| Agent Name |
Chloropicrin |
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| Alternative Name |
Trichloronitromethane |
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| CAS Number |
76-06-2 |
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| Formula |
C-Cl3-N-O2 |
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| Major Category |
Pesticides |
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| Synonyms |
Nitrochloroform; Nitrotrichloromethane; Trichloronitromethane; [NIOSH] |
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| Category |
Fumigants |
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| Description |
Colorless to faint-yellow, oily liquid with an intensely irritating odor. [pesticide] [NIOSH] |
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| Sources/Uses |
Used as a grain, crop, and soil fumigant; also used as an intermediate in organic synthesis and a warning odorant for odorless fumigants and gases; [NIOSH Guidelines for Chemical Hazards] |
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| Comments |
Liquid causes second or third degree burns after short contact; [CHRIS] Volunteers cannot tolerate concentrations of 15 ppm for longer than one minute. Chloropicrin can cause lacrimation, vomiting, and then death from pulmonary edema. Animals in chronic inhalation studies suffer from necrosis of liver, kidney, and muscle tissues. [ACGIH] A lachrymator; [HSDB] |
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| Restricted |
Restricted use as a pesticide; [NIOSH OSH Guidelines] |
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| Reference Link |
EXTOXNET - Chloropicrin |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TIH |
Yes |
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| TLV (ACGIH) |
0.1 ppm |
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| PEL (OSHA) |
0.1 ppm |
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| MAK |
0.1 ppm |
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| IDLH (NIOSH) |
2 ppm |
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| Excerpts from Documentation for IDLHs |
Other human data: It has been reported that 4 ppm for a few seconds renders a worker unfit for activity and that a 10�minute exposure to 7.5 ppm is intolerable [Flury and Zernik 1931]. |
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| Vapor Pressure |
18 mm Hg |
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| Odor Threshold Low |
1.1 ppm |
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| RD50 |
7 ppm |
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| Lethal Concentration |
LC50 (rats) = 14.4 ppm/4 hr |
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| Explanatory Notes |
Odor threshold from CHEMINFO; |
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| Flammability (NFPA) |
0: will not burn |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Lacrimator |
Yes |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: CHLOROPICRIN
|
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