| | This journal provides immediate access to some articles. Editorial PNAS Policy on Prior Publication The Editorial Board PMCID: PMC33553 Commentaries How plants learn Anthony Trewavas PMCID: PMC33554 Femtochemistry uncovers the nature of electron transfer reactions A. W. Castleman, Jr., Q. Zhong, and S. M. Hurley PMCID: PMC33555 Tossing monkey wrenches into the clock: New ways of treating cancer Jacqueline A. Lees and Robert A. Weinberg PMCID: PMC33556 Perspective Supernovae, an accelerating universe and the cosmological constant Robert P. Kirshner PMCID: PMC33557 Real or virtual large-scale structure? August E. Evrard PMCID: PMC33558 Observing the epoch of galaxy formation Charles C. Steidel PMCID: PMC33559 Scaling the universe: Gravitational lenses and the Hubble constant Steven T. Myers PMCID: PMC33560 Review New insights into tumor suppression: PTEN suppresses tumor formation by
restraining the phosphoinositide 3-kinase/AKT pathway Lewis C. Cantley and Benjamin G. Neel PMCID: PMC33561 Physical Sciences Chemistry V-Amylose at atomic resolution: X-ray structure of a cycloamylose with 26 glucose residues (cyclomaltohexaicosaose) Katrin Gessler, Isabel Usón, Takeshi Takaha, Norbert Krauss, Steven M. Smith, Shigetaka Okada, George M. Sheldrick, and Wolfram Saenger PMCID: PMC16317 Demonstration of the parity-violating energy difference between enantiomers Andrea Szabó-Nagy and Lajos Keszthelyi PMCID: PMC16318 A common pharmacophore for cytotoxic natural products that stabilize microtubules Iwao Ojima, Subrata Chakravarty, Tadashi Inoue, Songnian Lin, Lifeng He, Susan Band Horwitz, Scott D. Kuduk, and Samuel J. Danishefsky PMCID: PMC16319 Identification by UV resonance Raman spectroscopy of an imino tautomer of 5-hydroxy-2′-deoxycytidine, a powerful base analog transition mutagen with a much higher unfavored tautomer frequency than that of the natural residue 2′-deoxycytidine Wu Suen, Thomas G. Spiro, Lawrence C. Sowers, and Jacques R. Fresco PMCID: PMC16361 Physics Scaling in animal group-size distributions Eric Bonabeau, Laurent Dagorn, and Pierre Fréon PMCID: PMC16356 Biological Sciences Applied Biological Sciences High-efficiency gene transfer into skeletal muscle mediated by electric pulses Lluis M. Mir, Michel F. Bureau, Julie Gehl, Ravi Rangara, Didier Rouy, Jean-Michel Caillaud, Pia Delaere, Didier Branellec, Bertrand Schwartz, and Daniel Scherman PMCID: PMC16320 Biochemistry A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein α-subunit with impaired receptor-mediated activation because of elevated GTPase activity Dennis R. Warner and Lee S. Weinstein PMCID: PMC16321 Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase Alex M. Aronov, Stephen Suresh, Frederick S. Buckner, Wesley C. Van Voorhis, Christophe L. M. J. Verlinde, Fred R. Opperdoes, Wim G. J. Hol, and Michael H. Gelb PMCID: PMC16322 Rings and filaments of β protein from bacteriophage λ suggest a superfamily of recombination proteins Sophia I. Passy, Xiong Yu, Zhufang Li, Charles M. Radding, and Edward H. Egelman PMCID: PMC16323 Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles Matteo Pellegrini, Edward M. Marcotte, Michael J. Thompson, David Eisenberg, and Todd O. Yeates PMCID: PMC16324 Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-Å resolution Shinji Ikemizu, Lisa M. Sparks, P. Anton van der Merwe, Karl Harlos, David I. Stuart, E. Yvonne Jones, and Simon J. Davis PMCID: PMC16325 The Cys4 zinc finger of bacteriophage T7 primase in sequence-specific single-stranded DNA recognition Takahiro Kusakabe, Anna V. Hine, Sven G. Hyberts, and Charles C. Richardson PMCID: PMC16326 Location of translational initiation factor IF3 on the small ribosomal subunit John P. McCutcheon, Rajendra K. Agrawal, Shibu M. Philips, Robert A. Grassucci, Sue Ellen Gerchman, William M. Clemons, Jr., V. Ramakrishnan, and Joachim Frank PMCID: PMC16327 DRONC, an ecdysone-inducible Drosophila caspase Loretta Dorstyn, Paul A. Colussi, Leonie M. Quinn, Helena Richardson, and Sharad Kumar PMCID: PMC16328 A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 Yuan-Ching Liu, Julian Pan, Chunyu Zhang, Wufang Fan, Mark Collinge, Jeffrey R. Bender, and Sherman M. Weissman PMCID: PMC16329 Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins Bostjan Kobe, Rob J. Center, Bruce E. Kemp, and Pantelis Poumbourios PMCID: PMC16330 Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists Ying-Nan P. Chen, Sushil K. Sharma, Timothy M. Ramsey, Li Jiang, Mary S. Martin, Kayla Baker, Peter D. Adams, Kenneth W. Bair, and William G. Kaelin, Jr. PMCID: PMC16331 RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites Vincent Dive, Joël Cotton, Athanasios Yiotakis, Annie Michaud, Stamatia Vassiliou, Jiri Jiracek, Gilles Vazeux, Marie-Thérèse Chauvet, Philippe Cuniasse, and Pierre Corvol PMCID: PMC16332 BglG, the transcriptional antiterminator of the bgl system, interacts with the β′ subunit of the Escherichia coli RNA polymerase Anat Nussbaum-Shochat and Orna Amster-Choder PMCID: PMC16333 Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2 Joon H. Lee, Sang Ki Choi, Antonina Roll-Mecak, Stephen K. Burley, and Thomas E. Dever PMCID: PMC16334 The membrane-attached electron carrier cytochrome cy from Rhodobacter sphaeroides is functional in respiratory but not in photosynthetic electron transfer Hannu Myllykallio, Davide Zannoni, and Fevzi Daldal PMCID: PMC16335 The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria Harry C. Au, Byoung Boo Seo, Akemi Matsuno-Yagi, Takao Yagi, and Immo E. Scheffler PMCID: PMC16336 Acyl homoserine-lactone quorum-sensing signal generation Matthew R. Parsek, Dale L. Val, Brian L. Hanzelka, John E. Cronan, Jr., and E. P. Greenberg PMCID: PMC16337 A molecular trigger of lipid binding-induced opening of a helix bundle exchangeable apolipoprotein Vasanthy Narayanaswami, Jianjun Wang, Dean Schieve, Cyril M. Kay, and Robert O. Ryan PMCID: PMC16338 Oligoribonuclease is an essential component of the mRNA decay pathway Sandip Ghosh and Murray P. Deutscher PMCID: PMC16339 Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: Evidence that 15-lipoxygenase is a mutator gene Uddhav P. Kelavkar and Kamal F. Badr PMCID: PMC16340 Triple-helix formation of DNA oligomers with methylthiourea-linked nucleosides (DNmt): A kinetic and thermodynamic analysis Dev P. Arya and Thomas C. Bruice PMCID: PMC16341 RNA polymerase switch in transcription of yeast rDNA: Role of transcription factor UAF (upstream activation factor) in silencing rDNA transcription by RNA polymerase II Loan Vu, Imran Siddiqi, Bum-Soo Lee, Cathleen A. Josaitis, and Masayasu Nomura PMCID: PMC16342 Prebiotic cytosine synthesis: A critical analysis and implications for the origin of life Robert Shapiro PMCID: PMC16343 Biophysics Two heads of myosin are better than one for generating force and motion M. J. Tyska, D. E. Dupuis, W. H. Guilford, J. B. Patlak, G. S. Waller, K. M. Trybus, D. M. Warshaw, and S. Lowey PMCID: PMC16344 Singular value decomposition with self-modeling applied to
determine bacteriorhodopsin intermediate
spectra: Analysis of simulated data László Zimányi, Ágnes Kulcsár, Janos K. Lanyi, Donald F. Sears, Jr., and Jack Saltiel PMCID: PMC16345 Intermediate spectra and photocycle kinetics of the Asp96 → Asn mutant bacteriorhodopsin determined by singular value decomposition with self-modeling László Zimányi, Ágnes Kulcsár, Janos K. Lanyi, Donald F. Sears, Jr., and Jack Saltiel PMCID: PMC16346 Limiting dynamics of high-frequency electromechanical transduction of outer hair cells Gerhard Frank, Werner Hemmert, and Anthony W. Gummer PMCID: PMC16347 Cell Biology Hormone-induced secretory and nuclear translocation of calmodulin: Oscillations of calmodulin concentration with the nucleus as an integrator Madeleine Craske, Teruko Takeo, Oleg Gerasimenko, Camille Vaillant, Katalin Török, Ole H. Petersen, and Alexei V. Tepikin PMCID: PMC16348 Tamoxifen inhibits acidification in cells independent of the estrogen receptor Nihal Altan, Yu Chen, Melvin Schindler, and Sanford M. Simon PMCID: PMC16349 Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12–rapamycinassociated protein Randall T. Peterson, Bimal N. Desai, James S. Hardwick, and Stuart L. Schreiber PMCID: PMC16350 Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus Yumay Chen, Phang-Lang Chen, Chi-Fen Chen, Z. Dave Sharp, and Wen-Hwa Lee PMCID: PMC16351 Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity Themis R. Kyriakides, Kathleen J. Leach, Allan S. Hoffman, Buddy D. Ratner, and Paul Bornstein PMCID: PMC16352 Developmental Biology A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3 Yingcai Wang, Michal K. Spatz, Karuppiah Kannan, Hovhannisyan Hayk, Aaron Avivi, Marat Gorivodsky, Mark Pines, Avner Yayon, Peter Lonai, and David Givol PMCID: PMC16353 Bicoid functions without its TATA-binding protein-associated factor interaction domains Valérie Schaeffer, Florence Janody, Céline Loss, Claude Desplan, and Ernst A. Wimmer PMCID: PMC16354 Ecology Environmental variation shapes sexual dimorphism in red deer Eric Post, Rolf Langvatn, Mads C. Forchhammer, and Nils Chr. Stenseth PMCID: PMC16355 Scaling in animal group-size distributions Eric Bonabeau, Laurent Dagorn, and Pierre Fréon PMCID: PMC16356 A tradeoff between immunocompetence and sexual ornamentation in domestic fowl S. Verhulst, S. J. Dieleman, and H. K. Parmentier PMCID: PMC16357 Evolution Expression pattern and, surprisingly, gene length shape codon usage in Caenorhabditis, Drosophila, and Arabidopsis Laurent Duret and Dominique Mouchiroud PMCID: PMC16358 Genetics Genetic dissection of protein–protein interactions in multi-tRNA synthetase complex Seung Bae Rho, Min Jung Kim, Jong Sang Lee, Wongi Seol, Hiromi Motegi, Sunghoon Kim, and Kiyotaka Shiba PMCID: PMC16359 Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells Christoph A. Klein, Oleg Schmidt-Kittler, Julian A. Schardt, Klaus Pantel, Michael R. Speicher, and Gert Riethmüller PMCID: PMC16360 Identification by UV resonance Raman spectroscopy of an imino tautomer of 5-hydroxy-2′-deoxycytidine, a powerful base analog transition mutagen with a much higher unfavored tautomer frequency than that of the natural residue 2′-deoxycytidine Wu Suen, Thomas G. Spiro, Lawrence C. Sowers, and Jacques R. Fresco PMCID: PMC16361 High recombination rate in natural populations of Plasmodium falciparum David J. Conway, Cally Roper, Ayoade M. J. Oduola, David E. Arnot, Peter G. Kremsner, Martin P. Grobusch, Chris F. Curtis, and Brian M. Greenwood PMCID: PMC16362 Immunology Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity Igor M. Belyakov, Bernard Moss, Warren Strober, and Jay A. Berzofsky PMCID: PMC16363 A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor α gene expression: Molecular cloning, sequencing, characterization, and chromosomal assignment Fumio Myokai, Shogo Takashiba, Roger Lebo, and Salomon Amar PMCID: PMC16364 Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea Tariq M. Haqqi, Donald D. Anthony, Sanjay Gupta, Nihal Ahmad, M.-S. Lee, Ganesh K. Kumar, and Hasan Mukhtar PMCID: PMC16365 Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of α1→3 fucosyltransferase VII and newly cloned GlcNAcβ:6-sulfotransferase cDNA Naoko Kimura, Chikako Mitsuoka, Akiko Kanamori, Nozomu Hiraiwa, Kenji Uchimura, Takashi Muramatsu, Takuya Tamatani, Geoffrey S. Kansas, and Reiji Kannagi PMCID: PMC16366 Medical Sciences Millimeter-scale positioning of a nerve-growth-factor source and biological activity in the brain Melissa J. Mahoney and W. Mark Saltzman PMCID: PMC16367 Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression Lisa M. McGregor, Bryan K. McCune, Jeremy R. Graff, Philip R. McDowell, Katherine E. Romans, George D. Yancopoulos, Douglas W. Ball, Stephen B. Baylin, and Barry D. Nelkin PMCID: PMC16368 Distribution of human herpesvirus-8 latently infected cells in Kaposi’s sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma Nicolas Dupin, Cyril Fisher, Paul Kellam, Sam Ariad, Micheline Tulliez, Nathalie Franck, Eric van Marck, Dominique Salmon, Isabelle Gorin, Jean-Paul Escande, Robin A. Weiss, Kari Alitalo, and Chris Boshoff PMCID: PMC16369 Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia David A. Martin, Lixin Zheng, Richard M. Siegel, Baohua Huang, Galen H. Fisher, Jin Wang, Christine E. Jackson, Jennifer M. Puck, Janet Dale, Stephen E. Straus, Marcus E. Peter, Peter H. Krammer, Stephen Fesik, and Michael J. Lenardo PMCID: PMC16370 Hypervariable region 3 residues of HIV type 1 gp120 involved in CCR5 coreceptor utilization: Therapeutic and prophylactic implications Wei-Kung Wang, Tim Dudek, Max Essex, and Tun-Hou Lee PMCID: PMC16371 Virulence and transmission success of the malarial parasite Plasmodium falciparum Rhian E. Hayward, Bela Tiwari, Karen P. Piper, Dror I. Baruch, and Karen P. Day PMCID: PMC16372 Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography P. Antonio Tataranni, Jean-François Gautier, Kewei Chen, Anne Uecker, Daniel Bandy, Arline D. Salbe, Richard E. Pratley, Michael Lawson, Eric M. Reiman, and Eric Ravussin PMCID: PMC16373 A 500-bp region, ≈40 kb upstream of the human CYP19 (aromatase) gene, mediates placenta-specific expression in transgenic mice Amrita Kamat, Katherine H. Graves, Margaret E. Smith, James A. Richardson, and Carole R. Mendelson PMCID: PMC16374 Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression Huanliang Liu, David Chao, Emi E. Nakayama, Hitomi Taguchi, Mieko Goto, Xiaomi Xin, Jun-ki Takamatsu, Hidehiko Saito, Yoshihide Ishikawa, Tatsuya Akaza, Takeo Juji, Yutaka Takebe, Takeshi Ohishi, Katsuyuki Fukutake, Yoshikazu Maruyama, Shinji Yashiki, Shunro Sonoda, Tetsuya Nakamura, Yoshiyuki Nagai, Aikichi Iwamoto, and Tatsuo Shioda PMCID: PMC16375 Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging Guanglong He, Ravi A. Shankar, Michael Chzhan, Alexandre Samouilov, Periannan Kuppusamy, and Jay L. Zweier PMCID: PMC16376 A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors Akiko Saito, Takashi Yamashita, Yukiyasu Mariko, Yasuhito Nosaka, Katsutoshi Tsuchiya, Tomoyuki Ando, Tsuneji Suzuki, Takashi Tsuruo, and Osamu Nakanishi PMCID: PMC16377 Stable alphavirus packaging cell lines for Sindbis virus- and Semliki Forest virus-derived vectors John M. Polo, Barbara A. Belli, David A. Driver, Ilya Frolov, Scott Sherrill, Mangala J. Hariharan, Kay Townsend, Silvia Perri, Steven J. Mento, Douglas J. Jolly, Stephen M. W. Chang, Sondra Schlesinger, and Thomas W. Dubensky, Jr. PMCID: PMC16378 Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology Eberhard Scherzinger, Annie Sittler, Katja Schweiger, Volker Heiser, Rudi Lurz, Renate Hasenbank, Gillian P. Bates, Hans Lehrach, and Erich E. Wanker PMCID: PMC16379 Microbiology Escherichia coli genes regulated by cell-to-cell signaling Rita R. Baca-DeLancey, Mary M. T. South, Xuedong Ding, and Philip N. Rather PMCID: PMC16380 A corrinoid-dependent catabolic pathway for growth of a Methylobacterium strain with chloromethane Todd Vannelli, Michael Messmer, Alex Studer, Stéphane Vuilleumier, and Thomas Leisinger PMCID: PMC16381 Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible Cyril X. George and Charles E. Samuel PMCID: PMC16382 Neurobiology An intronic enhancer containing an N-box motif is required for synapse- and tissue-specific expression of the acetylcholinesterase gene in skeletal muscle fibers Roxanne Y. Y. Chan, Céline Boudreau-Larivière, Lindsay M. Angus, Fawzi A. Mankal, and Bernard J. Jasmin PMCID: PMC16383 Evectins: Vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes Ralf Krappa, Andrew Nguyen, Patrick Burrola, Dusanka Deretic, and Greg Lemke PMCID: PMC16384 Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division Paola Iacopetti, Monica Michelini, Ingo Stuckmann, Björn Oback, Eeva Aaku-Saraste, and Wieland B. Huttner PMCID: PMC16385 Quantization of continuous arm movements in humans with brain injury Hermano Igo Krebs, Mindy L. Aisen, Bruce T. Volpe, and Neville Hogan PMCID: PMC16386 A selective role of calcineurin Aα in synaptic depotentiation in hippocampus Min Zhuo, Wei Zhang, Hyeon Son, Isabelle Mansuy, Raymond A. Sobel, Jonathan Seidman, and Eric R. Kandel PMCID: PMC16387 Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the β-amyloid-precursor protein Fulvio Magara, Ulrike Müller, Zhi-Wei Li, Hans-Peter Lipp, Charles Weissmann, Marijana Stagljar, and David P. Wolfer PMCID: PMC16388 An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons Martin Stocker, Michael Krause, and Paola Pedarzani PMCID: PMC16389 Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Δ12,14-prostaglandin J2 Tatiana V. Petrova, Keith T. Akama, and Linda J. Van Eldik PMCID: PMC16390 Seasonal neuroplasticity in the songbird telencephalon: A role for melatonin George E. Bentley, Thomas J. Van’t Hof, and Gregory F. Ball PMCID: PMC16391 Pharmacology The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance Donald R. Schwartz, Gregg E. Homanics, Dale G. Hoyt, Ed Klein, John Abernethy, and John S. Lazo PMCID: PMC16392 Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium Teresa Improta-Brears, A. Richard Whorton, Franca Codazzi, John D. York, Tobias Meyer, and Donald P. McDonnell PMCID: PMC16393 Plant Biology Stable expression of human β1,4-galactosyltransferase in plant cells modifies N-linked glycosylation patterns Nirianne Q. Palacpac, Shohei Yoshida, Hiromi Sakai, Yoshinobu Kimura, Kazuhito Fujiyama, Toshiomi Yoshida, and Tatsuji Seki PMCID: PMC16394 Molecular cloning and functional expression of gibberellin 2- oxidases, multifunctional enzymes involved in gibberellin deactivation Stephen G. Thomas, Andrew L. Phillips, and Peter Hedden PMCID: PMC16395 Ligand specificity of a high-affinity binding site for lipo-chitooligosaccharidic Nod factors in Medicago cell suspension cultures Frédéric Gressent, Sophie Drouillard, Natacha Mantegazza, Eric Samain, Roberto A. Geremia, Hervé Canut, Andreas Niebel, Hugues Driguez, Raoul Ranjeva, Julie Cullimore, and Jean-Jacques Bono PMCID: PMC16396 INAUGURAL ARTICLE by a Recently Elected Academy Member: Natural allelic variation at seed size loci in relation to other life history traits of Arabidopsis thalianaCarlos Alonso-Blanco, Hetty Blankestijn-de Vries, Corrie J. Hanhart, and Maarten Koornneef PMCID: PMC16397 Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals Jörg Kudla, Qiang Xu, Klaus Harter, Wilhelm Gruissem, and Sheng Luan PMCID: PMC16398 Psychology Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit Yue Chen, Ken Nakayama, Deborah L. Levy, Steven Matthysse, and Philip S. Holzman PMCID: PMC16399 Social Sciences Economic Sciences Local instrumental variables and latent variable models for identifying and bounding treatment effects James J. Heckman and Edward J. Vytlacil PMCID: PMC16400 |
