| | Other Issues: previous | next | latest | archiveChemistry; Biosynthesis Differential Expression of the Smb Bacteriocin in Streptococcus mutans Isolates Hideo Yonezawa, Howard K. Kuramitsu, Shu-ichi Nakayama, Jiro Mitobe, Mizuho Motegi, Ryoma Nakao, Haruo Watanabe, and Hidenobu Senpuku PMCID: PMC2493135 Mechanisms of Action: Physiological Effects Restoration of Susceptibility of Intracellular Methicillin-Resistant Staphylococcus aureus to β-Lactams: Comparison of Strains, Cells, and Antibiotics Sandrine Lemaire, Aurélie Olivier, Françoise Van Bambeke, Paul M. Tulkens, Peter C. Appelbaum, and Youri Glupczynski PMCID: PMC2493141 Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors Alita A. Miller, Gordon L. Bundy, John E. Mott, Jill E. Skepner, Timothy P. Boyle, Douglas W. Harris, Alexander E. Hromockyj, Keith R. Marotti, Gary E. Zurenko, Jennifer B. Munzner, Michael T. Sweeney, Gary F. Bammert, Judith C. Hamel, Charles W. Ford, Wei-Zhu Zhong, David R. Graber, Gary E. Martin, Fusen Han, Lester A. Dolak, Eric P. Seest, J. Craig Ruble, Gregg M. Kamilar, John R. Palmer, Lee S. Banitt, Alexander R. Hurd, and Michael R. Barbachyn PMCID: PMC2493097 Copper and Quaternary Ammonium Cations Exert Synergistic Bactericidal and Antibiofilm Activity against Pseudomonas aeruginosa Joe J. Harrison, Raymond J. Turner, Daniel A. Joo, Michelle A. Stan, Catherine S. Chan, Nick D. Allan, Helen A. Vrionis, Merle E. Olson, and Howard Ceri PMCID: PMC2493123 The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice Fatima Bousejra-El Garah, Catherine Claparols, Françoise Benoit-Vical, Bernard Meunier, and Anne Robert PMCID: PMC2493093 Mechanisms of Resistance Role of Cj1211 in Natural Transformation and Transfer of Antibiotic Resistance Determinants in Campylobacter jejuni Byeonghwa Jeon, Wayne Muraoka, Orhan Sahin, and Qijing Zhang PMCID: PMC2493120 Comparative Study of the Susceptibilities of Major Epidemic Clones of Methicillin-Resistant Staphylococcus aureus to Oxacillin and to the New Broad-Spectrum Cephalosporin Ceftobiprole Marilyn Chung, Aude Antignac, Choonkeun Kim, and Alexander Tomasz PMCID: PMC2493090 Role of Global Regulators and Nucleotide Metabolism in Antibiotic Tolerance in Escherichia coli Sonja Hansen, Kim Lewis, and Marin Vulić PMCID: PMC2493092 Mechanism and Fitness Costs of PR-39 Resistance in Salmonella enterica Serovar Typhimurium LT2 Maria Pränting, Aurel Negrea, Mikael Rhen, and Dan I. Andersson PMCID: PMC2493140 Antibiotic Resistance in Haemophilus influenzae Decreased, except for β-Lactamase-Negative Amoxicillin-Resistant Isolates, in Parallel with Community Antibiotic Consumption in Spain from 1997 to 2007 Silvia García-Cobos, José Campos, Emilia Cercenado, Federico Román, Edurne Lázaro, María Pérez-Vázquez, Francisco de Abajo, and Jesús Oteo PMCID: PMC2493100 Emergence of Macrolide Resistance Gene mph(B) in Streptococcus uberis and Cooperative Effects with rdmC-Like Gene Adeline Achard, Véronique Guérin-Faublée, Vianney Pichereau, Corinne Villers, and Roland Leclercq PMCID: PMC2493112 Rifampin and Rifaximin Resistance in Clinical Isolates of Clostridium difficile Jennifer R. O'Connor, Minerva A. Galang, Susan P. Sambol, David W. Hecht, Gayatri Vedantam, Dale N. Gerding, and Stuart Johnson PMCID: PMC2493101 Molecular Characterization and Epidemiology of Extended-Spectrum- β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Isolates Causing Health Care-Associated Infection in Thailand, Where the CTX-M Family Is Endemic Pattarachai Kiratisin, Anucha Apisarnthanarak, Chaitat Laesripa, and Piyawan Saifon PMCID: PMC2493136 First Molecular Characterization of Group B Streptococci with Reduced Penicillin Susceptibility Kouji Kimura, Satowa Suzuki, Jun-ichi Wachino, Hiroshi Kurokawa, Kunikazu Yamane, Naohiro Shibata, Noriyuki Nagano, Haru Kato, Keigo Shibayama, and Yoshichika Arakawa PMCID: PMC2493108 Kinetic Characterization of VIM-7, a Divergent Member of the VIM Metallo-β-Lactamase Family Ørjan Samuelsen, Mariana Castanheira, Timothy R. Walsh, and James Spencer PMCID: PMC2493091 Mutagenesis in the α3α4 GyrA Helix and in the Toprim Domain of GyrB Refines the Contribution of Mycobacterium tuberculosis DNA Gyrase to Intrinsic Resistance to Quinolones Stéphanie Matrat, Alexandra Aubry, Claudine Mayer, Vincent Jarlier, and Emmanuelle Cambau PMCID: PMC2493125 Point Mutation in the Group B Streptococcal pbp2x Gene Conferring Decreased Susceptibility to β-Lactam Antibiotics Samira Dahesh, Mary E. Hensler, Nina M. Van Sorge, Robert E. Gertz, Jr., Stephanie Schrag, Victor Nizet, and Bernard W. Beall PMCID: PMC2493126 ISEcp1-Mediated Transposition of qnrB-Like Gene in Escherichia coli Vincent Cattoir, Patrice Nordmann, Jesus Silva-Sanchez, Paula Espinal, and Laurent Poirel PMCID: PMC2493098 Molecular Characterization of Ofloxacin-Resistant Mycobacterium tuberculosis Strains from Russia Igor Mokrousov, Tatiana Otten, Olga Manicheva, Yulia Potapova, Boris Vishnevsky, Olga Narvskaya, and Nalin Rastogi PMCID: PMC2493099 Metallo-β-Lactamase Gene blaIMP-15 in a Class 1 Integron, In95, from Pseudomonas aeruginosa Clinical Isolates from a Hospital in Mexico U. Garza-Ramos, R. Morfin-Otero, H. S. Sader, R. N. Jones, E. Hernández, E. Rodriguez-Noriega, A. Sanchez, B. Carrillo, S. Esparza-Ahumada, and J. Silva-Sanchez PMCID: PMC2493115 Identification of Mutations Related to Streptomycin Resistance in Clinical Isolates of Mycobacterium tuberculosis and Possible Involvement of Efflux Mechanism Fernanda S. Spies, Pedro E. Almeida da Silva, Marta O. Ribeiro, Maria Lucia Rossetti, and Arnaldo Zaha PMCID: PMC2493096 Spread of OXA-48-Positive Carbapenem-Resistant Klebsiella pneumoniae Isolates in Istanbul, Turkey Amélie Carrër, Laurent Poirel, Haluk Eraksoy, A. Atahan Cagatay, Selim Badur, and Patrice Nordmann PMCID: PMC2493117 Characterization of the Carbapenem-Hydrolyzing Oxacillinase Oxa-58 in an Acinetobacter Genospecies 3 Clinical Isolate Sara Marti, Javier Sánchez-Céspedes, M. Dolores Blasco, Marc Ruiz, Paula Espinal, Verónica Alba, Felipe Fernández-Cuenca, Alvaro Pascual, and Jordi Vila PMCID: PMC2493133 Plasmid-Mediated qnrB2 and Carbapenemase Gene blaKPC-2 Carried on the Same Plasmid in Carbapenem-Resistant Ciprofloxacin-Susceptible Enterobacter cloacae Isolates Inna Chmelnitsky, Shiri Navon-Venezia, Jacob Strahilevitz, and Yehuda Carmeli PMCID: PMC2493114 VIM-15 and VIM-16, Two New VIM-2-Like Metallo-β-Lactamases in Pseudomonas aeruginosa Isolates from Bulgaria and Germany Ines Schneider, Emma Keuleyan, Rudolf Rasshofer, Rumyana Markovska, Anne Marie Queenan, and Adolf Bauernfeind PMCID: PMC2493107 Alteration of GyrA Amino Acid Required for Ciprofloxacin Resistance in Klebsiella pneumoniae Isolates in China Yingmei Fu, Lishuang Guo, Yan Xu, Wenli Zhang, Jiaao Gu, Jianfeng Xu, Xiaobei Chen, Yuehui Zhao, Jiayu Ma, Xinghan Liu, and Fengmin Zhang PMCID: PMC2493132 blaIMP-4 in Different Genetic Contexts in Enterobacteriaceae Isolates from Australia Björn A. Espedido, Sally R. Partridge, and Jonathan R. Iredell PMCID: PMC2493119 Susceptibility Antimicrobial Susceptibilities of Geographically Diverse Clinical Human Isolates of Leptospira Roseanne A. Ressner, Matthew E. Griffith, Miriam L. Beckius, Guillermo Pimentel, R. Scott Miller, Katrin Mende, Susan L. Fraser, Renee L. Galloway, Duane R. Hospenthal, and Clinton K. Murray PMCID: PMC2493142 In Vitro Activity of Ferroquine Is Independent of Polymorphisms in Transport Protein Genes Implicated in Quinoline Resistance in Plasmodium falciparum Maud Henry, Sébastien Briolant, Albin Fontaine, Joel Mosnier, Eric Baret, Rémy Amalvict, Thierry Fusaï, Laurent Fraisse, Christophe Rogier, and Bruno Pradines PMCID: PMC2493139 Potent In Vitro Activity of Tomopenem (CS-023) against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Tetsufumi Koga, Nobuhisa Masuda, Masayo Kakuta, Eiko Namba, Chika Sugihara, and Takashi Fukuoka PMCID: PMC2493143 In Vitro Susceptibilities of Invasive Isolates of Candida Species: Rapid Increase in Rates of Fluconazole Susceptible-Dose Dependent Candida glabrata Isolates Sheng-Yuan Ruan, Chen-Chen Chu, and Po-Ren Hsueh PMCID: PMC2493111 Susceptibility Testing and Molecular Classification of Paecilomyces spp. Maria Victoria Castelli, Ana Alastruey-Izquierdo, Isabel Cuesta, Araceli Monzon, Emilia Mellado, Juan L. Rodriguez-Tudela, and Manuel Cuenca-Estrella PMCID: PMC2493137 In Vitro Activity of Tigecycline against Multidrug-Resistant Acinetobacter baumannii and Selection of Tigecycline-Amikacin Synergy Ellen S. Moland, David W. Craft, Seong-geun Hong, Soo-young Kim, Lucas Hachmeister, Shimon D. Sayed, and Kenneth S. Thomson PMCID: PMC2493109 Evaluation of Etest Method for Determining Isavuconazole MICs against Cryptococcus gattii and Cryptococcus neoformans George R. Thompson, III, Annette W. Fothergill, Nathan P. Wiederhold, Ana C. Vallor, Brian L. Wickes, and Thomas F. Patterson PMCID: PMC2493144 Activities of Ceftobiprole, Linezolid, Vancomycin, and Daptomycin against Community-Associated and Hospital-Associated Methicillin-Resistant Staphylococcus aureus Steven N. Leonard, Chrissy M. Cheung, and Michael J. Rybak PMCID: PMC2493094 Analytical Procedures Staphylococcus aureus Cell Wall Stress Stimulon Gene-lacZ Fusion Strains: Potential for Use in Screening for Cell Wall-Active Antimicrobials Rebecca Steidl, Stacy Pearson, Robert E. Stephenson, Nagender Ledala, Sutthirat Sitthisak, Brian J. Wilkinson, and Radheshyam K. Jayaswal PMCID: PMC2493131 Antiviral Agents Amphipathic DNA Polymers Exhibit Antiherpetic Activity In Vitro and In Vivo David I. Bernstein, Nathalie Goyette, Rhonda Cardin, Earl R. Kern, Guy Boivin, James Ireland, Jean-Marc Juteau, and Andrew Vaillant PMCID: PMC2493138 Inhibition of Cell-to-Cell Transmission of Human T-Cell Lymphotropic Virus Type 1 In Vitro by Carbohydrate-Binding Agents Emanuela Balestrieri, Arianna Ascolani, Yasuhiro Igarashi, Toshikazu Oki, Antonio Mastino, Jan Balzarini, and Beatrice Macchi PMCID: PMC2493145 Comparative Evaluation of Virus Transmission Inhibition by Dual-Acting Pyrimidinedione Microbicides Using the Microbicide Transmission and Sterilization Assay Karen M. Watson, Christa E. Buckheit, and Robert W. Buckheit, Jr. PMCID: PMC2493113 Impact of Nucleoside Reverse Transcriptase Inhibitors on Mitochondrial DNA and RNA in Human Skeletal Muscle Cells Akihiko Saitoh, Richard H. Haas, Robert K. Naviaux, Neurita G. Salva, Justine K. Wong, and Stephen A. Spector PMCID: PMC2493104 Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors Anneleen Hombrouck, Barbara Van Remoortel, Martine Michiels, Wim Noppe, Frauke Christ, Anders Eneroth, Britt Louise Sahlberg, Kurt Benkestock, Lotta Vrang, Nils Gunnar Johansson, Maria Letizia Barreca, Laura De Luca, Stefania Ferro, Alba Chimirri, Zeger Debyser, and Myriam Witvrouw PMCID: PMC2493095 Zidovudine Impairs Adipogenic Differentiation through Inhibition of Clonal Expansion Metodi V. Stankov, Reinhold E. Schmidt, Georg M. N. Behrens, and for the German Competence Network HIV/AIDS PMCID: PMC2493128 Experimental Therapeutics Quantitative Assessment of Combination Antimicrobial Therapy against Multidrug-Resistant Acinetobacter baumannii Tze-Peng Lim, Kimberly R. Ledesma, Kai-Tai Chang, Jing-Guo Hou, Andrea L. Kwa, Michael Nikolaou, John P. Quinn, Randall A. Prince, and Vincent H. Tam PMCID: PMC2493134 Evaluation of Antibiotic Therapy for Eradication of “Candidatus Helicobacter heilmannii” Hidenori Matsui, Chihiro Aikawa, Yukie Sekiya, Shinichi Takahashi, Somay Yamagata Murayama, and Masahiko Nakamura PMCID: PMC2493118 Clinical Therapeutics Effect of Chemotherapy with Praziquantel on the Production of Cytokines and Morbidity Associated with Schistosomiasis Mansoni P. Martins-Leite, G. Gazzinelli, L. F. Alves-Oliveira, A. Gazzinelli, L. C. C. Malaquias, R. Correa-Oliveira, A. Teixeira-Carvalho, and A. M. S. Silveira PMCID: PMC2493106 Lack of an Effect of Human Immunodeficiency Virus Coinfection on the Pharmacokinetics of Entecavir in Hepatitis B Virus-Infected Patients Min Zhu, Marc Bifano, Xu Xu, Yonghua Wang, Frank LaCreta, Dennis Grasela, and Marc Pfister PMCID: PMC2493122 Relationship between Various Definitions of Prior Antibiotic Exposure and Piperacillin-Tazobactam Resistance among Patients with Respiratory Tract Infections Caused by Pseudomonas aeruginosa Nimish Patel, Louise-Anne McNutt, and Thomas P. Lodise PMCID: PMC2493121 Pharmacology Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis R. Rustomjee, A. H. Diacon, J. Allen, A. Venter, C. Reddy, R. F. Patientia, T. C. P. Mthiyane, T. De Marez, R. van Heeswijk, R. Kerstens, A. Koul, K. De Beule, P. R. Donald, and D. F. McNeeley PMCID: PMC2493110 Enantioselective and Nonlinear Intestinal Absorption of Eflornithine in the Rat R. Jansson, M. Malm, C. Roth, and M. Ashton PMCID: PMC2493103 Pharmacokinetics of Miltefosine in Old World Cutaneous Leishmaniasis Patients Thomas P. C. Dorlo, Pieter P. A. M. van Thiel, Alwin D. R. Huitema, Ron J. Keizer, Henry J. C. de Vries, Jos H. Beijnen, and Peter J. de Vries PMCID: PMC2493105 Postantibiotic Effects and Bactericidal Activities of Levofloxacin and Gatifloxacin at Concentrations Simulating Those of Topical Ophthalmic Administration against Fluoroquinolone-Resistant and Fluoroquinolone-Sensitive Methicillin-Resistant Staphylococcus aureus Strains Saichi Hoshi, Ken Kikuchi, Takashi Sasaki, Chie Sotozono, Shigeru Kinoshita, and Keiichi Hiramatsu PMCID: PMC2493124 Letters to the Editor Plasmid-Mediated QnrS2 Determinant from a Clinical Aeromonas veronii Isolate Javier Sánchez-Céspedes, M. Dolores Blasco, Sara Marti, Verónica Alba, Elena Alcalde, Consuelo Esteve, and Jordi Vila PMCID: PMC2493130 Coprevalence of Plasmid-Mediated Quinolone Resistance Determinants QepA, Qnr, and AAC(6′)-Ib-cr among 16S rRNA Methylase RmtB-Producing Escherichia coli Isolates from Pigs Jian-Hua Liu, Yu-Ting Deng, Zhen-Ling Zeng, Jun-Hua Gao, Lin Chen, Yoshichika Arakawa, and Zhang-Liu Chen PMCID: PMC2493129 Detection of the Erythromycin rRNA Methylase Gene erm(A) in Enterococcus faecalis Karin Schwaiger and Johann Bauer PMCID: PMC2493116 Emergence of the Plasmid-Mediated Quinolone Resistance Gene qnrS1 in Escherichia coli Isolates in Greece Olga Vasilaki, Eleni Ntokou, Alexandros Ikonomidis, Danae Sofianou, Filanthi Frantzidou, Styliani Alexiou-Daniel, Antonios N. Maniatis, and Spyros Pournaras PMCID: PMC2493102 Antimicrobial Susceptibility Profile of Streptococcus pseudopneumoniae Isolated from Sputum Elaine R. Keith and David R. Murdoch PMCID: PMC2493127 |
