| Agent Name |
Aniline |
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| CAS Number |
62-53-3 |
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| Formula |
C6-H7-N |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
Aminobenzene; Aminophen; Anilin [Czech]; Anilina [Italian, Polish]; Aniline; Aniline oil; Anyvim; Arylamine; Benzenamine; Benzene, amino; Benzidam; Blue Oil; C.I. 76000; C.I. Oxidation Base 1; CI 76000; CI Oxidation Base 1; Cyanol; Huile d'aniline [French]; Krystallin; Kyanol; Phenylamine; [ChemIDplus] UN1547 |
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| Category |
Amines, Aromatic |
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| Description |
Colorless to brown, oily liquid with an aromatic amine-like odor; Note: A solid below 21 degrees F; [NIOSH] |
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| Sources/Uses |
Used in the synthesis of dyes, rubber additives, drugs, photographic chemicals, isocyanates, and pesticides. [ACGIH] Shake-out operators and other foundry workers were exposed to aniline from the decomposition of heated cold-box binders. [Appl Occup Environ Hyg 2001 Jan;16(1):66-77] |
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| Comments |
Skin contamination is the most common route of occupational exposure. Proper plant design and strict industrial hygiene are necessary to prevent spills and clothing contamination. [ILO Encyclo, Aromatic Amino Compounds, p. 104.1-104.416] Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] A severe eye irritant; Mild symptoms of methemoglobinemia have been reported after several hours exposure to 7-53 ppm. [CHEMINFO] |
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| Reference Link |
ATSDR - Medical Management Guidelines |
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| Exposure Assessment |
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| BEI |
Total p-aminophenol in urine = 50 mg/L; sample at end of shift; (See notations in ACGIH TLVs and BEIs.) |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
2 ppm |
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| PEL (OSHA) |
5 ppm |
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| MAK |
2 ppm |
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| IDLH (NIOSH) |
100 ppm |
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| Excerpts from Documentation for IDLHs |
Human data:. Volunteers tolerated 1-hour exposures ranging from 100-160 ppm with only moderate adverse health effects (undefined) [von Oettingen 1941]. It has also been reported that 100 to 160 ppm is the maximum concentration that can be inhaled for 1 hour without serious consequence [Henderson and Haggard 1943] and that 50 to 100 ppm can probably be tolerated for 60 minutes [AIHA 1955]. |
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| Vapor Pressure |
0.6 mm Hg |
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| Odor Threshold Low |
0.58 ppm |
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| Odor Threshold High |
10 ppm |
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| Lethal Concentration |
LCLo (rats) = 250 ppm/4H |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 2.4 ppm); Flash point = 70 deg C; |
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| Half Life |
Whole body: 4 hours; [TDR, p. 100] |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Primary |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ANILINE
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