| Agent Name |
Perchloryl fluoride |
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| CAS Number |
7616-94-6 |
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| Formula |
Cl-F-O3 |
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| Major Category |
Toxic Gases & Vapors |
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| Synonyms |
Chlorine fluoride oxide; Chlorine fluoride oxide (ClO3F); Chlorine oxyfluoride; Chloryl (per-)fluoride; Perchloryl fluoride; [ChemIDplus] UN3083 |
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| Category |
Oxidizers |
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| Description |
Colorless gas with a characteristic, sweet odor. [Note: Shipped as a liquefied compressed gas.]; [NIOSH] |
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| Sources/Uses |
Used as "a fluorinating agent in chemical syntheses and as a liquid oxidant in rocket fuels." [ACGIH] |
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| Comments |
In acute animal studies, methemoglobinemia, as high as 71%, is the prominent effect from exposure to the vapor. In subchronic inhalation studies, methemoglobinemia, fluorosis, liver and kidney injury, and pulmonary edema are observed. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Possible frostbite from contact with liquid; [NIOSH] May cause respiratory tract irritation and pulmonary edema; Can induce methemoglobinemia; May cause fluorosis; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TIH |
Yes |
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| TLV (ACGIH) |
3 ppm |
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| STEL (ACGIH) |
6 ppm |
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| PEL (OSHA) |
3 ppm |
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| IDLH (NIOSH) |
100 ppm |
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| Excerpts from Documentation for IDLHs |
"Dogs, rats, and mice exposed to perchloryl fluoride vapor developed methemoglobinemia. Dogs exposed to the vapor at 220 to 450 ppm for 4 hours and at 620 ppm for 2.5 hours were cyanotic and hyperpneic; methemoglobin values ranged from 29% to 71%. In dogs that died due to inhaled perchloryl fluoride, there were areas of pigment deposition in the liver, spleen, and bone marrow; areas of alveolar hemorrhage, alveolar collapse, and emphysema were also noted." [ACGIH] ?NIOSH vs ACGIH |
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| Odor Threshold Low |
10 ppm |
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| Lethal Concentration |
LC50 (rats) = 385 ppm/4H |
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| Explanatory Notes |
Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: TRIOXYCHLOROFLUORIDE
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