| Agent Name |
Propylene glycol monomethyl ether |
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| Alternative Name |
1-Methoxy-2-propanol |
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| CAS Number |
107-98-2 |
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| Formula |
C4-H10-O2 |
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| Major Category |
Solvents |
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| Synonyms |
1-Methoxy-2-hydroxypropane; 1-Methoxy-2-propanol; 2-Methoxy-1-methylethanol; 2-Propanol, 1-methoxy-; Closol; Dowanol 33B; Dowtherm 209; Methyl proxitol; PGME; Poly-Solve MPM; Propasol solvent M; Ucar Solvent LM (Obs.); [ChemIDplus] UN3092 |
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| Category |
Glycol Ethers |
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| Description |
Clear, colorless liquid with a mild, ethereal odor; [NIOSH] |
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| Sources/Uses |
Used as a solvent; [ACGIH] Used to make lacquers and paints, as a solvent for resins, celluloses, acrylics, dyes, and inks (gravure, flexographic and silk screening), as antifreeze, and in household cleaners and spot removers; [HSDB] |
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| Comments |
Rats inhaling 3000 ppm, 6 hours/day for 9 days, show signs of sedation, but tissue examination shows no evidence of gross or microscopic disease. Human volunteers experienced lacrimation at concentrations above 100 ppm. Anesthesia was produced at concentrations above 1000 ppm. [ACGIH] A lachrymator; [CHEMINFO] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] See "Glycol ethers." |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
100 ppm |
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| STEL (ACGIH) |
150 ppm |
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| MAK |
100 ppm |
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| Vapor Pressure |
12.5 mm Hg |
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| Odor Threshold Low |
10 ppm |
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| Odor Threshold High |
100 ppm |
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| Lethal Concentration |
LC50 (rats) = 10,000 ppm/5h |
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| Explanatory Notes |
Odor threshold from CHEMINFO, low (detection), high (objectionable); Flash point = 32 deg C; |
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| Reference Link |
International Chemical Safety Cards |
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| Flammability (NFPA) |
3: may ignite at ambient temperature |
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| Adverse Effects |
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| Lacrimator |
Yes |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Nephrotoxin |
Yes |
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| Reproductive Toxin |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1-METHOXY-2-HYDROXYPROPANE
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