pmc logo imageJournal ListSearchpmc logo image
Logo of ploscompPLoS Computational BiologyRead the JournalSubmit to PLoSGet E-mail AlertsContact UsPublic Library of Science (PLoS)
Other Issues:  previous | next | latest | archive
Volume 5(1);  January 2009
Education
A Primer on Regression Methods for Decoding cis-Regulatory Logic
Debopriya Das, Matteo Pellegrini, and Joe W. Gray
PLoS Comput Biol. 2009 January; 5(1): e1000269. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000269.
PMCID: PMC2607548
Editorial
A Review of 2008 for PLoS Computational Biology
Evie Browne, Rosemary Dickin, and Philip E. Bourne
PLoS Comput Biol. 2009 January; 5(1): e1000275. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000275.
PMCID: PMC2613517
Message from ISCB
Microblogging the ISMB: A New Approach to Conference Reporting
Neil Saunders, Pedro Beltrão, Lars Jensen, Daniel Jurczak, Roland Krause, Michael Kuhn, and Shirley Wu
PLoS Comput Biol. 2009 January; 5(1): e1000263. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000263.
PMCID: PMC2612753
Research Articles
Questioning the Ubiquity of Neofunctionalization
Todd A. Gibson and Debra S. Goldberg
PLoS Comput Biol. 2009 January; 5(1): e1000252. Published online 2009 January 2. doi: 10.1371/journal.pcbi.1000252.
PMCID: PMC2597716
Polyamine Sharing between Tubulin Dimers Favours Microtubule Nucleation and Elongation via Facilitated Diffusion
Alain Mechulam, Konstantin G. Chernov, Elodie Mucher, Loic Hamon, Patrick A. Curmi, and David Pastré
PLoS Comput Biol. 2009 January; 5(1): e1000255. Published online 2009 January 2. doi: 10.1371/journal.pcbi.1000255.
PMCID: PMC2599886
Shape, Size, and Robustness: Feasible Regions in the Parameter Space of Biochemical Networks
Adel Dayarian, Madalena Chaves, Eduardo D. Sontag, and Anirvan M. Sengupta
PLoS Comput Biol. 2009 January; 5(1): e1000256. Published online 2009 January 2. doi: 10.1371/journal.pcbi.1000256.
PMCID: PMC2599888
Predicting Cellular Growth from Gene Expression Signatures
Edoardo M. Airoldi, Curtis Huttenhower, David Gresham, Charles Lu, Amy A. Caudy, Maitreya J. Dunham, James R. Broach, David Botstein, and Olga G. Troyanskaya
PLoS Comput Biol. 2009 January; 5(1): e1000257. Published online 2009 January 2. doi: 10.1371/journal.pcbi.1000257.
PMCID: PMC2599889
Evolutionary Sequence Modeling for Discovery of Peptide Hormones
Kemal Sonmez, Naunihal T. Zaveri, Ilan A. Kerman, Sharon Burke, Charles R. Neal, Xinmin Xie, Stanley J. Watson, and Lawrence Toll
PLoS Comput Biol. 2009 January; 5(1): e1000258. Published online 2009 January 9. doi: 10.1371/journal.pcbi.1000258.
PMCID: PMC2603333
State Based Model of Long-Term Potentiation and Synaptic Tagging and Capture
Adam B. Barrett, Guy O. Billings, Richard G. M. Morris, and Mark C. W. van Rossum
PLoS Comput Biol. 2009 January; 5(1): e1000259. Published online 2009 January 16. doi: 10.1371/journal.pcbi.1000259.
PMCID: PMC2603667
Deterministic Mechanical Model of T-Killer Cell Polarization Reproduces the Wandering of Aim between Simultaneously Engaged Targets
Mun Ju Kim and Ivan V. Maly
PLoS Comput Biol. 2009 January; 5(1): e1000260. Published online 2009 January 9. doi: 10.1371/journal.pcbi.1000260.
PMCID: PMC2603019
An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcription Inhibitors
Katherine V. Wendelsdorf, Zhuo Song, Yang Cao, and David C. Samuels
PLoS Comput Biol. 2009 January; 5(1): e1000261. Published online 2009 January 9. doi: 10.1371/journal.pcbi.1000261.
PMCID: PMC2603287
Phylogenetic and Functional Assessment of Orthologs Inference Projects and Methods
Adrian M. Altenhoff and Christophe Dessimoz
PLoS Comput Biol. 2009 January; 5(1): e1000262. Published online 2009 January 16. doi: 10.1371/journal.pcbi.1000262.
PMCID: PMC2612752
Developmental Robustness by Obligate Interaction of Class B Floral Homeotic Genes and Proteins
Thorsten Lenser, Günter Theißen, and Peter Dittrich
PLoS Comput Biol. 2009 January; 5(1): e1000264. Published online 2009 January 16. doi: 10.1371/journal.pcbi.1000264.
PMCID: PMC2612583
Action Potential Initiation in the Hodgkin-Huxley Model
Lucy J. Colwell and Michael P. Brenner
PLoS Comput Biol. 2009 January; 5(1): e1000265. Published online 2009 January 16. doi: 10.1371/journal.pcbi.1000265.
PMCID: PMC2607014
Partial Order Optimum Likelihood (POOL): Maximum Likelihood Prediction of Protein Active Site Residues Using 3D Structure and Sequence Properties
Wenxu Tong, Ying Wei, Leonel F. Murga, Mary Jo Ondrechen, and Ronald J. Williams
PLoS Comput Biol. 2009 January; 5(1): e1000266. Published online 2009 January 16. doi: 10.1371/journal.pcbi.1000266.
PMCID: PMC2612599
Joint Evolutionary Trees: A Large-Scale Method To Predict Protein Interfaces Based on Sequence Sampling
Stefan Engelen, Ladislas A. Trojan, Sophie Sacquin-Mora, Richard Lavery, and Alessandra Carbone
PLoS Comput Biol. 2009 January; 5(1): e1000267. Published online 2009 January 23. doi: 10.1371/journal.pcbi.1000267.
PMCID: PMC2613531
Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility
Vijay Chickarmane, Tariq Enver, and Carsten Peterson
PLoS Comput Biol. 2009 January; 5(1): e1000268. Published online 2009 January 23. doi: 10.1371/journal.pcbi.1000268.
PMCID: PMC2613533
Coordinated Concentration Changes of Transcripts and Metabolites in Saccharomyces cerevisiae
Patrick H. Bradley, Matthew J. Brauer, Joshua D. Rabinowitz, and Olga G. Troyanskaya
PLoS Comput Biol. 2009 January; 5(1): e1000270. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000270.
PMCID: PMC2614473
Efficient Network Reconstruction from Dynamical Cascades Identifies Small-World Topology of Neuronal Avalanches
Sinisa Pajevic and Dietmar Plenz
PLoS Comput Biol. 2009 January; 5(1): e1000271. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000271.
PMCID: PMC2615076
Astrocytic Mechanisms Explaining Neural-Activity-Induced Shrinkage of Extraneuronal Space
Ivar Østby, Leiv Øyehaug, Gaute T. Einevoll, Erlend A. Nagelhus, Erik Plahte, Thomas Zeuthen, Catherine M. Lloyd, Ole P. Ottersen, and Stig W. Omholt
PLoS Comput Biol. 2009 January; 5(1): e1000272. Published online 2009 January 23. doi: 10.1371/journal.pcbi.1000272.
PMCID: PMC2613522
Model-Based Therapeutic Correction of Hypothalamic-Pituitary-Adrenal Axis Dysfunction
Amos Ben-Zvi, Suzanne D. Vernon, and Gordon Broderick
PLoS Comput Biol. 2009 January; 5(1): e1000273. Published online 2009 January 23. doi: 10.1371/journal.pcbi.1000273.
PMCID: PMC2613527
A Factor Graph Nested Effects Model To Identify Networks from Genetic Perturbations
Charles J. Vaske, Carrie House, Truong Luu, Bryan Frank, Chen-Hsiang Yeang, Norman H. Lee, and Joshua M. Stuart
PLoS Comput Biol. 2009 January; 5(1): e1000274. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000274.
PMCID: PMC2613752
Cohesive versus Flexible Evolution of Functional Modules in Eukaryotes
Like Fokkens and Berend Snel
PLoS Comput Biol. 2009 January; 5(1): e1000276. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000276.
PMCID: PMC2615111
Poisson-Nernst-Planck Models of Nonequilibrium Ion Electrodiffusion through a Protegrin Transmembrane Pore
Dan S. Bolintineanu, Abdallah Sayyed-Ahmad, H. Ted Davis, and Yiannis N. Kaznessis
PLoS Comput Biol. 2009 January; 5(1): e1000277. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000277.
PMCID: PMC2614469
Prediction of Protein–Protein Interaction Sites in Sequences and 3D Structures by Random Forests
Mile Šikić, Sanja Tomić, and Kristian Vlahoviček
PLoS Comput Biol. 2009 January; 5(1): e1000278. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000278.
PMCID: PMC2621338
Precise Regulation of Gene Expression Dynamics Favors Complex Promoter Architectures
Dirk Müller and Jörg Stelling
PLoS Comput Biol. 2009 January; 5(1): e1000279. Published online 2009 January 30. doi: 10.1371/journal.pcbi.1000279.
PMCID: PMC2615112
Other Issues:  previous | next | latest | archive