| Agent Name |
Piperazine dihydrochloride |
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| CAS Number |
142-64-3 |
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| Formula |
C4-H10-N2.2Cl-H |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
Diethylenediamine dihydrochloride; Dihydro Pip Wormer; Dihydrochloride salt of diethylenediamine; Dowzene DHC; Piperazine dihydrochloride; Piperazine wormer premix; [ChemIDplus] |
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| Category |
Amines, Heterocyclic |
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| Description |
White to cream-colored needles or powder; [NIOSH] |
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| Sources/Uses |
Used to manufacture fibers, pharmaceuticals, and insecticides; [ACGIH] Used as a veterinary antihelmintic medication and a curing agent for polychloroprene; [HSDB] |
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| Comments |
Piperazine dihydrochloride is well tolerated as an oral medication at a dose of 150 mg/kg for several days. Skin burns, allergic contact dermatitis, and asthma have been reported after occupational exposures to piperazine dust. [ACGIH] Piperazine, CAS # 110-85-0, is corrosive to skin. [Quick CPC] Asthma reported in pharmaceutical and chemical production workers; [Malo] Allergic contact dermatitis reported in pharmaceutical, laboratory, healthcare, and veterinary workers; [Kanerva, p. 1167] |
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| Reference Link |
Piperazine-induced occupational asthma |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
5 mg/m3 |
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| Adverse Effects |
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| Asthma |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: PIPERAZINE HYDROCHLORIDE
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