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Volume 102(48);  November 29, 2005
In This Issue
This Week in PNAS
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17253–17254. doi: 10.1073/iti4805102.
PMCID: PMC1297702
Commentary
Transgenic rice for allergy immunotherapy
Shengwu Ma and Anthony M. Jevnikar
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17255–17256. Published online 2005 November 21. doi: 10.1073/pnas.0509018102.
PMCID: PMC1297701
Physical Sciences
Chemistry
Charting biologically relevant chemical space: A structural classification of natural products (SCONP)
Marcus A. Koch, Ansgar Schuffenhauer, Michael Scheck, Stefan Wetzel, Marco Casaulta, Alex Odermatt, Peter Ertl, and Herbert Waldmann
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17272–17277. Published online 2005 November 21. doi: 10.1073/pnas.0503647102.
PMCID: PMC1297657
Light-switching excimer probes for rapid protein monitoring in complex biological fluids
Chaoyong James Yang, Steffen Jockusch, Marie Vicens, Nicholas J. Turro, and Weihong Tan
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17278–17283. Published online 2005 November 21. doi: 10.1073/pnas.0508821102.
PMCID: PMC1297691
Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
Adam M. Hawkridge, Denise M. Heublein, H. Robert Bergen, III, Alessandro Cataliotti, John C. Burnett, Jr., and David C. Muddiman
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17442–17447. Published online 2005 November 17. doi: 10.1073/pnas.0508782102.
PMCID: PMC1297688
Geophysics
Deep mantle structure and the postperovskite phase transition
D. Helmberger, T. Lay, S. Ni, and M. Gurnis
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17257–17263. Published online 2005 October 10. doi: 10.1073/pnas.0502504102.
PMCID: PMC1297654
Physics
Cooperative cargo transport by several molecular motors
Stefan Klumpp and Reinhard Lipowsky
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17284–17289. Published online 2005 November 15. doi: 10.1073/pnas.0507363102.
PMCID: PMC1283533
Biological Sciences
Agricultural Sciences
Glyphosate inhibits rust diseases in glyphosate-resistant wheat and soybean
Paul C. C. Feng, G. James Baley, William P. Clinton, Greg J. Bunkers, Murtaza F. Alibhai, Timothy C. Paulitz, and Kimberlee K. Kidwell
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17290–17295. Published online 2005 November 17. doi: 10.1073/pnas.0508873102.
PMCID: PMC1297694
Applied Biological Sciences
A data integration methodology for systems biology
Daehee Hwang, Alistair G. Rust, Stephen Ramsey, Jennifer J. Smith, Deena M. Leslie, Andrea D. Weston, Pedro de Atauri, John D. Aitchison, Leroy Hood, Andrew F. Siegel, and Hamid Bolouri
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17296–17301. Published online 2005 November 21. doi: 10.1073/pnas.0508647102.
PMCID: PMC1297682
A data integration methodology for systems biology: Experimental verification
Daehee Hwang, Jennifer J. Smith, Deena M. Leslie, Andrea D. Weston, Alistair G. Rust, Stephen Ramsey, Pedro de Atauri, Andrew F. Siegel, Hamid Bolouri, John D. Aitchison, and Leroy Hood
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17302–17307. Published online 2005 November 21. doi: 10.1073/pnas.0508649102.
PMCID: PMC1297683
Biochemistry
From the Cover:
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Peter Cherepanov, Andre L. B. Ambrosio, Shaila Rahman, Tom Ellenberger, and Alan Engelman
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17308–17313. Published online 2005 October 31. doi: 10.1073/pnas.0506924102.
PMCID: PMC1297672
Fcp1 directly recognizes the C-terminal domain (CTD) and interacts with a site on RNA polymerase II distinct from the CTD
Man-Hee Suh, Ping Ye, Mincheng Zhang, Stéphane Hausmann, Stewart Shuman, Averell L. Gnatt, and Jianhua Fu
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17314–17319. Published online 2005 November 21. doi: 10.1073/pnas.0507987102.
PMCID: PMC1297677
Structure of a nonheme globin in environmental stress signaling
James W. Murray, Olivier Delumeau, and Richard J. Lewis
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17320–17325. Published online 2005 November 21. doi: 10.1073/pnas.0506599102.
PMCID: PMC1297668
Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae
Mohammed A. S. Khan, P. Boon Chock, and Earl R. Stadtman
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17326–17331. Published online 2005 November 21. doi: 10.1073/pnas.0508120102.
PMCID: PMC1287485
Cell-free cloning using [var phi]29 DNA polymerase
Clyde A. Hutchison, III, Hamilton O. Smith, Cynthia Pfannkoch, and J. Craig Venter
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17332–17336. Published online 2005 November 14. doi: 10.1073/pnas.0508809102.
PMCID: PMC1283157
Oxygen isotopes indicate most intracellular water in log-phase Escherichia coli is derived from metabolism
Helen W. Kreuzer-Martin, James R. Ehleringer, and Eric L. Hegg
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17337–17341. Published online 2005 November 21. doi: 10.1073/pnas.0506531102.
PMCID: PMC1297667
Biophysics
3D structure of Alzheimer's amyloid-β(1–42) fibrils
Thorsten Lührs, Christiane Ritter, Marc Adrian, Dominique Riek-Loher, Bernd Bohrmann, Heinz Döbeli, David Schubert, and Roland Riek
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17342–17347. Published online 2005 November 17. doi: 10.1073/pnas.0506723102.
PMCID: PMC1297669
Probing structural heterogeneities and fluctuations of nucleic acids and denatured proteins
Ted A. Laurence, Xiangxu Kong, Marcus Jäger, and Shimon Weiss
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17348–17353. Published online 2005 November 15. doi: 10.1073/pnas.0508584102.
PMCID: PMC1297681
An allosteric model for heterogeneous receptor complexes: Understanding bacterial chemotaxis responses to multiple stimuli
Bernardo A. Mello and Yuhai Tu
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17354–17359. Published online 2005 November 17. doi: 10.1073/pnas.0506961102.
PMCID: PMC1297673
Cell Biology
Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes
Alla Grishok and Phillip A. Sharp
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17360–17365. Published online 2005 November 15. doi: 10.1073/pnas.0508989102.
PMCID: PMC1297700
The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8
Haitong Hou, Kanagaraj Subramanian, Tracy J. LaGrassa, Daniel Markgraf, Lars E. P. Dietrich, Jörg Urban, Nadine Decker, and Christian Ungermann
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17366–17371. Published online 2005 November 21. doi: 10.1073/pnas.0508885102.
PMCID: PMC1297695
Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins
Karl B. Shpargel and A. Gregory Matera
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17372–17377. Published online 2005 November 21. doi: 10.1073/pnas.0508947102.
PMCID: PMC1297697
Developmental Biology
β-Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells
Weijun Pan, Yingying Jia, Jiyong Wang, Donglei Tao, Xiaoqing Gan, Leonidas Tsiokas, Naihe Jing, Dianqing Wu, and Lin Li
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17378–17383. Published online 2005 November 21. doi: 10.1073/pnas.0505922102.
PMCID: PMC1297664
Environmental Sciences
Climatic unpredictability and parasitism of caterpillars: Implications of global warming
J. O. Stireman, III, L. A. Dyer, D. H. Janzen, M. S. Singer, J. T. Lill, R. J. Marquis, R. E. Ricklefs, G. L. Gentry, W. Hallwachs, P. D. Coley, J. A. Barone, H. F. Greeney, H. Connahs, P. Barbosa, H. C. Morais, and I. R. Diniz
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17384–17387. Published online 2005 November 17. doi: 10.1073/pnas.0508839102.
PMCID: PMC1283988
Evolution
“Clonal” population structure of the malaria agent Plasmodium falciparum in high-infection regions
F. G. Razakandrainibe, P. Durand, J. C. Koella, T. De Meeüs, F. Rousset, F. J. Ayala, and F. Renaud
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17388–17393. Published online 2005 November 21. doi: 10.1073/pnas.0508871102.
PMCID: PMC1297693
Coevolution of generalist feeding ecologies and gyrencephalic mushroom bodies in insects
Sarah M. Farris and Nathan S. Roberts
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17394–17399. Published online 2005 November 17. doi: 10.1073/pnas.0508430102.
PMCID: PMC1297680
Genetics
Identifying the conserved network of cis-regulatory sites of a eukaryotic genome
Ting Wang and Gary D. Stormo
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17400–17405. Published online 2005 November 21. doi: 10.1073/pnas.0505147102.
PMCID: PMC1297658
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
Philippe Clément-Lacroix, Minrong Ai, Frederic Morvan, Sergio Roman-Roman, Béatrice Vayssière, Cecille Belleville, Kenneth Estrera, Matthew L. Warman, Roland Baron, and Georges Rawadi
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17406–17411. Published online 2005 November 17. doi: 10.1073/pnas.0505259102.
PMCID: PMC1297659
Immunology
Visualization of a primary anti-tumor immune response by positron emission tomography
Chengyi J. Shu, Shuling Guo, Young J. Kim, Stephanie M. Shelly, Amar Nijagal, Pritha Ray, Sanjiv S. Gambhir, Caius G. Radu, and Owen N. Witte
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17412–17417. Published online 2005 November 17. doi: 10.1073/pnas.0508698102.
PMCID: PMC1283986
CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity
Leigh A. Stephens, David Gray, and Stephen M. Anderton
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17418–17423. Published online 2005 November 15. doi: 10.1073/pnas.0507454102.
PMCID: PMC1297676
Medical Sciences
The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues
Alexandre Havt, Andrew V. Schally, Gabor Halmos, Jozsef L. Varga, Gabor L. Toller, Judit E. Horvath, Karoly Szepeshazi, Frank Köster, Kevin Kovitz, Kate Groot, Marta Zarandi, and Celia A. Kanashiro
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17424–17429. Published online 2005 November 18. doi: 10.1073/pnas.0506844102.
PMCID: PMC1297670
Self renewal, expansion, and transfection of rat spermatogonial stem cells in culture
F. Kent Hamra, Karen M. Chapman, Derek M. Nguyen, Ashley A. Williams-Stephens, Robert E. Hammer, and David L. Garbers
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17430–17435. Published online 2005 November 17. doi: 10.1073/pnas.0508780102.
PMCID: PMC1283987
Transformation of breast cells by truncated neurokinin-1 receptor is secondary to activation by preprotachykinin-A peptides
Hiral J. Patel, Shakti H. Ramkissoon, Prem S. Patel, and Pranela Rameshwar
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17436–17441. Published online 2005 November 16. doi: 10.1073/pnas.0506351102.
PMCID: PMC1297665
Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
Adam M. Hawkridge, Denise M. Heublein, H. Robert Bergen, III, Alessandro Cataliotti, John C. Burnett, Jr., and David C. Muddiman
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17442–17447. Published online 2005 November 17. doi: 10.1073/pnas.0508782102.
PMCID: PMC1297688
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors
Katerina V. Gurova, Jason E. Hill, Canhui Guo, Anatoly Prokvolit, Lyudmila G. Burdelya, Eugenia Samoylova, Anna V. Khodyakova, Ram Ganapathi, Mahrukh Ganapathi, Natalia D. Tararova, Dmitry Bosykh, Dmitriy Lvovskiy, Thomas R. Webb, George R. Stark, and Andrei V. Gudkov
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17448–17453. Published online 2005 November 15. doi: 10.1073/pnas.0508888102.
PMCID: PMC1297696
Microbiology
Transcriptome profiling of bacterial responses to root exudates identifies genes involved in microbe-plant interactions
G. Louise Mark, J. Maxwell Dow, Patrick D. Kiely, Hazel Higgins, Jill Haynes, Christine Baysse, Abdelhamid Abbas, Tara Foley, Ashley Franks, John Morrissey, and Fergal O'Gara
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17454–17459. Published online 2005 November 21. doi: 10.1073/pnas.0506407102.
PMCID: PMC1297666
Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid
Brian K. Coombes, Mark E. Wickham, Michael J. Lowden, Nat F. Brown, and B. Brett Finlay
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17460–17465. Published online 2005 November 21. doi: 10.1073/pnas.0505401102.
PMCID: PMC1297660
Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2
Adnan Hasona, Paula J. Crowley, Celine M. Levesque, Richard W. Mair, Dennis G. Cvitkovitch, Arnold S. Bleiweis, and L. Jeannine Brady
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17466–17471. Published online 2005 November 17. doi: 10.1073/pnas.0508778102.
PMCID: PMC1297686
The genome sequence of Clostridium botulinum type C neurotoxin-converting phage and the molecular mechanisms of unstable lysogeny
Yoshihiko Sakaguchi, Tetsuya Hayashi, Ken Kurokawa, Keisuke Nakayama, Kenshiro Oshima, Yukako Fujinaga, Makoto Ohnishi, Eiichi Ohtsubo, Masahira Hattori, and Keiji Oguma
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17472–17477. Published online 2005 November 15. doi: 10.1073/pnas.0505503102.
PMCID: PMC1283531
Neuroscience
Experience induces structural and biochemical changes in the adult primate brain
Yevgenia Kozorovitskiy, Charles G. Gross, Catherine Kopil, Lisa Battaglia, Meghan McBreen, Alexis M. Stranahan, and Elizabeth Gould
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17478–17482. Published online 2005 November 18. doi: 10.1073/pnas.0508817102.
PMCID: PMC1297690
Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor
Ana Ledo, Rui M. Barbosa, Greg A. Gerhardt, Enrique Cadenas, and João Laranjinha
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17483–17488. Published online 2005 November 17. doi: 10.1073/pnas.0503624102.
PMCID: PMC1297656
From the Cover:
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299
Chad J. Swanson, Thomas P. Blackburn, Xuexiang Zhang, Kang Zheng, Zhi-Qing David Xu, Tomas Hökfelt, Toni D. Wolinsky, Michael J. Konkel, Heidi Chen, Huailing Zhong, Mary W. Walker, Douglas A. Craig, Christophe P. G. Gerald, and Theresa A. Branchek
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17489–17494. Published online 2005 November 15. doi: 10.1073/pnas.0508970102.
PMCID: PMC1283534
Pharmacology
From the Cover:
Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation
Wen Guo, Lei Shi, Marta Filizola, Harel Weinstein, and Jonathan A. Javitch
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17495–17500. Published online 2005 November 21. doi: 10.1073/pnas.0508950102.
PMCID: PMC1287488
Leukotriene B4 signaling through NF-κB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia
Magnus Bäck, De-xiu Bu, Robert Bränström, Yuri Sheikine, Zhong-Qun Yan, and Göran K. Hansson
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17501–17506. Published online 2005 November 17. doi: 10.1073/pnas.0505845102.
PMCID: PMC1297663
Physiology
The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption
Bram C. J. van der Eerden, Joost G. J. Hoenderop, Teun J. de Vries, Ton Schoenmaker, Cok J. Buurman, André G. Uitterlinden, Huibert A. P. Pols, René J. M. Bindels, and Johannes P. T. M. van Leeuwen
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17507–17512. Published online 2005 November 16. doi: 10.1073/pnas.0505789102.
PMCID: PMC1297662
Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation
Celso Caruso-Neves, Sang-Ho Kwon, and William B. Guggino
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17513–17518. Published online 2005 November 17. doi: 10.1073/pnas.0507255102.
PMCID: PMC1297674
Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction
Gang Zhi, Jeffrey W. Ryder, Jian Huang, Peiguo Ding, Yue Chen, Yingming Zhao, Kristine E. Kamm, and James T. Stull
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17519–17524. Published online 2005 November 18. doi: 10.1073/pnas.0506846102.
PMCID: PMC1297671
Plant Biology
From the Cover:
A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses
Hidenori Takagi, Takachika Hiroi, Lijun Yang, Yoshifumi Tada, Yoshikazu Yuki, Kaoru Takamura, Ryotaro Ishimitsu, Hideyuki Kawauchi, Hiroshi Kiyono, and Fumio Takaiwa
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17525–17530. Published online 2005 November 8. doi: 10.1073/pnas.0503428102.
PMCID: PMC1297655
MINISEED3 (MINI3), a WRKY family gene, and HAIKU2 (IKU2), a leucine-rich repeat (LRR) KINASE gene, are regulators of seed size in Arabidopsis
Ming Luo, Elizabeth S. Dennis, Frederic Berger, William James Peacock, and Abed Chaudhury
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17531–17536. Published online 2005 November 17. doi: 10.1073/pnas.0508418102.
PMCID: PMC1297679
Social Sciences
Anthropology
From the Cover:
Burning down the brewery: Establishing and evacuating an ancient imperial colony at Cerro Baúl, Peru
Michael E. Moseley, Donna J. Nash, Patrick Ryan Williams, Susan D. deFrance, Ana Miranda, and Mario Ruales
Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17264–17271. Published online 2005 November 17. doi: 10.1073/pnas.0508673102.
PMCID: PMC1297684
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