Agent Name |
Cyclohexane |
CAS Number |
110-82-7 |
Formula |
C6-H12 |
Major Category |
Solvents |
Synonyms |
Benzene, hexahydro-; Benzenehexahydride; Cicloesano [Italian]; Cyclohexaan [Dutch]; Cyclohexan [German]; Cyclohexane; Cykloheksan [Polish]; Hexahydrobenzene; Hexamethylene; Hexanaphthene; [ChemIDplus] UN1145 |
Category |
Aliphatics, Saturated |
Description |
Colorless liquid with a sweet, chloroform-like odor; Note: A solid below 44 degrees F; [NIOSH] |
Sources/Uses |
Used as a paint remover, solvent for surface coatings, and intermediate for organic synthesis; [ACGIH] |
Comments |
Exposed animals develop narcosis and minimal histopathological liver changes. The odor threshold was found to be 25 ppm and 300 ppm by 2 different investigators. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; [ICSC] |
Exposure Assessment |
Skin Designation (ACGIH) |
No |
TLV (ACGIH) |
100 ppm |
PEL (OSHA) |
300 ppm |
MAK |
200 ppm |
IDLH (NIOSH) |
1300 ppm |
Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: The chosen IDLH is based on a statement by Patty [1963] that 12,600 ppm produced evidence of lethargy, narcosis, increased respiration rate, and convulsions in animals [Treon et al. 1943]. Also, AIHA [1963] reported that 9,300 ppm for 30 minutes resulted in restlessness, impaired coordination, and exhaustion, but no narcosis or deaths in cats, rabbits, and pigs [Flury and Zernik 1931]. . . . Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [Lazarew 1929; Treon et al. 1943], a value of about 3,000 ppm would have been appropriate. However, the revised IDLH for cyclohexane is 1,300 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.3%). |
Vapor Pressure |
96.9 mm Hg |
Odor Threshold Low |
0.52 ppm |
Odor Threshold High |
784 ppm |
Lethal Concentration |
LCLo (mice) = 70,000 mg/m3/2H |
Explanatory Notes |
IDLH = 10% LEL; Detection odor threshold from AIHA (mean = 780 ppm); Flash point = -4 deg F; |
Flammability (NFPA) |
3: may ignite at ambient temperature |
Adverse Effects |
Neurotoxin |
CNS Solvent Syndrome |
Hepatotoxin |
Hepatotoxin, Secondary |
Links to Other NLM Databases |
Health Studies |
Human Health Effects from Hazardous Substances Data Bank: CYCLOHEXANE
|
|
|