| No. |
Title (click to view PDF) |
Publication Date |
Notice Number |
Link to Public Comments |
| 2008 |
| 1 |
73FR71003 - Availability of the ICCVAM Test Method Evaluation Report and Final Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products; Notice of Transmittal of ICCVAM Test Method Recommendations to Federal Agencies |
11-24-2008 |
E8-27790 |
NA
|
| 2 |
73FR63150 - Availability of the Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): NIH Publication No. 086529 |
10-23-2008 |
E8-25223 |
NA
|
| 3 |
73FR29136 - Peer Review Panel Report on the Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay (LLNA): A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products: Notice of Availability and Request for Public Comments |
05-20-2008 |
E8-11195 |
NA
|
| 4 |
73FR25754 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) |
05-07-2008 |
E8-10010 |
View
|
| 5 |
73FR18535 - Non-Animal Methods and Approach for Evaluating Eye Irritation Potential for Antimicrobial Cleaning Products (AMCPs): Request for Nominations for an Independent Expert Panel and Submission of Relevant Data |
04-04-2008 |
E8-6969 |
View
|
| 6 |
73FR15757 - Availability of the ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests and the Final Background Review Document for In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity; Notice of Transmittal of ICCVAM Test Method Recommendations to Federal Agencies |
03-25-2008 |
E8-5936 |
View
|
| 7 |
73FR1360 - Announcement of an Independent Scientific Peer Review Panel Meeting on the Murine Local Lymph Node Assay; Availability of Draft Background Review Documents; Request for Comments |
01-08-2008 |
E7-25553 |
View
|
| 8 |
73FR493 - Workshop on Acute Chemical Safety Testing |
01-03-2008 |
E7-25536 |
View
|
| 2007 |
| 1 |
72FR72727 - Ten-Year Anniversary Symposium and Five-Year Plan |
12-21-2007 |
E7-24799 |
NA
|
| 2 |
72FR65964 - Availability of TMER and Final BRDs on In Vitro Ocular Test Methods; Recommendations to Federal Agencies |
11-26-2007 |
E7-22906 |
View
|
| 3 |
72FR52130 - Draft Performance Standards for the Murine Local Lymph Node Assay: Request for Comments |
09-12-2007 |
E7-18011 |
View
|
| 4 |
72FR31582 - Request for Ocular Irritancy Test Data From Human, Rabbit, and In Vitro Studies Using Standardized Testing Methods |
06-07-2007 |
E7-10966 |
NA
|
| 5 |
72FR27815 - The Murine Local Lymph Node Assay: Request for Comments,
Nominations of Scientific Experts, and Submission of Data |
05-17-2007 |
E7-9544 |
View
|
| 6 |
72FR26395 - Peer Review Panel Report on Five In Vitro Pyrogen Test Methods: Availability and Request for Public Comments |
05-09-2007 |
E7-8896 |
View
|
| 7 |
72FR26396 - Request for Data on the Use of Topical Anesthetics and Systemic Analgesics for In Vivo Eye Irritation Testing |
05-09-2007 |
E7-8898 |
View
|
| 8 |
72FR23832 - Availability of Draft NICEATM-ICCVAM 5-Year Plan and Request for Public Comments; Announcement of a Town Meeting on
the Draft NICEATM-ICCVAM 5-Year Plan |
05-01-2007 |
E7-8290 |
View
|
| 9 |
72FR23831 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) |
05-01-2007 |
E7-8289 |
NA
|
| 2006 |
| 1 |
71FR74533 - Announcement of an Independent Scientific Peer Review Meeting on the Use of In Vitro Pyrogenicity Testing Methods; Request for Comments |
12-11-2006 |
E6-21038 |
View
|
| 2 |
71FR66959 - Availability of Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) |
11-16-2006 |
E6-19487 |
NA
|
| 3 |
71FR66172 - Development of a NICEATM/ICCVAM 5-Year Plan to Research, Develop, Translate, and Validate New and Revised Non-animal and Other Alternative Assays for Integration of Relevant and Reliable Methods into Federal Agency Testing Programs: Request for Public Comments |
11-09-2006 |
E6-19094 |
View
|
| 4 |
71FR62480 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) |
10-25-2006 |
E6-17889 |
NA
|
| 5 |
71FR60748 - Notice of Availability of the NICEATM Pre-Screen Evaluation of a Cell Proliferation Assay to Detect Estrogenic Activity: Request for Comments and Nominations of Other In Vitro Endocrine Disruptor Test Methods |
10-13-2006 |
E6-17134 |
View
|
| 6 |
71FR56997 - Notice of Availability of a Revised List of Recommended Reference Substances for Validation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays |
09-27-2006 |
E6-15972 |
NA
|
| 7 |
71FR47505 - Scientific Workshop on Alternative Methods to Refine, Reduce, or Replace the Mouse LD50 Assay for Botulinum Toxin Testing; Request for In Vivo and In Vitro Data |
08-16-2006 |
E6-13525 |
NA
|
| 8 |
71FR39121 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) |
07-10-2006 |
E6-10790 |
NA
|
| 9 |
71FR39122 - Availability of Peer Review Panel Report on the Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing and Request for Comments |
07-10-2006 |
E6-10789 |
View
|
| 10 |
71FR14229 - Announcement of an Independent Scientific Peer Review Meeting on the Use of In Vitro Testing Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests and Request for Comments |
03-20-2006 |
E6-4075 |
View
|
| 11 |
71FR13597 - Notice of Availability of a Revised List of Recommended Reference Substances for Validation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays: Request for Comments and Submission of In Vivo and In Vitro Data |
03-15-2006 |
E6-3763 |
NA
|
| 12 |
71FR4603 - Nomination to Hold a Workshop on Alternative Methods to Replace the Mouse LD50 Assay for Botulinum Toxin Potency Testing: Request for Comments, Nominations of Experts, and Submission of In Vivo and In Vitro Data |
01-26-2006 |
E6-1019 |
View
|
| 2005 |
| 1 |
70FR74833 - Peer Panel Evaluation of In Vitro Pyrogenicity Testing Methods: Request for Comments, Nominations of Experts, and Submission of In Vivo and In Vitro Data |
12-15-2005 |
E5-7410 |
View
|
| 2 |
70FR68069 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) |
11-08-2005 |
05-22320 |
NA
|
| 3 |
70FR66451 - Second Expert Panel Report on In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants |
11-01-2005 |
05-21830 |
View
|
| 4 |
70FR53676 - Announcement of Expert Panel Meeting to Evaluate Revised Analyses and Proposed Reference Substances for In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants |
09-08-2005 |
05-17939 |
NA
|
| 5 |
70FR43149 - Availability of Revised Analyses and Proposed Reference Substances for In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants |
07-25-2005 |
05-14707 |
View
|
| 6 |
70FR35687 - National Institute of Environmental Health Sciences 2006 Strategic Plan; Request for Comments and Nominations |
06-20-2005 |
05-12129 |
NA
|
| 7 |
70FR18037 - Ocular Toxicity Scientific Symposia: Mechanisms of Chemically-Induced Ocular Injury and Recovery and Minimizing Pain and Distress in Ocular Toxicity Testing |
04-07-2005 |
05-7002 |
NA
|
| 8 |
70FR14473 - Request for Nominations for an Independent Peer Review Panel to Evaluate In Vitro Testing Methods for Estimating Acute Oral Systemic Toxicity and Request for In Vivo and In Vitro Data |
03-21-2005 |
05-5564 |
View
|
| 9 |
70FR13513 - Availability of Expert Panel Report on the Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants |
03-18-2005 |
05-5473 |
View
|
| 10 |
70FR13512 - Request for Data on Non-Animal Methods and Approaches for Determining Skin and Eye Irritation Potential of Antimicrobial Cleaning Product Formulations; Request for Nominations for an Independent Expert Panel |
03-18-2005 |
05-5471 |
View
|
| 11 |
70FR9661 - Second Request for Data on Chemicals Evaluated by In Vitro or In Vivo Ocular Irritancy Test Methods |
02-25-2005 |
05-3831 |
View
|
| 2004 |
| 1 |
69FR70268 - Notice of Additional Data and Analyses for the Assessment of the Current Validation Status of In Vitro Testing Methods for Identifying Potential Ocular Irritants |
12-02-2004 |
04-26594 |
NA
|
| 2 |
69FR64081 - Notice of an Expert Panel Meeting to Assess the Current validation Status of In Vitro Testing Methods for Identifying Potential Ocular Irritants; Request for Comments |
11-02-2004 |
04-24481 |
View
|
| 3 |
69FR61504 - Availability of Updated Standardized In Vitro Cytotoxicity Test Method Protocols for Estimating Acute Oral Systemic Toxicity; Request for Existing In Vivo and In Vitro Acute Toxicity Data |
10-18-2004 |
04-23335 |
NA
|
| 4 |
69FR54298 - Notice of Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods |
09-07-2004 |
04-20292 |
NA
|
| 5 |
69FR30693 - Notice of Availability of Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion |
05-27-2004 |
04-12126 |
NA
|
| 6 |
69FR21565 - Request for Nominations of Scientific Experts for Independent Expert Panel Evaluations and/or Other Reviews of In Vitro Testing Methods for Identifying Potential Ocular Irritants |
04-20-2004 |
04-9032 |
NA
|
| 7 |
69FR21564 - In Vitro Endocrine Disruptor Test Methods: Request for Comments and Nominations |
04-20-2004 |
04-8980 |
NA
|
| 8 |
69FR13859 - Request for Public Comment on the Nomination for Ocular Toxicity Test Methods and Related Activities and Request for Data on Chemicals Evaluated by In Vitro or In Vivo Ocular Irritancy Test Methods |
03-23-2004 |
04-6487 |
NA
|
| 9 |
69FR11448 - Notice of Availability of Agency Responses to ICCVAM Test Recommendations for the Revised Up-and-Down Procedure for Determining Acute Oral Toxicity and In Vitro Methods for Assessing Acute Systemic Toxicity |
03-09-2004 |
04-5321 |
NA
|
| 10 |
69FR7777 - Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Notice of Availability |
02-18-2004 |
04-3528 |
NA
|
| 11 |
69FR6674 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods |
02-10-2004 |
04-2931 |
NA
|
| 2003 |
| 1 |
68FR64636 - Request for Nominations and Submissions fo Alternative Test Methods for Evaluation by ICCVAM; Notice of the Availability of the Updated Document, "ICCVAM Guidelines for Nomination and Submission of New, Revised, and Alternative Test Methods" |
11-13-2003 |
03-28560 |
NA
|
| 2 |
68FR42066 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods |
07-15-2003 |
03-18012 |
NA
|
| 3 |
68FR42067 - Request for Existing Dermal and Ocular Irritancy Chemical Test Data from Animal and Human Studies Using Standardized Testing Methods |
07-15-2003 |
03-18011 |
NA
|
| 4 |
68FR39104 - Notice of Availability of Proposed Minimum Performance Standards (MPS) for Three Types of In Vitro Methods for Assessing the Dermal Corrosivity Hazard Potential of Chemicals; Request for Comments |
06-30-2003 |
03-16506 |
View
|
| 5 |
68FR33171 - Notice of Availability of the Report: "Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays" |
06-02-2003 |
03-13839 |
NA
|
| 2002 |
| 1 |
67FR77064 - Environmental Protection Agency: Revised Final Health Effects Test Guidelines; Acute Toxicity Testing - Background and Acute Oral Toxicity; Notice of Availability |
12-12-2002 |
02-31612 |
NA
|
| 2 |
67FR67203 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods |
11-01-2002 |
02-27902 |
NA
|
| 3 |
67FR64902 - Notice of Availability of an Expert Panel Report on the Current Validation Status of In Vitro Endocrine Disruptor Screening Methods and a Proposed List of Substances for Validation of In Vitro Endocrine Disruptor Screening Methods; Request for Comments |
10-21-2002 |
02-26733 |
View
|
| 4 |
67FR49706 - Availability of the Report, Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Evaluation of EPISKIN(TM), EPIDERM(TM) (EPI-200), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals |
07-30-2002 |
02-19261 |
NA
|
| 5 |
67FR16415 - Notice of an Expert Panel Meeting to Assess the Current Validation Status of In Vitro Endocrine Disruptor Screening Methods; Request for Comments |
04-04-2002 |
02-8328 |
View
|
| 6 |
67FR11358 - Notice of Establishment; Scientific Advisory Committee on Alternative Toxicological Methods |
03-12-2002 |
02-5932 |
NA
|
| 7 |
67FR5842 - Report on the Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals; Notice of Availability and Request for Public Comments |
02-06-2002 |
02-2905 |
NA
|
| 8 |
67FR5845 - Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Notice of Availability |
02-06-2002 |
02-2907 |
NA
|
| 2001 |
| 1 |
66FR49685 - EPISKIN(TM), EPIDERM(TM), and Rat Skin Transcutaneous Electrical Resistance Methods: In Vitro Test methods Proposed for Assessing the Dermal Corrosivity Potential of Chemicals; Notice of Availability of a Background Review Document and Proposed ICCVAM Test Method Recommendations and Request for Public Comment |
09-27-2001 |
01-24371 |
View
|
| 2 |
66FR49686 - Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity; Notice of Availability and Request for Public Comment |
09-27-2001 |
01-24370 |
View
|
| 3 |
66FR49196 - Amended Notice of Meeting |
09-25-2001 |
01-24034 |
NA
|
| 4 |
66FR46066 - The Revised Draft Up-and-Down Procedure for Assessing Acute Oral Toxicity; Notice of Availability and Request for Public Comments: CORRECTION |
08-30-2001 |
C1-15770 |
NA
|
| 5 |
66FR46020 - Meeting of the Advisory Committee on Alternative Toxicological Methods |
08-30-2001 |
01-21987 |
NA
|
| 6 |
66FR36294 - Peer Review Panel for the Up-and-Down Procedure (UDP): Notice of Meeting |
07-10-2001 |
01-17288 |
View
|
| 7 |
66FR33550 - The Revised Draft Up-and-Down Procedure for Assessing Acute Oral Toxicity: Notice of Availability and Requests for Public Comments |
06-21-2001 |
01-15770 |
NA
|
| 8 |
66FR16278 - Request for Data and Nominations of Expert Scientists for an Independent Peer Review Evaluation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays for Endocrint Disruptor Screening |
03-22-2001 |
01-7228 |
NA
|
| 2000 |
| 1 |
65FR66549 - Meeting of the Advisory Committee on Alternative Toxicological Methods |
11-03-2000 |
00-28342 |
NA
|
| 2 |
65FR57203 - Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Workshop Agenda and Registration Information |
09-20-2000 |
00-24244 |
NA
|
| 3 |
65FR37400 - Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Request for Data and Suggested Expert Scientists |
06-13-2000 |
00-14968 |
NA
|
| 4 |
65FR35109 - Notice of Peer Review Meeting on the Revised Up-and-Down Procedure (UDP) as an Alternative Test Method for Assessing Acute Oral Toxicity; Request for Comments |
05-31-2000 |
00-13734 |
NA
|
| 5 |
65FR13289 - Notice of Expert Panel Meeting on the Frog Embryo Teratogenesis -- Xenopus |
03-10-2000 |
00-6013 |
NA
|
| 6 |
65FR8385 - Request for Data and Nomination of Expert Scientists To Participate in the Independent Peer Review Evaluation of the Revised Up-and-Down Procedure for Assessing Acute Oral Toxicity; Evaluation of the Up-and-Down Procedure |
02-17-2000 |
00-4010 |
NA
|
| 7 |
65FR7878 - Meeting of the Advisory Committee on Alternative Toxicological Methods |
02-15-2000 |
00-3590 |
NA
|
| 1999 |
| 1 |
64FR67579 - Availability and Request for Comments on the Revised Guidance Document: Evaluation of the Validation Status of Toxicological Methods: General Guidelines for Submissions to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) |
12-01-1999 |
99-31342 |
NA
|
| 2 |
64FR50297 - Meeting of the Advisory Committee on Alternative Toxicological Methods |
09-15-1999 |
99-24121 |
NA
|
| 3 |
64FR48662 - Request for Data and Suggested Expert Panelists for Evaluation of the Current Status of the Frog Embryo Teratogenesis Assay--Xenopus (FETAX) |
09-03-1999 |
99-23219 |
NA
|
| 4 |
64FR33109 - Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential fo Chemicals, Report Now Available |
06-18-1999 |
99-15725 |
NA
|
| 5 |
64FR18040 - National Toxicology Program Special Emphasis Panel; Notice of Meeting |
04-12-1999 |
99-9099 |
NA
|
| 6 |
64FR14006 - The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds, Report Now Available |
03-22-1999 |
99-6953 |
NA
|
| 7 |
64FR6111 - Meeting of the Advisory Committee on Alternative Toxicological Methods |
02-08-1999 |
99-24121 |
NA
|
| 1998 |
| 1 |
63FR57303 - Notice of Meeting to Review the Corrositex(R) Assay as an Alternative Test Method for Assessing the Skin Corrosivity Potential of Chemicals; Request for Comments |
10-26-1998 |
98-28713 |
NA
|
| 2 |
63FR40303 - Request for Comments on Test Methods Undergoing Review by the Interagency Coordinating Committee on the Validation fo Alternative Methods (ICCVAM) and the National Toxicology Program Interagency Center for the Evaluation of Alternative Methods |
07-27-1998 |
98-20040 |
NA
|
| 3 |
63FR37405 - Notice of Meeting to Review the Murine Local Lymph Node Assay (LLNA) as an Alternative Test Method for Contact Hypersensitivity; Request for Comments |
07-09-1998 |
98-18320 |
NA
|
| 1997 |
| 1 |
62FR55649 - Notice of Meeting to Discuss the Procedures and Activities of the National Toxicology Program (NTP) Center for the Evaluation of Alternative Toxicological Methods and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) |
10-24-1997 |
97-28373 |
NA
|
| 2 |
62FR48290 - Notice of Establishment |
09-12-1997 |
97-24273 |
NA
|
| 3 |
62FR11901 - Validation and Regulatory Acceptance of Toxicological Test methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods, Now Available |
03-12-1997 |
97-6288 |
NA
|
| 1994 |
| 1 |
Validation and Acceptance of Alternative Testing Methods; Request for Comments |
12-07-1994 |
94-30023 |
NA
|
