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Volume 104(11);  March 13, 2007
This Week in PNAS
In This Issue
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4241–4242. doi: 10.1073/iti1107104.
PMCID: PMC1838584
Commentaries
Regulation of carbon and nitrogen metabolism: Adding regulation of ion channels and another second messenger to the mix
Alexander J. Ninfa
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4243–4244. Published online 2007 March 7. doi: 10.1073/pnas.0700325104.
PMCID: PMC1838585
New mouse models of cancer: Single-cell knockouts
Guillermina Lozano and Richard R. Behringer
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4245–4246. Published online 2007 March 5. doi: 10.1073/pnas.0700173104.
PMCID: PMC1838586
Where's the water? Hydrotropism in plants
John Z. Kiss
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4247–4248. Published online 2007 March 12. doi: 10.1073/pnas.0700846104.
PMCID: PMC1838587
Physical Sciences
Applied Mathematics
Haplotype structure and selection of the MDM2 oncogene in humans
Gurinder Singh Atwal, Gareth L. Bond, Sally Metsuyanim, Moshe Papa, Eitan Friedman, Tal Distelman-Menachem, Edna Ben Asher, Doron Lancet, David A. Ross, John Sninsky, Tomas J. White, Arnold J. Levine, and Ronit Yarden
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4524–4529. Published online 2007 March 5. doi: 10.1073/pnas.0610998104.
PMCID: PMC1838634
Environmental Sciences
The changing carbon cycle at Mauna Loa Observatory
Wolfgang Buermann, Benjamin R. Lintner, Charles D. Koven, Alon Angert, Jorge E. Pinzon, Compton J. Tucker, and Inez Y. Fung
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4249–4254. doi: 10.1073/pnas.0611224104.
PMCID: PMC1810339
Biological Sciences
Anthropology
Nonlinear scaling of space use in human hunter–gatherers
Marcus J. Hamilton, Bruce T. Milne, Robert S. Walker, and James H. Brown
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4765–4769. Published online 2007 March 6. doi: 10.1073/pnas.0611197104.
PMCID: PMC1810510
Applied Biological Sciences
Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets
Anubhav Arora, Itzhak Hakim, Joy Baxter, Ruben Rathnasingham, Ravi Srinivasan, Daniel A. Fletcher, and Samir Mitragotri
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4255–4260. Published online 2007 March 6. doi: 10.1073/pnas.0700182104.
PMCID: PMC1838589
Biochemistry
Drug target interaction energies by the kernel energy method in aminoglycoside drugs and ribosomal A site RNA targets
Lulu Huang, Lou Massa, and Jerome Karle
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4261–4266. Published online 2007 March 1. doi: 10.1073/pnas.0610533104.
PMCID: PMC1838590
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases
Christian Castro, Eric Smidansky, Kenneth R. Maksimchuk, Jamie J. Arnold, Victoria S. Korneeva, Matthias Götte, William Konigsberg, and Craig E. Cameron
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4267–4272. Published online 2007 March 5. doi: 10.1073/pnas.0608952104.
PMCID: PMC1838591
A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship behavior in Drosophila melanogaster
Thomas Chertemps, Line Duportets, Carole Labeur, Ryu Ueda, Kuniaki Takahashi, Kaoru Saigo, and Claude Wicker-Thomas
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4273–4278. Published online 2007 March 6. doi: 10.1073/pnas.0608142104.
PMCID: PMC1838592
Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate
Dmitry A. Rodionov, Oleg V. Kurnasov, Boguslaw Stec, Yan Wang, Mary F. Roberts, and Andrei L. Osterman
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4279–4284. Published online 2007 March 2. doi: 10.1073/pnas.0609279104.
PMCID: PMC1838593
Relationship between the structure of SET/TAF-Iβ/INHAT and its histone chaperone activity
Shinsuke Muto, Miki Senda, Yusuke Akai, Lui Sato, Toru Suzuki, Ryozo Nagai, Toshiya Senda, and Masami Horikoshi
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4285–4290. Published online 2007 March 6. doi: 10.1073/pnas.0603762104.
PMCID: PMC1810507
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity
Chen Davidovich, Anat Bashan, Tamar Auerbach-Nevo, Rachel D. Yaggie, Richard R. Gontarek, and Ada Yonath
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4291–4296. Published online 2007 March 8. doi: 10.1073/pnas.0700041104.
PMCID: PMC1817833
Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains
Liang Guo, Aidong Han, Darren L. Bates, Jue Cao, and Lin Chen
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4297–4302. Published online 2007 March 5. doi: 10.1073/pnas.0608041104.
PMCID: PMC1838596
Production and characterization of monoclonal antibodies sensitive to conformation in the 5HT2c serotonin receptor
Filippo Mancia, Susan Brenner-Morton, Risa Siegel, Zahra Assur, Yonghua Sun, Ira Schieren, Monica Mendelsohn, Richard Axel, and Wayne A. Hendrickson
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4303–4308. Published online 2007 March 6. doi: 10.1073/pnas.0700301104.
PMCID: PMC1838597
Spiral structure of Escherichia coli HUαβ provides foundation for DNA supercoiling
Fusheng Guo and Sankar Adhya
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4309–4314. Published online 2007 March 5. doi: 10.1073/pnas.0611686104.
PMCID: PMC1838598
Structure and function of a hexameric copper-containing nitrite reductase
Masaki Nojiri, Yong Xie, Tsuyoshi Inoue, Takahiko Yamamoto, Hiroyoshi Matsumura, Kunishige Kataoka, Deligeer, Kazuya Yamaguchi, Yasushi Kai, and Shinnichiro Suzuki
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4315–4320. Published online 2007 March 5. doi: 10.1073/pnas.0609195104.
PMCID: PMC1838599
Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis
Lori Buetow, Terry K. Smith, Alice Dawson, Stewart Fyffe, and William N. Hunter
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4321–4326. Published online 2007 March 5. doi: 10.1073/pnas.0606356104.
PMCID: PMC1810333
Studies of nucleotide binding to the catalytic sites of Escherichia coli βY331W-F1-ATPase using fluorescence quenching
Vladimir V. Bulygin and Yakov M. Milgrom
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4327–4331. Published online 2007 March 5. doi: 10.1073/pnas.0700078104.
PMCID: PMC1838601
Biophysics
From the Cover:
Myosin Va maneuvers through actin intersections and diffuses along microtubules
M. Yusuf Ali, Elena B. Krementsova, Guy G. Kennedy, Rachel Mahaffy, Thomas D. Pollard, Kathleen M. Trybus, and David M. Warshaw
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4332–4336. Published online 2007 February 23. doi: 10.1073/pnas.0611471104.
PMCID: PMC1838602
Predicting protein–protein interactions based only on sequences information
Juwen Shen, Jian Zhang, Xiaomin Luo, Weiliang Zhu, Kunqian Yu, Kaixian Chen, Yixue Li, and Hualiang Jiang
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4337–4341. Published online 2007 March 5. doi: 10.1073/pnas.0607879104.
PMCID: PMC1838603
Insight into the selectivity and gating functions of Streptomyces lividans KcsA
Alexander Negoda, Mo Xian, and Rosetta N. Reusch
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4342–4346. Published online 2007 March 6. doi: 10.1073/pnas.0700495104.
PMCID: PMC1838604
Functional residues serve a dominant role in mediating the cooperativity of the protein ensemble
Tong Liu, Steven T. Whitten, and Vincent J. Hilser
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4347–4352. Published online 2007 March 5. doi: 10.1073/pnas.0607132104.
PMCID: PMC1838605
Domain-swapped dimerization of the HIV-1 capsid C-terminal domain
Dmitri Ivanov, Oleg V. Tsodikov, Jeremy Kasanov, Tom Ellenberger, Gerhard Wagner, and Tucker Collins
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4353–4358. Published online 2007 March 5. doi: 10.1073/pnas.0609477104.
PMCID: PMC1838606
MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST)
Peter C. M. van Zijl, Craig K. Jones, Jimin Ren, Craig R. Malloy, and A. Dean Sherry
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4359–4364. Published online 2007 March 5. doi: 10.1073/pnas.0700281104.
PMCID: PMC1838607
Cell Biology
Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways
Tao Lu, Liping Tian, Yulong Han, Michael Vogelbaum, and George R. Stark
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4365–4370. Published online 2007 March 5. doi: 10.1073/pnas.0700118104.
PMCID: PMC1810327
i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation
Ralph S. Pero, Michael T. Borchers, Karsten Spicher, Sergei I. Ochkur, Lyudmila Sikora, Savita P. Rao, Hiam Abdala-Valencia, Katie R. O'Neill, Huahao Shen, Michael P. McGarry, Nancy A. Lee, Joan M. Cook-Mills, P. Sriramarao, Melvin I. Simon, Lutz Birnbaumer, and James J. Lee
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4371–4376. Published online 2007 March 7. doi: 10.1073/pnas.0700185104.
PMCID: PMC1838609
Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction
Jens Fielitz, Eva van Rooij, Jeffrey A. Spencer, John M. Shelton, Shuaib Latif, Roel van der Nagel, Svetlana Bezprozvannaya, Leon de Windt, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4377–4382. Published online 2007 March 2. doi: 10.1073/pnas.0611726104.
PMCID: PMC1838610
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells
Mark E. Burkard, Catherine L. Randall, Stéphane Larochelle, Chao Zhang, Kevan M. Shokat, Robert P. Fisher, and Prasad V. Jallepalli
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4383–4388. Published online 2007 March 6. doi: 10.1073/pnas.0701140104.
PMCID: PMC1838611
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
Stephanie J. Leuenroth, Dayne Okuhara, Joseph D. Shotwell, Glen S. Markowitz, Zhiheng Yu, Stefan Somlo, and Craig M. Crews
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4389–4394. Published online 2007 March 6. doi: 10.1073/pnas.0700499104.
PMCID: PMC1838612
Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons
Fan Zhang, Jason H. Pomerantz, George Sen, Adam T. Palermo, and Helen M. Blau
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4395–4400. Published online 2007 March 7. doi: 10.1073/pnas.0700181104.
PMCID: PMC1838613
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
James A. Timmons, Kristian Wennmalm, Ola Larsson, Tomas B. Walden, Timo Lassmann, Natasa Petrovic, D. Lee Hamilton, Ruth E. Gimeno, Claes Wahlestedt, Keith Baar, Jan Nedergaard, and Barbara Cannon
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4401–4406. Published online 2007 March 5. doi: 10.1073/pnas.0610615104.
PMCID: PMC1810328
EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites
Christian Zuber, James H. Cormier, Bruno Guhl, Roger Santimaria, Daniel N. Hebert, and Jürgen Roth
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4407–4412. Published online 2007 March 6. doi: 10.1073/pnas.0700154104.
PMCID: PMC1810509
Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells
Xiaoqing Liu, Oleg V. Bulgakov, Keith N. Darrow, Basil Pawlyk, Michael Adamian, M. Charles Liberman, and Tiansen Li
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4413–4418. Published online 2007 March 5. doi: 10.1073/pnas.0610950104.
PMCID: PMC1838616
β cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo
Oliver Strobel, Yuval Dor, Amy Stirman, Amanda Trainor, Carlos Fernández-del Castillo, Andrew L. Warshaw, and Sarah P. Thayer
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4419–4424. Published online 2007 March 7. doi: 10.1073/pnas.0605248104.
PMCID: PMC1815470
p53-dependent integration of telomere and growth factor deprivation signals
Alain Beliveau, Ekaterina Bassett, Alvin T. Lo, James Garbe, Miguel A. Rubio, Mina J. Bissell, Judith Campisi, and Paul Yaswen
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4431–4436. Published online 2007 March 5. doi: 10.1073/pnas.0700260104.
PMCID: PMC1838618
Developmental Biology
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
Catherine Carrière, Elliott S. Seeley, Tobias Goetze, Daniel S. Longnecker, and Murray Korc
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4437–4442. Published online 2007 March 5. doi: 10.1073/pnas.0701117104.
PMCID: PMC1810329
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells
Elena Vasyutina, Diana C. Lenhard, Hagen Wende, Bettina Erdmann, Jonathan A. Epstein, and Carmen Birchmeier
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4443–4448. Published online 2007 March 7. doi: 10.1073/pnas.0610647104.
PMCID: PMC1815471
A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells
Dachun Wang, David L. Haviland, Alan R. Burns, Eva Zsigmond, and Rick A. Wetsel
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4449–4454. Published online 2007 March 2. doi: 10.1073/pnas.0700052104.
PMCID: PMC1838621
Developmental and adult phenotyping directly from mutant embryonic stem cells
Sophia H. L. George, Marina Gertsenstein, Kristina Vintersten, Ella Korets-Smith, John Murphy, Mary E. Stevens, Jody J. Haigh, and Andras Nagy
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4455–4460. Published online 2007 March 2. doi: 10.1073/pnas.0609277104.
PMCID: PMC1838622
Environmental Sciences
From the Cover:
Fish extinctions alter nutrient recycling in tropical freshwaters
Peter B. McIntyre, Laura E. Jones, Alexander S. Flecker, and Michael J. Vanni
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4461–4466. Published online 2007 February 20. doi: 10.1073/pnas.0608148104.
PMCID: PMC1838623
Evolution
Novel sex pheromone desaturases in the genomes of corn borers generated through gene duplication and retroposon fusion
Bingye Xue, Alejandro P. Rooney, Masaki Kajikawa, Norihiro Okada, and Wendell L. Roelofs
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4467–4472. Published online 2007 March 5. doi: 10.1073/pnas.0700422104.
PMCID: PMC1838624
A statistical phylogeography of influenza A H5N1
Robert G. Wallace, HoangMinh HoDac, Richard H. Lathrop, and Walter M. Fitch
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4473–4478. Published online 2007 March 7. doi: 10.1073/pnas.0700435104.
PMCID: PMC1838625
Retaliatory mafia behavior by a parasitic cowbird favors host acceptance of parasitic eggs
Jeffrey P. Hoover and Scott K. Robinson
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4479–4483. Published online 2007 March 5. doi: 10.1073/pnas.0609710104.
PMCID: PMC1838626
Experimental constraints on mate preferences in Drosophila pseudoobscura decrease offspring viability and fitness of mated pairs
Wyatt W. Anderson, Yong-Kyu Kim, and Patricia Adair Gowaty
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4484–4488. Published online 2007 March 6. doi: 10.1073/pnas.0611152104.
PMCID: PMC1838627
Global extent of horizontal gene transfer
In-Geol Choi and Sung-Hou Kim
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4489–4494. Published online 2007 March 7. doi: 10.1073/pnas.0611557104.
PMCID: PMC1815472
Genetics
From the Cover:
Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM)
Mandar Deepak Muzumdar, Liqun Luo, and Hui Zong
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4495–4500. Published online 2007 March 5. doi: 10.1073/pnas.0606491104.
PMCID: PMC1810340
From the Cover:
Induced mitotic recombination of p53 in vivo
Wei Wang, Madhuri Warren, and Allan Bradley
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4501–4505. Published online 2007 March 5. doi: 10.1073/pnas.0607953104.
PMCID: PMC1838630
Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency
Carmine Settembre, Ida Annunziata, Carmine Spampanato, Daniela Zarcone, Gilda Cobellis, Edoardo Nusco, Ester Zito, Carlo Tacchetti, Maria Pia Cosma, and Andrea Ballabio
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4506–4511. Published online 2007 March 6. doi: 10.1073/pnas.0700382104.
PMCID: PMC1810506
Impaired FGF signaling contributes to cleft lip and palate
Bridget M. Riley, M. Adela Mansilla, Jinghong Ma, Sandra Daack-Hirsch, Brion S. Maher, Lisa M. Raffensperger, Erilynn T. Russo, Alexandre R. Vieira, Catherine Dodé, Moosa Mohammadi, Mary L. Marazita, and Jeffrey C. Murray
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4512–4517. Published online 2007 March 6. doi: 10.1073/pnas.0607956104.
PMCID: PMC1810508
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells
Shan Zha, Frederick W. Alt, Hwei-Ling Cheng, James W. Brush, and Gang Li
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4518–4523. Published online 2007 March 7. doi: 10.1073/pnas.0611734104.
PMCID: PMC1838633
Haplotype structure and selection of the MDM2 oncogene in humans
Gurinder Singh Atwal, Gareth L. Bond, Sally Metsuyanim, Moshe Papa, Eitan Friedman, Tal Distelman-Menachem, Edna Ben Asher, Doron Lancet, David A. Ross, John Sninsky, Tomas J. White, Arnold J. Levine, and Ronit Yarden
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4524–4529. Published online 2007 March 5. doi: 10.1073/pnas.0610998104.
PMCID: PMC1838634
Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics
Haijin Meng, Iset Vera, Nam Che, Xuping Wang, Susanna S. Wang, Leslie Ingram-Drake, Eric E. Schadt, Thomas A. Drake, and Aldons J. Lusis
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4530–4535. Published online 2007 March 6. doi: 10.1073/pnas.0607620104.
PMCID: PMC1838635
Role of RNA polymerase IV in plant small RNA metabolism
Xiaoyu Zhang, Ian R. Henderson, Cheng Lu, Pamela J. Green, and Steven E. Jacobsen
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4536–4541. Published online 2007 March 5. doi: 10.1073/pnas.0611456104.
PMCID: PMC1810338
Immunology
Division and differentiation of natural antibody-producing cells in mouse spleen
Yang Yang, James W. Tung, Eliver E. B. Ghosn, Leonard A. Herzenberg, and Leonore A. Herzenberg
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4542–4546. Published online 2007 March 7. doi: 10.1073/pnas.0700001104.
PMCID: PMC1838637
Importance of culturing primary lymphocytes at physiological oxygen levels
Kondala R. Atkuri, Leonard A. Herzenberg, Anna-Kaisa Niemi, Tina Cowan, and Leonore A. Herzenberg
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4547–4552. Published online 2007 March 5. doi: 10.1073/pnas.0611732104.
PMCID: PMC1838638
Competition for antigen determines the stability of T cell–dendritic cell interactions during clonal expansion
Zacarias Garcia, Emmanuelle Pradelli, Susanna Celli, Hélène Beuneu, Aurélie Simon, and Philippe Bousso
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4553–4558. Published online 2007 March 2. doi: 10.1073/pnas.0610019104.
PMCID: PMC1838639
Embryonic chimerism does not induce tolerance in an invertebrate model organism
Monita Poudyal, Sabrina Rosa, Anahid E. Powell, Maria Moreno, Stephen L. Dellaporta, Leo W. Buss, and Fadi G. Lakkis
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4559–4564. Published online 2007 March 5. doi: 10.1073/pnas.0608696104.
PMCID: PMC1838640
Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection
Paola Agnellini, Petra Wolint, Manuela Rehr, Julia Cahenzli, Urs Karrer, and Annette Oxenius
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4565–4570. Published online 2007 March 7. doi: 10.1073/pnas.0610335104.
PMCID: PMC1815473
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
Bin Li, Arabinda Samanta, Xiaomin Song, Kathryn T. Iacono, Kathryn Bembas, Ran Tao, Samik Basu, James L. Riley, Wayne W. Hancock, Yuan Shen, Sandra J. Saouaf, and Mark I. Greene
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4571–4576. Published online 2007 March 7. doi: 10.1073/pnas.0700298104.
PMCID: PMC1838642
Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules
Shan Liao, Kevin Bentley, Marielle Lebrun, Werner Lesslauer, Frank H. Ruddle, and Nancy H. Ruddle
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4577–4582. Published online 2007 March 5. doi: 10.1073/pnas.0700334104.
PMCID: PMC1838643
Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
Irina Gavanescu, Benedikt Kessler, Hidde Ploegh, Christophe Benoist, and Diane Mathis
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4583–4587. Published online 2007 March 6. doi: 10.1073/pnas.0700259104.
PMCID: PMC1838644
Medical Sciences
Impaired angiogenesis in aminopeptidase N-null mice
Roberto Rangel, Yan Sun, Liliana Guzman-Rojas, Michael G. Ozawa, Jessica Sun, Ricardo J. Giordano, Carolyn S. Van Pelt, Peggy T. Tinkey, Richard R. Behringer, Richard L. Sidman, Wadih Arap, and Renata Pasqualini
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4588–4593. Published online 2007 March 7. doi: 10.1073/pnas.0611653104.
PMCID: PMC1815469
Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment
Cornelius Miething, Rebekka Grundler, Claudia Mugler, Simone Brero, Josef Hoepfl, Jochen Geigl, Michael R. Speicher, Oliver Ottmann, Christian Peschel, and Justus Duyster
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4594–4599. Published online 2007 March 5. doi: 10.1073/pnas.0604716104.
PMCID: PMC1810334
Noncell-autonomous photoreceptor degeneration in a zebrafish model of choroideremia
Bryan L. Krock, Joseph Bilotta, and Brian D. Perkins
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4600–4605. Published online 2007 March 5. doi: 10.1073/pnas.0605818104.
PMCID: PMC1810335
Microbiology
High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections
Lixin Zhang, Kezhi Yan, Yu Zhang, Ren Huang, Jiang Bian, Chuansen Zheng, Haixiang Sun, Zhihui Chen, Nuo Sun, Rong An, Fangui Min, Weibo Zhao, Ying Zhuo, Jianlan You, Yongjie Song, Zhenyan Yu, Zhiheng Liu, Keqian Yang, Hong Gao, Huanqin Dai, Xiaoli Zhang, Jian Wang, Chengzhang Fu, Gang Pei, Jintao Liu, Si Zhang, Michael Goodfellow, Yuanying Jiang, Jun Kuai, Guochun Zhou, and Xiaoping Chen
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4606–4611. Published online 2007 March 5. doi: 10.1073/pnas.0609370104.
PMCID: PMC1838648
A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps
Sune Lobedanz, Evert Bokma, Martyn F. Symmons, Eva Koronakis, Colin Hughes, and Vassilis Koronakis
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4612–4617. Published online 2007 March 5. doi: 10.1073/pnas.0610160104.
PMCID: PMC1838649
Spliced leader RNA trans-splicing in dinoflagellates
Huan Zhang, Yubo Hou, Lilibeth Miranda, David A. Campbell, Nancy R. Sturm, Terry Gaasterland, and Senjie Lin
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4618–4623. Published online 2007 March 2. doi: 10.1073/pnas.0700258104.
PMCID: PMC1838650
Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections
Antonio DiGiandomenico, Jayasimha Rao, Katie Harcher, Tanweer S. Zaidi, Jason Gardner, Alice N. Neely, Gerald B. Pier, and Joanna B. Goldberg
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4624–4629. Published online 2007 March 5. doi: 10.1073/pnas.0608657104.
PMCID: PMC1838651
General transcription factor specified global gene regulation in archaea
Marc T. Facciotti, David J. Reiss, Min Pan, Amardeep Kaur, Madhavi Vuthoori, Richard Bonneau, Paul Shannon, Alok Srivastava, Samuel M. Donohoe, Leroy E. Hood, and Nitin S. Baliga
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4630–4635. Published online 2007 March 7. doi: 10.1073/pnas.0611663104.
PMCID: PMC1838652
Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae
David M. Raskin, Nicholas Judson, and John J. Mekalanos
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4636–4641. Published online 2007 March 5. doi: 10.1073/pnas.0611650104.
PMCID: PMC1838653
Neuroscience
Paradoxical influence of hippocampal neurogenesis on working memory
Michael D. Saxe, Gaël Malleret, Svetlana Vronskaya, Indira Mendez, A. Denise Garcia, Michael V. Sofroniew, Eric R. Kandel, and René Hen
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4642–4646. Published online 2007 March 5. doi: 10.1073/pnas.0611718104.
PMCID: PMC1810330
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
Jennifer L. Warner-Schmidt and Ronald S. Duman
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4647–4652. Published online 2007 March 5. doi: 10.1073/pnas.0610282104.
PMCID: PMC1838655
GSK-3/Shaggy regulates olfactory habituation in Drosophila
Fred W. Wolf, Mark Eddison, Seonok Lee, William Cho, and Ulrike Heberlein
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4653–4657. Published online 2007 March 6. doi: 10.1073/pnas.0700493104.
PMCID: PMC1838656
Network activity-independent coordinated gene expression program for synapse assembly
Luis M. Valor, Paul Charlesworth, Lawrence Humphreys, Chris N. G. Anderson, and Seth G. N. Grant
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4658–4663. Published online 2007 March 5. doi: 10.1073/pnas.0609071104.
PMCID: PMC1810326
From the Cover:
Pleiotrophin is a neurotrophic factor for spinal motor neurons
Ruifa Mi, Weiran Chen, and Ahmet Höke
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4664–4669. Published online 2007 March 5. doi: 10.1073/pnas.0603243104.
PMCID: PMC1838658
Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice
Elena Choleris, Steven R. Little, Jessica A. Mong, Sidharth V. Puram, Robert Langer, and Donald W. Pfaff
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4670–4675. Published online 2007 March 5. doi: 10.1073/pnas.0700670104.
PMCID: PMC1838659
Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters
E. Dong, A. Guidotti, D. R. Grayson, and E. Costa
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4676–4681. Published online 2007 March 7. doi: 10.1073/pnas.0700529104.
PMCID: PMC1815468
Orai proteins interact with TRPC channels and confer responsiveness to store depletion
Yanhong Liao, Christian Erxleben, Eda Yildirim, Joel Abramowitz, David L. Armstrong, and Lutz Birnbaumer
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4682–4687. Published online 2007 March 7. doi: 10.1073/pnas.0611692104.
PMCID: PMC1838661
Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice
Aaron M. Rozeboom, Huda Akil, and Audrey F. Seasholtz
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4688–4693. Published online 2007 March 5. doi: 10.1073/pnas.0606067104.
PMCID: PMC1838662
TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity
Krisztián A. Kovács, Pascal Steullet, Myriam Steinmann, Kim Q. Do, Pierre J. Magistretti, Olivier Halfon, and Jean-René Cardinaux
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4700–4705. Published online 2007 March 6. doi: 10.1073/pnas.0607524104.
PMCID: PMC1838663
Modulation of Drosophila male behavioral choice
Sarah J. Certel, Mary Grace Savella, Dana C. F. Schlegel, and Edward A. Kravitz
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4706–4711. Published online 2007 March 5. doi: 10.1073/pnas.0700328104.
PMCID: PMC1810337
Accumulation of prion protein in the brain that is not associated with transmissible disease
Pedro Piccardo, Jean C. Manson, Declan King, Bernardino Ghetti, and Rona M. Barron
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4712–4717. Published online 2007 March 6. doi: 10.1073/pnas.0609241104.
PMCID: PMC1838665
Physiology
Scaling of number, size, and metabolic rate of cells with body size in mammals
Van M. Savage, Andrew P. Allen, James H. Brown, James F. Gillooly, Alexander B. Herman, William H. Woodruff, and Geoffrey B. West
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4718–4723. Published online 2007 March 1. doi: 10.1073/pnas.0611235104.
PMCID: PMC1838666
Plant Biology
From the Cover:
A gene essential for hydrotropism in roots
Akie Kobayashi, Akiko Takahashi, Yoko Kakimoto, Yutaka Miyazawa, Nobuharu Fujii, Atsushi Higashitani, and Hideyuki Takahashi
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4724–4729. Published online 2007 March 5. doi: 10.1073/pnas.0609929104.
PMCID: PMC1810325
Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays
Sorina C. Popescu, George V. Popescu, Shawn Bachan, Zimei Zhang, Montrell Seay, Mark Gerstein, Michael Snyder, and S. P. Dinesh-Kumar
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4730–4735. Published online 2007 February 23. doi: 10.1073/pnas.0611615104.
PMCID: PMC1838668
WD40 protein Mda1 is purified with Dnm1 and forms a dividing ring for mitochondria before Dnm1 in Cyanidioschyzon merolae
Keiji Nishida, Fumi Yagisawa, Haruko Kuroiwa, Yamato Yoshida, and Tsuneyoshi Kuroiwa
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4736–4741. Published online 2007 March 1. doi: 10.1073/pnas.0609364104.
PMCID: PMC1838669
Modulating seed β-ketoacyl-acyl carrier protein synthase II level converts the composition of a temperate seed oil to that of a palm-like tropical oil
Mark S. Pidkowich, Huu Tam Nguyen, Ingo Heilmann, Till Ischebeck, and John Shanklin
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4742–4747. Published online 2007 March 5. doi: 10.1073/pnas.0611141104.
PMCID: PMC1838670
The metabolic signature related to high plant growth rate in Arabidopsis thaliana
Rhonda C. Meyer, Matthias Steinfath, Jan Lisec, Martina Becher, Hanna Witucka-Wall, Ottó Törjék, Oliver Fiehn, Änne Eckardt, Lothar Willmitzer, Joachim Selbig, and Thomas Altmann
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4759–4764. Published online 2007 March 5. doi: 10.1073/pnas.0609709104.
PMCID: PMC1810331
Population Biology
A population genetics model with recombination hotspots that are heterogeneous across the population
Peter Calabrese
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4748–4752. Published online 2007 March 5. doi: 10.1073/pnas.0610195104.
PMCID: PMC1838671
Psychology
Developmental vision determines the reference frame for the multisensory control of action
Brigitte Röder, Anna Kusmierek, Charles Spence, and Tobias Schicke
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4753–4758. Published online 2007 March 7. doi: 10.1073/pnas.0607158104.
PMCID: PMC1838672
Sustainability Science
The metabolic signature related to high plant growth rate in Arabidopsis thaliana
Rhonda C. Meyer, Matthias Steinfath, Jan Lisec, Martina Becher, Hanna Witucka-Wall, Ottó Törjék, Oliver Fiehn, Änne Eckardt, Lothar Willmitzer, Joachim Selbig, and Thomas Altmann
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4759–4764. Published online 2007 March 5. doi: 10.1073/pnas.0609709104.
PMCID: PMC1810331
Social Sciences
Anthropology
Nonlinear scaling of space use in human hunter–gatherers
Marcus J. Hamilton, Bruce T. Milne, Robert S. Walker, and James H. Brown
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4765–4769. Published online 2007 March 6. doi: 10.1073/pnas.0611197104.
PMCID: PMC1810510
Correction
Correction for Huang et al., A functional SNP of interferon-γ gene is important for interferon-α-induced and spontaneous recovery from hepatitis C virus infection
Proc Natl Acad Sci U S A. 2007 March 13; 104(11): 4770. Published online 2007 February 28. doi: 10.1073/pnas.0701153104.
PMCID: PMC1838675
Corrects: Ying Huang, et al. A functional SNP of interferon-γ gene is important for interferon-α-induced and spontaneous recovery from hepatitis C virus infection. Proc Natl Acad Sci U S A. 2007 January 16; 104(3): 985–990.
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