| | Editorial A Changing Landscape Helen Doyle, Andy Gass, and Debra Lappin PMCID: PMC300697 Synopses Structural Mechanism Shows How Transferrin Receptor Binds Multiple Ligands and Sheds Light on a Hereditary Iron Disease PMCID: PMC300675 New Screen Identifies Elusive MicroRNA Targets PMCID: PMC270018 Dose of PTEN Gene Drives Progression of Prostate Cancer PMCID: PMC270021 Structure of Aquaporin Reveals Mechanism for Transport Selectivity PMCID: PMC300685 New Microarray Detects Antigen-Specific T Cells and Immune Responses PMCID: PMC300686 GAD2 Identified as Candidate Gene for Obesity PMCID: PMC270022 Distinct Mechanisms Control Transposon Inheritance through Overlapping Pathways PMCID: PMC300693 Chromosome Locus and Candidate Gene for Osteoporosis Identified PMCID: PMC270023 Gene Expression Profile Created for Mouse Stem Cells and Developing Embryo PMCID: PMC300695 Novel Receptor Guides Germ Cell Transepithelial Migration in Drosophila PMCID: PMC300696 Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth PMCID: PMC300698 Essay The Virus That Changed My World Lisa Fong Poh Ng PMCID: PMC300679 Features Economy of the Mind Kendall Powell PMCID: PMC300687 Human Epigenome Project—Up and Running Jane Bradbury PMCID: PMC300691 Unsolved Mystery How Are the Sizes of Cells, Organs, and Bodies Controlled? Ernst Hafen and Hugo Stocker PMCID: PMC300694 Book Review/Science in the Media Rose-Tinted Ecology Thomas Brooks PMCID: PMC300683 Journal Club A Wingless Flight Xiang Yu PMCID: PMC300676 Primer Antigen-Specific T Cells: Analyses of the Needles in the Haystack Jill E Slansky PMCID: PMC300688 How Mammals Acquire and Distribute Iron Needed for Oxygen-Based Metabolism Tracey A Rouault PMCID: PMC300689 Community Page Research Advocacy: Why Every Scientist Should Participate Elizabeth Marincola PMCID: PMC300681 Research Articles Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor Anthony M Giannetti, Peter M Snow, Olga Zak, and Pamela J Björkman PMCID: PMC300677 Pten Dose Dictates Cancer Progression in the Prostate Lloyd C Trotman, Masaru Niki, Zohar A Dotan, Jason A Koutcher, Antonio Di Cristofano, Andrew Xiao, Alan S Khoo, Pradip Roy-Burman, Norman M Greenberg, Terry Van Dyke, Carlos Cordon-Cardo, and Pier Paolo Pandolfi PMCID: PMC270016 Identification of Drosophila MicroRNA Targets Alexander Stark, Julius Brennecke, Robert B Russell, and Stephen M Cohen PMCID: PMC270017 Detection and Characterizationof Cellular Immune Responses Using Peptide–MHC Microarrays Yoav Soen, Daniel S Chen, Daniel L Kraft, Mark M Davis, and Patrick O Brown PMCID: PMC300678 Distinct Mechanisms Determine Transposon Inheritance and Methylation via Small Interfering RNA and Histone Modification Zachary Lippman, Bruce May, Cristy Yordan, Tatjana Singer, and Rob Martienssen PMCID: PMC300680 GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity Philippe Boutin, Christian Dina, Francis Vasseur, Séverine Dubois, Laetitia Corset, Karin Séron, Lynn Bekris, Janice Cabellon, Bernadette Neve, Valérie Vasseur-Delannoy, Mohamed Chikri, M. Aline Charles, Karine Clement, Ake Lernmark, and Philippe Froguel PMCID: PMC270019 Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2 Unnur Styrkarsdottir, Jean-Baptiste Cazier, Augustine Kong, Ottar Rolfsson, Helene Larsen, Emma Bjarnadottir, Vala D Johannsdottir, Margret S Sigurdardottir, Yu Bagger, Claus Christiansen, Inga Reynisdottir, Struan F. A Grant, Kristjan Jonasson, Michael L Frigge, Jeffrey R Gulcher, Gunnar Sigurdsson, and Kari Stefansson PMCID: PMC270020 Architecture and Selectivity in Aquaporins: 2.5 Å X-Ray Structure of Aquaporin Z David F Savage, Pascal F Egea, Yaneth Robles-Colmenares, Joseph D. O'Connell III, and Robert M Stroud PMCID: PMC300682 Transcriptome Analysis of Mouse Stem Cells and Early Embryos Alexei A Sharov, Yulan Piao, Ryo Matoba, Dawood B Dudekula, Yong Qian, Vincent VanBuren, Geppino Falco, Patrick R Martin, Carole A Stagg, Uwem C Bassey, Yuxia Wang, Mark G Carter, Toshio Hamatani, Kazuhiro Aiba, Hidenori Akutsu, Lioudmila Sharova, Tetsuya S Tanaka, Wendy L Kimber, Toshiyuki Yoshikawa, Saied A Jaradat, Serafino Pantano, Ramaiah Nagaraja, Kenneth R Boheler, Dennis Taub, Richard J Hodes, Dan L Longo, David Schlessinger, Jonathan Keller, Emily Klotz, Garnett Kelsoe, Akihiro Umezawa, Angelo L Vescovi, Janet Rossant, Tilo Kunath, Brigid L. M Hogan, Anna Curci, Michele D'Urso, Janet Kelso, Winston Hide, and Minoru S. H Ko PMCID: PMC300684 Tre1, a G Protein-Coupled Receptor, Directs Transepithelial Migration of Drosophila Germ Cells Prabhat S Kunwar, Michelle Starz-Gaiano, Roland J Bainton, Ulrike Heberlein, and Ruth Lehmann PMCID: PMC300690 Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth Keiichi Kondo, William Y Kim, Mirna Lechpammer, and William G Kaelin, Jr PMCID: PMC300692 Corrections In PLoS Biology, volume 1, issue 1:: What Controls Variation in Human Skin Color? Gregory S Barsh PMCID: PMC300699 Corrects: Gregory S Barsh. What Controls Variation in Human Skin Color? PLoS Biol. 2003 October; 1(1): e27. In PLoS Biology, volume 1, issue 1:: Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action Inês BarrosoJian'an LuanRita P. S MiddelbergAnne-Helen HardingPaul W FranksRupert W JakesDavid ClaytonAlan J SchaferStephen O'RahillyNicholas J Wareham PMCID: PMC300700 Corrects: Inês Barroso, et al. Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action. PLoS Biol. 2003 October; 1(1): e20. |
