| | Other Issues: previous | next | latest | archiveSpotlight Articles of Significant Interest Selected from This Issue by the Editors PMCID: PMC2493231 Minireview Bacteria in the Intestine, Helpful Residents or Enemies from Within? Geraldine O. Canny and Beth A. McCormick PMCID: PMC2493210 Molecular Pathogenesis A Genome-Wide Proteome Array Reveals a Limited Set of Immunogens in Natural Infections of Humans and White-Footed Mice with Borrelia burgdorferi Alan G. Barbour, Algimantas Jasinskas, Matthew A. Kayala, D. Huw Davies, Allen C. Steere, Pierre Baldi, and Philip L. Felgner PMCID: PMC2493225 CcpA-Mediated Repression of Streptolysin S Expression and Virulence in the Group A Streptococcus Traci L. Kinkel and Kevin S. McIver PMCID: PMC2493232 Specific Roles of the iroBCDEN Genes in Virulence of an Avian Pathogenic Escherichia coli O78 Strain and in Production of Salmochelins Mélissa Caza, François Lépine, Sylvain Milot, and Charles M. Dozois PMCID: PMC2493193 Sortase A Utilizes an Ancillary Protein Anchor for Efficient Cell Wall Anchoring of Pili in Streptococcus agalactiae Angela H. Nobbs, Roberto Rosini, C. Daniela Rinaudo, Domenico Maione, Guido Grandi, and John L. Telford PMCID: PMC2493207 Screen for Leukotoxin Mutants in Aggregatibacter actinomycetemcomitans: Genes of the Phosphotransferase System Are Required for Leukotoxin Biosynthesis Maria P. Isaza, Matthew S. Duncan, Jeffrey B. Kaplan, and Scott C. Kachlany PMCID: PMC2493242 Metal Binding Specificity of the MntABC Permease of Neisseria gonorrhoeae and Its Influence on Bacterial Growth and Interaction with Cervical Epithelial Cells Karen H. L. Lim, Christopher E. Jones, Rachel N. vanden Hoven, Jennifer L. Edwards, Megan L. Falsetta, Michael A. Apicella, Michael P. Jennings, and Alastair G. McEwan PMCID: PMC2493241 Phenotypic and Genotypic Analyses of Neisseria gonorrhoeae Isolates That Express Frequently Recovered PorB PIA Variable Region Types Suggest that Certain P1a Porin Sequences Confer a Selective Advantage for Urogenital Tract Infection Lotisha E. Garvin, Margaret C. Bash, Christine Keys, Douglas M. Warner, Sanjay Ram, William M. Shafer, and Ann E. Jerse PMCID: PMC2493220 The Capsule Sensitizes Streptococcus pneumoniae to α-Defensins Human Neutrophil Proteins 1 to 3 Katharina Beiter, Florian Wartha, Robert Hurwitz, Staffan Normark, Arturo Zychlinsky, and Birgitta Henriques-Normark PMCID: PMC2493227 Yersinia pestis Type III Secretion System-Dependent Inhibition of Human Polymorphonuclear Leukocyte Function Justin L. Spinner, Jennifer A. Cundiff, and Scott D. Kobayashi PMCID: PMC2493194 Noncytotoxic Clostridium perfringens Enterotoxin (CPE) Variants Localize CPE Intestinal Binding and Demonstrate a Relationship between CPE-Induced Cytotoxicity and Enterotoxicity James G. Smedley, III, Juliann Saputo, Jacquelyn C. Parker, Mariano E. Fernandez-Miyakawa, Susan L. Robertson, Bruce A. McClane, and Francisco A. Uzal PMCID: PMC2493238 Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Epidermal Growth Factor Inhibits Campylobacter jejuni-Induced Claudin-4 Disruption, Loss of Epithelial Barrier Function, and Escherichia coli Translocation Jennifer M. Lamb-Rosteski, Lisa D. Kalischuk, G. Douglas Inglis, and Andre G. Buret PMCID: PMC2493239 MglA and Igl Proteins Contribute to the Modulation of Francisella tularensis Live Vaccine Strain-Containing Phagosomes in Murine Macrophages Linda Bönquist, Helena Lindgren, Igor Golovliov, Tina Guina, and Anders Sjöstedt PMCID: PMC2493230 A Triacylated Lipoprotein from Mycoplasma genitalium Activates NF-κB through Toll-Like Receptor 1 (TLR1) and TLR2 Takashi Shimizu, Yutaka Kida, and Koichi Kuwano PMCID: PMC2493199 Shiga Toxin 2 Causes Apoptosis in Human Brain Microvascular Endothelial Cells via C/EBP Homologous Protein Jun Fujii, Katie Wood, Fumiko Matsuda, Benedito A. Carneiro-Filho, Keilo H. Schlegel, Takashi Yutsudo, Beth Binnington-Boyd, Clifford A. Lingwood, Fumiko Obata, Kwang S. Kim, Shin-ichi Yoshida, and Tom Obrig PMCID: PMC2493216 Bacterial Infections Cathelicidin LL-37 in Severe Streptococcus pyogenes Soft Tissue Infections in Humans Linda Johansson, Pontus Thulin, Parham Sendi, Erika Hertzén, Adam Linder, Per Åkesson, Donald E. Low, Birgitta Agerberth, and Anna Norrby-Teglund PMCID: PMC2493236 Hypercholesterolemia Impairs Immunity to Tuberculosis Gregory W. Martens, Meltem Cevik Arikan, Jinhee Lee, Fucheng Ren, Therese Vallerskog, and Hardy Kornfeld PMCID: PMC2493195 Identification of fevR, a Novel Regulator of Virulence Gene Expression in Francisella novicida Anna Brotcke and Denise M. Monack PMCID: PMC2493208 Rat Pneumonia and Soft-Tissue Infection Models for the Study of Acinetobacter baumannii Biology Thomas A. Russo, Janet M. Beanan, Ruth Olson, Ulrike MacDonald, Nicole R. Luke, Steven R. Gill, and Anthony A. Campagnari PMCID: PMC2493229 d-Alanylation of Lipoteichoic Acid Contributes to the Virulence of Streptococcus suis Nahuel Fittipaldi, Tsutomu Sekizaki, Daisuke Takamatsu, Josée Harel, María de la Cruz Domínguez-Punaro, Sonja Von Aulock, Christian Draing, Corinne Marois, Marylène Kobisch, and Marcelo Gottschalk PMCID: PMC2493214 Vibrio cholerae RND Family Efflux Systems Are Required for Antimicrobial Resistance, Optimal Virulence Factor Production, and Colonization of the Infant Mouse Small Intestine Xiaowen R. Bina, Daniele Provenzano, Nathalie Nguyen, and James E. Bina PMCID: PMC2493215 Combined Deletion of Four Francisella novicida Acid Phosphatases Attenuates Virulence and Macrophage Vacuolar Escape Nrusingh P. Mohapatra, Shilpa Soni, Thomas J. Reilly, Jirong Liu, Karl E. Klose, and John S. Gunn PMCID: PMC2493204 The Absence of Toll-Like Receptor 4 Signaling in C3H/HeJ Mice Predisposes Them to Overwhelming Rickettsial Infection and Decreased Protective Th1 Responses Jeffrey M. Jordan, Michael E. Woods, Juan Olano, and David H. Walker PMCID: PMC2493240 Differential Activation of Human and Mouse Toll-Like Receptor 4 by the Adjuvant Candidate LpxL1 of Neisseria meningitidis Liana Steeghs, A. Marijke Keestra, Andries van Mourik, Heli Uronen-Hansson, Peter van der Ley, Robin Callard, Nigel Klein, and Jos P. M. van Putten PMCID: PMC2493235 The Fibrinogen- and Fibronectin-Binding Domains of Staphylococcus aureus Fibronectin-Binding Protein A Synergistically Promote Endothelial Invasion and Experimental Endocarditis Lionel Piroth, Yok-Ai Que, Eleonora Widmer, Alexandre Panchaud, Stéphane Piu, José M. Entenza, and Philippe Moreillon PMCID: PMC2493224 Host Response and Inflammation Proteomic Analysis of and Immune Responses to Ehrlichia chaffeensis Lipoproteins Haibin Huang, Mingqun Lin, Xueqi Wang, Takane Kikuchi, Heather Mottaz, Angela Norbeck, and Yasuko Rikihisa PMCID: PMC2493228 Mutans Streptococcal Infection Induces Salivary Antibody to Virulence Proteins and Associated Functional Domains R. D. Nogueira, W. F. King, G. Gunda, S. Culshaw, M. A. Taubman, R. O. Mattos-Graner, and D. J. Smith PMCID: PMC2493197 Distinct Isoforms of Phospholipase A2 Mediate the Ability of Salmonella enterica Serotype Typhimurium and Shigella flexneri To Induce the Transepithelial Migration of Neutrophils Karen L. Mumy, Jeffrey D. Bien, Michael A. Pazos, Karsten Gronert, Bryan P. Hurley, and Beth A. McCormick PMCID: PMC2493202 Interleukin-12 (IL-12) and IL-23 Induction of Substance P Synthesis in Murine T Cells and Macrophages Is Subject to IL-10 and Transforming Growth Factor β Regulation Arthur Blum, Tommy Setiawan, Long Hang, Korynn Stoyanoff, and Joel V. Weinstock PMCID: PMC2493212 An Interleukin-1β (IL-1β) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1β in Diseased Periodontal Tissues Samuel B. Ferreira, Jr., Ana Paula F. Trombone, Carlos E. Repeke, Cristina R. Cardoso, Walter Martins, Jr., Carlos F. Santos, Paula Cristina Trevilatto, Mario J. Ávila-Campos, Ana Paula Campanelli, João S. Silva, and Gustavo P. Garlet PMCID: PMC2493201 Fungal and Parasitic Infections The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells Zhongyu Li, Ding Chen, Youmin Zhong, Shiping Wang, and Guangming Zhong PMCID: PMC2493211 Aspergillus fumigatus Stimulates Leukocyte Adhesion Molecules and Cytokine Production by Endothelial Cells In Vitro and during Invasive Pulmonary Disease Lisa Y. Chiang, Donald C. Sheppard, Fabrice N. Gravelat, Thomas F. Patterson, and Scott G. Filler PMCID: PMC2493209 Pneumocystis murina Infection and Cigarette Smoke Exposure Interact To Cause Increased Organism Burden, Development of Airspace Enlargement, and Pulmonary Inflammation in Mice Paul J. Christensen, Angela M. Preston, Tony Ling, Ming Du, W. Bradley Fields, Jeffrey L. Curtis, and James M. Beck PMCID: PMC2493196 Temporal and Spatial Distribution of Toxoplasma gondii Differentiation into Bradyzoites and Tissue Cyst Formation In Vivo Manlio Di Cristina, Daniela Marocco, Roberto Galizi, Carla Proietti, Roberta Spaccapelo, and Andrea Crisanti PMCID: PMC2493213 Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung Joshua J. Reece, Mark C. Siracusa, Teresa L. Southard, Cory F. Brayton, Joseph F. Urban, Jr., and Alan L. Scott PMCID: PMC2493237 Persistently Infected Horses Are Reservoirs for Intrastadial Tick-Borne Transmission of the Apicomplexan Parasite Babesia equi Massaro W. Ueti, Guy H. Palmer, Glen A. Scoles, Lowell S. Kappmeyer, and Donald P. Knowles PMCID: PMC2493223 A Novel Immunoprecipitation Strategy Identifies a Unique Functional Mimic of the Glial Cell Line-Derived Neurotrophic Factor Family Ligands in the Pathogen Trypanosoma cruzi Bo Lu and Mercio PereiraPerrin PMCID: PMC2493206 Effector CD8+ T Lymphocytes against Liver Stages of Plasmodium yoelii Do Not Require Gamma Interferon for Antiparasite Activity Sumana Chakravarty, G. Christian Baldeviano, Michael G. Overstreet, and Fidel Zavala PMCID: PMC2493192 In Vivo Analysis of Aspergillus fumigatus Developmental Gene Expression Determined by Real-Time Reverse Transcription-PCR Fabrice N. Gravelat, Thomas Doedt, Lisa Y. Chiang, Hong Liu, Scott G. Filler, Thomas F. Patterson, and Donald C. Sheppard PMCID: PMC2493243 Cooperative Role of Macrophages and Neutrophils in Host Antiprotozoan Resistance in Mice Acutely Infected with Cryptosporidium parvum Dan Takeuchi, Vickie C. Jones, Makiko Kobayashi, and Fujio Suzuki PMCID: PMC2493226 The Terminal Sialic Acid of Glycoconjugates on the Surface of Intestinal Epithelial Cells Activates Excystation of Cryptosporidium parvum Naheed Choudhry, Mona Bajaj-Elliott, and Vincent McDonald PMCID: PMC2493191 Inhibition of Apoptosis in Cryptosporidium parvum-Infected Intestinal Epithelial Cells Is Dependent on Survivin Jin Liu, Shinichiro Enomoto, Cheryl A. Lancto, Mitchell S. Abrahamsen, and Mark S. Rutherford PMCID: PMC2493198 Microbial Immunity and Vaccines Selected prfA* Mutations in Recombinant Attenuated Listeria monocytogenes Strains Augment Expression of Foreign Immunogens and Enhance Vaccine-Elicited Humoral and Cellular Immune Responses Lin Yan, Jin Qiu, Jianbo Chen, Bridgett Ryan-Payseur, Dan Huang, Yunqi Wang, Lijun Rong, Jody A. Melton-Witt, Nancy E. Freitag, and Zheng W. Chen PMCID: PMC2493218 Effective Plague Vaccination via Oral Delivery of Plant Cells Expressing F1-V Antigens in Chloroplasts Philip A. Arlen, Michael Singleton, Jeffrey J. Adamovicz, Yi Ding, Abdolreza Davoodi-Semiromi, and Henry Daniell PMCID: PMC2493203 Native Outer Membrane Proteins Protect Mice against Pulmonary Challenge with Virulent Type A Francisella tularensis Jason F. Huntley, Patrick G. Conley, David A. Rasko, Kayla E. Hagman, Michael A. Apicella, and Michael V. Norgard PMCID: PMC2493219 Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains Peter Lauer, Bill Hanson, Edward E. Lemmens, Weiqun Liu, William S. Luckett, Meredith L. Leong, Heather E. Allen, Justin Skoble, Keith S. Bahjat, Nancy E. Freitag, Dirk G. Brockstedt, and Thomas W. Dubensky, Jr. PMCID: PMC2493200 Impaired Opsonization with C3b and Phagocytosis of Streptococcus pneumoniae in Sera from Subjects with Defects in the Classical Complement Pathway Jose Yuste, Ashwin Sen, Lennart Truedsson, Göran Jönsson, Liang-Seah Tay, Catherine Hyams, Helen E. Baxendale, Fiona Goldblatt, Marina Botto, and Jeremy S. Brown PMCID: PMC2493217 Oral Vaccination of Guinea Pigs with a Mycobacterium bovis Bacillus Calmette-Guérin Vaccine in a Lipid Matrix Protects against Aerosol Infection with Virulent M. bovis Simon Clark, Martin L. Cross, Allan Nadian, Julia Vipond, Pinar Court, Ann Williams, R. Glyn Hewinson, Frank E. Aldwell, and Mark A. Chambers PMCID: PMC2493221 Immunization with a Toll-Like Receptor 7 and/or 8 Agonist Vaccine Adjuvant Increases Protective Immunity against Leishmania major in BALB/c Mice Wen-Wei Zhang and Greg Matlashewski PMCID: PMC2493222 Oral Vaccination against Bubonic Plague Using a Live Avirulent Yersinia pseudotuberculosis Strain Thierry Blisnick, Patrick Ave, Michel Huerre, Elisabeth Carniel, and Christian E. Demeure PMCID: PMC2493205 The Oligomerization Domain of C4-Binding Protein (C4bp) Acts as an Adjuvant, and the Fusion Protein Comprised of the 19-Kilodalton Merozoite Surface Protein 1 Fused with the Murine C4bp Domain Protects Mice against Malaria Solabomi A. Ogun, Laurence Dumon-Seignovert, Jean-Baptiste Marchand, Anthony A. Holder, and Fergal Hill PMCID: PMC2493234 |
