A Year of Progress

Conformational stability of dimeric proteins: quantitative studies by equilibrium denaturation.

Thermodynamic characterization of an equilibrium folding intermediate of staphylococcal nuclease.

Six new candidate members of the alpha/beta twisted open-sheet family detected by sequence similarity to flavodoxin.

Cavities and packing at protein interfaces.

A revised set of potentials for beta-turn formation in proteins.

Contributions of a hydrogen bond/salt bridge network to the stability of secondary and tertiary structure in lambda repressor.

Hydrogen exchange in BPTI variants that do not share a common disulfide bond.

Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV.

Crystal structure of p-hydroxybenzoate hydroxylase reconstituted with the modified FAD present in alcohol oxidase from methylotrophic yeasts: evidence for an arabinoflavin.

The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.

On the nature of the unfolded intermediate in the in vitro transition of the colicin E1 channel domain from the aqueous to the membrane phase.

Structure-function analysis of human IL-6: identification of two distinct regions that are important for receptor binding.

Ligand-induced conformational changes in the lactose permease of Escherichia coli: evidence for two binding sites.

The role of transmembrane domain III in the lactose permease of Escherichia coli.

Two domains of interaction with calcium binding proteins can be mapped using fragments of calponin.

The structures of RNase A complexed with 3'-CMP and d(CpA): active site conformation and conserved water molecules.

Conserved sequence features of inteins (protein introns) and their use in identifying new inteins and related proteins.

Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting.

Determinants of protein side-chain packing.

Residue-residue contact substitution probabilities derived from aligned three-dimensional structures and the identification of common folds.

Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP).

Conservation of polyproline II helices in homologous proteins: implications for structure prediction by model building.

Mass spectrometric measurement of protein amide hydrogen exchange rates of apo- and holo-myoglobin.

Disulfide crosslinks to probe the structure and flexibility of a designed four-helix bundle protein.

Topographic study of arrestin using differential chemical modifications and hydrogen/deuterium exchange.

High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target.

Crystallization and preliminary X-ray analysis of glucose-fructose oxidoreductase from Zymomonas mobilis.

Crystallization and preliminary X-ray crystallographic analysis of the 38-kDa immunodominant antigen of Mycobacterium tuberculosis.

High mobility group protein, HMG-1, contains insignificant glycosyl modification.

The subunit interfaces of oligomeric enzymes are conserved to a similar extent to the overall protein sequences.

Reaction mechanisms, catalysis, and movement.

Dorothy Crowfoot Hodgkin (1910-1994).