| Agent Name |
Chlorobromomethane |
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| Alternative Name |
Bromochloromethane |
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| CAS Number |
74-97-5 |
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| Formula |
C-H2-Br-Cl |
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| Major Category |
Solvents |
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| Synonyms |
Bromochloromethane; Chloromethyl bromide; Fluorocarbon 1011; Halon 1011; Methane, bromochloro-; Methylene chlorobromide; Mil-B-4394-B; Mono-chloro-mono-bromo-methane; [ChemIDplus] UN1887 |
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| Category |
Chlorofluorocarbons |
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| Description |
Colorless to pale-yellow liquid with a chloroform-like odo; Note: May be used as a fire extinguishing agen; [NIOSH] |
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| Sources/Uses |
Used in fire extinguishers; [ACGIH] |
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| Comments |
In animal studies, causes reversible liver injury, narcosis, and anesthesia; Fire fighters exposed to high concentrations lost consciousness. [ACGIH] |
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| Restricted |
See CHLOROFLUOROCARBONS |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
200 ppm |
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| PEL (OSHA) |
200 ppm |
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| IDLH (NIOSH) |
2000 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: Patty [1963] reported that light narcosis could be produced in animals at 3,000 ppm, and pulmonary edema and deaths during exposure at 27,000 ppm; delayed deaths occurred after exposure to 20,000 ppm [Comstock et al. 1953]. Patty [1963] also reported that guinea pigs survived 1�hour exposures but 1 of 3 guinea pigs died after 2�hour exposures to 8,000 to 10,000 ppm [Matson and Dufour 1948]. . . . Basis for revised IDLH: The revised IDLH for chlorobromomethane is 2,000 ppm based on acute inhalation toxicity data in animals [Comstock et al. 1952; Comstock and Oberst 1953; Matson and Dufour 1948]. This may be a conservative value due to the lack of relevant acute toxicity data for workers. |
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| Vapor Pressure |
142 mm Hg |
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| Odor Threshold Low |
397 ppm |
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| Lethal Concentration |
LCLo (rats) = 28,800 ppm/15 min |
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| Explanatory Notes |
Odor threshold from ACGIH; |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: CHLOROBROMOMETHANE
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