| Agent Name |
Phosphorus oxychloride |
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| CAS Number |
10025-87-3 |
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| Formula |
Cl3-O-P |
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| Major Category |
Toxic Gases & Vapors |
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| Synonyms |
Fosforoxychlorid [Czech]; Oxychlorid fosforecny [Czech]; Phosphoric trichloride; Phosphoroxychloride; Phosphorus chloride oxide (POCl3); Phosphorus oxide trichloride; Phosphorus oxychloride; Phosphorus oxytrichloride; Phosphoryl chloride; Phosphoryl trichloride; Trichlorophosphine oxide; Trichlorophosphorus oxide; [ChemIDplus] UN1810 |
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| Category |
Acid Halides |
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| Description |
Clear, colorless to yellow, oily liquid with a pungent & musty odor. [Note: A solid below 34 degrees F.]; [NIOSH] |
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| Sources/Uses |
Used in chemical synthesis as a chlorinating agent and catalyst and to produce plasticizers, hydraulic fluids, gasoline additives, and fire retardants; [ACGIH] |
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| Comments |
Liquid causes second or third degree burns after short contact; [CHRIS] Highly corrosive to skin; [Quick CPC] Mucous membrane irritation, bronchitis, pulmonary edema, and nephritis have been reported after occupational exposure. [ACGIH] Liver injury in animals in a chronic study; [Desai, H. Phosphorus and Phosphorus Compounds. In: Sullivan J, Krieger G (eds). Hazardous Materials Toxicology.Baltimore:Williams & Wilkins,1992;939] A corrosive substance that can cause pulmonary edema; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TIH |
Yes |
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| TLV (ACGIH) |
0.1 ppm |
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| MAK |
0.2 ppm |
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| Lethal Concentration |
LC50 (rats) = 32 ppm/4h |
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| Explanatory Notes |
VP = 40 mmHg @ 81 deg F; [Sax] |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
0: will not burn |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Nephrotoxin |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: PHOSPHORUS OXYCHLORIDE
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