All Clinical Studies

The Clinical Studies Database includes information on major completed and ongoing clinical research supported by the NEI since 1970. This area includes Clinical Trials, Epidemiology and Natural History Studies, and Health Services Research sections of the database.

Table of Contents (alphabetically by study)

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• Advanced Glaucoma Intervention Study (AGIS)
• Age-Related Eye Disease Study (AREDS)
• Age-Related Eye Disease Study 2 (AREDS2)
• Amblyopia Treatment Study: Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia
• Amblyopia Treatment Study: A Randomized Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children 3 to <7 Years Old
• Berkeley Orthokeratology Study, The
• Bilateral Refractive Amblyopia Treatment Study
• Branch Vein Occlusion Study
• Central Vein Occlusion Study (CVOS)
• Clinical Trial of Eye Prophylaxis in the Newborn
• Collaborative Corneal Transplantation Studies (CCTS)
• Collaborative Initial Glaucoma Treatment Study (CIGTS)
• Collaborative Italian-American Clinical Trial of Nutritional Supplements and Age-related Cataract (CTNS)
• Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study, The
• Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study
• Collaborative Ocular Melanoma Study (COMS)
• Comparison of Age-related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial (CATT)
• Complications of Age-Related Macular Degeneration Prevention Trial (CAPT)
• Congenital Esotropia Observational Study (CEOS)
• Contact Lens and Myopia Progression (CLAMP) Study, The
• Convergence Insufficiency Treatment Trial (CITT)
• Cornea Donor Study (CDS)
• Correction of Myopia Evaluation Trial (COMET)
• Correction of Myopia Evaluation Trial 2 (COMET2): A randomized trial of the effect of progressive addition lenses versus single vision lenses on low myopia associated with large accommodative lags and near esophoria in children
• Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) - Outcome Study of Cryotherapy for Retinopathy of Prematurity
• Diabetic Retinopathy Study (DRS)
• Diabetic Retinopathy Vitrectomy Study (DRVS)
• Digital Image Based Determination of Ocular Surface Vital Dye Staining
• Early Manifest Glaucoma Trial (EMGT)
• Early Treatment Diabetic Retinopathy Study (ETDRS)
• Early Treatment for Retinopathy of Prematurity Study (ETROP), The
• Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP), The
• Eliminating Trachoma with Repeat Mass Drug Treatment (TANA)
• Endophthalmitis Vitrectomy Study (EVS)
• An Evaluation Of Treatment Of Amblyopia In Children 7 To <18 Years Old
• Evaluation of Vitrectomy for Diabetic Macular Edema Study
• Fluorouracil Filtering Surgery Study (FFSS)
• Ganciclovir Implant Study for Cytomegalovirus Retinitis
• Glaucoma Laser Trial (GLT) Glaucoma Laser Trial Followup Study (GLTFS)
• Herpetic Eye Disease Study (HEDS) I
• Herpetic Eye Disease Study (HEDS) II
• Improving Function in AMD (IF-AMD)
• Infant Aphakia Treatment Study (IATS)
• Intravenous Immunoglobulin Therapy in Optic Neuritis
• Intravitreal Ranibizumab or Triamcinolone Acetonide as Adjunctive Treatment to Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
• Intravitreal Ranibizumab or Triamcinolone Acetonide in Combination with Laser Photocoagulation for Diabetic Macular Edema
• Ischemic Optic Neuropathy Decompression Trial (IONDT)
• Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup)
• Krypton-Argon Regression of Neovascularization Study (KARNS)
• Longitudinal Optic Neuritis Study (LONS)
• Macular Photocoagulation Study (MPS)
• Multi-Center, Randomized, Phase II Clinical Trial to Study the Effects of Preservative-Free Triamcinolone Acetonide and Avastin® in Combination with Photodynamic Therapy in Participants with Neovascular Age Related Macular Degeneration (VERTACL)
• Multicenter Uveitis Steroid Treatment (MUST) Trial
• An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia
• An Observational Study of Optical Correction for Strabismic Amblyopia in Children 3 to <7 Years Old
• An Observational Study of the Development of Diabetic Macular Edema Following Scatter Laser Photocoagulation
• An Observational Study on Recurrence of Amblyopia After Discontinuation of Treatment
• Ocular Hypertension Treatment Study (OHTS)
• Optic Neuritis Treatment Trial (ONTT)
• A Phase 2 Evaluation of Anti-VEGF Therapy for Diabetic Macular Edema: Bevacizumab (Avastin)
• A Pilot Study of Laser Photocoagulation for Diabetic Macular Edema
• A Pilot Study of Peribulbar Triamcinolone Acetonide for Diabetic Macular Edema
• A Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia in 8 to 17 Year Olds
• Prism Adaptation Study (PAS), The
• Prospective Evaluation of Radial Keratotomy (PERK) Study
• A Prospective Study of Central Corneal Thickness in Children Less than 18 Years Old
• A Prospective Study of Primary Surgical Treatment of Nasolacrimal Duct Obstruction in Children Less Than Four Years Old
• A Prospective Study of Surgical Procedures for the Treatment of Persistent Nasolacrimal Duct Obstruction in Children less than Four Years Old
• Randomized Clinical Trial for Retinitis Pigmentosa
• A Randomized Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye As Prescribed Treatments for Amblyopia in Children 3 to <7 Years Old
• A Randomized Trial Comparing Daily Atropine Versus Weekend Atropine
• A Randomized Trial Comparing Immediate Probing in an Office Setting with Deferred Probing in a Facility Setting for Treatment of Nasolacrimal Duct Obstruction in Children 6 to <10 Months Old
• A Randomized Trial Comparing Intravitreal Triamcinolone Acetonide and Laser Photocoagulation for Diabetic Macular Edema
• A Randomized Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old
• A Randomized Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia
• A Randomized Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia
• A Randomized Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds
• A Randomized Trial Comparing Patching with Active Vision Therapy to Patching with Control Vision Therapy as Treatment for Amblyopia in Children 7 to <13 Years Old
• Randomized Trial for Retinitis Pigmentosa
• Randomized Trial of Acetazolamide for Uveitis-Associated Cystoid Macular Edema
• Randomized Trial of Aspirin and Cataracts in U.S. Physicians
• Randomized Trial of Beta-Carotene and Macular Degeneration
• A Randomized Trial of Full-time Bangerter Filters versus Part-time Daily Patching for the Treatment of Moderate Amblyopia in Children
• Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa
• A Randomized Trial to Evaluate Combined Patching-Atropine for Residual Amblyopia
• Randomized Trials of Vitamin Supplements and Eye Disease
• Silicone Study, The
• Sorbinil Retinopathy Trial (SRT)
• Steroids for Corneal Ulcers Trial (SCUT)
• Studies of Ocular Complications of AIDS (SOCA)--Ganciclovir-Cidofovir CMV Retinitis Trial (GCCRT)
• Studies of the Ocular Complications of AIDS (SOCA)--Cytomegalovirus Retinitis Retreatment Trial (CRRT)
• Studies of the Ocular Complications of AIDS (SOCA)--Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT)
• Studies of the Ocular Complications of AIDS (SOCA)--HPMPC Peripheral CMV Retinitis Trial (HPCRT)
• Studies of the Ocular Complications of AIDS (SOCA)--Longitudinal Study of Ocular Complications of AIDS (LSOCA)
• Studies of the Ocular Complications of AIDS (SOCA)--Monoclonal Antibody CMV Retinitis Trial (MACRT)
• Subclinical Diabetic Macular Edema Study
• Submacular Surgery Trials (SST)
• Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity (the STOP-ROP Multicenter Trial)
• Surgery for Trichiasis, Antibiotics to Prevent Recurrence (STAR)
• Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study
• Temporal Variation in Optical Coherence Tomography Measurements of Retinal Thickening in Diabetic Macular Edema
• The Standard Care vs. COrticosteroid for REtinal Vein Occlusion (SCORE) Study: Two Randomized Trials to Compare the Efficacy and Safety of Intravitreal Injection(s) of Triamcinolone Acetonide with Standard Care to Treat Macular Edema
• The Course of Response to Focal Photocoagulation for Diabetic Macular Edema
• Trial of Bifocals in Myopic Children With Esophoria, A
• Vision In Preschoolers Study (VIP Study)