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Volume 100(22);  October 28, 2003
Commentaries
The energetics of structural change in maltose-binding protein
David E. Wemmer
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12529–12530. Published online 2003 October 20. doi: 10.1073/pnas.2335923100.
PMCID: PMC240646
Detecting elusive surface atoms with atomic force microscopy
Mark C. Hersam and Yip-Wah Chung
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12531–12532. Published online 2003 October 20. doi: 10.1073/pnas.2335865100.
PMCID: PMC240647
Convergent evolution of bright coloration and toxicity in frogs
Kyle Summers
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12533–12534. Published online 2003 October 20. doi: 10.1073/pnas.2335928100.
PMCID: PMC240648
The single capillary and the active brain
Gordon M. Shepherd
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12535–12536. Published online 2003 October 20. doi: 10.1073/pnas.2336089100.
PMCID: PMC240649
Using nonequilibrium measurements to determine macromolecule free-energy differences
Ronald F. Fox
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12537–12538. Published online 2003 October 20. doi: 10.1073/pnas.2336065100.
PMCID: PMC240650
Physical Sciences
Applied Physical Sciences
From the Cover:
Revealing the hidden atom in graphite by low-temperature atomic force microscopy
Stefan Hembacher, Franz J. Giessibl, Jochen Mannhart, and Calvin F. Quate
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12539–12542. Published online 2003 September 22. doi: 10.1073/pnas.2134173100.
PMCID: PMC240651
Chemistry
DNA-mediated charge transport for DNA repair
Elizabeth M. Boon, Alison L. Livingston, Nikolas H. Chmiel, Sheila S. David, and Jacqueline K. Barton
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12543–12547. Published online 2003 October 14. doi: 10.1073/pnas.2035257100.
PMCID: PMC240652
Combinatorial discovery of two-photon photoremovable protecting groups
Michael C. Pirrung, Wolfgang H. Pieper, Krishna P. Kaliappan, and Mugunthu R. Dhananjeyan
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12548–12553. Published online 2003 October 13. doi: 10.1073/pnas.2131115100.
PMCID: PMC240653
Geology
Branched aliphatic alkanes with quaternary substituted carbon atoms in modern and ancient geologic samples
Fabien Kenig, Dirk-Jan H. Simons, David Crich, James P. Cowen, Gregory T. Ventura, Tatiana Rehbein-Khalily, Todd C. Brown, and Ken B. Anderson
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12554–12558. Published online 2003 October 9. doi: 10.1073/pnas.1735581100.
PMCID: PMC240654
Ancient maize from Chacoan great houses: Where was it grown?
Larry Benson, Linda Cordell, Kirk Vincent, Howard Taylor, John Stein, G. Lang Farmer, and Kiyoto Futa
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13111–13115. Published online 2003 October 16. doi: 10.1073/pnas.2135068100.
PMCID: PMC240753
Mathematics
Signature quantization
Victor Guillemin, Shlomo Sternberg, and Jonathan Weitsman
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12559–12560. Published online 2003 October 20. doi: 10.1073/pnas.1735527100.
PMCID: PMC398041
The Nagata automorphism is wild
Ivan P. Shestakov and Ualbai U. Umirbaev
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12561–12563. Published online 2003 October 20. doi: 10.1073/pnas.1735483100.
PMCID: PMC240656
Physics
From the Cover:
Bias and error in estimates of equilibrium free-energy differences from nonequilibrium measurements
Jeff Gore, Felix Ritort, and Carlos Bustamante
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12564–12569. Published online 2003 October 3. doi: 10.1073/pnas.1635159100.
PMCID: PMC240657
Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins
O. Miyashita, J. N. Onuchic, and P. G. Wolynes
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12570–12575. Published online 2003 October 17. doi: 10.1073/pnas.2135471100.
PMCID: PMC240658
Coloration strategies in peacock feathers
Jian Zi, Xindi Yu, Yizhou Li, Xinhua Hu, Chun Xu, Xingjun Wang, Xiaohan Liu, and Rongtang Fu
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12576–12578. Published online 2003 October 13. doi: 10.1073/pnas.2133313100.
PMCID: PMC240659
Statistics
Predicting protein functions from redundancies in large-scale protein interaction networks
Manoj Pratim Samanta and Shoudan Liang
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12579–12583. Published online 2003 October 17. doi: 10.1073/pnas.2132527100.
PMCID: PMC240660
Biological Sciences
Applied Biological Sciences
Nitric oxide-donating aspirin inhibits β-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear β-catenin–TCF association
Niharika Nath, Khosrow Kashfi, Jie Chen, and Basil Rigas
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12584–12589. Published online 2003 October 17. doi: 10.1073/pnas.2134840100.
PMCID: PMC240661
Biochemistry
DNA-mediated charge transport for DNA repair
Elizabeth M. Boon, Alison L. Livingston, Nikolas H. Chmiel, Sheila S. David, and Jacqueline K. Barton
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12543–12547. Published online 2003 October 14. doi: 10.1073/pnas.2035257100.
PMCID: PMC240652
The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy
Norbert Schülke, Olga A. Varlamova, Gerald P. Donovan, Dangshe Ma, Jason P Gardner, Donna M. Morrissey, Robert R. Arrigale, Cenchen Zhan, Amy J. Chodera, Kenneth G. Surowitz, Paul J. Maddon, Warren D. W. Heston, and William C. Olson
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12590–12595. doi: 10.1073/pnas.1735443100.
PMCID: PMC240662
A plant virus replication system to assay the formation of RNA pseudotriloop motifs in RNA–protein interactions
P. C. Joost Haasnoot, John F. Bol, and René C. L. Olsthoorn
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12596–12600. Published online 2003 October 20. doi: 10.1073/pnas.2135413100.
PMCID: PMC240663
Processive phosphorylation of alternative splicing factor/splicing factor 2
Brandon E. Aubol, Sutapa Chakrabarti, Jacky Ngo, Jennifer Shaffer, Brad Nolen, Xiang-Dong Fu, Gourisankar Ghosh, and Joseph A. Adams
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12601–12606. Published online 2003 October 10. doi: 10.1073/pnas.1635129100.
PMCID: PMC240664
Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvβ2-subunit
Olga Sokolova, Alessio Accardi, David Gutierrez, Adrian Lau, Mike Rigney, and Nikolaus Grigorieff
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12607–12612. Published online 2003 October 20. doi: 10.1073/pnas.2235650100.
PMCID: PMC240665
Capture of an intermediate in the catalytic cycle of l-aspartate-β-semialdehyde dehydrogenase
Julio Blanco, Roger A. Moore, and Ronald E. Viola
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12613–12617. Published online 2003 October 14. doi: 10.1073/pnas.1634958100.
PMCID: PMC240666
Active sites of thioredoxin reductases: Why selenoproteins?
Stephan Gromer, Linda Johansson, Holger Bauer, L. David Arscott, Susanne Rauch, David P. Ballou, Charles H. Williams, Jr., R. Heiner Schirmer, and Elias S. J. Arnér
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12618–12623. Published online 2003 October 20. doi: 10.1073/pnas.2134510100.
PMCID: PMC240667
Hypothalamic malonyl-CoA as a mediator of feeding behavior
Zhiyuan Hu, Seung Hun Cha, Shigeru Chohnan, and M. Daniel Lane
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12624–12629. Published online 2003 October 7. doi: 10.1073/pnas.1834402100.
PMCID: PMC240668
AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins
Visvanathan Ramamurthy, Melanie Roberts, Focco van den Akker, Gregory Niemi, T. A. Reh, and James B. Hurley
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12630–12635. Published online 2003 October 10. doi: 10.1073/pnas.2134194100.
PMCID: PMC240669
Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases
Siiri E. Iismaa, Sara Holman, Merridee A. Wouters, Laszlo Lorand, Robert M. Graham, and Ahsan Husain
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12636–12641. Published online 2003 October 17. doi: 10.1073/pnas.1635052100.
PMCID: PMC240670
Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice
Zhongqiu Zhang, Manabu Futamura, Haris G. Vikis, Min Wang, Jie Li, Yian Wang, Kun-Liang Guan, and Ming You
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12642–12647. doi: 10.1073/pnas.2133947100.
PMCID: PMC240671
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit
Hu Pan, Sanjay Agarwalla, Demetri T. Moustakas, Janet Finer-Moore, and Robert M. Stroud
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12648–12653. Published online 2003 October 17. doi: 10.1073/pnas.2135585100.
PMCID: PMC240672
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
Nikolaus Schiering, Stefan Knapp, Marina Marconi, Maria M. Flocco, Jean Cui, Rita Perego, Luisa Rusconi, and Cinzia Cristiani
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12654–12659. Published online 2003 October 14. doi: 10.1073/pnas.1734128100.
PMCID: PMC240673
Contrasting patterns of expression of transcription factors in pancreatic α and β cells
Jie Wang, Gene Webb, Yun Cao, and Donald F. Steiner
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12660–12665. Published online 2003 October 13. doi: 10.1073/pnas.1735286100.
PMCID: PMC240674
The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA
Meisheng Zhou, Longwen Deng, Fatah Kashanchi, John N. Brady, Aaron J. Shatkin, and Ajit Kumar
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12666–12671. Published online 2003 October 20. doi: 10.1073/pnas.1835726100.
PMCID: PMC240675
Biophysics
From the Cover:
Bias and error in estimates of equilibrium free-energy differences from nonequilibrium measurements
Jeff Gore, Felix Ritort, and Carlos Bustamante
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12564–12569. Published online 2003 October 3. doi: 10.1073/pnas.1635159100.
PMCID: PMC240657
Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins
O. Miyashita, J. N. Onuchic, and P. G. Wolynes
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12570–12575. Published online 2003 October 17. doi: 10.1073/pnas.2135471100.
PMCID: PMC240658
Principles of cell-free genetic circuit assembly
Vincent Noireaux, Roy Bar-Ziv, and Albert Libchaber
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12672–12677. Published online 2003 October 14. doi: 10.1073/pnas.2135496100.
PMCID: PMC240676
Fast protein folding kinetics
Jack Schonbrun and Ken A. Dill
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12678–12682. Published online 2003 October 20. doi: 10.1073/pnas.1735417100.
PMCID: PMC240677
Energetics of hydrogen bonds in peptides
Sheh-Yi Sheu, Dah-Yen Yang, H. L. Selzle, and E. W. Schlag
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12683–12687. Published online 2003 October 14. doi: 10.1073/pnas.2133366100.
PMCID: PMC240678
Damped elastic recoil of the titin spring in myofibrils of human myocardium
Christiane A. Opitz, Michael Kulke, Mark C. Leake, Ciprian Neagoe, Horst Hinssen, Roger J. Hajjar, and Wolfgang A. Linke
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12688–12693. Published online 2003 October 16. doi: 10.1073/pnas.2133733100.
PMCID: PMC240679
DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a
Kylie J. Walters, Patrycja J. Lech, Amanda M. Goh, Qinghua Wang, and Peter M. Howley
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12694–12699. Published online 2003 October 13. doi: 10.1073/pnas.1634989100.
PMCID: PMC240680
From the Cover:
The energetic cost of domain reorientation in maltose-binding protein as studied by NMR and fluorescence spectroscopy
Oscar Millet, Rhea P. Hudson, and Lewis E. Kay
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12700–12705. Published online 2003 October 6. doi: 10.1073/pnas.2134311100.
PMCID: PMC240681
Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli
José Luis Vázquez-Ibar, Lan Guan, Maja Svrakic, and H. Ronald Kaback
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12706–12711. Published online 2003 October 17. doi: 10.1073/pnas.1835645100.
PMCID: PMC240682
Cell Biology
Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture
Yang Hong, Larry Ackerman, Lily Yeh Jan, and Yuh-Nung Jan
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12712–12717. Published online 2003 October 20. doi: 10.1073/pnas.2135347100.
PMCID: PMC240683
Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
Yu-Wen Zhang, Yanli Su, Olga V. Volpert, and George F. Vande Woude
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12718–12723. Published online 2003 October 10. doi: 10.1073/pnas.2135113100.
PMCID: PMC240684
Dynamic structures in Escherichia coli: Spontaneous formation of MinE rings and MinD polar zones
Kerwyn Casey Huang, Yigal Meir, and Ned S. Wingreen
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12724–12728. Published online 2003 October 20. doi: 10.1073/pnas.2135445100.
PMCID: PMC240685
Eradication of pathogenic β-catenin by Skp1/Cullin/F box ubiquitination machinery
Yunyun Su, Shinji Ishikawa, Masayuki Kojima, and Bo Liu
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12729–12734. Published online 2003 October 16. doi: 10.1073/pnas.2133261100.
PMCID: PMC240686
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery
Amy L. Hitchcock, Kathryn Auld, Steven P. Gygi, and Pamela A. Silver
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12735–12740. Published online 2003 October 13. doi: 10.1073/pnas.2135500100.
PMCID: PMC240687
Developmental Biology
Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds
Shulamit Levenberg, Ngan F. Huang, Erin Lavik, Arlin B. Rogers, Joseph Itskovitz-Eldor, and Robert Langer
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12741–12746. Published online 2003 October 15. doi: 10.1073/pnas.1735463100.
PMCID: PMC240688
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
Gonçalo Castelo-Branco, Joseph Wagner, Francisco J. Rodriguez, Julianna Kele, Kyle Sousa, Nina Rawal, Hilda Amalia Pasolli, Elaine Fuchs, Jan Kitajewski, and Ernest Arenas
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12747–12752. Published online 2003 October 13. doi: 10.1073/pnas.1534900100.
PMCID: PMC240689
Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis
Mira C. Puri and Alan Bernstein
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12753–12758. Published online 2003 October 6. doi: 10.1073/pnas.2133552100.
PMCID: PMC240690
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
Yao Yao, Wei Li, Junwei Wu, Ursula A. Germann, Michael S. S. Su, Keisuke Kuida, and Diane M. Boucher
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12759–12764. Published online 2003 October 17. doi: 10.1073/pnas.2134254100.
PMCID: PMC240691
Ecology
Biodiversity as spatial insurance in heterogeneous landscapes
Michel Loreau, Nicolas Mouquet, and Andrew Gonzalez
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12765–12770. Published online 2003 October 20. doi: 10.1073/pnas.2235465100.
PMCID: PMC240692
Helical Lévy walks: Adjusting searching statistics to resource availability in microzooplankton
Frederic Bartumeus, Francesc Peters, Salvador Pueyo, Cèlia Marrasé, and Jordi Catalan
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12771–12775. Published online 2003 October 17. doi: 10.1073/pnas.2137243100.
PMCID: PMC240693
Mixotrophs combine resource use to outcompete specialists: Implications for aquatic food webs
Jörg Tittel, Vera Bissinger, Barbara Zippel, Ursula Gaedke, Elanor Bell, Andreas Lorke, and Norbert Kamjunke
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12776–12781. Published online 2003 October 20. doi: 10.1073/pnas.2130696100.
PMCID: PMC240694
Evolution
Fitness consequences of a regulatory polymorphism in a seasonal environment
Amy M. Suiter, Otmar Bänziger, and Antony M. Dean
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12782–12786. Published online 2003 October 10. doi: 10.1073/pnas.2134994100.
PMCID: PMC240695
Alu elements and hominid phylogenetics
Abdel-Halim Salem, David A. Ray, Jinchuan Xing, Pauline A. Callinan, Jeremy S. Myers, Dale J. Hedges, Randall K. Garber, David J. Witherspoon, Lynn B. Jorde, and Mark A. Batzer
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12787–12791. Published online 2003 October 15. doi: 10.1073/pnas.2133766100.
PMCID: PMC240696
From the Cover:
Multiple, recurring origins of aposematism and diet specialization in poison frogs
Juan Carlos Santos, Luis A. Coloma, and David C. Cannatella
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12792–12797. Published online 2003 October 10. doi: 10.1073/pnas.2133521100.
PMCID: PMC240697
The complexity of alternative splicing of hagoromo mRNAs is increased in an explosively speciated lineage in East African cichlids
Yohey Terai, Naoko Morikawa, Koichi Kawakami, and Norihiro Okada
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12798–12803. Published online 2003 October 20. doi: 10.1073/pnas.2132833100.
PMCID: PMC240698
Synchronous coadaptation in an ancient case of herbivory
Judith X. Becerra
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12804–12807. Published online 2003 October 10. doi: 10.1073/pnas.2133013100.
PMCID: PMC240699
Evolution of eusociality and the soldier caste in termites: Influence of intraspecific competition and accelerated inheritance
Barbara L. Thorne, Nancy L. Breisch, and Mario L. Muscedere
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12808–12813. Published online 2003 October 10. doi: 10.1073/pnas.2133530100.
PMCID: PMC240700
Differential regulation of symmetry genes and the evolution of floral morphologies
Lena C. Hileman, Elena M. Kramer, and David A. Baum
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12814–12819. Published online 2003 October 10. doi: 10.1073/pnas.1835725100.
PMCID: PMC240701
Evolution of the yeast protein interaction network
Hong Qin, Henry H. S. Lu, Wei B. Wu, and Wen-Hsiung Li
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12820–12824. Published online 2003 October 13. doi: 10.1073/pnas.2235584100.
PMCID: PMC240702
Probable extirpation of a breeding colony of Short-tailed Albatross (Phoebastria albatrus) on Bermuda by Pleistocene sea-level rise
Storrs L. Olson and Paul J. Hearty
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12825–12829. Published online 2003 October 17. doi: 10.1073/pnas.1934576100.
PMCID: PMC240703
Proteorhodopsin genes are distributed among divergent marine bacterial taxa
José R. de la Torre, Lynne M. Christianson, Oded Béjà, Marcelino T. Suzuki, David M. Karl, John Heidelberg, and Edward F. DeLong
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12830–12835. Published online 2003 October 17. doi: 10.1073/pnas.2133554100.
PMCID: PMC240704
Worker policing without genetic conflicts in a clonal ant
A. Hartmann, J. Wantia, J. A. Torres, and J. Heinze
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12836–12840. Published online 2003 October 13. doi: 10.1073/pnas.2132993100.
PMCID: PMC240705
Genetics
An endogenous retroviral long terminal repeat is the dominant promoter for human β1,3-galactosyltransferase 5 in the colon
Catherine A. Dunn, Patrik Medstrand, and Dixie L. Mager
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12841–12846. Published online 2003 October 8. doi: 10.1073/pnas.2134464100.
PMCID: PMC240706
Adaptive mutation: General mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac
E. Susan Slechta, Kim L. Bunny, Elisabeth Kugelberg, Eric Kofoid, Dan I. Andersson, and John R. Roth
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12847–12852. Published online 2003 October 14. doi: 10.1073/pnas.1735464100.
PMCID: PMC240707
Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells
Jason H. Bielas and John A. Heddle
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12853–12858. Published online 2003 October 20. doi: 10.1073/pnas.2235595100.
PMCID: PMC240708
Methylated DNA-binding domain 1 and methylpurine–DNA glycosylase link transcriptional repression and DNA repair in chromatin
Sugiko Watanabe, Takaya Ichimura, Naoyuki Fujita, Shu Tsuruzoe, Izuru Ohki, Masahiro Shirakawa, Michio Kawasuji, and Mitsuyoshi Nakao
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12859–12864. Published online 2003 October 10. doi: 10.1073/pnas.2131819100.
PMCID: PMC240709
Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition
Sophie Tessé, Aurora Storlazzi, Nancy Kleckner, Silvana Gargano, and Denise Zickler
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12865–12870. Published online 2003 October 16. doi: 10.1073/pnas.2034282100.
PMCID: PMC240710
Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer
Michael M. Vilenchik and Alfred G. Knudson
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12871–12876. Published online 2003 October 17. doi: 10.1073/pnas.2135498100.
PMCID: PMC240711
Twin concordance and sibling recurrence rates in multiple sclerosis
C. J. Willer, D. A. Dyment, N. J. Risch, A. D. Sadovnick, G. C. Ebers, and The Canadian Collaborative Study Group
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12877–12882. Published online 2003 October 20. doi: 10.1073/pnas.1932604100.
PMCID: PMC240712
Immunology
Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies
Lars Hangartner, Beatrice M. Senn, Birgit Ledermann, Ulrich Kalinke, Peter Seiler, Etienne Bucher, Raphaël M. Zellweger, Katja Fink, Bernhard Odermatt, Kurt Bürki, Rolf M. Zinkernagel, and Hans Hengartner
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12883–12888. Published online 2003 October 20. doi: 10.1073/pnas.2135542100.
PMCID: PMC240713
Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens
Anne L. Ackerman, Christoph Kyritsis, Robert Tampé, and Peter Cresswell
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12889–12894. Published online 2003 October 15. doi: 10.1073/pnas.1735556100.
PMCID: PMC240714
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells
Tomonori Eto, Kazuo Kinoshita, Kiyotsugu Yoshikawa, Masamichi Muramatsu, and Tasuku Honjo
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12895–12898. Published online 2003 October 14. doi: 10.1073/pnas.2135587100.
PMCID: PMC240715
Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
David M. Koelle, Zhi Liu, Christopher L. McClurkan, Randal C. Cevallos, Jeffrey Vieira, Nancy A. Hosken, Clement A. Meseda, Devon C. Snow, Anna Wald, and Lawrence Corey
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12899–12904. Published online 2003 October 17. doi: 10.1073/pnas.2131705100.
PMCID: PMC240716
A genetic lesion that arrests plasma cell homing to the bone marrow
Loren D. Erickson, Ling-Li Lin, Biyan Duan, Laurence Morel, and Randolph J. Noelle
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12905–12910. Published online 2003 October 10. doi: 10.1073/pnas.2131686100.
PMCID: PMC240717
Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI
Jiro Kitaura, Jinming Song, Mindy Tsai, Koichi Asai, Mari Maeda-Yamamoto, Attila Mocsai, Yuko Kawakami, Fu-Tong Liu, Clifford A. Lowell, B. George Barisas, Stephen J. Galli, and Toshiaki Kawakami
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12911–12916. Published online 2003 October 20. doi: 10.1073/pnas.1735525100.
PMCID: PMC240718
Medical Sciences
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
Guido Bocci, Giulio Francia, Shan Man, Jack Lawler, and Robert S. Kerbel
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12917–12922. Published online 2003 October 15. doi: 10.1073/pnas.2135406100.
PMCID: PMC240719
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
Chang-Hyuk Kwon, Xiaoyan Zhu, Junyuan Zhang, and Suzanne J. Baker
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12923–12928. Published online 2003 October 8. doi: 10.1073/pnas.2132711100.
PMCID: PMC240720
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age
Jörg J. Jacoby, April Kalinowski, Mu-Gen Liu, Samuel S.-M. Zhang, Qian Gao, Gui-Xuan Chai, Lan Ji, Yoshiki Iwamoto, En Li, Michael Schneider, Kerry S. Russell, and Xin-Yuan Fu
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12929–12934. Published online 2003 October 17. doi: 10.1073/pnas.2134694100.
PMCID: PMC240721
The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss
Feng X. Li, Jing W. Zhu, Jeffery S. Tessem, Joshua Beilke, Marileila Varella-Garcia, Jan Jensen, Christopher J. Hogan, and James DeGregori
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12935–12940. Published online 2003 October 17. doi: 10.1073/pnas.2231861100.
PMCID: PMC240722
The detection and quantitation of free desmosine and isodesmosine in human urine and their peptide-bound forms in sputum
Shuren Ma, Seymour Lieberman, Gerard M. Turino, and Yong Y. Lin
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12941–12943. Published online 2003 October 16. doi: 10.1073/pnas.2235344100.
PMCID: PMC240723
Treatment of Helicobacter gastritis with IL-4 requires somatostatin
Yana Zavros, Sivaprakash Rathinavelu, John Y. Kao, Andrea Todisco, John Del Valle, Joel V. Weinstock, Malcolm J. Low, and Juanita L. Merchant
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12944–12949. Published online 2003 October 10. doi: 10.1073/pnas.2135193100.
PMCID: PMC240724
Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero
Regine Choe, Turgut Durduran, Guoqiang Yu, Mark J. M. Nijland, Britton Chance, Arjun G. Yodh, and Nirmala Ramanujam
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12950–12954. Published online 2003 October 16. doi: 10.1073/pnas.1735462100.
PMCID: PMC240725
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
David G. Brooks, Philip A. Arlen, Lianying Gao, Christina M. R. Kitchen, and Jerome A. Zack
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12955–12960. Published online 2003 October 20. doi: 10.1073/pnas.2233345100.
PMCID: PMC240726
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2
Georgia L. Wiesner, Denise Daley, Susan Lewis, Christine Ticknor, Petra Platzer, James Lutterbaugh, Melissa MacMillen, Boris Baliner, Joseph Willis, Robert C. Elston, and Sanford D. Markowitz
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12961–12965. Published online 2003 October 17. doi: 10.1073/pnas.2132286100.
PMCID: PMC240727
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome
Anna Richards, Elizabeth J. Kemp, M. Kathryn Liszewski, Judith A. Goodship, Anne K. Lampe, Ronny Decorte, M. Hamza Müslümanogğlu, Salih Kavukcu, Guido Filler, Yves Pirson, Leana S. Wen, John P. Atkinson, and Timothy H. J. Goodship
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12966–12971. Published online 2003 October 17. doi: 10.1073/pnas.2135497100.
PMCID: PMC240728
HIV-1 in genital tract and plasma of women: Compartmentalization of viral sequences, coreceptor usage, and glycosylation
Kimdar Sherefa Kemal, Brian Foley, Harold Burger, Kathryn Anastos, Howard Minkoff, Christina Kitchen, Sean M. Philpott, Wei Gao, Esther Robison, Susan Holman, Carolyn Dehner, Suzanne Beck, William A. Meyer, III, Alan Landay, Andrea Kovacs, James Bremer, and Barbara Weiser
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12972–12977. Published online 2003 October 13. doi: 10.1073/pnas.2134064100.
PMCID: PMC240729
Microbiology
The small RING finger protein Z drives arenavirus budding: Implications for antiviral strategies
Mar Perez, Rebecca C. Craven, and Juan C. de la Torre
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12978–12983. Published online 2003 October 16. doi: 10.1073/pnas.2133782100.
PMCID: PMC240730
The genome of Nanoarchaeum equitans: Insights into early archaeal evolution and derived parasitism
Elizabeth Waters, Michael J. Hohn, Ivan Ahel, David E. Graham, Mark D. Adams, Mary Barnstead, Karen Y. Beeson, Lisa Bibbs, Randall Bolanos, Martin Keller, Keith Kretz, Xiaoying Lin, Eric Mathur, Jingwei Ni, Mircea Podar, Toby Richardson, Granger G. Sutton, Melvin Simon, Dieter Söll, Karl O. Stetter, Jay M. Short, and Michiel Noordewier
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12984–12988. Published online 2003 October 17. doi: 10.1073/pnas.1735403100.
PMCID: PMC240731
Genetic requirements for mycobacterial survival during infection
Christopher M. Sassetti and Eric J. Rubin
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12989–12994. Published online 2003 October 20. doi: 10.1073/pnas.2134250100.
PMCID: PMC240732
Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
Boyd Yount, Kristopher M. Curtis, Elizabeth A. Fritz, Lisa E. Hensley, Peter B. Jahrling, Erik Prentice, Mark R. Denison, Thomas W. Geisbert, and Ralph S. Baric
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12995–13000. Published online 2003 October 20. doi: 10.1073/pnas.1735582100.
PMCID: PMC240733
Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
Sarah A. Stanley, Sridharan Raghavan, William W. Hwang, and Jeffery S. Cox
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13001–13006. Published online 2003 October 13. doi: 10.1073/pnas.2235593100.
PMCID: PMC240734
Induction of crossreactive antibodies against the Plasmodium falciparum variant protein
Sylvie Gratepanche, Benoit Gamain, Joseph D. Smith, Bridget A. Robinson, Allan Saul, and Louis H. Miller
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13007–13012. Published online 2003 October 20. doi: 10.1073/pnas.2235588100.
PMCID: PMC240735
Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution
Sandra Blaise, Nathalie de Parseval, Laurence Bénit, and Thierry Heidmann
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13013–13018. Published online 2003 October 13. doi: 10.1073/pnas.2132646100.
PMCID: PMC240736
Neuroscience
The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia
Candice E. Junge, Taku Sugawara, Guido Mannaioni, Sudar Alagarsamy, P. Jeffrey Conn, Daniel J. Brat, Pak H. Chan, and Stephen F. Traynelis
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13019–13024. Published online 2003 October 14. doi: 10.1073/pnas.2235594100.
PMCID: PMC240737
Cyclothiazide potently inhibits γ-aminobutyric acid type A receptors in addition to enhancing glutamate responses
Lunbin Deng and Gong Chen
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13025–13029. Published online 2003 October 8. doi: 10.1073/pnas.2133370100.
PMCID: PMC240738
Elevated gene expression levels distinguish human from non-human primate brains
Mario Cáceres, Joel Lachuer, Matthew A. Zapala, John C. Redmond, Lili Kudo, Daniel H. Geschwind, David J. Lockhart, Todd M. Preuss, and Carrolee Barlow
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13030–13035. Published online 2003 October 13. doi: 10.1073/pnas.2135499100.
PMCID: PMC240739
Glia-independent chains of neuroblasts through the subcortical parenchyma of the adult rabbit brain
F. Luzzati, P. Peretto, P. Aimar, G. Ponti, A. Fasolo, and L. Bonfanti
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13036–13041. Published online 2003 October 14. doi: 10.1073/pnas.1735482100.
PMCID: PMC240740
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis
Maaria Ikonen, Bingrong Liu, Yuichi Hashimoto, Liqun Ma, Kuk-Wha Lee, Takako Niikura, Ikuo Nishimoto, and Pinchas Cohen
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13042–13047. Published online 2003 October 15. doi: 10.1073/pnas.2135111100.
PMCID: PMC240741
Expression of T cell receptor βlocus in central nervous system neurons
Josh Syken and Carla J. Shatz
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13048–13053. Published online 2003 October 20. doi: 10.1073/pnas.1735415100.
PMCID: PMC240742
Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: Electrophysiology-coordinated photochemistry and mass spectrometry
John F. Leite, Michael P. Blanton, Mona Shahgholi, Dennis A. Dougherty, and Henry A. Lester
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13054–13059. Published online 2003 October 20. doi: 10.1073/pnas.2133028100.
PMCID: PMC240743
Developmental amnesia and its relationship to degree of hippocampal atrophy
E. B. Isaacs, F. Vargha-Khadem, K. E. Watkins, A. Lucas, M. Mishkin, and D. G. Gadian
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13060–13063. Published online 2003 October 10. doi: 10.1073/pnas.1233825100.
PMCID: PMC240744
Olivo-cerebellar cluster-based universal control system
V. B. Kazantsev, V. I. Nekorkin, V. I. Makarenko, and R. Llinás
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13064–13068. Published online 2003 October 9. doi: 10.1073/pnas.1635110100.
PMCID: PMC240745
Brain-derived neurotrophic factor-dependent unmasking of “silent” synapses in the developing mouse barrel cortex
Chiaki Itami, Fumitaka Kimura, Tomoko Kohno, Masato Matsuoka, Masumi Ichikawa, Tadaharu Tsumoto, and Shun Nakamura
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13069–13074. Published online 2003 October 13. doi: 10.1073/pnas.2131948100.
PMCID: PMC240746
A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
Eric H. Schroeter, Ma. Xenia G. Ilagan, Anne L. Brunkan, Silva Hecimovic, Yue-ming Li, Min Xu, Huw D. Lewis, Meera T. Saxena, Bart De Strooper, Archie Coonrod, Taisuke Tomita, Takeshi Iwatsubo, Chad L. Moore, Alison Goate, Michael S. Wolfe, Mark Shearman, and Raphael Kopan
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13075–13080. Published online 2003 October 17. doi: 10.1073/pnas.1735338100.
PMCID: PMC240747
Two-photon imaging of capillary blood flow in olfactory bulb glomeruli
Emmanuelle Chaigneau, Martin Oheim, Etienne Audinat, and Serge Charpak
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13081–13086. Published online 2003 October 20. doi: 10.1073/pnas.2133652100.
PMCID: PMC240748
Trace but not delay fear conditioning requires attention and the anterior cingulate cortex
C. J. Han, Colm M. O'Tuathaigh, Laurent van Trigt, Jennifer J. Quinn, Michael S. Fanselow, Raymond Mongeau, Christof Koch, and David J. Anderson
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13087–13092. Published online 2003 October 10. doi: 10.1073/pnas.2132313100.
PMCID: PMC240749
Physiology
β-Adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15
Joanne T. Hulme, Teddy W.-C. Lin, Ruth E. Westenbroek, Todd Scheuer, and William A. Catterall
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13093–13098. Published online 2003 October 20. doi: 10.1073/pnas.2135335100.
PMCID: PMC240750
Plant Biology
MADS box genes control vernalization-induced flowering in cereals
Ben Trevaskis, David J. Bagnall, Marc H. Ellis, W. James Peacock, and Elizabeth S. Dennis
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13099–13104. Published online 2003 October 13. doi: 10.1073/pnas.1635053100.
PMCID: PMC240751
Psychology
A modulatory role for facial expressions in prosopagnosia
Beatrice de Gelder, Ilja Frissen, Jason Barton, and Nouchine Hadjikhani
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13105–13110. Published online 2003 October 15. doi: 10.1073/pnas.1735530100.
PMCID: PMC240752
Social Sciences
Anthropology
Ancient maize from Chacoan great houses: Where was it grown?
Larry Benson, Linda Cordell, Kirk Vincent, Howard Taylor, John Stein, G. Lang Farmer, and Kiyoto Futa
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13111–13115. Published online 2003 October 16. doi: 10.1073/pnas.2135068100.
PMCID: PMC240753
Correction
Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13116. Published online 2003 October 1. doi: 10.1073/pnas.2235532100.
PMCID: PMC305274
Corrects: Florence J. Dallo, et al. Effectiveness of diabetes mellitus screening recommendations. Proc Natl Acad Sci U S A. 2003 September 2; 100(18): 10574–10579.
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