| | Other Issues: previous | next | latest | archiveIn This Issue STIM1 strengthens clotting Hema Bashyam PMCID: PMC2442621 Timing tolerance to cancer Hema Bashyam PMCID: PMC2442622 Why less is worse for lupus Hema Bashyam PMCID: PMC2442623 Tumor suppressor fends off lung fibrosis Hema Bashyam PMCID: PMC2442624 Two paths lead to MS Hema Bashyam PMCID: PMC2442625 People & Ideas Jane Skok: Choreography of allelic exclusion Hema Bashyam PMCID: PMC2442626 Commentaries A rush to judgment on Th17 Lawrence Steinman PMCID: PMC2442627 Differential recognition of double-stranded RNA by RIG-I–like receptors in antiviral immunity Takeshi Saito and Michael Gale, Jr. PMCID: PMC2442628 Polymers and inflammation: disease mechanisms of the serpinopathies Bibek Gooptu and David A. Lomas PMCID: PMC2442629 Brief Definitive Reports IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition Mark A. Kroenke, Thaddeus J. Carlson, Anuska V. Andjelkovic, and Benjamin M. Segal PMCID: PMC2442630 Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells Ludovic de Beaucoudrey, Anne Puel, Orchidée Filipe-Santos, Aurélie Cobat, Pegah Ghandil, Maya Chrabieh, Jacqueline Feinberg, Horst von Bernuth, Arina Samarina, Lucile Jannière, Claire Fieschi, Jean-Louis Stéphan, Catherine Boileau, Stanislas Lyonnet, Guillaume Jondeau, Valérie Cormier-Daire, Martine Le Merrer, Cyrille Hoarau, Yvon Lebranchu, Olivier Lortholary, Marie-Olivia Chandesris, François Tron, Eleonora Gambineri, Lucia Bianchi, Carlos Rodriguez-Gallego, Simona E. Zitnik, Julia Vasconcelos, Margarida Guedes, Artur Bonito Vitor, Laszlo Marodi, Helen Chapel, Brenda Reid, Chaim Roifman, David Nadal, Janine Reichenbach, Isabel Caragol, Ben-Zion Garty, Figen Dogu, Yildiz Camcioglu, Sanyie Gülle, Ozden Sanal, Alain Fischer, Laurent Abel, Birgitta Stockinger, Capucine Picard, and Jean-Laurent Casanova PMCID: PMC2442631 Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3 Cindy S. Ma, Gary Y.J. Chew, Nicholas Simpson, Archana Priyadarshi, Melanie Wong, Bodo Grimbacher, David A. Fulcher, Stuart G. Tangye, and Matthew C. Cook PMCID: PMC2442632 Foxp3+ regulatory T cells maintain immune homeostasis in the skin Jan C. Dudda, Nikole Perdue, Eva Bachtanian, and Daniel J. Campbell PMCID: PMC2442633 Sγ3 switch sequences function in place of endogenous Sγ1 to mediate antibody class switching Ali A. Zarrin, Peter H. Goff, Kate Senger, and Frederick W. Alt PMCID: PMC2442634 Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake Lisa C. Willcocks, Paul A. Lyons, Menna R. Clatworthy, James I. Robinson, Wanling Yang, Stephen A. Newland, Vincent Plagnol, Naomi N. McGovern, Alison M. Condliffe, Edwin R. Chilvers, Dwomoa Adu, Elaine C. Jolly, Richard Watts, Yu Lung Lau, Ann W. Morgan, Gerard Nash, and Kenneth G.C. Smith PMCID: PMC2442635 The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction David Varga-Szabo, Attila Braun, Christoph Kleinschnitz, Markus Bender, Irina Pleines, Mirko Pham, Thomas Renné, Guido Stoll, and Bernhard Nieswandt PMCID: PMC2442636 CNI-1493 inhibits Aβ production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease Michael Bacher, Richard Dodel, Bayan Aljabari, Kathy Keyvani, Philippe Marambaud, Rakez Kayed, Charles Glabe, Nicole Goertz, Anne Hoppmann, Norbert Sachser, Jens Klotsche, Susanne Schnell, Lars Lewejohann, and Yousef Al-Abed PMCID: PMC2442637 Articles Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5 Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, Reiko Hirai, Tomoji Kawai, Kazufumi Matsushita, Akane Hiiragi, Terence S. Dermody, Takashi Fujita, and Shizuo Akira PMCID: PMC2442638 TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice Minghui Tang, Xudong Wei, Yinshi Guo, Peter Breslin, Shubin Zhang, Shanshan Zhang, Wei Wei, Zhenbiao Xia, Manuel Diaz, Shizuo Akira, and Jiwang Zhang PMCID: PMC2442639 Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells Corine H. GeurtsvanKessel, Monique A.M. Willart, Leonie S. van Rijt, Femke Muskens, Mirjam Kool, Chantal Baas, Kris Thielemans, Clare Bennett, Björn E. Clausen, Henk C. Hoogsteden, Albert D.M.E. Osterhaus, Guus F. Rimmelzwaan, and Bart N. Lambrecht PMCID: PMC2442640 Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs Jodi McGill, Nico Van Rooijen, and Kevin L. Legge PMCID: PMC2442641 An MHC class Ib–restricted CD8 T cell response confers antiviral immunity Phillip A. Swanson, II, Christopher D. Pack, Annette Hadley, Chyung-Ru Wang, Iwona Stroynowski, Peter E. Jensen, and Aron E. Lukacher PMCID: PMC2442642 Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis Hong Xia, Deanna Diebold, Richard Nho, David Perlman, Jill Kleidon, Judy Kahm, Svetlana Avdulov, Mark Peterson, John Nerva, Peter Bitterman, and Craig Henke PMCID: PMC2442643 Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages Jose Rafael Sierra, Simona Corso, Luisa Caione, Virna Cepero, Paolo Conrotto, Alessandro Cignetti, Wanda Piacibello, Atsushi Kumanogoh, Hitoshi Kikutani, Paolo Maria Comoglio, Luca Tamagnone, and Silvia Giordano PMCID: PMC2442644 Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness Gerald Willimsky, Melinda Czéh, Christoph Loddenkemper, Johanna Gellermann, Karin Schmidt, Peter Wust, Harald Stein, and Thomas Blankenstein PMCID: PMC2442645 Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets Claude Sportès, Frances T. Hakim, Sarfraz A. Memon, Hua Zhang, Kevin S. Chua, Margaret R. Brown, Thomas A. Fleisher, Michael C. Krumlauf, Rebecca R. Babb, Catherine K. Chow, Terry J. Fry, Julie Engels, Renaud Buffet, Michel Morre, Robert J. Amato, David J. Venzon, Robert Korngold, Andrew Pecora, Ronald E. Gress, and Crystal L. Mackall PMCID: PMC2442646 |
