Adenylation of plant miRNAs
Shanfa Lu, Ying-Hsuan Sun, and Vincent L. Chiang
Nucleic Acids Res. 2009 April; 37(6): 1878–1885. Published online 2009 April. doi: 10.1093/nar/gkp031.
PMCID: PMC2665221
A minimized rRNA-binding site for ribosomal protein S4 and its implications for 30S assembly
Deepti L. Bellur and Sarah A. Woodson
Nucleic Acids Res. 2009 April; 37(6): 1886–1896. Published online 2009 April. doi: 10.1093/nar/gkp036.
PMCID: PMC2665224
Kinetoplastid RNA editing involves a 3′ nucleotidyl phosphatase activity
Moritz Niemann, Heike Kaibel, Elke Schlüter, Kerstin Weitzel, Michael Brecht, and H. Ulrich Göringer
Nucleic Acids Res. 2009 April; 37(6): 1897–1906. Published online 2009 April. doi: 10.1093/nar/gkp049.
PMCID: PMC2665232
U1-independent pre-mRNA splicing contributes to the regulation of alternative splicing
Kazuhiro Fukumura, Ichiro Taniguchi, Hiroshi Sakamoto, Mutsuhito Ohno, and Kunio Inoue
Nucleic Acids Res. 2009 April; 37(6): 1907–1914. Published online 2009 April. doi: 10.1093/nar/gkp050.
PMCID: PMC2665233
Structural Biology
Structural insights into TDP-43 in nucleic-acid binding and domain interactions
Pan-Hsien Kuo, Lyudmila G. Doudeva, Yi-Ting Wang, Che-Kun James Shen, and Hanna S. Yuan
Nucleic Acids Res. 2009 April; 37(6): 1799–1808. Published online 2009 April. doi: 10.1093/nar/gkp013.
PMCID: PMC2665213
Crystal structure of KorA bound to operator DNA: insight into repressor cooperation in RP4 gene regulation
Bettina König, Jürgen J. Müller, Erich Lanka, and Udo Heinemann
Nucleic Acids Res. 2009 April; 37(6): 1915–1924. Published online 2009 April. doi: 10.1093/nar/gkp044.
PMCID: PMC2665229
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
Diana A. Pippig, Johannes C. Hellmuth, Sheng Cui, Axel Kirchhofer, Katja Lammens, Alfred Lammens, Andreas Schmidt, Simon Rothenfusser, and Karl-Peter Hopfner
Nucleic Acids Res. 2009 April; 37(6): 2014–2025. Published online 2009 April. doi: 10.1093/nar/gkp059.
PMCID: PMC2665237
Survey and Summary
Circular dichroism and conformational polymorphism of DNA
Jaroslav Kypr, Iva Kejnovská, Daniel Renčiuk, and Michaela Vorlíčková
Nucleic Acids Res. 2009 April; 37(6): 1713–1725. Published online 2009 April. doi: 10.1093/nar/gkp026.
PMCID: PMC2665218
An evaluation of custom microarray applications: the oligonucleotide design challenge
Sophie Lemoine, Florence Combes, and Stéphane Le Crom
Nucleic Acids Res. 2009 April; 37(6): 1726–1739. Published online 2009 April. doi: 10.1093/nar/gkp053.
PMCID: PMC2665234
Genomics
Centromere sequence and dynamics in Dictyostelium discoideum
Gernot Glöckner and Andrew J. Heidel
Nucleic Acids Res. 2009 April; 37(6): 1809–1816. Published online 2009 April. doi: 10.1093/nar/gkp017.
PMCID: PMC2665215
Methods Online
A library-based method to rapidly analyse chromatin accessibility at multiple genomic regions
Asjad Basheer, Harald Berger, Yazmid Reyes-Dominguez, Markus Gorfer, and Joseph Strauss
Nucleic Acids Res. 2009 April; 37(6): e42. Published online 2009 April. doi: 10.1093/nar/gkp037.
PMCID: PMC2665225
Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells
Takeshi Haraguchi, Yuka Ozaki, and Hideo Iba
Nucleic Acids Res. 2009 April; 37(6): e43. Published online 2009 April. doi: 10.1093/nar/gkp040.
PMCID: PMC2665227
Manipulating transgenes using a chromosome vector
Masashi Ikeno, Nobutaka Suzuki, Yoshinori Hasegawa, and Tsuneko Okazaki
Nucleic Acids Res. 2009 April; 37(6): e44. Published online 2009 April. doi: 10.1093/nar/gkp058.
PMCID: PMC2665236
Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data
J. M. Ruijter, C. Ramakers, W. M. H. Hoogaars, Y. Karlen, O. Bakker, M. J. B. van den Hoff, and A. F. M. Moorman
Nucleic Acids Res. 2009 April; 37(6): e45. Published online 2009 April. doi: 10.1093/nar/gkp045.
PMCID: PMC2665230
Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing
Jane M. Liu, Jonathan Livny, Michael S. Lawrence, Marc D. Kimball, Matthew K. Waldor, and Andrew Camilli
Nucleic Acids Res. 2009 April; 37(6): e46. Published online 2009 April. doi: 10.1093/nar/gkp080.
PMCID: PMC2665243
Ariadne: a database search engine for identification and chemical analysis of RNA using tandem mass spectrometry data
Hiroshi Nakayama, Misaki Akiyama, Masato Taoka, Yoshio Yamauchi, Yuko Nobe, Hideaki Ishikawa, Nobuhiro Takahashi, and Toshiaki Isobe
Nucleic Acids Res. 2009 April; 37(6): e47. Published online 2009 April. doi: 10.1093/nar/gkp099.
PMCID: PMC2665244
Identification of RNA molecules by specific enzyme digestion and mass spectrometry: software for and implementation of RNA mass mapping
Rune Matthiesen and Finn Kirpekar
Nucleic Acids Res. 2009 April; 37(6): e48. Published online 2009 April. doi: 10.1093/nar/gkp139.
PMCID: PMC2665245
Nucleic Acid Enzymes
Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family
Víctor M. Castillo-Acosta, Luis M. Ruiz-Pérez, Wei Yang, Dolores González-Pacanowska, and Antonio E. Vidal
Nucleic Acids Res. 2009 April; 37(6): 1829–1842. Published online 2009 April. doi: 10.1093/nar/gkp021.
PMCID: PMC2665217
Human DNA polymerase θ possesses 5′-dRP lyase activity and functions in single-nucleotide base excision repair in vitro
Rajendra Prasad, Matthew J. Longley, Farida S. Sharief, Esther W. Hou, William C. Copeland, and Samuel H. Wilson
Nucleic Acids Res. 2009 April; 37(6): 1868–1877. Published online 2009 April. doi: 10.1093/nar/gkp035.
PMCID: PMC2665223
A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4
Kirk Tevebaugh Ehmsen and Wolf-Dietrich Heyer
Nucleic Acids Res. 2009 April; 37(6): 2026–2036. Published online 2009 April. doi: 10.1093/nar/gkp038.
PMCID: PMC2665226
Characterization of DNA polymerase X from Thermus thermophilus HB8 reveals the POLXc and PHP domains are both required for 3′–5′ exonuclease activity
Shuhei Nakane, Noriko Nakagawa, Seiki Kuramitsu, and Ryoji Masui
Nucleic Acids Res. 2009 April; 37(6): 2037–2052. Published online 2009 April. doi: 10.1093/nar/gkp064.
PMCID: PMC2665239
Atomic force microscopy of the EcoKI Type I DNA restriction enzyme bound to DNA shows enzyme dimerization and DNA looping
Kelly J. Neaves, Laurie P. Cooper, John H. White, Stewart M. Carnally, David T. F. Dryden, J. Michael Edwardson, and Robert M. Henderson
Nucleic Acids Res. 2009 April; 37(6): 2053–2063. Published online 2009 April. doi: 10.1093/nar/gkp042.
PMCID: PMC2665228
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