| | Editorial PLoS Medicine Barbara Cohen PMCID: PMC340963 Synopses Gene Expression Signature of a Fibroblast Serum Response Predicts Cancer Progression PMCID: PMC314301 T-Cell Differentiation and Progression of HIV Infection PMCID: PMC340946 Mutation Rates and Gene Location: Some Like It Hot PMCID: PMC340953 Engineering Bacteria to Make “Unnatural” Natural Drugs PMCID: PMC340957 Activating p53 in Cancer Cells with Protein Therapy Shows Preclinical Promise PMCID: PMC340958 A New Breast Cancer Model PMCID: PMC340959 When Monkeys Learn Directional Tasks, Neurons Learn Too PMCID: PMC340960 Diverse Signals Establish the Left-Right Body Axis PMCID: PMC340961 Learning to Discern Images Modifies Neural Activity PMCID: PMC340962 Comparing the Networks that Power Bacterial Chemotaxis PMCID: PMC340964 Essay A New Trade Framework for Global Healthcare R&D Tim Hubbard and James Love PMCID: PMC340954 Features New Antibiotics—Resistance Is Futile Tabitha M Powledge PMCID: PMC340955 PLoS Biol. 2004 February; 2(2): e54. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020054.PMCID: PMC340956 Unsolved Mystery What Causes Stuttering? Christian Büchel and Martin Sommer PMCID: PMC340949 Book Review/Science in the Media Dissecting the Urge to Create Nancy C Andreasen PMCID: PMC340950 Journal Club Tumour Suppressor Genes—One Hit Can Be Enough Peter Hohenstein PMCID: PMC340945 Primer Cracking the Polyketide Code David A Hopwood PMCID: PMC340943 Community Page Bridging the Science–Policy Divide Walter V Reid PMCID: PMC340939 Quality Information for Improved Health Patricia L Thibodeau and Carla J Funk PMCID: PMC340951 Research Articles Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds Howard Y Chang, Julie B Sneddon, Ash A Alizadeh, Ruchira Sood, Rob B West, Kelli Montgomery, Jen-Tsan Chi, Matt van de Rijn, David Botstein, and Patrick O Brown PMCID: PMC314300 Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection Laura Papagno, Celsa A Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J McMichael, Douglas D Richman, Sarah L Rowland-Jones, and Victor Appay PMCID: PMC340937 pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia Karl Simin, Hua Wu, Lucy Lu, Dan Pinkel, Donna Albertson, Robert D Cardiff, and Terry Van Dyke PMCID: PMC340938 Functional Bias and Spatial Organization of Genes in Mutational Hot and Cold Regions in the Human Genome Jeffrey H Chuang and Hao Li PMCID: PMC340940 Lefty Blocks a Subset of TGFβ Signals by Antagonizing EGF-CFC Coreceptors Simon K Cheng, Felix Olale, Ali H Brivanlou, and Alexander F Schier PMCID: PMC340941 Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases Yi Tang, Taek Soon Lee, and Chaitan Khosla PMCID: PMC340942 Treatment of Terminal Peritoneal Carcinomatosis by a Transducible p53-Activating Peptide Eric L Snyder, Bryan R Meade, Cheryl C Saenz, and Steven F Dowdy PMCID: PMC340944 The Effect of Learning on the Function of Monkey Extrastriate Visual Cortex Gregor Rainer, Han Lee, and Nikos K Logothetis PMCID: PMC340947 Learning-Induced Improvement in Encoding and Decoding of Specific Movement Directions by Neurons in the Primary Motor Cortex Rony Paz and Eilon Vaadia PMCID: PMC340948 Design and Diversity in Bacterial Chemotaxis: A Comparative Study in Escherichia coli and Bacillus subtilis Christopher V Rao, John R Kirby, and Adam P Arkin PMCID: PMC340952 |
