| | This journal provides immediate access to some articles. Commentaries Once there were  twenty Uttam L. RajBhandary PMCID: PMC33776 Recombinational crossroads: Eukaryotic enzymes and the limits of
bacterial precedents Michael M. Cox PMCID: PMC33777 Phosphotyrosine signaling and the single cell:metazoan boundary James E. Darnell, Jr. PMCID: PMC33778 Twist and shout (and pull): Molecular chiropractors undo DNA John F. Marko PMCID: PMC33779 Perspective Fluorescence correlation spectroscopy: Diagnostics for
sparse molecules Sudipta Maiti, Ulrich Haupts, and Watt W. Webb PMCID: PMC33774 IκB kinase: Beginning, not the end Inder M. Verma and Jennifer Stevenson PMCID: PMC33775 Physical Sciences Chemistry On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism Chao-Hsiung Lin, Timothy Z. Hoffman, Peter Wirsching, Carlos F. Barbas, III, Kim D. Janda, and Richard A. Lerner PMCID: PMC23568 Making chemistry selectable by linking it to infectivity Changshou Gao, Chao-Hsiung Lin, Chih-Hung L. Lo, Shenlan Mao, Peter Wirsching, Richard A. Lerner, and Kim D. Janda PMCID: PMC23570 Electrophilic nitration of alkanes with nitronium hexafluorophosphate George A. Olah, Pichika Ramaiah, and G. K. Surya Prakash PMCID: PMC23573 Biological Sciences Biochemistry Protein–protein interactions among the Aux/IAA proteins Jungmook Kim, Klaus Harter, and Athanasios Theologis PMCID: PMC23574 Characterization of recombinant phytochrome from the cyanobacterium SynechocystisTilman Lamparter, Franz Mittmann, Wolfgang Gärtner, Thomas Börner, Elmar Hartmann, and Jon Hughes PMCID: PMC23587 Prp43: An RNA helicase-like factor involved in spliceosome disassembly Jaime E. Arenas and John N. Abelson PMCID: PMC23592 Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43 Sherry Gee, Sharon Wald Krauss, Estelle Miller, Kazuko Aoyagi, Jaime Arenas, and John G. Conboy PMCID: PMC23596 Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases Joseph N. Varghese, Peter M. Colman, Albertus van Donkelaar, Tony J. Blick, Anjali Sahasrabudhe, and Jennifer L. McKimm-Breschkin PMCID: PMC23599 The crystal structure of human interferon β at 2.2-Å resolution Michael Karpusas, Matthias Nolte, Christopher B. Benton, Werner Meier, William N. Lipscomb, and Susan Goelz PMCID: PMC23607 INAUGURAL ARTICLE by a Recently Elected Academy Member: Glu-tRNA Gln amidotransferase: A novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation Alan W. Curnow, Kwang-won Hong, Robert Yuan, Sung-il Kim, Orlando Martins, Wade Winkler, Tina M. Henkin, and Dieter Söll PMCID: PMC23611 Cloning of the cDNA for the TATA-binding protein-associated factor II170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and DrosophilaJan A. van der Knaap, Jan Willem Borst, Peter C. van der Vliet, Reiner Gentz, and H. Th. Marc Timmers PMCID: PMC23617 Synthesis and screening of small molecule libraries active in binding to DNA Gerald W. Shipps, Jr., Kent E. Pryor, Jun Xian, David A. Skyler, Eric H. Davidson, and Julius Rebek, Jr. PMCID: PMC23622 The amino-terminal region of Tyk2 sustains the level of interferon α receptor 1, a component of the interferon α/β receptor M. Cristina Gauzzi, Giovanna Barbieri, Marc F. Richter, Gilles Uzé, Leona Ling, Marc Fellous, and Sandra Pellegrini PMCID: PMC23625 Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug Pablo Fuentes-Prior, Christiane Noeske-Jungblut, Peter Donner, Wolf-Dieter Schleuning, Robert Huber, and Wolfram Bode PMCID: PMC23629 Characterization of a genetically engineered inactivation-resistant coagulation factor VIIIa Steven W. Pipe and Randal J. Kaufman PMCID: PMC23634 Respiratory chain is required to maintain oxidized states of the DsbA-DsbB disulfide bond formation system in aerobically growing Escherichia colicells Taeko Kobayashi, Satoshi Kishigami, Michio Sone, Hachiro Inokuchi, Tatsushi Mogi, and Koreaki Ito PMCID: PMC23636 RecA tests homology at both pairing and strand exchange L. Rochelle Bazemore, Ewa Folta-Stogniew, Masayuki Takahashi, and Charles M. Radding PMCID: PMC23638 Extensive purification of a putative RNA polymerase I holoenzyme from plants that accurately initiates rRNA gene transcription invitroJulio Saez-Vasquez and Craig S. Pikaard PMCID: PMC23640 Growth and viability of macrophages continuously stimulated to produce nitric oxide John C. Zhuang and Gerald N. Wogan PMCID: PMC23642 Conformation of coenzyme pyrroloquinoline quinone and role of
Ca 2+ in the catalytic mechanism of quinoprotein
methanol dehydrogenase Ya-Jun Zheng and Thomas C. Bruice PMCID: PMC23644 Molding a peptide into an RNA site by in vivo peptide evolution Kazuo Harada, Shelley S. Martin, Ruoying Tan, and Alan D. Frankel PMCID: PMC23646 Participation of the nuclear cap binding complex in pre-mRNA 3′ processing Sean M. Flaherty, Puri Fortes, Elisa Izaurralde, Iain W. Mattaj, and Gregory M. Gilmartin PMCID: PMC23648 Both N-terminal myosin-binding and C-terminal actin-binding sites on smooth muscle caldesmon are required for caldesmon-mediated inhibition of actin filament velocity Ze Wang, He Jiang, Zhi-Qiong Yang, and Samuel Chacko PMCID: PMC23649 Biophysics Molecular switch in signal transduction: Reaction paths of the conformational changes in rasp21 Jianpeng Ma and Martin Karplus PMCID: PMC23651 A structural census of the current population of protein sequences Mark Gerstein and Michael Levitt PMCID: PMC23653 Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: Role in restricted conformational mobility and compaction of native state Brent S. Kendrick, Byeong S. Chang, Tsutomu Arakawa, Brian Peterson, Theodore W. Randolph, Mark C. Manning, and John F. Carpenter PMCID: PMC23655 Effects of extracellular Ca 2+ concentration on hair-bundle stiffness and gating-spring integrity in hair cells Robert E. Marquis and A. J. Hudspeth PMCID: PMC23657 Assigning folds to the proteins encoded by the genome of MycoplasmagenitaliumDaniel Fischer and David Eisenberg PMCID: PMC23659 Mechanical separation of the complementary strands of DNA B. Essevaz-Roulet, U. Bockelmann, and F. Heslot PMCID: PMC23661 Cell Biology Human deoxycytidine kinase is located in the cell nucleus Magnus Johansson, Sophia Brismar, and Anna Karlsson PMCID: PMC23663 Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth Wataru Araki and Richard J. Wurtman PMCID: PMC23665 Activation of distinct caspase-like proteases by Fas and reaper in Drosophilacells Toru Kondo, Takakazu Yokokura, and Shigekazu Nagata PMCID: PMC23666 Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase Chuanshu Huang, Wei-Ya Ma, Clarence A. Ryan, and Zigang Dong PMCID: PMC23668 Conversion of cysteine to formylglycine: A protein modification in the endoplasmic reticulum Thomas Dierks, Bernhard Schmidt, and Kurt von Figura PMCID: PMC23670 Abnormalities of pancreatic islets by targeted expression of a dominant-negative K ATPchannel Takashi Miki, Fumi Tashiro, Toshihiko Iwanaga, Kazuaki Nagashima, Hideyuki Yoshitomi, Hiroyuki Aihara, Yoshio Nitta, Tohru Gonoi, Nobuya Inagaki, Jun-ichi Miyazaki, and Susumu Seino PMCID: PMC23672 Developmental Biology Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function Pin-Xian Xu, Jane Cheng, Jonathan A. Epstein, and Richard L. Maas PMCID: PMC23674 Xenopus Zic3, a primary regulator both in neural and neural crest development Katsunori Nakata, Takeharu Nagai, Jun Aruga, and Katsuhiko Mikoshiba PMCID: PMC23676 Evolution Identification of active sites in amidase: Evolutionary relationship between amide bond- and peptide bond-cleaving enzymes Michihiko Kobayashi, Yoshie Fujiwara, Masahiko Goda, Hidenobu Komeda, and Sakayu Shimizu PMCID: PMC23678 Convergent evolution of apolipoprotein(a) in primates and hedgehog Richard M. Lawn, Karen Schwartz, and Laszlo Patthy PMCID: PMC23680 Phalangeal curvature and positional behavior in extinct sloth lemurs (Primates, Palaeopropithecidae) William L. Jungers, Laurie R. Godfrey, Elwyn L. Simons, and Prithijit S. Chatrath PMCID: PMC23681 Evolution of gilled mushrooms and puffballs inferred from ribosomal DNA sequences David S. Hibbett, Elizabeth M. Pine, Ewald Langer, Gitta Langer, and Michael J. Donoghue PMCID: PMC23683 Origin and evolution of the slime molds (Mycetozoa) Sandra L. Baldauf and W. Ford Doolittle PMCID: PMC23686 Genetics Endosperm balance number manipulation for direct in vivo germplasm introgression to potato from a sexually isolated relative ( Solanum commersoniiDun.) Domenico Carputo, Amalia Barone, Teodoro Cardi, Angela Sebastiano, Luigi Frusciante, and Stanley J. Peloquin PMCID: PMC23688 Highly conservative reciprocal translocations formed by apparent joining of exchanged DNA double-strand break ends Peng Wang, Rui-Hua Zhou, Ying Zou, Colleen K. Jackson-Cook, and Lawrence F. Povirk PMCID: PMC23689 DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis Ginger E. Carney, Andrew A. Wade, Rajat Sapra, Elliott S. Goldstein, and Michael Bender PMCID: PMC23691 A gene spans the pseudoautosomal boundary in mice Steve Palmer, Jo Perry, David Kipling, and Alan Ashworth PMCID: PMC23693 Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function Gregory A. Otterson, Wei-dong Chen, Amy B. Coxon, Samir N. Khleif, and Frederic J. Kaye PMCID: PMC23695 Immunology Epstein–Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin Odile Devergne, Mark Birkenbach, and Elliott Kieff PMCID: PMC23696 Interaction of pigeon cytochrome c-(43–58) peptide analogs with either T cell antigen receptor or I-A bmolecule Yasushi Itoh, Kiichi Kajino, Kazumasa Ogasawara, Akio Takahashi, Ken-ichi Namba, Izumi Negishi, Naoto Matsuki, Kazuya Iwabuchi, Mitsuaki Kakinuma, Robert A. Good, and Kazunori Onoé PMCID: PMC23698 Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2 William A. Kuziel, Sharon J. Morgan, Tracey C. Dawson, Stephanie Griffin, Oliver Smithies, Klaus Ley, and Nobuyo Maeda PMCID: PMC23699 Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion protein Theresa J. Goletz, Kurt R. Klimpel, Naveen Arora, Stephen H. Leppla, Jerry M. Keith, and Jay A. Berzofsky PMCID: PMC23701 Prevention of development of autoimmune disease in BXSB mice by mixed bone marrow transplantation Bing-Yan Wang, Cherry, Nagwa S. El-Badri, and Robert A. Good PMCID: PMC23703 Medical Sciences Posttranslational regulation of cyclin D1 by retinoic acid: A chemoprevention mechanism John Langenfeld, Hiroaki Kiyokawa, David Sekula, Jay Boyle, and Ethan Dmitrovsky PMCID: PMC23705 Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains Ying Jin, Xie L. Xu, Meng-Chun W. Yang, Fanglin Wei, Teck-Choon Ayi, Anne M. Bowcock, and Richard Baer PMCID: PMC23707 INAUGURAL ARTICLE by a Recently Elected Academy Member: Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF 121 and VEGF 165 but not VEGF 189Shi-Yuan Cheng, Motoo Nagane, H.-J. Su Huang, and Webster K. Cavenee PMCID: PMC23709 Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung Gerald B. Pier, Martha Grout, and Tanweer S. Zaidi PMCID: PMC23711 Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins Andrew V. Samuelson and Scott W. Lowe PMCID: PMC23714 Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer Shahab A. Akhter, Christine A. Skaer, Alan P. Kypson, Patricia H. McDonald, Karsten C. Peppel, Donald D. Glower, Robert J. Lefkowitz, and Walter J. Koch PMCID: PMC23716 Evaluating treatment protocols to prevent antibiotic resistance Sebastian Bonhoeffer, Marc Lipsitch, and Bruce R. Levin PMCID: PMC23718 Mechanical stretch induces vascular permeability factor in human mesangial cells: Mechanisms of signal transduction Gabriella Gruden, Stephen Thomas, Davina Burt, Stephen Lane, Gary Chusney, Steven Sacks, and GianCarlo Viberti PMCID: PMC23720 INAUGURAL ARTICLE by a Recently Elected Academy Member: Gene-based approach to human gene-phenotype correlations Thaddeus P. Dryja PMCID: PMC23721 Alternative genetic pathways in colorectal carcinogenesis Sylviane Olschwang, Richard Hamelin, Pierre Laurent-Puig, Bénédicte Thuille, Yann De Rycke, You-Jun Li, Françoise Muzeau, Jacques Girodet, Rémy-Jacques Salmon, and Gilles Thomas PMCID: PMC23723 Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia Michael Kaplan, Paul Renbaum, Ephrat Levy-Lahad, Cathy Hammerman, Amnon Lahad, and Ernest Beutler PMCID: PMC23725 Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease Harry L. Malech, Phillip B. Maples, Narda Whiting-Theobald, Gilda F. Linton, Sudhir Sekhsaria, Sarah J. Vowells, Fei Li, Judi A. Miller, Ellen DeCarlo, Steven M. Holland, Susan F. Leitman, Charles S. Carter, Robert E. Butz, Elizabeth J. Read, Thomas A. Fleisher, Richard D. Schneiderman, Dennis E. Van Epps, S. Kaye Spratt, Christopher A. Maack, Joseph A. Rokovich, Lawrence K. Cohen, and John I. Gallin PMCID: PMC23727 Microbiology Cloning and characterization of the Flavobacterium johnsoniae ( Cytophaga johnsonae) gliding motility gene, gldASarika Agarwal, David W. Hunnicutt, and Mark J. McBride PMCID: PMC23729 Probing the assembly of transcription initiation complexes through changes in σ N protease sensitivity Paul Casaz and Martin Buck PMCID: PMC23731 Neurobiology Operative GABAergic inhibition in hippocampal CA1 pyramidal neurons in experimental epilepsy M. Esclapez, J. C. Hirsch, R. Khazipov, Y. Ben-Ari, and C. Bernard PMCID: PMC23733 Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice Monique R. Adams, Eugene P. Brandon, Elena H. Chartoff, Rejean L. Idzerda, Daniel M. Dorsa, and G. Stanley McKnight PMCID: PMC23735 The Caenorhabditis elegans seven-transmembrane protein ODR-10 functions as an odorant receptor in mammalian cells Yinong Zhang, Joseph H. Chou, Jonathan Bradley, Cornelia I. Bargmann, and Kai Zinn PMCID: PMC23737 Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity Franco Onofri, Silvia Giovedì, Paola Vaccaro, Andrew J. Czernik, Flavia Valtorta, Pietro De Camilli, Paul Greengard, and Fabio Benfenati PMCID: PMC23739 Response-reinforcement learning is dependent on N-methyl- d-aspartate receptor activation in the nucleus accumbens core Ann E. Kelley, Stephanie L. Smith-Roe, and Matthew R. Holahan PMCID: PMC23741 The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport Clare M. Waterman-Storer, Sher B. Karki, Sergei A. Kuznetsov, Joel S. Tabb, Dieter G. Weiss, George M. Langford, and Erika L. F. Holzbaur PMCID: PMC23743 Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion V. O’Connor, C. Heuss, W. M. De Bello, T. Dresbach, M. P. Charlton, J. H. Hunt, L. L. Pellegrini, A. Hodel, M. M. Burger, H. Betz, G. J. Augustine, and T. Schäfer PMCID: PMC23745 Protein kinase C as a signal for exocytosis Julia Billiard, Duk-Su Koh, Donner F. Babcock, and Bertil Hille PMCID: PMC23747 Recurrent excitatory postsynaptic potentials induced by synchronized fast cortical oscillations Miles A. Whittington, Roger D. Traub, Howard J. Faulkner, Ian M. Stanford, and John G. R. Jefferys PMCID: PMC23749 HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling Xiajun Li and Iva Greenwald PMCID: PMC23751 INAUGURAL ARTICLE by a Recently Elected Academy Member: Defective γ-aminobutyric acid type B receptor-activated inwardly rectifying K + currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice Paul A. Slesinger, Markus Stoffel, Yuh Nung Jan, and Lily Y. Jan PMCID: PMC23753 Pharmacology Design of compounds that increase the absorption of polar molecules Caryn Lang Bowe, Leila Mokhtarzadeh, Pushpa Venkatesan, Suresh Babu, Helena R. Axelrod, Michael J. Sofia, Ramesh Kakarla, Tin Yau Chan, Jae Seung Kim, Hye J. Lee, Gordon L. Amidon, Sally Y. Choe, Suzanne Walker, and Daniel Kahne PMCID: PMC23755 Physiology Muscarinic stimulation of synaptic activity by protein kinase C is inhibited by adenosine in cultured hippocampal neurons Alexandre Bouron and Harald Reuter PMCID: PMC23756 Plant Biology Two hemoglobin genes in Arabidopsis thaliana: The evolutionary origins of leghemoglobins Ben Trevaskis, Richard. A. Watts, Carol R. Andersson, Danny J. Llewellyn, Mark S. Hargrove, John S. Olson, Elizabeth S. Dennis, and W. James Peacock PMCID: PMC23758 Genetic control of abscisic acid biosynthesis in maize Bao Cai Tan, Steven H. Schwartz, Jan A. D. Zeevaart, and Donald R. McCarty PMCID: PMC23760 Corrections Proc Natl Acad Sci U S A. 1997 October 28; 94(22): 12241. PMCID: PMC56157 Corrects: Joanna Szczepanowska, et al. Identification by mass spectrometry of the phosphorylated residue responsible for activation of the catalytic domain of myosin I heavy chain kinase, a member of the PAK/STE20family. Proc Natl Acad Sci U S A. 1997 August 5; 94(16): 8503–8508. Proc Natl Acad Sci U S A. 1997 October 28; 94(22): 12241. PMCID: PMC56159 Corrects: Zao-Zhong Su, et al. Subtraction hybridization identifies a transformation progression-associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-induciblegene. Proc Natl Acad Sci U S A. 1997 August 19; 94(17): 9125–9130. Proc Natl Acad Sci U S A. 1997 October 28; 94(22): 12241. PMCID: PMC56160 Corrects: Laura L. Dugan, et al. Carboxyfullerenes as neuroprotectiveagents. Proc Natl Acad Sci U S A. 1997 August 19; 94(17): 9434–9439. Proc Natl Acad Sci U S A. 1997 October 28; 94(22): 12241. PMCID: PMC56161 Corrects: Paul E. Schulz. Long-term potentiation involves increases in the probability of neurotransmitterrelease. Proc Natl Acad Sci U S A. 1997 May 27; 94(11): 5888–5893. |
