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Volume 173(1);  July 2008
Editorial
What’s Next at AJP?
Michael P. Lisanti
Am J Pathol. 2008 July; 173(1): 1. doi: 10.2353/ajpath.2008.080390.
PMCID: PMC2438279
Biological Perspective
Role of the Peroxynitrite-Poly(ADP-Ribose) Polymerase Pathway in Human Disease
Pal Pacher and Csaba Szabo
Am J Pathol. 2008 July; 173(1): 2–13. doi: 10.2353/ajpath.2008.080019.
PMCID: PMC2438280
Review
Beyond Wavy Hairs: The Epidermal Growth Factor Receptor and Its Ligands in Skin Biology and Pathology
Marlon R. Schneider, Sabine Werner, Ralf Paus, and Eckhard Wolf
Am J Pathol. 2008 July; 173(1): 14–24. doi: 10.2353/ajpath.2008.070942.
PMCID: PMC2438281
Commentary
YKL-40: A Candidate Biomarker for Simian Immunodeficiency Virus and Human Immunodeficiency Virus Encephalitis?
Dennis L. Kolson
Am J Pathol. 2008 July; 173(1): 25–29. doi: 10.2353/ajpath.2008.080389.
PMCID: PMC2438282
Regular Articles
Cardiovascular, Pulmonary and Renal Pathology
Hepatocyte Growth Factor Exerts Its Anti-Inflammatory Action by Disrupting Nuclear Factor-κB Signaling
Myrto Giannopoulou, Chunsun Dai, Xiaoyue Tan, Xiaoyan Wen, George K. Michalopoulos, and Youhua Liu
Am J Pathol. 2008 July; 173(1): 30–41. doi: 10.2353/ajpath.2008.070583.
PMCID: PMC2438283
Fas-Ligand-Induced Apoptosis of Respiratory Epithelial Cells Causes Disruption of Postcanalicular Alveolar Development
Monique E. De Paepe, Sravanthi Gundavarapu, Umadevi Tantravahi, John R. Pepperell, Sheila A. Haley, Francois I. Luks, and Quanfu Mao
Am J Pathol. 2008 July; 173(1): 42–56. doi: 10.2353/ajpath.2008.071123.
PMCID: PMC2438284
Interleukin-1 Receptor Type I Signaling Critically Regulates Infarct Healing and Cardiac Remodeling
Marcin Bujak, Marcin Dobaczewski, Khaled Chatila, Leonardo H. Mendoza, Na Li, Anilkumar Reddy, and Nikolaos G. Frangogiannis
Am J Pathol. 2008 July; 173(1): 57–67. doi: 10.2353/ajpath.2008.070974.
PMCID: PMC2438285
Cell Injury, Repair, Aging and Apoptosis
Absence of Smad3 Induces Neutrophil Migration after Cutaneous Irradiation : Possible Contribution to Subsequent Radioprotection
Kathleen C. Flanders, Benjamin M. Ho, Praveen R. Arany, Christina Stuelten, Mizuko Mamura, Miya Okada Paterniti, Anastasia Sowers, James B. Mitchell, and Anita B. Roberts
Am J Pathol. 2008 July; 173(1): 68–76. doi: 10.2353/ajpath.2008.070937.
PMCID: PMC2438286
Egr-1 Regulates Expression of the Glial Scar Component Phosphacan in Astrocytes after Experimental Stroke
Heike Beck, Matthias Semisch, Carsten Culmsee, Nikolaus Plesnila, and Antonis K. Hatzopoulos
Am J Pathol. 2008 July; 173(1): 77–92. doi: 10.2353/ajpath.2008.070648.
PMCID: PMC2438287
Immunopathology and Infectious Disease
CD4 T Cells Mediate Axonal Damage and Spinal Cord Motor Neuron Apoptosis in Murine P0106–125-Induced Experimental Autoimmune Neuritis
Anna Brunn, Olaf Utermöhlen, Mariana Carstov, Monica Sánchez Ruiz, Hrvoje Miletic, Dirk Schlüter, and Martina Deckert
Am J Pathol. 2008 July; 173(1): 93–105. doi: 10.2353/ajpath.2008.071101.
PMCID: PMC2438288
CCAAT/Enhancer Binding Protein β Is a Major Mediator of Inflammation and Viral Replication in the Gastrointestinal Tract of Simian Immunodeficiency Virus-Infected Rhesus Macaques
Mahesh Mohan, Pyone P. Aye, Juan T. Borda, Xavier Alvarez, and Andrew A. Lackner
Am J Pathol. 2008 July; 173(1): 106–118. doi: 10.2353/ajpath.2008.080108.
PMCID: PMC2438289
Amelioration of Experimental Autoimmune Encephalomyelitis in IL-4Rα−/− Mice Implicates Compensatory Up-Regulation of Th2-Type Cytokines
Stefanie Gaupp, Barbara Cannella, and Cedric S. Raine
Am J Pathol. 2008 July; 173(1): 119–129. doi: 10.2353/ajpath.2008.071156.
PMCID: PMC2438290
YKL-40, a Marker of Simian Immunodeficiency Virus Encephalitis, Modulates the Biological Activity of Basic Fibroblast Growth Factor
Dafna Bonneh-Barkay, Stephanie J. Bissel, Gouji Wang, Kenneth N. Fish, Georgina C.B. Nicholl, Samuel W. Darko, Rafael Medina-Flores, Michael Murphey-Corb, Premeela A. Rajakumar, Julia Nyaundi, John W. Mellors, Robert Bowser, and Clayton A. Wiley
Am J Pathol. 2008 July; 173(1): 130–143. doi: 10.2353/ajpath.2008.080045.
PMCID: PMC2438291
Matrix Metalloproteinase-8 Facilitates Neutrophil Migration through the Corneal Stromal Matrix by Collagen Degradation and Production of the Chemotactic Peptide Pro-Gly-Pro
Michelle Lin, Patricia Jackson, Angus M. Tester, Eugenia Diaconu, Christopher M. Overall, J. Edwin Blalock, and Eric Pearlman
Am J Pathol. 2008 July; 173(1): 144–153. doi: 10.2353/ajpath.2008.080081.
PMCID: PMC2438292
Suppression by CD4+CD25+ Regulatory T Cells Is Dependent on Expression of Heme Oxygenase-1 in Antigen-Presenting Cells
James F. George, Andrea Braun, Todd M. Brusko, Reny Joseph, Subhashini Bolisetty, Clive H. Wasserfall, Mark A. Atkinson, Anupam Agarwal, and Matthias H. Kapturczak
Am J Pathol. 2008 July; 173(1): 154–160. doi: 10.2353/ajpath.2008.070963.
PMCID: PMC2438293
Musculoskeletal Pathology
Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage
Valeria M. Dejica, John S. Mort, Sheila Laverty, M. David Percival, John Antoniou, David J. Zukor, and A. Robin Poole
Am J Pathol. 2008 July; 173(1): 161–169. doi: 10.2353/ajpath.2008.070494.
PMCID: PMC2438294
Inhibition of Proteasome Activity Promotes the Correct Localization of Disease-Causing α-Sarcoglycan Mutants in HEK-293 Cells Constitutively Expressing β-, γ-, and δ-Sarcoglycan
Stefano Gastaldello, Simona D'Angelo, Susanna Franzoso, Marina Fanin, Corrado Angelini, Romeo Betto, and Dorianna Sandonà
Am J Pathol. 2008 July; 173(1): 170–181. doi: 10.2353/ajpath.2008.071146.
PMCID: PMC2438295
Neurobiology
Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Lionel M. Igaz, Linda K. Kwong, Yan Xu, Adam C. Truax, Kunihiro Uryu, Manuela Neumann, Christopher M. Clark, Lauren B. Elman, Bruce L. Miller, Murray Grossman, Leo F. McCluskey, John Q. Trojanowski, and Virginia M.-Y. Lee
Am J Pathol. 2008 July; 173(1): 182–194. doi: 10.2353/ajpath.2008.080003.
PMCID: PMC2438296
Tumorigenesis and Neoplastic Progression
Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin’s Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells
Karl R.N. Baumforth, Anna Birgersdotter, Gary M. Reynolds, Wenbin Wei, Georgia Kapatai, Joanne R. Flavell, Emma Kalk, Karen Piper, Steve Lee, Lee Machado, Kerry Hadley, Anne Sundblad, Jan Sjoberg, Magnus Bjorkholm, Anna A. Porwit, Lee-Fah Yap, Soohwang Teo, Richard G. Grundy, Lawrence S. Young, Ingemar Ernberg, Ciaran B.J. Woodman, and Paul G. Murray
Am J Pathol. 2008 July; 173(1): 195–204. doi: 10.2353/ajpath.2008.070845.
PMCID: PMC2438297
Modification of the Primary Tumor Microenvironment by Transforming Growth Factor α-Epidermal Growth Factor Receptor Signaling Promotes Metastasis in an Orthotopic Colon Cancer Model
Takamitsu Sasaki, Toru Nakamura, Robert B. Rebhun, Hua Cheng, Katherine Stemke Hale, Rachel Z. Tsan, Isaiah J. Fidler, and Robert R. Langley
Am J Pathol. 2008 July; 173(1): 205–216. doi: 10.2353/ajpath.2008.071147.
PMCID: PMC2438298
Regulation of Skp2-p27 Axis by the Cdh1/Anaphase-Promoting Complex Pathway in Colorectal Tumorigenesis
Takeo Fujita, Weijun Liu, Hiroyoshi Doihara, and Yong Wan
Am J Pathol. 2008 July; 173(1): 217–228. doi: 10.2353/ajpath.2008.070957.
PMCID: PMC2438299
Dietary n-3 Polyunsaturated Fatty Acids Enhance Hormone Ablation Therapy in Androgen-Dependent Prostate Cancer
Michael F. McEntee, Carol Ziegler, Danielle Reel, Kenneth Tomer, Ahmed Shoieb, Mark Ray, Xiaoou Li, Nancy Neilsen, Fred B. Lih, Dorcas O'Rourke, and Jay Whelan
Am J Pathol. 2008 July; 173(1): 229–241. doi: 10.2353/ajpath.2008.070989.
PMCID: PMC2438300
MicroRNA-Mediated Down-Regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg Cells: A Potential Pathogenetic Lesion in Hodgkin Lymphomas
Kui Nie, Mario Gomez, Pablo Landgraf, Jose-Francisco Garcia, Yifang Liu, Leonard H.C. Tan, Amy Chadburn, Thomas Tuschl, Daniel M. Knowles, and Wayne Tam
Am J Pathol. 2008 July; 173(1): 242–252. doi: 10.2353/ajpath.2008.080009.
PMCID: PMC2438301
C-C Chemokine Receptor 5 on Pulmonary Fibrocytes Facilitates Migration and Promotes Metastasis via Matrix Metalloproteinase 9
Hendrik W. van Deventer, Qing Ping Wu, Daniel T. Bergstralh, Beckley K. Davis, Brian P. O'Connor, Jenny P.-Y. Ting, and Jonathan S. Serody
Am J Pathol. 2008 July; 173(1): 253–264. doi: 10.2353/ajpath.2008.070732.
PMCID: PMC2438302
Vascular Biology, Atherosclerosis and Endothelium Biology
Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor
Cornelia Halin, Hermann Fahrngruber, Josef G. Meingassner, Guido Bold, Amanda Littlewood-Evans, Anton Stuetz, and Michael Detmar
Am J Pathol. 2008 July; 173(1): 265–277. doi: 10.2353/ajpath.2008.071074.
PMCID: PMC2438303
Integrin-Linked Kinase in the Vascular Smooth Muscle Cell Response to Injury
Bernard Ho, Guangpei Hou, J. Geoffrey Pickering, Gregory Hannigan, B. Lowell Langille, and Michelle P. Bendeck
Am J Pathol. 2008 July; 173(1): 278–288. doi: 10.2353/ajpath.2008.071046.
PMCID: PMC2438304
Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload
Francesca Vinchi, Stefania Gastaldi, Lorenzo Silengo, Fiorella Altruda, and Emanuela Tolosano
Am J Pathol. 2008 July; 173(1): 289–299. doi: 10.2353/ajpath.2008.071130.
PMCID: PMC2438305
Correction
Corrections
Am J Pathol. 2008 July; 173(1): 300. doi: 10.2353/ajpath.2008.080387.
PMCID: PMC2438306
Corrects:Guohong Li, et al. CD40 Ligand Promotes Mac-1 Expression, Leukocyte Recruitment, and Neointima Formation after Vascular Injury. Am J Pathol. 2008 April; 172(4): 1141–1152.
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