| Agent Name |
Dimethyl acetamide |
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| Alternative Name |
N,N-Dimethylacetamide |
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| CAS Number |
127-19-5 |
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| Formula |
C4-H9-N-O |
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| Major Category |
Solvents |
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| Synonyms |
Acetamide, N,N-dimethyl-; Acetdimethylamide; Acetic acid, dimethylamide; Acetyldimethylamine; CBC 510337; DMA; DMAc; Dimethylacetamide; Dimethylacetone amide; Dimethylamid kyseliny octove [Czech]; Dimethylamide acetate; N,N-Dimethylacetamide; N,N-Dimethylethanamide; SK 7176; U-5954; [ChemIDplus] UN1993 |
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| Category |
Amides |
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| Description |
Colorless liquid with a weak, ammonia- or fish-like odor; [NIOSH] |
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| Sources/Uses |
Used as a solvent for many different purposes; [ACGIH] Used as a solvent in plastics, resins, and gums; Also used as a catalyst and paint remover; [Hawley] Used in synthetic fiber and resin industries; Used as a solvent in elastane fiber factories; [Reference #1] |
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| Comments |
Toxic hepatitis has been reported in workers after inhalation and dermal exposure. DMA is embryotoxic when administered at high doses to female rats by dermal or oral routes. [ACGIH] A skin and eye irritant; Inhalation of high concentrations may cause liver and CNS effects; [ICSC] In a study of 440 new elastone fiber workers, 28 cases with elevated liver enzymes were detected in a 31 month period from 2002 to 2004. Using the BEI of 30 mg/g creatinine as a cutoff, the incidence of hepatic injury was about 7 times greater in the high exposure group. [Reference #1] |
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| Reference Link |
Incidence of dimethylacetamide induced hepatic inj...[Occup Environ Med. 2006] - PubMed Result |
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| Exposure Assessment |
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| BEI |
M-Methylacetamide in urine = 30 mg/g creatinine; end of shift at end of workweek; |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
10 ppm |
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| PEL (OSHA) |
10 ppm |
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| MAK |
10 ppm |
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| IDLH (NIOSH) |
300 ppm |
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| Excerpts from Documentation for IDLHs |
The chosen IDLH is based on the statement by Deichmann and Gerarde [1969] that acute inhalation at 406 and 575 ppm causes some deaths and degeneration of the liver in several species of laboratory animals. Although no time period is specified for that exposure, the chosen IDLH is probably reasonable, and perhaps even conservative, because Patty [1963] reported that liver injury was noted only in some rats and dogs exposed to repeated inhalation at 100 to 200 ppm [Horn]. |
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| Vapor Pressure |
2 mm Hg |
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| Odor Threshold Low |
21 ppm |
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| Odor Threshold High |
47 ppm |
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| Lethal Concentration |
LC50 (rats) = 2,475 ppm/1H |
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| Explanatory Notes |
Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; Flash point = 70 deg C; |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Primary |
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| Reproductive Toxin |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: N,N-DIMETHYLACETAMIDE
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