| Agent Name |
Acrylamide |
|---|
| CAS Number |
79-06-1 |
|---|
| Formula |
C3-H5-N-O |
|---|
| Major Category |
Plastics & Rubber |
|---|
| Synonyms |
Acrylamide monomer; Acrylic amide; Propenamide; 2-Propenamide; [NIOSH] |
|---|
| Category |
Other Monomers |
|---|
| Description |
White crystalline, odorless solid; [NIOSH] |
|---|
| Sources/Uses |
Used as a polymer or copolymer to produce sealants, adhesives, fibers, paper sizing, molded parts, water coagulants, and textiles. [ACGIH] |
|---|
| Comments |
Can cause sensorimotor neuropathy after occupational exposure; [ACGIH] Allergic contact dermatitis reported in laboratory workers using polyacrylamide gels for electrophoresis; [Kanerva, p. 1125] In high-dose reproductive studies of animals, acrylamide can cause testicular damage and increased fetal losses; exposed fetuses may suffer neurotoxic effects. [Frazier, p. 333-4] |
|---|
| Reference Link |
OSHA: Acrylamide Exposure During Chemical Grouting Operations |
|---|
| Exposure Assessment |
|---|
| Skin Designation (ACGIH) |
Yes |
|---|
| TLV (ACGIH) |
0.03 mg/m3, inhalable fraction and vapor |
|---|
| PEL (OSHA) |
0.3 mg/m3 |
|---|
| IDLH (NIOSH) |
60 mg/m3 |
|---|
| Excerpts from Documentation for IDLHs |
Calculations based on an oral LD50 of 150 to 180 mg/kg for guinea pigs, rabbits, and rats [McCollister et al. 1964] indicate that a worker should be able to escape within 30 minutes without injury or irreversible health effects from 600 mg/m3. . . . the revised IDLH for acrylamide is 60 mg/m3 based on being 2,000 times the OSHA PEL of 0.03 mg/m3 that was promulgated in 1989 (2,000 is an assigned protection factor for respirators; only the most reliable respirators are recommended above 2,000 times the OSHA PEL). [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for acrylamide at concentrations above 0.03 mg/m3.] |
|---|
| Vapor Pressure |
0.007 mm Hg |
|---|
| Half Life |
Plasma (animal studies): 2 days; whole body (animal studies): 6-18 days; [TDR, p. 40] |
|---|
| Reference Link |
HSDB: Acrylamide |
|---|
| Flammability (NFPA) |
2: high ambient temperature required |
|---|
| Adverse Effects |
|---|
| Skin Sensitizer |
Yes |
|---|
| Neurotoxin |
Sensorimotor Neuropathy |
|---|
| Reproductive Toxin |
Yes |
|---|
| IARC Carcinogen |
Probable Carcinogen |
|---|
| Links to Other NLM Databases |
|---|
| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ACRYLAMIDE
|
|---|
|
|
