| Disease/Syndrome |
Cytomegalovirus infection |
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| Category |
Infection, Occupational |
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| Acute/Chronic |
Subacute |
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| Synonyms |
CMV infection, Cytomegalic inclusion disease |
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| Biomedical References |
Search PubMed |
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| Comments |
About 5%-10% infants infected in utero will develop the most severe form of this disease. Neonatal CMV infection damages the central nervous system; survivors have mental retardation and chronic liver disease. CMV infection in adults may be inapparent or cause a mononucleosis-like disease. CMV causes up to 10% of mononucleosis cases in young adults. CMV is transmitted by intimate mucosal exposure, by blood transfusion, and by soiled diapers of infants. [CCDM, p. 142-6] Most patients have elevated liver function tests and atypical lymphocytes. Pharyngitis and lymphadenopathy are less common in CMV mononucleosis than in EBV mononucleosis. Leukopenia occurs in infected transplant patients. In the normal host, infrequent to rare complications include leukopenia, Bell's palsy, Guillain-Barre syndrome, interstitial pneumonia, colitis, and encephalitis. [ID, p. 1545] Splenomegaly is not a common feature of CMV mononucleosis. Patients with CMV mononucleosis are older (median age 29 years), and they may have fever for 9-35 days (mean of 19 days). [PPID, p. 1789] Approximately 60% to 90% of adults have antibodies from a previous infection. CMV is a common cause of retinitis and ulcerations of the GI tract in AIDS patients. [Merck Manual, p. 1605] |
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| Latency/Incubation |
3 weeks to 2 months |
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| Diagnostic |
Viral culture; PCR; Antigen detection; IgM antibodies; Paired sera |
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| ICD-9 Code |
078.5 |
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| Reference Link |
CDC - Cytomegalovirus |
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| Related Information in Haz-Map |
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| Symptoms/Findings |
Symptoms/Findings associated with this disease:
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| Job Tasks |
High risk job tasks associated with this disease:
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