News & Events
- Upcoming Meetings & Events
  - Public Health Genomics

Upcoming Meetings & Events

Public Health Genomics: "Closing the Gap Between Human Genome Discoveries and Population Health"

2007 Sessions

Jan | Feb | Mar | Apr | May | Jul | Sep | Oct | Nov

Organized by:
Muin J. Khoury, M.D., Ph.D.
National Office of Public Health Genomics
Centers for Disease Control and Prevention

Location:
Executive Plaza North
Conference Rooms C-F
6130 Executive Boulevard
Rockville, Maryland

Time:
1:00 PM - 3:00 PM

January 18, 2007
What is "Public Health Genomics" and Why Should We Care? An Overview of the Series.
Topic	Speakers
Overview	Muin J. Khoury, M.D., Ph.D., CDC (presentation; pdf 2.5mb) (videocast; ram, 49:56 min)
"Omics" 101 for Medicine and Public Health	Stephen Chanock, M.D., NCI (presentation; pdf 4.1mb) (videocast; ram, 1:08 min)
Selected Readings:
Burke W, Khoury MJ, Stewart A, Zimmern RL. The path from genome-based research to population health: Development of an international public health genomics network. Genetics In Medicine 2006; 8(7):451-8. (pdf, 1.12mb) Genome-based Research and Population Health. Report of an expert workshop held at the Rockefeller Foundation Study and Conference Centre Bellagio, Italy, 14 - 20 April 2005. (pdf, 1.15mb)

February 15, 2007
How Do We Assess the Contribution of Complex Genotypes and Gene-Environment Interaction to the Population Burden of Common Diseases?
Topic	Speakers
Introduction (presentation; pdf 337kb)	Muin J. Khoury, M.D., Ph.D., CDC
Cancer genetic epidemiology: what has worked and what has not worked?	Robert Hoover, M.D., Sc.D., NCI (presentation; pdf 606kb) (videocast; ram, 56:12 min)
Cohort studies and case-control studies in the era of whole genome associations	Teri Manolio, M.D., Ph.D., NHGRI (presentation; pdf 1.2mb) (videocast; ram, 34:22 min)
Selected Readings:
Manolio TA, Bailey-Wilson JE, and Collins FS. Genes, environment and the value of prospective cohort studies. Nature 2006;7:812-20. (pdf, 439.67kb) Willett WC, et al. Commentary: Merging and emerging cohorts. Nature 2007;445:257-8. (pdf, 248.97kb) Collins FS, and Manolio TA. Commentary: Necessary but not sufficient. Nature 2007. (pdf, 110.27kb) Hoover RN. The Evolution of Epidemiologic Research: From Cottage Industry to "Big" Science. Epidemiology 2007;18(1):13-7. (pdf, 392.54kb)

March 12, 2007
What is the Role of Behavioral and Social Sciences in Translating Genetic Research Into Population Health Benefits?
Topic	Speakers
Introduction	Muin J. Khoury, M.D., Ph.D., CDC (presentation; pdf 321kb)
Beyond Nature/Nurture: trans-disciplinary approach to genomic, behavioral and social science research	David Abrams, Ph.D., NIH OBSSR (presentation; pdf 3.2mb) (videocast; ram, 57:53 min)
Using genomics to change health behavior	Colleen McBride, Ph.D., NHGRI (presentation; pdf 2.6mb);(videocast; ram, 48:12 min)
Selected Readings:
McBride, CM. Blazing a trail: A public health research agenda in genomics and chronic disease. Preventing Chronic Disease 2005;2(2):1-5. (pdf, 181.04kb) Moffitt TE, Caspi A, Rutter M. Interactions in psychopathology: Concepts, research strategies, and implications for research, intervention, and public understanding of genetics. Perspective Psychological Science 2006;1(1):5-27. (pdf, 228.51kb)

April 19, 2007
Knowledge Integration in Public Health Genomics: Evaluation of the Epidemiologic Evidence
Topic	Speakers
Grading cumulative evidence, integrating biology, and developing online knowledge base	Muin J. Khoury, M.D., Ph.D., CDC (presentation; pdf 1.3mb) (videocast; ram, 45:45 min)
Cancer example: Genetic polymorphisms, environmental exposures and bladder cancer	Nat Rothman, M.D., M.P.H., NCI (presentation; pdf 703kb) (videocast; ram, 52:33 min)
Selected Readings:
García-Closas M, Malats N, Silverman D, Dosemeci M, Kogevinas M, Hein DW, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Castaño-Vinyals G, Yeager M, Welch R, Chanock S, Chatterjee N, Wacholder S, Samanic C, Torá M, Fernández F, Real FX, Rothman N. NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet 2005; 366:649-59. (pdf, 159.29kb) Ioannidis JPA, Gwinn M, Little J, Higgins JPT, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam A, Danesh J, Smith GD, Dolan S, Duncan R, Gruis NA, Hartge P, Hashibe M, Hunter DJ, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, O'Brien TR, Petersen G, Riboli E, Salanti G, Seminara D, Smeeth L, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Khoury MJ. A road map for efficient and reliable human genome epidemiology. Nature Genetics 2006; 38:3-5. (pdf, 124.24kb) Lin BK, Clyne M, Walsh M, Gomez O, Yu W, Gwinn M, Khoury MJ. Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature Database. Am J Epidemiol. 2006 Jul 1;164(1):1-4. (pdf, 59.16kb) Seminara D, Khoury MJ, O'Brien TR, Manolio T, Gwinn ML, Little J, Higgins JP, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam AP, Danesh J, Davey SG, Dolan S, Duncan R, Gruis NA, Hashibe M, Hunter D, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, Riboli E, Salanti G, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Ioannidis JP. The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology 2007; 18(1):1-8. (pdf, 291.89kb)

May 17, 2007
Knowledge Integration in Public Health Genomics: Evaluation of Genetic and Genomic Tests
Topic	Speakers
A public health framework for genetic test evaluation	Muin J. Khoury, M.D., Ph.D., CDC (presentation; pdf, 1.52mb) (videocast; ram, 32:28 min)
The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative	Alfred Berg, M.D., M.P.H., University of Washington (presentation; pdf, 4.31mb) (videocast; ram, 32:27 min)
Selected Readings:
CDC Information on Genetic Testing (featuring ACCE) Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative Janssens AC, Gwinn M, Valdez R, Narayan KM, Khoury MJ. Predictive genetic testing for type 2 diabetes. BMJ 2006 ;333(7567):509-10. (pdf, 71.44kb) Grosse SD, Khoury MJ. What is the clinical utility of genetic testing? Genet Med 2006;8(7):448-50. (pdf, 110.10kb)

July 26, 2007
But How Do We Translate New Genetic Knowledge Into Practice?
Topic	Speakers
How do we actually translate guidelines into action?	Jon Kerner, Ph.D., NCI (presentation; pdf 1.6mb) (videocast; ram, 51 min)
What is the role of professional organizations, consumers, oversight and regulation?	Kathy Hudson, Ph.D., Johns Hopkins University (presentation; pdf 2.4mb) (videocast; ram, 36:58 min)
Selected Readings:
Hudson K. 2007. Prohibiting genetic discrimination. New England Journal of Medicine 356(20): 2021-2023. (pdf, 125kb) Javitt G. and Hudson K. 2007. The right prescription for personalized genetic medicine. Personalized Medicine 4(2): 115-118. (pdf, 164kb) Hudson K., Murphy J., Kaufman D., Javitt G., Katsanis S., and Scott J. 2006. Oversight of US genetic testing laboratories. Nature Biotechnology 24(9): 1083-1090. (pdf, 195kb) Kerner J.F,Guirguis-Blake J., Hennessy K.D., Brounstein P.J., Vinson C., Schwartz R.H., Myers B.A., and Briss P. 2005. Translating research into improved outcomes in comprehensive cancer control. Cancer Causes and Control 16(Suppl. 1): 27-40. (pdf, 274kb) Kerner J.F. 2006. Knowledge translation versus knowledge integration: a "funder’s" perspective. The Journal of Continuing Education in the Health Professions Vol. 26, 72-80. (pdf, 187kb) Park E.R., Kleimann S., Shields A.E., and Pelan J.A. 2007. Anticipating clinical integration of genetically tailored tobacco dependence treatment: Perspectives of primary care physicians Nicotine & Tobacco Research, 9(2), 271 - 279. (pdf, 255kb) Lerman C. and Shields A.E. 2004. Genetic testing for cancer susceptibility: the promise and the pitfalls Nature Reviews Cancer, 4(March), 235 - 241 (pdf, 258kb) Parthasarathy S. 2005. Architectures of genetic medicine: comparing genetic testing for breast cancer in the USA and the UK. Social Studies of Science 35(1) 5-40. (pdf, 2.86mb)

September 20, 2007
How Do We Monitor the Impact of Genomics on Population Health?
Topic	Speakers
Role of public health agencies in assuring appropriate use of genomics in population health	Muin J. Khoury, M.D., Ph.D., CDC (presentation; pdf, 11.41mb) (videocast; ram, 32:37 min)
Applied research for genomic applications in clinical practice	Louise Wideroff, Ph.D., NCI (presentation; pdf, 11.41mb) (videocast; ram, 39:43 min)
Selected Readings:
Beskow L, Khoury MJ, Baker TG, Thrasher J. The Integration of Genomics into Public Health Research, Policy, and Practice in the United States. Community Genetics 2001;4:2-11. Available online at http://www.cdc.gov/genomics/training/perspectives/other/wheel.htm Khoury MJ, McCabe L, McCabe ERB. Population screening in the age of genomic medicine. New Engl J Med 2003;348:50-58. Available online at: http://content.nejm.org/cgi/reprint/348/1/50.pdf Lindegren ML, Lyn S, Moore CA. The role of human genomics in acute public health investigations: current practice and future strategies. CDC Genomics and Population Health Report 2005. Available online at: http://www.cdc.gov/genomics/activities/ogdp/2005/chap01.htm Goddard KAB, Moore C, Ottman D, Bradley L, Khoury MJ. Awareness and use of direct to consumer nutrigenomic tests, United States, 2006. Genet Med 2007;9:510-517. Available online at: http://www.cdc.gov/genomics/update/file/print/Goddard_DTC.pdf Meropol NJ, Schulman KA. 2007. Cost of Cancer Care: Issues and Implications. J Clin Oncol 25(2), 180-186. (pdf, 135kb) Genetic Tests for Cancer. Prepared for the Agency for Healthcare Research and Quality. (pdf, 487kb) Hall MJ, Olopade OI. Disparities in Genetic Testing: Thinking Outside the BRCA Box. J Clin Oncol 2006;24(14), 2197-2203. (pdf, 105kb)

October 18, 2007
Can We Use Family History as a Tool For Disease Prevention and Public Health?
Topic	Speakers
Introduction	Muin J. Khoury, M.D., Ph.D., CDC (presentation; pdf, 69.9kb)
The Surgeon General family history initiative: why is family history important in the genomics age?	Alan Guttmacher, M.D., NHGRI (presentation; pdf, 1.23mb) (videocast; ram, 35.49 min)
Family health history in the control and prevention of cancer, heart disease and diabetes.	Paula Yoon, Sc.D., M.P.H., CDC (presentation; pdf, 1.62mb) (videocast; ram, 52:47 min)
Selected Readings:
Guttmacher AE, Collins FS, Carmona RH. The Family History - More Important Than Ever. The New England Journal of Medicine 2004; 351(22);2333-2336. (pdf, 71.1kb) Scheumer MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ. Familial risk assessment for early-onset coronary heart disease. Genet Med 2006:8(8):525-531. (pdf, 103kb) Valdez R, Greenhund KJ, Khoury MJ, Yoon PW. Is Family History a Useful Tool for Detecting Children at Risk for Diabetes and Cardiovascular Diseases? A Public Health Perspective. Pediatrics 2007;120;S78-S86. (pdf, 272kb) Valdez R, Liu T, Yoon PW, Khoury MJ. Family History and Prevalence of Diabetes in the U.S. Population. Diabetes Care 2007; 30:2517-2522. (pdf, 120kb)

November 29, 2007
Can Genomics Help Heal the Schism Between Medicine and Public Health?
Topic	Speakers
Genomic medicine and health disparities	Charles Rotimi, Ph.D., M.P.H., Howard University (presentation; pdf, 102mb)(videocast; ram, 48:36 min)
Will genomics widen or help heal the schism between medicine and public health?	Muin J. Khoury, M.D., Ph.D., CDC (presentation; pdf, 2.29mb)(videocast; ram, 40:33 min)
Selected Readings:
Khoury MJ, Gwinn M, Burke W, Bowen S, Zimmern R. Will Genomics Widen or Help Heal the Schism Between Medicine and Public Health?. Am J Prev Med 2007; 33(4); 310-3117. (pdf, 116.76kb) Scheumer MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ. Familial risk assessment for early-onset coronary heart disease. Genet Med 2007:9(10):665-674. (pdf, 323.76kb) Foster MW and Sharp RR. Beyond race: towards a whole-genome perspective on human populations and genetic variation. Nat Rev Genet 2004;5(10):790-796. (pdf, 198kb) Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES, & The International HapMap Consortium. Genome-wide detection and characterization of positive selection in human populations. Nature 2007;449(7164):913-913. (pdf, 1mb) Rotimi CN. Are medical and nonmedical users of large-scale genomic markers conflating genetics and 'race'?. Nat Genet 36(11 Suppl):S43-47. (pdf, 118kb) Genes, drugs and race. Nat Genet 2001;29(3):239-240. (pdf, 52kb) Duster T. Race and Reification in Science. Science 2005;307(5712):1050-1051. (pdf, 110kb) Slicing soup. Nat Biotechnol 2002;20(7):637. (pdf, 62kb) Garcia RS. The Misuse of Race in Medical Diagnosis. Pediatrics 2004;113:1394-1395. (pdf, 225kb) Sankar P, Cho MK, Mountain J. Race and Ethnicity in Genetic Research. Am J Med Genet A 2007;143(9):961-970. (pdf, 127 kb)

NIH VideoCast Disclaimer

Streaming video is best viewed with a high-speed network connection. On the NIH campus, most computers are capable of displaying a VideoCast. Outside NIH, computers with broadband speeds of 350Kbps or faster can view world-accessible VideoCasts. Hardware and Software You Will Need: NIH staff should download RealPlayer Enterprise for Windows or RealPlayer Macintosh. Others should download free RealPlayer.

Windows software (NIH staff only)
Macintosh software
Free Real Player

Quick Links

Upcoming Meetings & Events

Public Health Genomics: "Closing the Gap Between Human Genome Discoveries and Population Health"

NIH VideoCast Disclaimer