| Agent Name |
Chloroacetyl chloride |
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| CAS Number |
79-04-9 |
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| Formula |
C2-H2-Cl2-O |
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| Major Category |
Toxic Gases & Vapors |
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| Synonyms |
Acetyl chloride, chloro-; Chloracetyl chloride; Chlorid kyseliny chloroctove [Czech]; Chloroacetic acid chloride; Chloroacetic chloride; Chlorure de chloracetyle [French]; Monochloroacetyl chloride; [ChemIDplus] UN1752 |
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| Category |
Acid Halides |
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| Description |
Colorless to yellowish liquid with a strong, pungent odor; [NIOSH] |
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| Sources/Uses |
Used in organic synthesis; [ACGIH] |
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| Comments |
Liquid causes second or third degree burns after short contact; [CHRIS] Corrosive to skin; [Quick CPC] Hydrolysis of chloroacetyl chloride yields chloroacetic acid and hydrogen chloride gas. It causes "clinical and pathologic evidence of respiratory effects" at the lowest concentrations tested in experimental animals; [ACGIH] A lachrymator; [HSDB] A corrosive substance that can cause pulmonary edema; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| TIH |
Yes |
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| TLV (ACGIH) |
0.05 ppm |
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| STEL (ACGIH) |
0.15 ppm |
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| Vapor Pressure |
25.2 mm Hg |
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| Lethal Concentration |
LC50 (rats) = 660 ppm/1h |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
0: will not burn |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Lacrimator |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: CHLOROACETYL CHLORIDE
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