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Volume 99(3);  February 5, 2002
Commentaries
Viewing protein folding from many perspectives
Charles L. Brooks, III
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1099–1100. doi: 10.1073/pnas.042708199.
PMCID: PMC122148
Unstable molecules form stable tissues
Anton V. Persikov and Barbara Brodsky
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1101–1103. doi: 10.1073/pnas.042707899.
PMCID: PMC122149
The methylator meets the terminator
Steven Clarke
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1104–1106. doi: 10.1073/pnas.042004099.
PMCID: PMC122150
Antigen-presenting cells control T cell proliferation by regulating amino acid availability
Aimee L. Edinger and Craig B. Thompson
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1107–1109. doi: 10.1073/pnas.042707999.
PMCID: PMC122151
Location alters tRNA identity: Trypanosoma brucei's cytosolic elongator tRNAMet is both the initiator and elongator in mitochondria
Nancy C. Martin
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1110–1112. doi: 10.1073/pnas.042011199.
PMCID: PMC122152
Dissecting the molecular mechanisms of olfaction in a malaria-vector mosquito
A. Nighorn and J. G. Hildebrand
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1113–1114. doi: 10.1073/pnas.042708099.
PMCID: PMC122153
Review
Calcium signaling: A tale for all seasons
Ernesto Carafoli
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1115–1122. doi: 10.1073/pnas.032427999.
PMCID: PMC122154
Physical Sciences
Applied Mathematics
Stochastic and mesoscopic models for tropical convection
Andrew J. Majda and Boualem Khouider
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1123–1128. doi: 10.1073/pnas.032663199.
PMCID: PMC123720
Physics
The calculation of transport properties in quantum liquids using the maximum entropy numerical analytic continuation method: Application to liquid para-hydrogen
Eran Rabani, David R. Reichman, Goran Krilov, and Bruce J. Berne
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1129–1133. doi: 10.1073/pnas.261540698.
PMCID: PMC122155
Biological Sciences
Anthropology
The evolution and development of cranial form in Homo sapiens
Daniel E. Lieberman, Brandeis M. McBratney, and Gail Krovitz
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1134–1139. Published online 2002 January 22. doi: 10.1073/pnas.022440799.
PMCID: PMC122156
Applied Biological Sciences
Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3β but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of τ: Implications for Alzheimer's disease
Sozos Ch. Papasozomenos and Alikunju Shanavas
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1140–1145. Published online 2002 January 22. doi: 10.1073/pnas.032646799.
PMCID: PMC122157
Biochemistry
A direct role of SRY and SOX proteins in pre-mRNA splicing
Kenji Ohe, Enzo Lalli, and Paolo Sassone-Corsi
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1146–1151. Published online 2002 January 29. doi: 10.1073/pnas.022645899.
PMCID: PMC122158
Eukaryotic-type elongator tRNAMet of Trypanosoma brucei becomes formylated after import into mitochondria
Timothy H. P. Tan, Natacha Bochud-Allemann, Elke K. Horn, and André Schneider
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1152–1157. Published online 2002 January 15. doi: 10.1073/pnas.022522299.
PMCID: PMC122159
Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of IspH (LytB) protein
Felix Rohdich, Stefan Hecht, Katrin Gärtner, Petra Adam, Cornelia Krieger, Sabine Amslinger, Duilio Arigoni, Adelbert Bacher, and Wolfgang Eisenreich
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1158–1163. Published online 2002 January 29. doi: 10.1073/pnas.032658999.
PMCID: PMC122160
Self-generated DNA termini relax the specificity of SgrAI restriction endonuclease
Jurate Bitinaite and Ira Schildkraut
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1164–1169. Published online 2002 January 29. doi: 10.1073/pnas.022346799.
PMCID: PMC122161
Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades
Fernando Ortega, Luis Acerenza, Hans V. Westerhoff, Francesc Mas, and Marta Cascante
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1170–1175. doi: 10.1073/pnas.022267399.
PMCID: PMC122162
The mechanism of catalysis of the chorismate to prephenate reaction by the Escherichia coli mutase enzyme
Sun Hur and Thomas C. Bruice
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1176–1181. Published online 2002 January 29. doi: 10.1073/pnas.022628599.
PMCID: PMC122163
Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex
Zhong-Hua Gao, Joni M. Seeling, Virginia Hill, April Yochum, and David M. Virshup
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1182–1187. Published online 2002 January 29. doi: 10.1073/pnas.032468199.
PMCID: PMC122164
Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein
Jianjun Wang, Brian D. Sykes, and Robert O. Ryan
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1188–1193. Published online 2002 January 29. doi: 10.1073/pnas.032565999.
PMCID: PMC122165
Discrimination against purine–pyrimidine mispairs in the polymerase active site of DNA polymerase I: A structural explanation
Dana T. Minnick, Lixing Liu, Nigel D. F. Grindley, Thomas A. Kunkel, and Catherine M. Joyce
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1194–1199. doi: 10.1073/pnas.032457899.
PMCID: PMC122166
Dynamic association of transcriptional activation domains and regulatory regions in Saccharomyces cerevisiae heat shock factor
Tianxin Chen and Carl S. Parker
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1200–1205. Published online 2002 January 29. doi: 10.1073/pnas.032681299.
PMCID: PMC122167
The regulatory role for the ERCC3 helicase of general transcription factor TFIIH during promoter escape in transcriptional activation
Aya Fukuda, Yasuhisa Nogi, and Koji Hisatake
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1206–1211. Published online 2002 January 29. doi: 10.1073/pnas.251674198.
PMCID: PMC122168
Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP
Nobuo Maita, Kengo Okada, Kazuyuki Hatakeyama, and Toshio Hakoshima
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1212–1217. Published online 2002 January 29. doi: 10.1073/pnas.022646999.
PMCID: PMC122169
Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution
David A. Bushnell, Patrick Cramer, and Roger D. Kornberg
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1218–1222. Published online 2002 January 22. doi: 10.1073/pnas.251664698.
PMCID: PMC122170
Extracellular ubiquitination and proteasome-mediated degradation of the ascidian sperm receptor
Hitoshi Sawada, Naoyuki Sakai, Yukichi Abe, Etsuko Tanaka, Youko Takahashi, Junko Fujino, Eri Kodama, Satoshi Takizawa, and Hideyoshi Yokosawa
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1223–1228. Published online 2002 January 29. doi: 10.1073/pnas.032389499.
PMCID: PMC122171
Structural diversity of heparan sulfate binding domains in chemokines
Hugues Lortat-Jacob, Aurélien Grosdidier, and Anne Imberty
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1229–1234. doi: 10.1073/pnas.032497699.
PMCID: PMC122172
Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status
Yinghui Mao, Issac R. Mehl, and Mark T. Muller
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1235–1240. Published online 2002 January 22. doi: 10.1073/pnas.022631899.
PMCID: PMC122173
Human Elongator facilitates RNA polymerase II transcription through chromatin
Jae-Hyun Kim, William S. Lane, and Danny Reinberg
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1241–1246. Published online 2002 January 29. doi: 10.1073/pnas.251672198.
PMCID: PMC122174
The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides
Rahul M. Kohli, Junichi Takagi, and Christopher T. Walsh
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1247–1252. Published online 2002 January 22. doi: 10.1073/pnas.251668398.
PMCID: PMC122175
Probing protein conformational changes in living cells by using designer binding proteins: Application to the estrogen receptor
Akiko Koide, Stacy Abbatiello, Lisa Rothgery, and Shohei Koide
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1253–1258. Published online 2002 January 29. doi: 10.1073/pnas.032665299.
PMCID: PMC122176
Cytochrome c release from mitochondria proceeds by a two-step process
Martin Ott, John D. Robertson, Vladimir Gogvadze, Boris Zhivotovsky, and Sten Orrenius
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1259–1263. Published online 2002 January 29. doi: 10.1073/pnas.241655498.
PMCID: PMC122177
From the Cover:
γ-Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates
Pradip K. Bandyopadhyay, James E. Garrett, Reshma P. Shetty, Tyler Keate, Craig S. Walker, and Baldomero M. Olivera
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1264–1269. Published online 2002 January 29. doi: 10.1073/pnas.022637099.
PMCID: PMC122178
Biophysics
Combinatorial computational method gives new picomolar ligands for a known enzyme
Bartosz A. Grzybowski, Alexey V. Ishchenko, Chu-Young Kim, George Topalov, Robert Chapman, David W. Christianson, George M. Whitesides, and Eugene I. Shakhnovich
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1270–1273. Published online 2002 January 29. doi: 10.1073/pnas.032673399.
PMCID: PMC122179
Flexibility and packing in proteins
Bertil Halle
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1274–1279. Published online 2002 January 29. doi: 10.1073/pnas.032522499.
PMCID: PMC122180
Protein topology and stability define the space of allowed sequences
Patrice Koehl and Michael Levitt
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1280–1285. Published online 2002 January 22. doi: 10.1073/pnas.032405199.
PMCID: PMC122181
Translocation of a functional protein by a voltage-dependent ion channel
Stephen L. Slatin, Angèle Nardi, Karen S. Jakes, Daniel Baty, and Denis Duché
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1286–1291. doi: 10.1073/pnas.022480199.
PMCID: PMC122182
Direct visualization at the single-cell level of electrically mediated gene delivery
Muriel Golzio, Justin Teissié, and Marie-Pierre Rols
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1292–1297. Published online 2002 January 29. doi: 10.1073/pnas.022646499.
PMCID: PMC122183
The enthalpy of the alanine peptide helix measured by isothermal titration calorimetry using metal-binding to induce helix formation
Maria M. Lopez, Der-Hang Chin, Robert L. Baldwin, and George I. Makhatadze
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1298–1302. Published online 2002 January 29. doi: 10.1073/pnas.032665199.
PMCID: PMC122184
Stable “zeta” peptides that act as potent antagonists of the high-affinity IgE receptor
Gerald R. Nakamura, Mark E. Reynolds, Yvonne M. Chen, Melissa A. Starovasnik, and Henry B. Lowman
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1303–1308. doi: 10.1073/pnas.022635599.
PMCID: PMC122185
Role of backbone solvation in determining thermodynamic β propensities of the amino acids
Franc Avbelj and Robert L. Baldwin
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1309–1313. Published online 2002 January 22. doi: 10.1073/pnas.032665499.
PMCID: PMC122186
From the Cover:
Type I collagen is thermally unstable at body temperature
E. Leikina, M. V. Mertts, N. Kuznetsova, and S. Leikin
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1314–1318. Published online 2002 January 22. doi: 10.1073/pnas.032307099.
PMCID: PMC122187
Photoactivation of the flavin cofactor in Xenopus laevis (6–4) photolyase: Observation of a transient tyrosyl radical by time-resolved electron paramagnetic resonance
Stefan Weber, Christopher W. M. Kay, Heike Mögling, Klaus Möbius, Kenichi Hitomi, and Takeshi Todo
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1319–1322. Published online 2002 January 22. doi: 10.1073/pnas.032469399.
PMCID: PMC122188
Coherent infrared emission from myoglobin crystals: An electric field measurement
Marie-Louise Groot, Marten H. Vos, Ilme Schlichting, Frank van Mourik, Manuel Joffre, Jean-Christophe Lambry, and Jean-Louis Martin
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1323–1328. Published online 2002 January 29. doi: 10.1073/pnas.251662698.
PMCID: PMC122189
Conformational landscape of cytochrome c folding studied by microsecond-resolved small-angle x-ray scattering
Shuji Akiyama, Satoshi Takahashi, Tetsunari Kimura, Koichiro Ishimori, Isao Morishima, Yukihiro Nishikawa, and Tetsuro Fujisawa
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1329–1334. Published online 2002 January 2. doi: 10.1073/pnas.012458999.
PMCID: PMC122190
Cell Biology
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
Yih-Cherng Liou, Akihide Ryo, Han-Kuei Huang, Pei-Jung Lu, Roderick Bronson, Fumihiro Fujimori, Takafumi Uchida, Tony Hunter, and Kun Ping Lu
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1335–1340. Published online 2002 January 22. doi: 10.1073/pnas.032404099.
PMCID: PMC122191
Muscle-derived hematopoietic stem cells are hematopoietic in origin
Shannon L. McKinney-Freeman, Kathyjo A. Jackson, Fernando D. Camargo, Giuliana Ferrari, Fulvio Mavilio, and Margaret A. Goodell
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1341–1346. doi: 10.1073/pnas.032438799.
PMCID: PMC122192
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes
Jeanette Gowen Cook, Chi-Hyun Park, Thomas W. Burke, Gustavo Leone, James DeGregori, Amber Engel, and Joseph R. Nevins
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1347–1352. Published online 2002 January 22. doi: 10.1073/pnas.032677499.
PMCID: PMC122193
Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm
Peggy P. Li, Akira Nakanishi, Sean W. Clark, and Harumi Kasamatsu
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1353–1358. Published online 2002 January 22. doi: 10.1073/pnas.032668699.
PMCID: PMC122194
The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R
M. Resnati, I. Pallavicini, J. M. Wang, J. Oppenheim, C. N. Serhan, M. Romano, and F. Blasi
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1359–1364. Published online 2002 January 29. doi: 10.1073/pnas.022652999.
PMCID: PMC122195
The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain
Stefan F. Lichtenthaler, Dirk Beher, Heike S. Grimm, Rong Wang, Mark S. Shearman, Colin L. Masters, and Konrad Beyreuther
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1365–1370. Published online 2002 January 22. doi: 10.1073/pnas.032395699.
PMCID: PMC122196
Developmental Biology
A cell number-counting factor regulates the cytoskeleton and cell motility in Dictyostelium
Lei Tang, Tong Gao, Catherine McCollum, Wonhee Jang, Michael G. Vicker, Robin R. Ammann, and Richard H. Gomer
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1371–1376. Published online 2002 January 29. doi: 10.1073/pnas.022516099.
PMCID: PMC122197
Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system
Katharine O. Hartley, Stephen L. Nutt, and Enrique Amaya
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1377–1382. Published online 2002 January 29. doi: 10.1073/pnas.022646899.
PMCID: PMC122198
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
Mito Kanatsu-Shinohara, Atsuo Ogura, Masaya Ikegawa, Kimiko Inoue, Narumi Ogonuki, Kei Tashiro, Shinya Toyokuni, Tasuku Honjo, and Takashi Shinohara
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1383–1388. Published online 2002 January 29. doi: 10.1073/pnas.022646399.
PMCID: PMC122199
Ecology
Projecting the future of the U.S. carbon sink
G. C. Hurtt, S. W. Pacala, P. R. Moorcroft, J. Caspersen, E. Shevliakova, R. A. Houghton, and B. Moore, III
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1389–1394. doi: 10.1073/pnas.012249999.
PMCID: PMC122200
Anthropogenic modification of New England salt marsh landscapes
Mark D. Bertness, Patrick J. Ewanchuk, and Brian Reed Silliman
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1395–1398. Published online 2002 January 29. doi: 10.1073/pnas.022447299.
PMCID: PMC122201
Evolution
mtDNA from fossils reveals a radiation of Hawaiian geese recently derived from the Canada goose (Branta canadensis)
Ellen E. Paxinos, Helen F. James, Storrs L. Olson, Michael D. Sorenson, Jennifer Jackson, and Robert C. Fleischer
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1399–1404. Published online 2002 January 29. doi: 10.1073/pnas.032166399.
PMCID: PMC122202
Redundancy, antiredundancy, and the robustness of genomes
David C. Krakauer and Joshua B. Plotkin
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1405–1409. Published online 2002 January 29. doi: 10.1073/pnas.032668599.
PMCID: PMC122203
Spirochete and protist symbionts of a termite (Mastotermes electrodominicus) in Miocene amber
Andrew Wier, Michael Dolan, David Grimaldi, Ricardo Guerrero, Jorge Wagensberg, and Lynn Margulis
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1410–1413. Published online 2002 January 29. doi: 10.1073/pnas.022643899.
PMCID: PMC122204
The analysis of 100 genes supports the grouping of three highly divergent amoebae: Dictyostelium, Entamoeba, and Mastigamoeba
Eric Bapteste, Henner Brinkmann, Jennifer A. Lee, Dorothy V. Moore, Christoph W. Sensen, Paul Gordon, Laure Duruflé, Terry Gaasterland, Philippe Lopez, Miklós Müller, and Hervé Philippe
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1414–1419. doi: 10.1073/pnas.032662799.
PMCID: PMC122205
The origin of the eukaryotic cell: A genomic investigation
Hyman Hartman and Alexei Fedorov
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1420–1425. Published online 2002 January 22. doi: 10.1073/pnas.032658599.
PMCID: PMC122206
Molecular phylogenetic evidence for the independent evolutionary origin of an arthropod compound eye
Todd H. Oakley and Clifford W. Cunningham
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1426–1430. Published online 2002 January 29. doi: 10.1073/pnas.032483599.
PMCID: PMC122207
Microbat paraphyly and the convergent evolution of a key innovation in Old World rhinolophoid microbats
Emma C. Teeling, Ole Madsen, Ronald A. Van Den Bussche, Wilfried W. de Jong, Michael J. Stanhope, and Mark S. Springer
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1431–1436. Published online 2002 January 22. doi: 10.1073/pnas.022477199.
PMCID: PMC122208
Genetics
The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage
Lorel M. Colgin, Alden F. M. Hackmann, Mary J. Emond, and Raymond J. Monnat, Jr.
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1437–1442. Published online 2002 January 29. doi: 10.1073/pnas.032655699.
PMCID: PMC122209
Stable suppression of gene expression by RNAi in mammalian cells
Patrick J. Paddison, Amy A. Caudy, and Gregory J. Hannon
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1443–1448. Published online 2002 January 29. doi: 10.1073/pnas.032652399.
PMCID: PMC122210
Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone
Harmit S. Malik, Danielle Vermaak, and Steven Henikoff
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1449–1454. Published online 2002 January 22. doi: 10.1073/pnas.032664299.
PMCID: PMC122211
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice
Mingjian James You, Diego H. Castrillon, Boris C. Bastian, Rónán C. O'Hagan, Marcus W. Bosenberg, Ramon Parsons, Lynda Chin, and Ronald A. DePinho
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1455–1460. Published online 2002 January 29. doi: 10.1073/pnas.022632099.
PMCID: PMC122212
Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341
James A. Fleming, Eric S. Lightcap, Seth Sadis, Vala Thoroddsen, Christine E. Bulawa, and Ronald K. Blackman
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1461–1466. doi: 10.1073/pnas.032516399.
PMCID: PMC122213
Cho, a second endonuclease involved in Escherichia coli nucleotide excision repair
Geri F. Moolenaar, Sari van Rossum-Fikkert, Marian van Kesteren, and Nora Goosen
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1467–1472. Published online 2002 January 29. doi: 10.1073/pnas.032584099.
PMCID: PMC122214
From the Cover:
HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination
Kenji Nakahigashi, Naoko Kubo, Shin-ichiro Narita, Takeshi Shimaoka, Simon Goto, Taku Oshima, Hirotada Mori, Maki Maeda, Chieko Wada, and Hachiro Inokuchi
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1473–1478. Published online 2002 January 22. doi: 10.1073/pnas.032488499.
PMCID: PMC122215
Immunology
The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness
Alison A. Humbles, Bao Lu, Daniel S. Friend, Shoji Okinaga, Jose Lora, Amal Al-garawi, Thomas R. Martin, Norma P. Gerard, and Craig Gerard
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1479–1484. doi: 10.1073/pnas.261462598.
PMCID: PMC122216
Conformational Abs recognizing a generic amyloid fibril epitope
Brian O'Nuallain and Ronald Wetzel
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1485–1490. Published online 2002 January 29. doi: 10.1073/pnas.022662599.
PMCID: PMC122217
From the Cover:
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation
Giovanna Angelini, Stefania Gardella, Massimo Ardy, Maria Rosa Ciriolo, Giuseppe Filomeni, Giovanna Di Trapani, Frank Clarke, Roberto Sitia, and Anna Rubartelli
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1491–1496. Published online 2002 January 15. doi: 10.1073/pnas.022630299.
PMCID: PMC122218
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes
Hajir Dadgostar, Brian Zarnegar, Alexander Hoffmann, Xiao-Feng Qin, Uyen Truong, Govinda Rao, David Baltimore, and Genhong Cheng
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1497–1502. doi: 10.1073/pnas.032665099.
PMCID: PMC122219
Human macrophage activation programs induced by bacterial pathogens
Gerard J. Nau, Joan F. L. Richmond, Ann Schlesinger, Ezra G. Jennings, Eric S. Lander, and Richard A. Young
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1503–1508. Published online 2002 January 22. doi: 10.1073/pnas.022649799.
PMCID: PMC122220
IL-6 transgenic mouse model for extraosseous plasmacytoma
Alexander L. Kovalchuk, Joong Su Kim, Sung Sup Park, Allen E. Coleman, Jerrold M. Ward, Herbert C. Morse, III, Tadamitsu Kishimoto, Michael Potter, and Siegfried Janz
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1509–1514. Published online 2002 January 22. doi: 10.1073/pnas.022643999.
PMCID: PMC122221
Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments
Cécile Lagaudrière-Gesbert, Sherri L. Newmyer, Tone F. Gregers, Oddmund Bakke, and Hidde L. Ploegh
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1515–1520. Published online 2002 January 29. doi: 10.1073/pnas.042688099.
PMCID: PMC122222
Medical Sciences
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis
Reade B. Roberts, Lu Min, M. Kay Washington, Sandra J. Olsen, Stephen H. Settle, Robert J. Coffey, and David W. Threadgill
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1521–1526. Published online 2002 January 29. doi: 10.1073/pnas.032678499.
PMCID: PMC122223
Targeting the prostate for destruction through a vascular address
Wadih Arap, Wolfgang Haedicke, Michele Bernasconi, Renate Kain, Daniel Rajotte, Stanislaw Krajewski, H. Michael Ellerby, Dale E. Bredesen, Renata Pasqualini, and Erkki Ruoslahti
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1527–1531. doi: 10.1073/pnas.241655998.
PMCID: PMC122224
Functional p53 chimeras containing the Epstein–Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis
Stijn Heessen, Ainars Leonchiks, Natalia Issaeva, Anatoly Sharipo, Galina Selivanova, Maria G. Masucci, and Nico P. Dantuma
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1532–1537. Published online 2002 January 22. doi: 10.1073/pnas.022306499.
PMCID: PMC122225
Determinants of cluster distribution in the molecular epidemiology of tuberculosis
Megan Murray
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1538–1543. Published online 2002 January 29. doi: 10.1073/pnas.022618299.
PMCID: PMC122226
Microbiology
The Brucella suis virB operon is induced intracellularly in macrophages
Maria Laura Boschiroli, Safia Ouahrani-Bettache, Vincent Foulongne, Sylvie Michaux-Charachon, Gisele Bourg, Annick Allardet-Servent, Chantal Cazevieille, Jean Pierre Liautard, Michel Ramuz, and David O'Callaghan
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1544–1549. doi: 10.1073/pnas.032514299.
PMCID: PMC122227
The murMN operon: A functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae
Sergio R. Filipe, Elena Severina, and Alexander Tomasz
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1550–1555. doi: 10.1073/pnas.032671699.
PMCID: PMC122228
Comparative genomic analysis of Vibrio cholerae: Genes that correlate with cholera endemic and pandemic disease
Michelle Dziejman, Emmy Balon, Dana Boyd, Clare M. Fraser, John F. Heidelberg, and John J. Mekalanos
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1556–1561. Published online 2002 January 29. doi: 10.1073/pnas.042667999.
PMCID: PMC122229
DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete
Andrew T. Revel, Adel M. Talaat, and Michael V. Norgard
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1562–1567. doi: 10.1073/pnas.032667699.
PMCID: PMC122230
Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
Li Wu, Arman A. Bashirova, Thomas D. Martin, Loreley Villamide, Erin Mehlhop, Andrei O. Chertov, Derya Unutmaz, Melissa Pope, Mary Carrington, and Vineet N. KewalRamani
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1568–1573. Published online 2002 January 29. doi: 10.1073/pnas.032654399.
PMCID: PMC122231
The capsular polysaccharide of Enterococcus faecalis and its relationship to other polysaccharides in the cell wall
Lynn E. Hancock and Michael S. Gilmore
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1574–1579. doi: 10.1073/pnas.032448299.
PMCID: PMC122232
Neurobiology
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity
Hiroshi Kawasaki, Hirofumi Suemori, Kenji Mizuseki, Kiichi Watanabe, Fumi Urano, Hiroshi Ichinose, Masatoshi Haruta, Masayo Takahashi, Kanako Yoshikawa, Shin-Ichi Nishikawa, Norio Nakatsuji, and Yoshiki Sasai
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1580–1585. Published online 2002 January 29. doi: 10.1073/pnas.032662199.
PMCID: PMC122233
Guiding the study of brain dynamics by using first-person data: Synchrony patterns correlate with ongoing conscious states during a simple visual task
Antoine Lutz, Jean-Philippe Lachaux, Jacques Martinerie, and Francisco J. Varela
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1586–1591. Published online 2002 January 22. doi: 10.1073/pnas.032658199.
PMCID: PMC122234
Cerebellar cortical inhibition and classical eyeblink conditioning
Shaowen Bao, Lu Chen, Jeansok J. Kim, and Richard F. Thompson
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1592–1597. Published online 2002 January 22. doi: 10.1073/pnas.032655399.
PMCID: PMC122235
Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegans
Jasper M. Simon and Paul W. Sternberg
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1598–1603. Published online 2002 January 29. doi: 10.1073/pnas.032225799.
PMCID: PMC122236
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
David S. Howland, Jian Liu, Yijin She, Beth Goad, Nicholas J. Maragakis, Benjamin Kim, Jamie Erickson, John Kulik, Lisa DeVito, George Psaltis, Louis J. DeGennaro, Don W. Cleveland, and Jeffrey D. Rothstein
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1604–1609. Published online 2002 January 29. doi: 10.1073/pnas.032539299.
PMCID: PMC122237
β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
Milla Koistinaho, Mikko I. Kettunen, Gundars Goldsteins, Riitta Keinänen, Antero Salminen, Michael Ort, Jan Bures, David Liu, Risto A. Kauppinen, Linda S. Higgins, and Jari Koistinaho
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1610–1615. Published online 2002 January 29. doi: 10.1073/pnas.032670899.
PMCID: PMC122238
Oscillatory brain states and learning: Impact of hippocampal theta-contingent training
Matthew A. Seager, Lynn D. Johnson, Elizabeth S. Chabot, Yukiko Asaka, and Stephen D. Berry
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1616–1620. Published online 2002 January 29. doi: 10.1073/pnas.032662099.
PMCID: PMC122239
Cultured rat hippocampal neural progenitors generate spontaneously active neural networks
Sanjay K. Mistry, Edward W. Keefer, Bruce A. Cunningham, Gerald M. Edelman, and Kathryn L. Crossin
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1621–1626. Published online 2002 January 29. doi: 10.1073/pnas.022646599.
PMCID: PMC122240
The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis
Jakob B. Sørensen, Ulf Matti, Shun-Hui Wei, Ralf B. Nehring, Thomas Voets, Uri Ashery, Thomas Binz, Erwin Neher, and Jens Rettig
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1627–1632. doi: 10.1073/pnas.251673298.
PMCID: PMC122241
From the Cover:
Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae
C. E. Merrill, J. Riesgo-Escovar, R. J. Pitts, F. C. Kafatos, J. R. Carlson, and L. J. Zwiebel
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1633–1638. Published online 2002 January 15. doi: 10.1073/pnas.022505499.
PMCID: PMC122242
Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons
Peter W. Vanderklish and Gerald M. Edelman
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1639–1644. Published online 2002 January 29. doi: 10.1073/pnas.032681099.
PMCID: PMC122243
Spatial frequency and orientation tuning dynamics in area V1
James A. Mazer, William E. Vinje, Josh McDermott, Peter H. Schiller, and Jack L. Gallant
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1645–1650. Published online 2002 January 29. doi: 10.1073/pnas.022638499.
PMCID: PMC122244
Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception
Arpad Dobolyi, Hiroshi Ueda, Hitoshi Uchida, Miklós Palkovits, and Ted B. Usdin
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1651–1656. Published online 2002 January 29. doi: 10.1073/pnas.042416199.
PMCID: PMC122245
Neurotrophic factor intervention restores auditory function in deafened animals
Takayuki Shinohara, Göran Bredberg, Mats Ulfendahl, Ilmari Pyykkö, N. Petri Olivius, Risto Kaksonen, Bo Lindström, Richard Altschuler, and Josef M. Miller
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1657–1660. Published online 2002 January 29. doi: 10.1073/pnas.032677999.
PMCID: PMC122246
Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation
Lena Scott, Maria Sol Kruse, Hans Forssberg, Hjalmar Brismar, Paul Greengard, and Anita Aperia
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1661–1664. Published online 2002 January 29. doi: 10.1073/pnas.032654599.
PMCID: PMC122247
C2A activates a cryptic Ca2+-triggered membrane penetration activity within the C2B domain of synaptotagmin I
Jihong Bai, Ping Wang, and Edwin R. Chapman
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1665–1670. Published online 2002 January 22. doi: 10.1073/pnas.032541099.
PMCID: PMC122248
Pharmacology
Adenovirus-directed expression of Q227L-Gαs inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice
Tara Ann Santore, Yibang Chen, Martine J. Smit, and Ravi Iyengar
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1671–1676. Published online 2002 January 22. doi: 10.1073/pnas.032661999.
PMCID: PMC122249
Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis
Mark J. Paul-Clark, Lucia Mancini, Piero Del Soldato, Roderick J. Flower, and Mauro Perretti
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1677–1682. Published online 2002 January 22. doi: 10.1073/pnas.022641099.
PMCID: PMC122250
Generation of an activating Zn2+ switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Claus Juul Loland, Lene Norregaard, Thomas Litman, and Ulrik Gether
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1683–1688. Published online 2002 January 29. doi: 10.1073/pnas.032386299.
PMCID: PMC122251
Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis
Claudio Napoli, Giancarlo Aldini, John L. Wallace, Filomena de Nigris, Roberto Maffei, Pasquale Abete, Domenico Bonaduce, Gianluigi Condorelli, Franco Rengo, Vincenzo Sica, Francesco P. D'Armiento, Chiara Mignogna, Gaetano de Rosa, Mario Condorelli, Lilach O. Lerman, and Louis J. Ignarro
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1689–1694. Published online 2002 January 29. doi: 10.1073/pnas.022639399.
PMCID: PMC122252
Physiology
Type 3 ryanodine receptors of skeletal muscle are segregated in a parajunctional position
Edward Felder and Clara Franzini-Armstrong
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1695–1700. Published online 2002 January 29. doi: 10.1073/pnas.032657599.
PMCID: PMC122253
Circulating relaxin acts on subfornical organ neurons to stimulate water drinking in the rat
N. Sunn, M. Egli, T. C. D. Burazin, P. Burns, L. Colvill, P. Davern, D. A. Denton, B. J. Oldfield, R. S. Weisinger, M. Rauch, H. A. Schmid, and M. J. McKinley
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1701–1706. doi: 10.1073/pnas.022647699.
PMCID: PMC122254
Cytosolic malate dehydrogenase confers selectivity of the nucleic acid-conducting channel
Basil Hanss, Edgar Leal-Pinto, Avelino Teixeira, Robert E. Christian, Jeffery Shabanowitz, Donald F. Hunt, and Paul E. Klotman
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1707–1712. Published online 2002 January 22. doi: 10.1073/pnas.022355499.
PMCID: PMC122255
Plant Biology
Leaf-to-shoot apex movement of symplastic tracer is restricted coincident with flowering in Arabidopsis
Andreas Gisel, Frederick D. Hempel, Sandra Barella, and Patricia Zambryski
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1713–1717. Published online 2002 January 29. doi: 10.1073/pnas.251675698.
PMCID: PMC122256
A gene encoding a protein modified by the phytohormone indoleacetic acid
Alexander Walz, Seijin Park, Janet P. Slovin, Jutta Ludwig-Müller, Yoshie S. Momonoki, and Jerry D. Cohen
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1718–1723. doi: 10.1073/pnas.032450399.
PMCID: PMC122257
Enhanced ADP-glucose pyrophosphorylase activity in wheat endosperm increases seed yield
Eric D. Smidansky, Maureen Clancy, Fletcher D. Meyer, Susan P. Lanning, Nancy K. Blake, Luther E. Talbert, and Michael J. Giroux
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1724–1729. doi: 10.1073/pnas.022635299.
PMCID: PMC122258
Nitrogen assimilation and growth of wheat under elevated carbon dioxide
Arnold J. Bloom, David R. Smart, Duy T. Nguyen, and Peter S. Searles
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1730–1735. Published online 2002 January 29. doi: 10.1073/pnas.022627299.
PMCID: PMC122259
Psychology
Dissociation in human prefrontal cortex of affective influences on working memory-related activity
William M. Perlstein, Thomas Elbert, and V. Andrew Stenger
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1736–1741. Published online 2002 January 29. doi: 10.1073/pnas.241650598.
PMCID: PMC122260
Social Sciences
Psychology
Global organization of the Wordnet lexicon
Mariano Sigman and Guillermo A. Cecchi
Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1742–1747. doi: 10.1073/pnas.022341799.
PMCID: PMC122261
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