pmc logo imageJournal ListSearchpmc logo image
Logo of pnasPNAS Home page.PNAS Editorial BoardPNAS AboutPNAS SubscriptionsPNAS Info for Authors
This journal provides immediate access to some articles.
Other Issues:  previous | next | latest | archive
Volume 97(6);  March 14, 2000
Commentaries
From the Cover:
Insights into DNA replication from the third domain of life
Bik K. Tye
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2399–2401.
PMCID: PMC33970
The science of literacy: From the laboratory to the classroom
Paula Tallal
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2402–2404.
PMCID: PMC33971
Connecting oxidative stress, auxin, and cell cycle regulation through a plant mitogen-activated protein kinase pathway
Heribert Hirt
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2405–2407.
PMCID: PMC33972
Physical Sciences
Applied Physical Sciences
Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems
Daniel T. Chiu, Noo Li Jeon, Sui Huang, Ravi S. Kane, Christopher J. Wargo, Insung S. Choi, Donald E. Ingber, and George M. Whitesides
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2408–2413. Published online 2000 February 18.
PMCID: PMC15942
Visualization of gas flow and diffusion in porous media
Lana G. Kaiser, Thomas Meersmann, John W. Logan, and Alexander Pines
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2414–2418. Published online 2000 March 7.
PMCID: PMC15943
Chemistry
Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors
Dustin J. Maly, Ingrid C. Choong, and Jonathan A. Ellman
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2419–2424.
PMCID: PMC15944
Geology
From the Cover:
The missing organic molecules on Mars
Steven A. Benner, Kevin G. Devine, Lidia N. Matveeva, and David H. Powell
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2425–2430. Published online 2000 March 7.
PMCID: PMC15945
Physics
Monopoles and fractional vortices in chiral superconductors
G. E. Volovik
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2431–2436.
PMCID: PMC15946
Ultrafast dynamics of many-body processes and fundamental quantum mechanical phenomena in semiconductors
Daniel S. Chemla and Jagdeep Shah
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2437–2444.
PMCID: PMC15947
Biological Sciences
Agricultural Sciences
Isotope-labeled immunoassays without radiation waste
Guomin Shan, Wei Huang, Shirley J. Gee, Bruce A. Buchholz, John S. Vogel, and Bruce D. Hammock
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2445–2449. Published online 2000 March 7.
PMCID: PMC15948
Applied Biological Sciences
Selecting protein targets for structural genomics of Pyrobaculum aerophilum: Validating automated fold assignment methods by using binary hypothesis testing
Parag Mallick, Kenneth E. Goodwill, Sorel Fitz-Gibbon, Jeffrey H. Miller, and David Eisenberg
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2450–2455. Published online 2000 March 7.
PMCID: PMC15949
Biochemistry
Different functional domains of TAFII250 modulate expression of distinct subsets of mammalian genes
Thomas O'Brien and Robert Tjian
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2456–2461.
PMCID: PMC15950
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene
Jens C. Brüning, Jennifer A. Gillette, Yi Zhao, Christian Bjorbaeck, Jörg Kotzka, Birgit Knebel, Haluk Avci, Bettina Hanstein, Philipp Lingohr, David E. Moller, Wilhelm Krone, C. Ronald Kahn, and Dirk Müller-Wieland
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2462–2467.
PMCID: PMC15951
Erythroid Krüppel-like factor is recruited to the CACCC box in the β-globin promoter but not to the CACCC box in the γ-globin promoter: The role of the neighboring promoter elements
Jong-Soo Lee, Hailong Ngo, David Kim, and Jay H. Chung
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2468–2473. Published online 2000 March 7.
PMCID: PMC15952
Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit
Andrei Chabes, Vladimir Domkin, Göran Larsson, Aimin Liu, Astrid Gräslund, Sybren Wijmenga, and Lars Thelander
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2474–2479.
PMCID: PMC15953
On the interpretation of quantitative structure–function activity relationship data for lactate oxidase
Kazuko Yorita, Hideo Misaki, Bruce A. Palfey, and Vincent Massey
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2480–2485. Published online 2000 March 7.
PMCID: PMC15954
Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-d-erythritol 2-phosphate to 2C-methyl-d-erythritol 2,4-cyclodiphosphate
Stefan Herz, Juraithip Wungsintaweekul, Christoph A. Schuhr, Stefan Hecht, Holger Lüttgen, Sylvia Sagner, Monika Fellermeier, Wolfgang Eisenreich, Meinhart H. Zenk, Adelbert Bacher, and Felix Rohdich
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2486–2490. Published online 2000 February 29.
PMCID: PMC15955
The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism
Masaru Shinyashiki, Kenneth T. Chiang, Christopher H. Switzer, Edith B. Gralla, Joan S. Valentine, Dennis J. Thiele, and Jon M. Fukuto
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2491–2496. Published online 2000 February 29.
PMCID: PMC15956
Physical association of ubiquitin ligases and the 26S proteasome
Youming Xie and Alexander Varshavsky
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2497–2502. Published online 2000 February 25.
PMCID: PMC15957
Zinc transfer potentials of the α- and β-clusters of metallothionein are affected by domain interactions in the whole molecule
Li-Juan Jiang, Milan Vašák, Bert L. Vallee, and Wolfgang Maret
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2503–2508.
PMCID: PMC15958
The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates
David E. Ehmann, Cathryn A. Shaw-Reid, Heather C. Losey, and Christopher T. Walsh
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2509–2514. Published online 2000 February 25.
PMCID: PMC15959
Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein
Zuben E. Sauna and Suresh V. Ambudkar
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2515–2520.
PMCID: PMC15960
Mammalian thioredoxin reductase: Oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity
Seung-Rock Lee, Shoshana Bar-Noy, Jaeyul Kwon, Rodney L. Levine, Thressa C. Stadtman, and Sue Goo Rhee
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2521–2526. Published online 2000 February 25.
PMCID: PMC15961
Biophysics
Protein folding and unfolding on a complex energy landscape
Daan Thorn Leeson, Feng Gai, Hector M. Rodriguez, Lydia M. Gregoret, and R. Brian Dyer
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2527–2532. Published online 2000 February 18.
PMCID: PMC15962
Processive movement of single 22S dynein molecules occurs only at low ATP concentrations
Emi Hirakawa, Hideo Higuchi, and Yoko Y. Toyoshima
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2533–2537. Published online 2000 March 7.
PMCID: PMC15963
Extension of transverse relaxation-optimized spectroscopy techniques to allosteric proteins: CO- and paramagnetic fluoromet-hemoglobin [β(15N-valine)]
Judith M. Nocek, Kai Huang, and Brian M. Hoffman
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2538–2543.
PMCID: PMC15964
Mechanisms and kinetics of β-hairpin formation
D. K. Klimov and D. Thirumalai
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2544–2549.
PMCID: PMC15965
Environment-dependent residue contact energies for proteins
Chao Zhang and Sung-Hou Kim
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2550–2555. Published online 2000 March 7.
PMCID: PMC15966
Clustering of connexin 43–enhanced green fluorescent protein gap junction channels and functional coupling in living cells
Feliksas F. Bukauskas, Karen Jordan, Angele Bukauskiene, Michael V. L. Bennett, Paul D. Lampe, Dale W. Laird, and Vytas K. Verselis
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2556–2561. Published online 2000 March 7.
PMCID: PMC15967
The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure
Peer R. E. Mittl, Christine Deillon, David Sargent, Niankun Liu, Stephan Klauser, Richard M. Thomas, Bernd Gutte, and Markus G. Grütter
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2562–2566.
PMCID: PMC15968
Cell Biology
Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex
Ryoichi Yamaji, Ronald Adamik, Kazuyo Takeda, Akira Togawa, Gustavo Pacheco-Rodriguez, Victor J. Ferrans, Joel Moss, and Martha Vaughan
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2567–2572.
PMCID: PMC15969
Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity
Michael L. Gagnon, Diane R. Bielenberg, Ze'ev Gechtman, Hua-Quan Miao, Seiji Takashima, Shay Soker, and Michael Klagsbrun
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2573–2578. Published online 2000 February 25.
PMCID: PMC15970
Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis
Per U. Christensen, Nicola J. Bentley, Rui G. Martinho, Olaf Nielsen, and Antony M. Carr
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2579–2584.
PMCID: PMC15971
Isolation of a vascular cell wall-specific monoclonal antibody recognizing a cell polarity by using a phage display subtraction method
Naoki Shinohara, Taku Demura, and Hiroo Fukuda
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2585–2590. Published online 2000 March 7.
PMCID: PMC15972
5-Hydroxytryptamine 2B receptor regulates cell-cycle progression: Cross-talk with tyrosine kinase pathways
Canan G. Nebigil, Jean-Marie Launay, Pierre Hickel, Claire Tournois, and Luc Maroteaux
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2591–2596. Published online 2000 February 25.
PMCID: PMC15973
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
Hong Zhang, Qunli Xu, Stanislaw Krajewski, Maryla Krajewska, Zhihua Xie, Sally Fuess, Shinichi Kitada, Krzysztof Pawłowski, Adam Godzik, and John C. Reed
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2597–2602.
PMCID: PMC15974
Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ
Kung Meng, A. Rodríguez-Peña, Todor Dimitrov, Wen Chen, Moshe Yamin, Masaharu Noda, and Thomas F. Deuel
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2603–2608. Published online 2000 March 7.
PMCID: PMC15975
Developmental Biology
Notch signaling directly controls cell proliferation in the Drosophila wing disc
A. Baonza and A. Garcia-Bellido
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2609–2614. Published online 2000 March 7.
PMCID: PMC15976
From the Cover:
Thyroid hormone-dependent metamorphosis in a direct developing frog
Elizabeth M. Callery and Richard P. Elinson
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2615–2620. Published online 2000 March 7.
PMCID: PMC15977
The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision
Ruth T. Yu, Ming-Yi Chiang, Teruyo Tanabe, Mime Kobayashi, Kunio Yasuda, Ronald M. Evans, and Kazuhiko Umesono
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2621–2625. Published online 2000 March 7.
PMCID: PMC15978
Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis
S. Paul Oh, Tsugio Seki, Kendrick A. Goss, Takeshi Imamura, Youngsuk Yi, Patricia K. Donahoe, Li Li, Kohei Miyazono, Peter ten Dijke, Seongjin Kim, and En Li
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2626–2631.
PMCID: PMC15979
Ecology
Defensive use of a fecal thatch by a beetle larva (Hemisphaerota cyanea)
Thomas Eisner and Maria Eisner
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2632–2636. Published online 2000 February 18.
PMCID: PMC15980
Learning improves growth rate in grasshoppers
Reuven Dukas and Elizabeth A. Bernays
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2637–2640. Published online 2000 March 7.
PMCID: PMC15981
Evolution
Linking development with generation of novelty in mammalian teeth
Jukka Jernvall
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2641–2645. Published online 2000 March 7.
PMCID: PMC15982
Widanelfarasia, a diminutive placental from the late Eocene of Egypt
Erik R. Seiffert and Elwyn L. Simons
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2646–2651. Published online 2000 February 29.
PMCID: PMC15983
Genetics
Genetic analysis of speciation by means of introgression into Drosophila melanogaster
Kyoichi Sawamura, Andrew W. Davis, and Chung-I Wu
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2652–2655. Published online 2000 March 7.
PMCID: PMC15984
A Bacillus subtilis operon containing genes of unknown function senses tRNATrp charging and regulates expression of the genes of tryptophan biosynthesis
Joseph P. Sarsero, Enrique Merino, and Charles Yanofsky
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2656–2661. Published online 2000 March 7.
PMCID: PMC15985
Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis
Robert B. Chadwick, Guang-Liang Jiang, Garth A. Bennington, Bo Yuan, Cheryl K. Johnson, Michael W. Stevens, Theodore H. Niemann, Paivi Peltomaki, Shi Huang, and Albert de la Chapelle
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2662–2667. Published online 2000 February 25.
PMCID: PMC15986
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
Yansong Gu, JoAnn Sekiguchi, Yijie Gao, Pieter Dikkes, Karen Frank, David Ferguson, Paul Hasty, Jerold Chun, and Frederick W. Alt
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2668–2673.
PMCID: PMC15987
The genetics of ivermectin resistance in Caenorhabditis elegans
Joseph A. Dent, McHardy M. Smith, Demetrios K. Vassilatis, and Leon Avery
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2674–2679.
PMCID: PMC15988
Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis
D. W. Voehringer, D. L. Hirschberg, J. Xiao, Q. Lu, M. Roederer, C. B. Lock, L. A. Herzenberg, L. Steinman, and L. A. Herzenberg
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2680–2685.
PMCID: PMC15989
Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo
Emi Torigoi, Idriss M. Bennani-Baïti, Christina Rosen, Katie Gonzalez, Patrick Morcillo, Mark Ptashne, and Dale Dorsett
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2686–2691. Published online 2000 February 25.
PMCID: PMC15990
Human cytomegalovirus UL69 protein is required for efficient accumulation of infected cells in the G1 phase of the cell cycle
Mansuo Lu Hayashi, Catherine Blankenship, and Thomas Shenk
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2692–2696. Published online 2000 March 7.
PMCID: PMC15991
Immunology
Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells
Zlatko Dembic, Karl Schenck, and Bjarne Bogen
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2697–2702. Published online 2000 March 7.
PMCID: PMC15992
Estrogen up-regulates Bcl-2 and blocks tolerance induction of naïve B cells
Margaret S. Bynoe, Christine M. Grimaldi, and Betty Diamond
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2703–2708. Published online 2000 February 29.
PMCID: PMC15993
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors
Stephen A. Migueles, M. Shirin Sabbaghian, W. Lesley Shupert, Maria P. Bettinotti, Francesco M. Marincola, Lisa Martino, Clair W. Hallahan, Sara M. Selig, David Schwartz, John Sullivan, and Mark Connors
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2709–2714. Published online 2000 February 29.
PMCID: PMC15994
Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells
Jianlin Gong, David Avigan, Dongshu Chen, Zekui Wu, Shigeo Koido, Masahiro Kashiwaba, and Donald Kufe
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2715–2718. Published online 2000 February 25.
PMCID: PMC15995
Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: Isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens
Z.-G. Wang, L. J. Williams, X.-F. Zhang, A. Zatorski, V. Kudryashov, G. Ragupathi, M. Spassova, W. Bornmann, S. F. Slovin, H. I. Scher, P. O. Livingston, K. O. Lloyd, and S. J. Danishefsky
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2719–2724.
PMCID: PMC15996
Postexposure vaccination massively increases the prevalence of γ-herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice
Gabrielle T. Belz, Philip G. Stevenson, Maria R. Castrucci, John D. Altman, and Peter C. Doherty
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2725–2730. Published online 2000 February 29.
PMCID: PMC15997
In vivo natural killer cell activities revealed by natural killer cell-deficient mice
Sungjin Kim, Koho Iizuka, Hector L. Aguila, Irving L. Weissman, and Wayne M. Yokoyama
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2731–2736. Published online 2000 February 29.
PMCID: PMC15998
Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells
Sazuku Nisitani, Anne B. Satterthwaite, Koichi Akashi, Irving L. Weissman, Owen N. Witte, and Matthew I. Wahl
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2737–2742. Published online 2000 February 25.
PMCID: PMC15999
A B-cell receptor-specific selection step governs immature to mature B cell differentiation
Matthew H. Levine, Ann M. Haberman, Derek B. Sant'Angelo, Lynn G. Hannum, Michael P. Cancro, Charles A. Janeway, Jr., and Mark J. Shlomchik
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2743–2748. Published online 2000 February 25.
PMCID: PMC16000
Viral persistence in vivo through selection of neutralizing antibody-escape variants
Adrian Ciurea, Paul Klenerman, Lukas Hunziker, Edit Horvath, Beatrice M. Senn, Adrian F. Ochsenbein, Hans Hengartner, and Rolf M. Zinkernagel
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2749–2754. Published online 2000 February 25.
PMCID: PMC16001
The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
Katsuhiko Hayashi, Ryo Nittono, Noriaki Okamoto, Sachiyo Tsuji, Yasushi Hara, Ryo Goitsuka, and Daisuke Kitamura
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2755–2760. Published online 2000 February 25.
PMCID: PMC16002
Redox regulation of chemokine receptor expression
Alessandra Saccani, Simona Saccani, Simone Orlando, Marina Sironi, Sergio Bernasconi, Pietro Ghezzi, Alberto Mantovani, and Antonio Sica
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2761–2766.
PMCID: PMC16003
Medical Sciences
Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
Vasilis Ntziachristos, A. G. Yodh, Mitchell Schnall, and Britton Chance
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2767–2772. Published online 2000 March 7.
PMCID: PMC16004
Mantle cell lymphoma is characterized by inactivation of the ATM gene
Claudia Schaffner, Irina Idler, Stephan Stilgenbauer, Hartmut Döhner, and Peter Lichter
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2773–2778. Published online 2000 March 7.
PMCID: PMC16005
Rat strain-specific actions of 17β-estradiol in the mammary gland: Correlation between estrogen-induced lobuloalveolar hyperplasia and susceptibility to estrogen-induced mammary cancers
Djuana M. E. Harvell, Tracy E. Strecker, Martin Tochacek, Benjamin Xie, Karen L. Pennington, Rodney D. McComb, Shyamal K. Roy, and James D. Shull
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2779–2784. Published online 2000 February 25.
PMCID: PMC16006
A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography
Sanjiv S. Gambhir, Eileen Bauer, Margaret E. Black, Qianwa Liang, Mark S. Kokoris, Jorge R. Barrio, Meera Iyer, Mohammad Namavari, Michael E. Phelps, and Harvey R. Herschman
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2785–2790.
PMCID: PMC16007
Expression and function of wingless and frizzled homologs in rheumatoid arthritis
Malini Sen, Kevin Lauterbach, Hani El-Gabalawy, Gary S. Firestein, Maripat Corr, and Dennis A. Carson
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2791–2796. Published online 2000 February 25.
PMCID: PMC16008
The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation
Corrado Caslini, Ali Shilatifard, Liping Yang, and Jay L. Hess
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2797–2802. Published online 2000 February 25.
PMCID: PMC16009
Generation and rescue of a murine model of platelet dysfunction: The Bernard-Soulier syndrome
Jerry Ware, Susan Russell, and Zaverio M. Ruggeri
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2803–2808. Published online 2000 March 7.
PMCID: PMC16010
An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness
Mohammad Asif, John Egan, Sara Vasan, Garikiparthy N. Jyothirmayi, Malthi R. Masurekar, Santos Lopez, Chandra Williams, Ramon L. Torres, Dilip Wagle, Peter Ulrich, Anthony Cerami, Michael Brines, and Timothy J. Regan
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2809–2813. Published online 2000 March 7.
PMCID: PMC16011
Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors
Maureen D. Megonigal, Nai-Kong V. Cheung, Eric F. Rappaport, Peter C. Nowell, Robert B. Wilson, Douglas H. Jones, Kathakali Addya, Debra G. B. Leonard, Brian H. Kushner, Terence M. Williams, Beverly J. Lange, and Carolyn A. Felix
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2814–2819. Published online 2000 March 7.
PMCID: PMC16012
Glucose stimulates protein modification by O-linked GlcNAc in pancreatic β cells: Linkage of O-linked GlcNAc to β cell death
Kan Liu, Andrew J. Paterson, Edward Chin, and Jeffrey E. Kudlow
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2820–2825.
PMCID: PMC16013
Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates
Joel M. Weinberg, Manjeri A. Venkatachalam, Nancy F. Roeser, and Itzhak Nissim
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2826–2831.
PMCID: PMC16014
Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298
M. Tesauro, W. C. Thompson, P. Rogliani, L. Qi, P. P. Chaudhary, and J. Moss
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2832–2835.
PMCID: PMC16015
Specific association of estrogen receptor β with the cell cycle spindle assembly checkpoint protein, MAD2
Gerhard Poelzl, Yasuyo Kasai, Naoki Mochizuki, Philip W. Shaul, Myles Brown, and Michael E. Mendelsohn
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2836–2839. Published online 2000 March 7.
PMCID: PMC16016
CD38 expressed on human monocytes: A coaccessory molecule in the superantigen-induced proliferation
Marie-Thérèse Zilber, Stéphane Gregory, Roberto Mallone, Silvia Deaglio, Fabio Malavasi, Dominique Charron, and Catherine Gelin
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2840–2845. Published online 2000 March 7.
PMCID: PMC16017
Stress-induced enhancement of skin immune function: A role for γ interferon
Firdaus S. Dhabhar, Abhay R. Satoskar, Horst Bluethmann, John R. David, and Bruce S. McEwen
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2846–2851. Published online 2000 March 7.
PMCID: PMC16018
Dominant negative down-regulation of endotoxin-induced tumor necrosis factor α production by Lpsd/Ran
Quan Yuan, Fangping Zhao, Siu-Wah Chung, Peidong Fan, Barnet M. Sultzer, Y. W. Kan, and Peter M. C. Wong
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2852–2857. Published online 2000 March 7.
PMCID: PMC16019
Microbiology
A nonpetide integrin antagonist can inhibit epithelial cell ingestion of Streptococcus pyogenes by blocking formation of integrin α5β1-fibronectin-M1 protein complexes
David Cue, Sarka O. Southern, Peter J. Southern, Jadhar Prabhakar, William Lorelli, Joanne M. Smallheer, Shaker A. Mousa, and P. Patrick Cleary
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2858–2863. Published online 2000 March 7.
PMCID: PMC16020
A protein-based therapeutic for human cytomegalovirus infection
François Jean, Laurel Thomas, Sean S. Molloy, Gseping Liu, Michael A. Jarvis, Jay A. Nelson, and Gary Thomas
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2864–2869. Published online 2000 February 18.
PMCID: PMC16021
Neurobiology
The olfactory receptor gene repertoire in primates and mouse: Evidence for reduction of the functional fraction in primates
Sylvie Rouquier, Antoine Blancher, and Dominique Giorgi
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2870–2874. Published online 2000 March 7.
PMCID: PMC16022
Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
Andreas Hartmann, Stéphane Hunot, Patrick P. Michel, Marie-Paule Muriel, Sheela Vyas, Baptiste A. Faucheux, Annick Mouatt-Prigent, Hélène Turmel, Anu Srinivasan, Merle Ruberg, Gerard I. Evan, Yves Agid, and Etienne C. Hirsch
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2875–2880. Published online 2000 February 25.
PMCID: PMC16023
Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task
Ewan C. McNay, Thomas M. Fries, and Paul E. Gold
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2881–2885. Published online 2000 March 7.
PMCID: PMC16024
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase
Philip C. Wong, Darrel Waggoner, Jamuna R. Subramaniam, Lino Tessarollo, Thomas B. Bartnikas, Valeria C. Culotta, Donald L. Price, Jeffrey Rothstein, and Jonathan D. Gitlin
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2886–2891. Published online 2000 February 29.
PMCID: PMC16025
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
David M. Holtzman, Kelly R. Bales, Tanya Tenkova, Anne M. Fagan, Maia Parsadanian, Leah J. Sartorius, Brian Mackey, John Olney, Daniel McKeel, David Wozniak, and Steven M. Paul
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2892–2897. Published online 2000 February 29.
PMCID: PMC16026
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
Andreas Wyttenbach, Jenny Carmichael, Jina Swartz, Robert A. Furlong, Yolanda Narain, Julia Rankin, and David C. Rubinsztein
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2898–2903.
PMCID: PMC16027
Pharmacology
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
Paraskevi Giannakakou, Rick Gussio, Eva Nogales, Kenneth H. Downing, Daniel Zaharevitz, Birgit Bollbuck, George Poy, Dan Sackett, K. C. Nicolaou, and Tito Fojo
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2904–2909. Published online 2000 February 25.
PMCID: PMC16028
Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5
Michael K. Ahlijanian, Nestor X. Barrezueta, Robert D. Williams, Amy Jakowski, Kim P. Kowsz, Sheryl McCarthy, Timothy Coskran, Anthony Carlo, Patricia A. Seymour, John E. Burkhardt, Robert B. Nelson, and John D. McNeish
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2910–2915. Published online 2000 March 7.
PMCID: PMC16029
Physiology
Requirement of a leucine residue for (apical) membrane expression of type IIb NaPi cotransporters
Zoubida Karim-Jimenez, Nati Hernando, Jürg Biber, and Heini Murer
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2916–2921.
PMCID: PMC16030
The inhibitory effect of hormones associated with stress on Na appetite of sheep
R. S. Weisinger, J. R. Blair-West, P. Burns, D. A. Denton, M. J. McKinley, B. Purcell, W. Vale, J. Rivier, and K. Sunagawa
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2922–2927. Published online 2000 February 25.
PMCID: PMC16031
Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses
Tomas C. Bellamy, John Wood, David A. Goodwin, and John Garthwaite
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2928–2933.
PMCID: PMC16032
Plant Biology
Probing essential oil biosynthesis and secretion by functional evaluation of expressed sequence tags from mint glandular trichomes
B. Markus Lange, Mark R. Wildung, Einar J. Stauber, Christopher Sanchez, Derek Pouchnik, and Rodney Croteau
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2934–2939.
PMCID: PMC16033
From the Cover:
Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants
Yelena Kovtun, Wan-Ling Chiu, Guillaume Tena, and Jen Sheen
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2940–2945.
PMCID: PMC16034
Psychology
Place recognition monitored by location-driven operant responding during passive transport of the rat over a circular trajectory
D. Klement and J. Bures
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2946–2951. Published online 2000 February 25.
PMCID: PMC16035
Social Sciences
Psychology
Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task
Ewan C. McNay, Thomas M. Fries, and Paul E. Gold
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2881–2885. Published online 2000 March 7.
PMCID: PMC16024
From the Cover:
Dynamic sensory sensitivity and children's word decoding skills
Joel B. Talcott, Caroline Witton, Maggie F. McLean, Peter C. Hansen, Adrian Rees, Gary G. R. Green, and John F. Stein
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2952–2957. Published online 2000 February 25.
PMCID: PMC16036
Correction
Correction
Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2958.
PMCID: PMC55977
Corrects: Jeong Hee Lee, et al. A highly conserved kinase is an essential component for stress tolerance in yeast and plant cells. Proc Natl Acad Sci U S A. 1999 May 11; 96(10): 5873–5877.
Other Issues:  previous | next | latest | archive