| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 May 16; 103(20): 7531–7532. doi: 10.1073/iti0606103.PMCID: PMC1472478 Commentaries Covalent chemistry on distended proteins Dennis E. Discher, Nishant Bhasin, and Colin P. Johnson PMCID: PMC1472479 The real estate of cardiac signaling: Location, location, location Meena S. George and Geoffrey S. Pitt PMCID: PMC1472480 Highly conserved proteins that modify plant ethylene responses Harry Klee PMCID: PMC1472481 Profile Profile of David W. McLaughlin Regina Nuzzo PMCID: PMC1472482 Physical Sciences Applied Mathematics On the dynamics of molecular conformation Igor Mezić PMCID: PMC1472483 Stable time filtering of strongly unstable spatially extended systems Marcus J. Grote and Andrew J. Majda PMCID: PMC1472484 Chemistry The deprotonated guanine-cytosine base pair Maria C. Lind, Partha P. Bera, Nancy A. Richardson, Steven E. Wheeler, and Henry F. Schaefer, III PMCID: PMC1472485 Local molecular field theory for effective attractions between like charged objects in systems with strong Coulomb interactions Yng-Gwei Chen and John D. Weeks PMCID: PMC1472486 Statistics A likelihood approach to analysis of network data Carsten Wiuf, Markus Brameier, Oskar Hagberg, and Michael P. H. Stumpf PMCID: PMC1472487 Biological Sciences Agricultural Sciences Farm-scale evaluation of the impacts of transgenic cotton on biodiversity, pesticide use, and yield Manda G. Cattaneo, Christine Yafuso, Chris Schmidt, Cho-ying Huang, Magfurar Rahman, Carl Olson, Christa Ellers-Kirk, Barron J. Orr, Stuart E. Marsh, Larry Antilla, Pierre Dutilleul, and Yves Carrière PMCID: PMC1457091 Applied Biological Sciences An antibody produced in tobacco expressing a hybrid β-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes Hans Bakker, Gerard J. A. Rouwendal, Anton S. Karnoup, Dion E. A. Florack, Geert M. Stoopen, Johannes P. F. G. Helsper, Ronald van Ree, Irma van Die, and Dirk Bosch PMCID: PMC1472489 Protease specificity determination by using cellular libraries of peptide substrates (CLiPS) Kevin T. Boulware and Patrick S. Daugherty PMCID: PMC1456804 Sverdlovsk revisited: Modeling human inhalation anthrax Dean A. Wilkening PMCID: PMC1564296 Biochemistry A common allosteric site and mechanism in caspases Justin M. Scheer, Michael J. Romanowski, and James A. Wells PMCID: PMC1458511 Evidence that feedback inhibition of NAD kinase controls responses to oxidative stress Julianne H. Grose, Lisa Joss, Sidney F. Velick, and John R. Roth PMCID: PMC1472491 The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria Lothar Kussmaul and Judy Hirst PMCID: PMC1472492 Minichromosome maintenance helicase activity is controlled by N- and C-terminal motifs and requires the ATPase domain helix-2 insert Elizabeth R. Jenkinson and James P. J. Chong PMCID: PMC1472493 Probing a protein–protein interaction by in vitro evolution George Thom, Alexis C. Cockroft, Andrew G. Buchanan, Cathy Joberty Candotti, E. Suzanne Cohen, David Lowne, Phill Monk, Celia P. Shorrock-Hart, Lutz Jermutus, and Ralph R. Minter PMCID: PMC1458619 A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues Lata T. Gooljarsingh, Christine Fernandes, Kang Yan, Hong Zhang, Michael Grooms, Kyung Johanson, Robert H. Sinnamon, Robert B. Kirkpatrick, John Kerrigan, Tia Lewis, Marc Arnone, Alastair J. King, Zhihong Lai, Robert A. Copeland, and Peter J. Tummino PMCID: PMC1458618 The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, defines a third class of sulfatases Gregor Hagelueken, Thorsten M. Adams, Lutz Wiehlmann, Ute Widow, Harald Kolmar, Burkhard Tümmler, Dirk W. Heinz, and Wolf-Dieter Schubert PMCID: PMC1472496 Crystal structure of the SOCS2–elongin C–elongin B complex defines a prototypical SOCS box ubiquitin ligase Alex N. Bullock, Judit É. Debreczeni, Aled M. Edwards, Michael Sundström, and Stefan Knapp PMCID: PMC1472497 Structure of the ternary signaling complex of a TGF-β superfamily member George P. Allendorph, Wylie W. Vale, and Senyon Choe PMCID: PMC1456805 Biophysics Local molecular field theory for effective attractions between like charged objects in systems with strong Coulomb interactions Yng-Gwei Chen and John D. Weeks PMCID: PMC1472486 Allosteric action in real time: Time-resolved crystallographic studies of a cooperative dimeric hemoglobin James E. Knapp, Reinhard Pahl, Vukica Šrajer, and William E. Royer, Jr. PMCID: PMC1472499 Pannexin 1 in erythrocytes: Function without a gap Silviu Locovei, Li Bao, and Gerhard Dahl PMCID: PMC1472500 Hydrodynamic narrowing of tubes extruded from cells F. Brochard-Wyart, N. Borghi, D. Cuvelier, and P. Nassoy PMCID: PMC1472501 Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations Wenjun Zheng, Bernard R. Brooks, and D. Thirumalai PMCID: PMC1472502 Cell Biology Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1 Ralph N. Watts, Clare Hawkins, Prem Ponka, and Des R. Richardson PMCID: PMC1472503 Ordered assembly of the duplicating Golgi in Trypanosoma brucei Helen H. Ho, Cynthia Y. He, Christopher L. de Graffenried, Lindsay J. Murrells, and Graham Warren PMCID: PMC1472504 siRNA in human cells selectively localizes to target RNA sites Svitlana Y. Berezhna, Lubica Supekova, Frantisek Supek, Peter G. Schultz, and Ashok A. Deniz PMCID: PMC1472505 The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences Christine Moulton Clemson, Lisa L. Hall, Meg Byron, John McNeil, and Jeanne Bentley Lawrence PMCID: PMC1472506 The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation Antje Schirenbeck, Rajesh Arasada, Till Bretschneider, Theresia E. B. Stradal, Michael Schleicher, and Jan Faix PMCID: PMC1457090 Elimination of damaged proteins during differentiation of embryonic stem cells Malin Hernebring, Gabriella Brolén, Hugo Aguilaniu, Henrik Semb, and Thomas Nyström PMCID: PMC1472508 Developmental Biology Attenuated spread of X-inactivation in an X;autosome translocation Bilyana C. Popova, Takashi Tada, Nobuo Takagi, Neil Brockdorff, and Tatyana B. Nesterova PMCID: PMC1472509 Expression profiling reveals meiotic male germ cell mRNAs that are translationally up- and down-regulated Naoko Iguchi, John W. Tobias, and Norman B. Hecht PMCID: PMC1472510 Evolution The road from Santa Rosalia: A faster tempo of evolution in tropical climates Shane Wright, Jeannette Keeling, and Len Gillman PMCID: PMC1472511 Evidence for a clade composed of molluscs with serially repeated structures: Monoplacophorans are related to chitons Gonzalo Giribet, Akiko Okusu, Annie R. Lindgren, Stephanie W. Huff, Michael Schrödl, and Michele K. Nishiguchi PMCID: PMC1472512 Genetics Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: Implications for 22q11 deletion syndrome Richard Paylor, Beate Glaser, Annalisa Mupo, Paris Ataliotis, Corinne Spencer, Angela Sobotka, Chelsey Sparks, Chul-Hee Choi, John Oghalai, Sarah Curran, Kieran C. Murphy, Stephen Monks, Nigel Williams, Michael C. O’Donovan, Michael J. Owen, Peter J. Scambler, and Elizabeth Lindsay PMCID: PMC1472513 Genetic variation in putative regulatory loci controlling gene expression in breast cancer Vessela N. Kristensen, Hege Edvardsen, Anya Tsalenko, Silje H. Nordgard, Therese Sørlie, Roded Sharan, Aditya Vailaya, Amir Ben-Dor, Per Eystein Lønning, Sigbjørn Lien, Stig Omholt, Ann-Christine Syvänen, Zohar Yakhini, and Anne-Lise Børresen-Dale PMCID: PMC1458617 Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism Daniel Mertens, Stephan Wolf, Cordula Tschuch, Cora Mund, Dirk Kienle, Sibylle Ohl, Petra Schroeter, Frank Lyko, Hartmut Döhner, Stephan Stilgenbauer, and Peter Lichter PMCID: PMC1472515 Immunology Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity C. Sirac, C. Carrion, S. Duchez, I. Comte, and M. Cogné PMCID: PMC1472516 Transferable anticancer innate immunity in spontaneous regression/complete resistance mice Amy M. Hicks, Gregory Riedlinger, Mark C. Willingham, Martha A. Alexander-Miller, C. Von Kap-Herr, Mark J. Pettenati, Anne M. Sanders, Holly M. Weir, Wei Du, Joseph Kim, Andrew J. G. Simpson, Lloyd J. Old, and Zheng Cui PMCID: PMC1458507 Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process Jill Donelan, William Boucher, Nikoletta Papadopoulou, Michael Lytinas, Dean Papaliodis, Paul Dobner, and Theoharis C. Theoharides PMCID: PMC1472518 Loss of Siglec expression on T lymphocytes during human evolution Dzung H. Nguyen, Nancy Hurtado-Ziola, Pascal Gagneux, and Ajit Varki PMCID: PMC1472519 Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation J.-P. Lai, W. Z. Ho, L. E. Kilpatrick, X. Wang, F. Tuluc, H. M. Korchak, and S. D. Douglas PMCID: PMC1457089 Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells Meenakshi Arora, Li Chen, Melissa Paglia, Iain Gallagher, Judith E. Allen, Yatin M. Vyas, Anuradha Ray, and Prabir Ray PMCID: PMC1472521 Langerhans cells cross-present antigen derived from skin Patrizia Stoitzner, Christoph H. Tripp, Andreas Eberhart, Kylie M. Price, Jae Y. Jung, Laura Bursch, Franca Ronchese, and Nikolaus Romani PMCID: PMC1472522 Medical Sciences Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor Li Xin, Michael A. Teitell, Devon A. Lawson, Andrew Kwon, Ingo K. Mellinghoff, and Owen N. Witte PMCID: PMC1458510 A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer Wenle Xia, Sarah Bacus, Priti Hegde, Intisar Husain, Jay Strum, Leihua Liu, Georgina Paulazzo, Ljuba Lyass, Patricia Trusk, Jason Hill, Jennifer Harris, and Neil L. Spector PMCID: PMC1472524 Multiorgan engraftment and differentiation of human cord blood CD34+Lin− cells in goats assessed by gene expression profiling Fanyi Zeng, Mei-jue Chen, Don A. Baldwin, Zhi-juan Gong, Jing-bin Yan, Hui Qian, Juan Wang, Xiaoyan Jiang, Zhao-rui Ren, Deming Sun, and Shu-zhen Huang PMCID: PMC1472525 From the Cover:
V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity Taka-aki Koshimizu, Yoshihisa Nasa, Akito Tanoue, Ryo Oikawa, Yuji Kawahara, Yasushi Kiyono, Tetsuya Adachi, Toshiki Tanaka, Tomoyuki Kuwaki, Toyoki Mori, Satoshi Takeo, Hitoshi Okamura, and Gozoh Tsujimoto PMCID: PMC1472526 Short-course postexposure antibiotic prophylaxis combined with vaccination protects against experimental inhalational anthrax Nicholas J. Vietri, Bret K. Purcell, James V. Lawler, Elizabeth K. Leffel, Pedro Rico, Christopher S. Gamble, Nancy A. Twenhafel, Bruce E. Ivins, Henry S. Heine, Ryan Sheeler, Mary E. Wright, and Arthur M. Friedlander PMCID: PMC1472527 Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors Hongbin Ji, Xiaojun Zhao, Yuki Yuza, Takeshi Shimamura, Danan Li, Alexei Protopopov, Boonim L. Jung, Kate McNamara, Huili Xia, Karen A. Glatt, Roman K. Thomas, Hidefumi Sasaki, James W. Horner, Michael Eck, Albert Mitchell, Yangping Sun, Ruqayyah Al-Hashem, Roderick T. Bronson, Sridhar K. Rabindran, Carolyn M. Discafani, Elizabeth Maher, Geoffrey I. Shapiro, Matthew Meyerson, and Kwok-Kin Wong PMCID: PMC1456806 Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: Chemoprevention by budesonide and N-acetylcysteine Roumen Balansky, Francesco D'Agostini, Gancho Ganchev, Alberto Izzotti, Barbara Di Marco, Ronald A. Lubet, Nicola Zanesi, Carlo M. Croce, and Silvio De Flora PMCID: PMC1472529 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Kathryn L. Kavanagh, Kunde Guo, James E. Dunford, Xiaoqiu Wu, Stefan Knapp, Frank H. Ebetino, Michael J. Rogers, R. Graham G. Russell, and Udo Oppermann PMCID: PMC1472530 Microbiology Neurons produce type I interferon during viral encephalitis Sophie Delhaye, Sophie Paul, Gjon Blakqori, Muriel Minet, Friedemann Weber, Peter Staeheli, and Thomas Michiels PMCID: PMC1458506 Neuroscience Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP Bulent Ataman, James Ashley, David Gorczyca, Michael Gorczyca, Dennis Mathew, Carolin Wichmann, Stephan J. Sigrist, and Vivian Budnik PMCID: PMC1472532 Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator Jianxue Li, Yinghua Ma, Yang D. Teng, Kangni Zheng, Timothy K. Vartanian, Evan Y. Snyder, and Richard L. Sidman PMCID: PMC1472533 Development of NG2 neural progenitor cells requires Olig gene function Keith L. Ligon, Santosh Kesari, Masaaki Kitada, Tao Sun, Heather A. Arnett, John A. Alberta, David J. Anderson, Charles D. Stiles, and David H. Rowitch PMCID: PMC1472534 Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination Ben Emery, Holly S. Cate, Mark Marriott, Tobias Merson, Michele D. Binder, Cameron Snell, Pik Ying Soo, Simon Murray, Ben Croker, Jian-Guo Zhang, Warren S. Alexander, Helen Cooper, Helmut Butzkueven, and Trevor J. Kilpatrick PMCID: PMC1472535 Motor cortex maps articulatory features of speech sounds Friedemann Pulvermüller, Martina Huss, Ferath Kherif, Fermin Moscoso del Prado Martin, Olaf Hauk, and Yury Shtyrov PMCID: PMC1472536 Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells Yasuhiro Ito, Stefan Wiese, Natalja Funk, Alexandra Chittka, Wilfried Rossoll, Heike Bömmel, Kazuhiko Watabe, Michael Wegner, and Michael Sendtner PMCID: PMC1472537 Adenosine A2a blockade prevents synergy between μ-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats Lina Yao, Krista McFarland, Peidong Fan, Zhan Jiang, Takashi Ueda, and Ivan Diamond PMCID: PMC1458620 From the Cover:
μ Opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers Katarina Drakenberg, Andrej Nikoshkov, Monika Cs Horváth, Pernilla Fagergren, Anna Gharibyan, Kati Saarelainen, Sadia Rahman, Ingrid Nylander, Georgy Bakalkin, Jovan Rajs, Eva Keller, and Yasmin L. Hurd PMCID: PMC1472539 Sex-specific influences of vasopressin on human social communication R. R. Thompson, K. George, J. C. Walton, S. P. Orr, and J. Benson PMCID: PMC1472540 Pharmacology Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression Erica J. Carrier, John A. Auchampach, and Cecilia J. Hillard PMCID: PMC1472541 Physiology From the Cover:
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction Michael S. Bonkowski, Juliana S. Rocha, Michal M. Masternak, Khalid A. Al Regaiey, and Andrzej Bartke PMCID: PMC1458512 Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias Stephan E. Lehnart, Cecile Terrenoire, Steven Reiken, Xander H. T. Wehrens, Long-Sheng Song, Erik J. Tillman, Salvatore Mancarella, James Coromilas, W. J. Lederer, Robert S. Kass, and Andrew R. Marks PMCID: PMC1472543 Plant Biology The sulfur acclimation SAC3 kinase is required for chloroplast transcriptional repression under sulfur limitation in Chlamydomonas reinhardtii Vered Irihimovitch and David B. Stern PMCID: PMC1472544 From The Cover:
REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis Josephine S. Resnick, Chi-Kuang Wen, Jason A. Shockey, and Caren Chang PMCID: PMC1458508 From The Cover:
Ripening in the tomato Green-ripe mutant is inhibited by ectopic expression of a protein that disrupts ethylene signaling Cornelius S. Barry and James J. Giovannoni PMCID: PMC1458509 Social Sciences Economic Sciences Medicare prescription drug coverage: Consumer information and preferences Joachim Winter, Rowilma Balza, Frank Caro, Florian Heiss, Byung-hill Jun, Rosa Matzkin, and Daniel McFadden PMCID: PMC1472547 Psychology Sex-specific influences of vasopressin on human social communication R. R. Thompson, K. George, J. C. Walton, S. P. Orr, and J. Benson PMCID: PMC1472540 Social Sciences Sverdlovsk revisited: Modeling human inhalation anthrax Dean A. Wilkening PMCID: PMC1564296 Corrections Correction for Tan et al., SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos Xungang Tan, Josep Rotllant, Huiqing Li, Patrick De Deyne, and Shao Jun Du PMCID: PMC1472548 Corrects: Xungang Tan, et al. SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos. Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2713–2718. Correction for Wall et al., Functional genomic analysis of the rates of protein evolution PMCID: PMC1472549 Corrects: Dennis P. Wall, et al. Functional genomic analysis of the rates of protein evolution. Proc Natl Acad Sci U S A. 2005 April 12; 102(15): 5483–5488. |
