| Agent Name |
1,2,3-Trichloropropane |
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| CAS Number |
96-18-4 |
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| Formula |
C3-H5-Cl3 |
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| Major Category |
Solvents |
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| Synonyms |
1,2,3-Trichloropropane; Allyl trichloride; Glycerol trichlorohydrin; Glyceryl trichlorohydrin; Trichlorohydrin; Trichloropropane; [ChemIDplus] UN2810 |
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| Category |
Chlorinated Aliphatic |
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| Description |
Colorless liquid with a chloroform-like odor; [NIOSH] |
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| Sources/Uses |
Used as a curing agent for polysulfides and a chemical intermediate; [ACGIH] Used as a degreaser, paint remover, and solvent for resins, waxes, and oils; [HSDB] |
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| Comments |
Exposure at 500 ppm for four hours induces elevated liver enzymes in rats and mice. Workers complained of unpleasant odor and irritation of the eyes and throat at 100 ppm. [ACGIH] A skin, eye, and respiratory tract irritant; May cause liver and kidney injury; Inhalation of high concentrations can cause CNS depression; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
10 ppm |
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| PEL (OSHA) |
50 ppm |
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| IDLH (NIOSH) |
100 ppm |
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| Excerpts from Documentation for IDLHs |
It has been reported that objectionable ocular and mucosal irritation were experienced after 15 minutes of exposure to 100 ppm [Silverman et al. 1946]. |
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| Vapor Pressure |
3 mm Hg |
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| Odor Threshold Low |
100 ppm |
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| Lethal Concentration |
LCLo (rats) = 500 ppm/4H |
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| Explanatory Notes |
Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; Flash point = 180 deg F; |
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| Half Life |
Animal studies (whole body): 1 day; [TDR, p. 1194] |
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| Reference Link |
ATSDR - ToxFAQs - 1,2,3-Trichloropropane |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Nephrotoxin |
Yes |
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| IARC Carcinogen |
Probable Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,2,3-TRICHLOROPROPANE
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