| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18243–18244. doi: 10.1073/iti5105102.PMCID: PMC1317898 Commentaries When the B-team runs plasticity: GluR2 receptor trafficking in cerebellar long-term potentiation Christian Hansel Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18245–18246. Published online 2005 December 12. doi: 10.1073/pnas.0509686102.PMCID: PMC1317989 The chemistry of child neglect: Do oxytocin and vasopressin mediate the effects of early experience? C. Sue Carter Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18247–18248. Published online 2005 December 12. doi: 10.1073/pnas.0509376102.PMCID: PMC1317979 Profile Profile of Raymond C. Kelly Nick Zagorski Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18249–18251. Published online 2005 December 13. doi: 10.1073/pnas.0506968102.PMCID: PMC1317930 Physical Sciences Applied Physical Sciences Volumetric tomography of fluorescent proteins through small animals in vivo Giannis Zacharakis, Hirokazu Kambara, Helen Shih, Jorge Ripoll, Jan Grimm, Yoshinaga Saeki, Ralph Weissleder, and Vasilis Ntziachristos Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18252–18257. Published online 2005 December 12. doi: 10.1073/pnas.0504628102.PMCID: PMC1317905 Solvent and mutation effects on the nucleation of amyloid β-protein folding Luis Cruz, Brigita Urbanc, Jose M. Borreguero, Noel D. Lazo, David B. Teplow, and H. Eugene Stanley Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18258–18263. Published online 2005 December 9. doi: 10.1073/pnas.0509276102.PMCID: PMC1317965 Chemistry In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles Young Jik Kwon, Edward James, Nilabh Shastri, and Jean M. J. Fréchet Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18264–18268. Published online 2005 December 12. doi: 10.1073/pnas.0509541102.PMCID: PMC1317987 Controlling ligand substitution reactions of organometallic complexes: Tuning cancer cell cytotoxicity Fuyi Wang, Abraha Habtemariam, Erwin P. L. van der Geer, Rafael Fernández, Michael Melchart, Robert J. Deeth, Rhona Aird, Sylvie Guichard, Francesca P. A. Fabbiani, Patricia Lozano-Casal, Iain D. H. Oswald, Duncan I. Jodrell, Simon Parsons, and Peter J. Sadler Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18269–18274. Published online 2005 December 13. doi: 10.1073/pnas.0505798102.PMCID: PMC1317918 Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging Galina E. Pavlovskaya, Zackary I. Cleveland, Karl F. Stupic, Randall J. Basaraba, and Thomas Meersmann Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18275–18279. Published online 2005 December 12. doi: 10.1073/pnas.0509419102.PMCID: PMC1317982 Modulation of the electronic structure and the Ni–Fe distance in heterobimetallic models for the active site in [NiFe]hydrogenase Wenfeng Zhu, Andrew C. Marr, Qiang Wang, Frank Neese, Douglas J. E. Spencer, Alexander J. Blake, Paul A. Cooke, Claire Wilson, and Martin Schröder Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18280–18285. Published online 2005 December 13. doi: 10.1073/pnas.0505779102.PMCID: PMC1317917 Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method Hiroaki Gouda, Toshiaki Sunazuka, Hideaki Ui, Masaki Handa, Yusuke Sakoh, Yuzuru Iwai, Shuichi Hirono, and Satoshi Ōmura Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18286–18291. Published online 2005 December 12. doi: 10.1073/pnas.0508425102.PMCID: PMC1317948 Environmental Sciences Microbial origin of excess methane in glacial ice and implications for life on Mars H. C. Tung, N. E. Bramall, and P. B. Price Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18292–18296. Published online 2005 December 7. doi: 10.1073/pnas.0507601102.PMCID: PMC1308353 Geophysics Microbial origin of excess methane in glacial ice and implications for life on Mars H. C. Tung, N. E. Bramall, and P. B. Price Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18292–18296. Published online 2005 December 7. doi: 10.1073/pnas.0507601102.PMCID: PMC1308353 Statistics Information-based clustering Noam Slonim, Gurinder Singh Atwal, Gašper Tkačik, and William Bialek Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18297–18302. Published online 2005 December 13. doi: 10.1073/pnas.0507432102.PMCID: PMC1317937 Biological Sciences Agricultural Sciences Bacillus thuringiensis subsp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor Claudia Pérez, Luisa E. Fernandez, Jianguang Sun, Jorge Luis Folch, Sarjeet S. Gill, Mario Soberón, and Alejandra Bravo Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18303–18308. Published online 2005 December 9. doi: 10.1073/pnas.0505494102.PMCID: PMC1317914 Anthropology Cranial morphology of early Americans from Lagoa Santa, Brazil: Implications for the settlement of the New World Walter A. Neves and Mark Hubbe Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18309–18314. Published online 2005 December 12. doi: 10.1073/pnas.0507185102.PMCID: PMC1317934 An Asian origin for a 10,000-year-old domesticated plant in the Americas David L. Erickson, Bruce D. Smith, Andrew C. Clarke, Daniel H. Sandweiss, and Noreen Tuross Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18315–18320. Published online 2005 December 13. doi: 10.1073/pnas.0509279102.PMCID: PMC1311910 Applied Biological Sciences From the Cover: Generating highly ordered DNA nanostrand arrays Jingjiao Guan and L. James Lee Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18321–18325. Published online 2005 December 13. doi: 10.1073/pnas.0506902102.PMCID: PMC1317928 Biochemistry The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation Michael Sacher, Alessandra Di Bacco, Vladimir V. Lunin, Zheng Ye, John Wagner, Grace Gill, and Miroslaw Cygler Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18326–18331. Published online 2005 December 12. doi: 10.1073/pnas.0505071102.PMCID: PMC1317909 Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design Mi Li, Gary S. Laco, Mariusz Jaskolski, Jan Rozycki, Jerry Alexandratos, Alexander Wlodawer, and Alla Gustchina Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18332–18337. Published online 2005 December 13. doi: 10.1073/pnas.0509335102.PMCID: PMC1317974 The tethered motor domain of a kinesin-microtubule complex catalyzes reversible synthesis of bound ATP David D. Hackney Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18338–18343. Published online 2005 December 9. doi: 10.1073/pnas.0505288102.PMCID: PMC1317912 Sequence determinants of a conformational switch in a protein structure Thomas A. Anderson, Matthew H. J. Cordes, and Robert T. Sauer Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18344–18349. Published online 2005 December 12. doi: 10.1073/pnas.0509349102.PMCID: PMC1317976 Human La is found at RNA polymerase III-transcribed genes in vivo Jennifer A. Fairley, Theodoros Kantidakis, Niall S. Kenneth, Robert V. Intine, Richard J. Maraia, and Robert J. White Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18350–18355. Published online 2005 December 12. doi: 10.1073/pnas.0506415102.PMCID: PMC1317925 The proficiency of a thermophilic chorismate mutase enzyme is solely through an entropic advantage in the enzyme reaction Xiaohua Zhang and Thomas C. Bruice Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18356–18360. Published online 2005 December 12. doi: 10.1073/pnas.0509234102.PMCID: PMC1317962 Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases η and REV1 Parie Garg and Peter M. Burgers Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18361–18366. Published online 2005 December 12. doi: 10.1073/pnas.0505949102.PMCID: PMC1317920 Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans Leslie I. Grad, Leanne C. Sayles, and Bernard D. Lemire Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18367–18372. Published online 2005 December 12. doi: 10.1073/pnas.0506939102.PMCID: PMC1311736 Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A Jason G. S. Ho, Antonio Greco, Maja Rupnik, and Kenneth K.-S. Ng Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18373–18378. Published online 2005 December 12. doi: 10.1073/pnas.0506391102.PMCID: PMC1317924 Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein Jin-Shan Hu, Hanqiao Feng, Wangyong Zeng, Guang-xin Lin, and Xu Guang Xi Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18379–18384. Published online 2005 December 9. doi: 10.1073/pnas.0509380102.PMCID: PMC1317980 Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling Bing Li, Samantha G. Pattenden, Daeyoup Lee, José Gutiérrez, Jie Chen, Chris Seidel, Jennifer Gerton, and Jerry L. Workman Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18385–18390. Published online 2005 December 12. doi: 10.1073/pnas.0507975102.PMCID: PMC1317944 Biophysics Solvent and mutation effects on the nucleation of amyloid β-protein folding Luis Cruz, Brigita Urbanc, Jose M. Borreguero, Noel D. Lazo, David B. Teplow, and H. Eugene Stanley Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18258–18263. Published online 2005 December 9. doi: 10.1073/pnas.0509276102.PMCID: PMC1317965 Structure of the streptococcal cell wall C5a peptidase C. Kent Brown, Zu-Yi Gu, Yury V. Matsuka, Sai S. Purushothaman, Laurie A. Winter, P. Patrick Cleary, Stephen B. Olmsted, Douglas H. Ohlendorf, and Cathleen A. Earhart Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18391–18396. Published online 2005 December 12. doi: 10.1073/pnas.0504954102.PMCID: PMC1317908 Snapshots of cytochrome c folding Ekaterina V. Pletneva, Harry B. Gray, and Jay R. Winkler Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18397–18402. Published online 2005 December 12. doi: 10.1073/pnas.0509076102.PMCID: PMC1317956 Diffusion and scaling during early embryonic pattern formation Thomas Gregor, William Bialek, Rob R. de Ruyter van Steveninck, David W. Tank, and Eric F. Wieschaus Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18403–18407. Published online 2005 December 13. doi: 10.1073/pnas.0509483102.PMCID: PMC1311912 Mechanism of metal ion activation of the diphtheria toxin repressor DtxR J. Alejandro D'Aquino, Jaclyn Tetenbaum-Novatt, Andre White, Fred Berkovitch, and Dagmar Ringe Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18408–18413. Published online 2005 December 13. doi: 10.1073/pnas.0500908102.PMCID: PMC1317899 Topology of biological networks and reliability of information processing Konstantin Klemm and Stefan Bornholdt Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18414–18419. Published online 2005 December 8. doi: 10.1073/pnas.0509132102.PMCID: PMC1317958 Cell Biology An antiviral role for the RNA interference machinery in Caenorhabditis elegans Daniel H. Schott, David K. Cureton, Sean P. Whelan, and Craig P. Hunter Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18420–18424. Published online 2005 December 9. doi: 10.1073/pnas.0507123102.PMCID: PMC1317933 Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes Gabrielle G. M. Pinkse, Odette H. M. Tysma, Cees A. M. Bergen, Michel G. D. Kester, Ferry Ossendorp, Peter A. van Veelen, Bart Keymeulen, Danny Pipeleers, Jan W. Drijfhout, and Bart O. Roep Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18425–18430. Published online 2005 December 9. doi: 10.1073/pnas.0508621102.PMCID: PMC1317949 Up-regulation of β-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells Kyung Lib Jang, Julia Shackelford, So Young Seo, and Joseph S. Pagano Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18431–18436. Published online 2005 December 12. doi: 10.1073/pnas.0504054102.PMCID: PMC1317901 Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element Izumi Horikawa, Y. Jeffrey Chiang, Tricia Patterson, Lionel Feigenbaum, Sun-Hee Leem, Eriko Michishita, Vladimir Larionov, Richard J. Hodes, and J. Carl Barrett Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18437–18442. Published online 2005 December 12. doi: 10.1073/pnas.0508964102.PMCID: PMC1317953 The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells Jean J. Zhao, Zhenning Liu, Li Wang, Eyoung Shin, Massimo F. Loda, and Thomas M. Roberts Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18443–18448. Published online 2005 December 8. doi: 10.1073/pnas.0508988102.PMCID: PMC1317954 Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment Christina Abrahamsberg, Peter Fuchs, Selma Osmanagic-Myers, Irmgard Fischer, Friedrich Propst, Adelheid Elbe-Bürger, and Gerhard Wiche Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18449–18454. Published online 2005 December 12. doi: 10.1073/pnas.0505380102.PMCID: PMC1317913 Developmental Biology From the Cover: Epicardial retinoid X receptor α is required for myocardial growth and coronary artery formation Esther Merki, Mónica Zamora, Angel Raya, Yasuhiko Kawakami, Jianming Wang, Xiaoxue Zhang, John Burch, Steven W. Kubalak, Perla Kaliman, Juan Carlos Izpisua Belmonte, Kenneth R. Chien, and Pilar Ruiz-Lozano Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18455–18460. Published online 2005 December 13. doi: 10.1073/pnas.0504343102.PMCID: PMC1317903 Two types of precursor cells in a multipotential hematopoietic cell line Zhi-jia Ye, Yuval Kluger, Zheng Lian, and Sherman M. Weissman Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18461–18466. Published online 2005 December 13. doi: 10.1073/pnas.0509314102.PMCID: PMC1317970 Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis Soojin Ryu, Jochen Holzschuh, Simone Erhardt, Anne-Kathrin Ettl, and Wolfgang Driever Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18467–18472. Published online 2005 December 8. doi: 10.1073/pnas.0506187102.PMCID: PMC1317923 The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney Sung-Kook Hong, Caroline E. Haldin, Nathan D. Lawson, Brant M. Weinstein, Igor B. Dawid, and Neil A. Hukriede Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18473–18478. Published online 2005 December 12. doi: 10.1073/pnas.0509457102.PMCID: PMC1311743 Mapping Dmef2-binding regulatory modules by using a ChIP-enriched in silico targets approach Guillaume Junion, Teresa Jagla, Sebastien Duplant, Romain Tapin, Jean-Philippe Da Ponte, and Krzysztof Jagla Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18479–18484. Published online 2005 December 9. doi: 10.1073/pnas.0507030102.PMCID: PMC1317932 A mouse atlas of gene expression: Large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells Asim S. Siddiqui, Jaswinder Khattra, Allen D. Delaney, Yongjun Zhao, Caroline Astell, Jennifer Asano, Ryan Babakaiff, Sarah Barber, Jaclyn Beland, Slavita Bohacec, Mabel Brown-John, Steve Chand, David Charest, Anita M. Charters, Rebecca Cullum, Noreen Dhalla, Ruth Featherstone, Daniela S. Gerhard, Brad Hoffman, Robert A. Holt, Juan Hou, Byron Y.-L. Kuo, Lisa L. C. Lee, Stephanie Lee, Derek Leung, Kevin Ma, Corey Matsuo, Michael Mayo, Helen McDonald, Anna-liisa Prabhu, Pawan Pandoh, Gregory J. Riggins, Teresa Ruiz de Algara, James L. Rupert, Duane Smailus, Jeff Stott, Miranda Tsai, Richard Varhol, Pavle Vrljicak, David Wong, Mona K. Wu, Yuan-Yun Xie, George Yang, Ida Zhang, Martin Hirst, Steven J. M. Jones, Cheryl D. Helgason, Elizabeth M. Simpson, Pamela A. Hoodless, and Marco A. Marra Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18485–18490. Published online 2005 December 13. doi: 10.1073/pnas.0509455102.PMCID: PMC1311911 The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: Analysis of ESTs from the hermaphroditic strain Ricardo M. Zayas, Alvaro Hernández, Bianca Habermann, Yuying Wang, Joel M. Stary, and Phillip A. Newmark Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18491–18496. Published online 2005 December 12. doi: 10.1073/pnas.0509507102.PMCID: PMC1317986 Ecology Pinpointing and preventing imminent extinctions Taylor H. Ricketts, Eric Dinerstein, Tim Boucher, Thomas M. Brooks, Stuart H. M. Butchart, Michael Hoffmann, John F. Lamoreux, John Morrison, Mike Parr, John D. Pilgrim, Ana S. L. Rodrigues, Wes Sechrest, George E. Wallace, Ken Berlin, Jon Bielby, Neil D. Burgess, Don R. Church, Neil Cox, David Knox, Colby Loucks, Gary W. Luck, Lawrence L. Master, Robin Moore, Robin Naidoo, Robert Ridgely, George E. Schatz, Gavin Shire, Holly Strand, Wes Wettengel, and Eric Wikramanayake Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18497–18501. Published online 2005 December 12. doi: 10.1073/pnas.0509060102.PMCID: PMC1311739 Slow growth rates of Amazonian trees: Consequences for carbon cycling Simone Vieira, Susan Trumbore, Plinio B. Camargo, Diogo Selhorst, Jeffrey Q. Chambers, Niro Higuchi, and Luiz Antonio Martinelli Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18502–18507. Published online 2005 December 9. doi: 10.1073/pnas.0505966102.PMCID: PMC1310511 Evolution Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes Benjamin F. Voight, Alison M. Adams, Linda A. Frisse, Yudong Qian, Richard R. Hudson, and Anna Di Rienzo Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18508–18513. Published online 2005 December 13. doi: 10.1073/pnas.0507325102.PMCID: PMC1311907 Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection Simon D. W. Frost, Terri Wrin, Davey M. Smith, Sergei L. Kosakovsky Pond, Yang Liu, Ellen Paxinos, Colombe Chappey, Justin Galovich, Jeff Beauchaine, Christos J. Petropoulos, Susan J. Little, and Douglas D. Richman Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18514–18519. Published online 2005 December 9. doi: 10.1073/pnas.0504658102.PMCID: PMC1310509 Genetics Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations Ronald Roepman, Stef J. F. Letteboer, Heleen H. Arts, Sylvia E. C. van Beersum, Xinrong Lu, Elmar Krieger, Paulo A. Ferreira, and Frans P. M. Cremers Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18520–18525. Published online 2005 December 9. doi: 10.1073/pnas.0505774102.PMCID: PMC1317916 A high-resolution whole-genome cattle–human comparative map reveals details of mammalian chromosome evolution Annelie Everts-van der Wind, Denis M. Larkin, Cheryl A. Green, Janice S. Elliott, Colleen A. Olmstead, Readman Chiu, Jacqueline E. Schein, Marco A. Marra, James E. Womack, and Harris A. Lewin Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18526–18531. Published online 2005 December 9. doi: 10.1073/pnas.0509285102.PMCID: PMC1317968 Immunology Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc Hiroyuki O. Ishikawa, Shunsuke Higashi, Tomonori Ayukawa, Takeshi Sasamura, Motoo Kitagawa, Kenichi Harigaya, Kazuhisa Aoki, Nobuhiro Ishida, Yutaka Sanai, and Kenji Matsuno Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18532–18537. Published online 2005 December 12. doi: 10.1073/pnas.0504115102.PMCID: PMC1317902 Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer Eiichi Sato, Sara H. Olson, Jiyoung Ahn, Brian Bundy, Hiroyoshi Nishikawa, Feng Qian, Achim A. Jungbluth, Denise Frosina, Sacha Gnjatic, Christine Ambrosone, James Kepner, Tosin Odunsi, Gerd Ritter, Shashikant Lele, Yao-Tseng Chen, Haruo Ohtani, Lloyd J. Old, and Kunle Odunsi Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18538–18543. Published online 2005 December 12. doi: 10.1073/pnas.0509182102.PMCID: PMC1311741 Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders Domenico Rosa, Giulietta Saletti, Ennio De Gregorio, Francesca Zorat, Consuelo Comar, Ugo D'Oro, Sandra Nuti, Michael Houghton, Vincenzo Barnaba, Gabriele Pozzato, and Sergio Abrignani Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18544–18549. Published online 2005 December 9. doi: 10.1073/pnas.0509402102.PMCID: PMC1310512 Social relationships, sleep quality, and interleukin-6 in aging women Elliot M. Friedman, Mary S. Hayney, Gayle D. Love, Heather L. Urry, Melissa A. Rosenkranz, Richard J. Davidson, Burton H. Singer, and Carol D. Ryff Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18757–18762. Published online 2005 December 8. doi: 10.1073/pnas.0509281102.PMCID: PMC1317967 Medical Sciences Three independent biological mechanisms cause exercise-associated hyponatremia: Evidence from 2,135 weighed competitive athletic performances T. D. Noakes, K. Sharwood, D. Speedy, T. Hew, S. Reid, J. Dugas, C. Almond, P. Wharam, and L. Weschler Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18550–18555. Published online 2005 December 12. doi: 10.1073/pnas.0509096102.PMCID: PMC1311740 Human cancers overexpress genes that are specific to a variety of normal human tissues Joseph Lotem, Dvir Netanely, Eytan Domany, and Leo Sachs Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18556–18561. Published online 2005 December 8. doi: 10.1073/pnas.0509360102.PMCID: PMC1317977 Epstein–Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase Jason S. Knight, Nikhil Sharma, and Erle S. Robertson Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18562–18566. Published online 2005 December 13. doi: 10.1073/pnas.0503886102.PMCID: PMC1317900 Repression of β-catenin function in malignant cells by nonsteroidal antiinflammatory drugs Desheng Lu, Howard B. Cottam, Maripat Corr, and Dennis A. Carson Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18567–18571. Published online 2005 December 13. doi: 10.1073/pnas.0509316102.PMCID: PMC1317972 Microbiology Poxvirus multiprotein entry–fusion complex Tatiana G. Senkevich, Suany Ojeda, Alan Townsley, Gretchen E. Nelson, and Bernard Moss Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18572–18577. Published online 2005 December 8. doi: 10.1073/pnas.0509239102.PMCID: PMC1309049 Bordetella filamentous hemagglutinin plays a critical role in immunomodulation, suggesting a mechanism for host specificity Carol S. Inatsuka, Steven M. Julio, and Peggy A. Cotter Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18578–18583. Published online 2005 December 9. doi: 10.1073/pnas.0507910102.PMCID: PMC1317942 Posttranslational conversion of l-serines to d-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147 Paul D. Cotter, Paula M. O'Connor, Lorraine A. Draper, Elaine M. Lawton, Lucy H. Deegan, Colin Hill, and R. Paul Ross Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18584–18589. Published online 2005 December 8. doi: 10.1073/pnas.0509371102.PMCID: PMC1317978 The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host G. Gabriel, B. Dauber, T. Wolff, O. Planz, H.-D. Klenk, and J. Stech Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18590–18595. Published online 2005 December 8. doi: 10.1073/pnas.0507415102.PMCID: PMC1317936 Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis Ke Shi, C. Kent Brown, Zu-Yi Gu, Briana K. Kozlowicz, Gary M. Dunny, Douglas H. Ohlendorf, and Cathleen A. Earhart Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18596–18601. Published online 2005 December 8. doi: 10.1073/pnas.0506163102.PMCID: PMC1317922 The cell-shape protein MreC interacts with extracytoplasmic proteins including cell wall assembly complexes in Caulobacter crescentus Arun V. Divakaruni, Rachel R. Ogorzalek Loo, Yongming Xie, Joseph A. Loo, and James W. Gober Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18602–18607. Published online 2005 December 12. doi: 10.1073/pnas.0507937102.PMCID: PMC1317943 Two independent spiral structures control cell shape in Caulobacter Natalie A. Dye, Zachary Pincus, Julie A. Theriot, Lucy Shapiro, and Zemer Gitai Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18608–18613. Published online 2005 December 12. doi: 10.1073/pnas.0507708102.PMCID: PMC1317941 Neuroscience Unexceptional sharpness of frequency tuning in the human cochlea Mario A. Ruggero and Andrei N. Temchin Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18614–18619. Published online 2005 December 12. doi: 10.1073/pnas.0509323102.PMCID: PMC1311742 Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis G. Gobbi, F. R. Bambico, R. Mangieri, M. Bortolato, P. Campolongo, M. Solinas, T. Cassano, M. G. Morgese, G. Debonnel, A. Duranti, A. Tontini, G. Tarzia, M. Mor, V. Trezza, S. R. Goldberg, V. Cuomo, and D. Piomelli Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18620–18625. Published online 2005 December 13. doi: 10.1073/pnas.0509591102.PMCID: PMC1317988 Control over brain activation and pain learned by using real-time functional MRI R. Christopher deCharms, Fumiko Maeda, Gary H. Glover, David Ludlow, John M. Pauly, Deepak Soneji, John D. E. Gabrieli, and Sean C. Mackey Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18626–18631. Published online 2005 December 13. doi: 10.1073/pnas.0505210102.PMCID: PMC1311906 Modulation of neuropeptide Y expression in adult mice does not affect feeding Linda Ste. Marie, Serge Luquet, Toby B. Cole, and Richard D. Palmiter Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18632–18637. Published online 2005 December 8. doi: 10.1073/pnas.0509240102.PMCID: PMC1309050 Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types Vikaas S. Sohal and John R. Huguenard Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18638–18643. Published online 2005 December 8. doi: 10.1073/pnas.0509291102.PMCID: PMC1317969 Development of functional human embryonic stem cell-derived neurons in mouse brain Alysson R. Muotri, Kinichi Nakashima, Nicolas Toni, Vladislav M. Sandler, and Fred H. Gage Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18644–18648. Published online 2005 December 13. doi: 10.1073/pnas.0509315102.PMCID: PMC1317971 The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal Angelo Contarino and Francesco Papaleo Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18649–18654. Published online 2005 December 8. doi: 10.1073/pnas.0506999102.PMCID: PMC1317931 Neurons of the cerebral cortex exhibit precise interspike timing in correspondence to behavior Tomer Shmiel, Rotem Drori, Oren Shmiel, Yoram Ben-Shaul, Zoltan Nadasdy, Moshe Shemesh, Mina Teicher, and Moshe Abeles Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18655–18657. Published online 2005 December 9. doi: 10.1073/pnas.0509346102.PMCID: PMC1317975 Recombinant human nerve growth factor with a marked activity in vitro and in vivo Anna M. Colangelo, Nicoletta Finotti, Michela Ceriani, Lilia Alberghina, Enzo Martegani, Luigi Aloe, Laura Lenzi, and Rita Levi-Montalcini Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18658–18663. Published online 2005 December 8. doi: 10.1073/pnas.0508734102.PMCID: PMC1317951 Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1 J.-S. Rhee, L. Y. Li, O.-H. Shin, J.-C. Rah, J. Rizo, T. C. Südhof, and C. Rosenmund Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18664–18669. Published online 2005 December 13. doi: 10.1073/pnas.0509153102.PMCID: PMC1311909 From the Cover: Galactocerebrosidase-deficient oligodendrocytes maintain stable central myelin by exogenous replacement of the missing enzyme in mice Yoichi Kondo, David A. Wenger, Vittorio Gallo, and Ian D. Duncan Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18670–18675. Published online 2005 December 13. doi: 10.1073/pnas.0506473102.PMCID: PMC1317926 Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration Wanli W. Smith, Zhong Pei, Haibing Jiang, Darren J. Moore, Yideng Liang, Andrew B. West, Valina L. Dawson, Ted M. Dawson, and Christopher A. Ross Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18676–18681. Published online 2005 December 13. doi: 10.1073/pnas.0508052102.PMCID: PMC1317945 Unconscious fear influences emotional awareness of faces and voices B. de Gelder, J. S. Morris, and R. J. Dolan Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18682–18687. Published online 2005 December 13. doi: 10.1073/pnas.0509179102.PMCID: PMC1317960 Beyond the olfactory bulb: An odotopic map in the forebrain Alexander A. Nikonov, Thomas E. Finger, and John Caprio Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18688–18693. Published online 2005 December 7. doi: 10.1073/pnas.0505241102.PMCID: PMC1317911 Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity Shengjun Chang, Tian ran Ma, R. Dennis Miranda, Maureen E. Balestra, Robert W. Mahley, and Yadong Huang Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18694–18699. Published online 2005 December 12. doi: 10.1073/pnas.0508254102.PMCID: PMC1311737 Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target Shiming Ye, Yadong Huang, Karin Müllendorff, Liming Dong, Gretchen Giedt, Elaine C. Meng, Fred E. Cohen, Irwin D. Kuntz, Karl H. Weisgraber, and Robert W. Mahley Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18700–18705. Published online 2005 December 12. doi: 10.1073/pnas.0508693102.PMCID: PMC1311738 Pharmacology Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells Muriel Nobles, Amy Benians, and Andrew Tinker Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18706–18711. Published online 2005 December 13. doi: 10.1073/pnas.0504778102.PMCID: PMC1317907 From the Cover: A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo Kayo Mitsukawa, Rina Yamamoto, Silvio Ofner, Joachim Nozulak, Oliver Pescott, Snezana Lukic, Natacha Stoehr, Cedric Mombereau, Rainer Kuhn, Kevin H. McAllister, Herman van der Putten, John F. Cryan, and Peter J. Flor Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18712–18717. Published online 2005 December 9. doi: 10.1073/pnas.0508063102.PMCID: PMC1317946 Physiology Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor John P. A. Bannister, Baron Chanda, Francisco Bezanilla, and Diane M. Papazian Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18718–18723. Published online 2005 December 9. doi: 10.1073/pnas.0505766102.PMCID: PMC1317915 Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear Hong-Bo Zhao, Ning Yu, and Carrie R. Fleming Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18724–18729. Published online 2005 December 12. doi: 10.1073/pnas.0506481102.PMCID: PMC1317927 Plant Biology A regulator of nutritional copper signaling in Chlamydomonas is an SBP domain protein that recognizes the GTAC core of copper response element Janette Kropat, Stephen Tottey, Rainer P. Birkenbihl, Nathalie Depège, Peter Huijser, and Sabeeha Merchant Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18730–18735. Published online 2005 December 13. doi: 10.1073/pnas.0507693102.PMCID: PMC1311908 RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth Keiko Sugimoto-Shirasu, Gethin R. Roberts, Nicola J. Stacey, Maureen C. McCann, Anthony Maxwell, and Keith Roberts Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18736–18741. Published online 2005 December 8. doi: 10.1073/pnas.0505883102.PMCID: PMC1309048 From the Cover: Shoot circumnutation and winding movements require gravisensing cells Daisuke Kitazawa, Yasuko Hatakeda, Motoshi Kamada, Nobuharu Fujii, Yutaka Miyazawa, Atsushi Hoshino, Shigeru Iida, Hidehiro Fukaki, Miyo Terao Morita, Masao Tasaka, Hiroshi Suge, and Hideyuki Takahashi Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18742–18747. Published online 2005 December 9. doi: 10.1073/pnas.0504617102.PMCID: PMC1310508 Psychology Auditory-visual fusion in speech perception in children with cochlear implants Efrat A. Schorr, Nathan A. Fox, Virginie van Wassenhove, and Eric I. Knudsen Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18748–18750. Published online 2005 December 8. doi: 10.1073/pnas.0508862102.PMCID: PMC1317952 The spread of attention across modalities and space in a multisensory object Laura Busse, Kenneth C. Roberts, Roy E. Crist, Daniel H. Weissman, and Marty G. Woldorff Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18751–18756. Published online 2005 December 9. doi: 10.1073/pnas.0507704102.PMCID: PMC1317940 Social Sciences Anthropology An Asian origin for a 10,000-year-old domesticated plant in the Americas David L. Erickson, Bruce D. Smith, Andrew C. Clarke, Daniel H. Sandweiss, and Noreen Tuross Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18315–18320. Published online 2005 December 13. doi: 10.1073/pnas.0509279102.PMCID: PMC1311910 Psychology Social relationships, sleep quality, and interleukin-6 in aging women Elliot M. Friedman, Mary S. Hayney, Gayle D. Love, Heather L. Urry, Melissa A. Rosenkranz, Richard J. Davidson, Burton H. Singer, and Carol D. Ryff Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18757–18762. Published online 2005 December 8. doi: 10.1073/pnas.0509281102.PMCID: PMC1317967 Corrections Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18763. Published online 2005 December 7. doi: 10.1073/pnas.0509848102.PMCID: PMC1317990 Corrects: A. Bilkei-Gorzo, et al. Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. Proc Natl Acad Sci U S A. 2005 October 25; 102(43): 15670–15675. Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18763. Published online 2005 December 7. doi: 10.1073/pnas.0509997102.PMCID: PMC1317991 Corrects: Haiying Meng, et al. From the Cover: DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proc Natl Acad Sci U S A. 2005 November 22; 102(47): 17053–17058. |